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More than half of DFUs become infected due to frequent colonization with Staphylococcus aureus. The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. In this study, 13 different phytochemicals\u2014namely chalcone, juglone, cinnamic acid, trigonelline, Furvina\u2014and four nitrovinylfuran derivatives\u2014guaiazulene, \u03b1-bisabolol, farnesol and nerolidol\u2014were selected to be tested as antibiotic enhancers. After minimum inhibitory and bactericidal concentration (MIC and MBC) determination of each molecule against different strains of S. aureus, including clinical isolates from diabetic foot wounds (CECT 976, Xu212, SA 1199B, RN4220, MJMC102, MJMC109, MJMC110 and MJMC111), their potentiation effects on the antibiotics fusidic acid, mupirocin, gentamicin, oxacillin and methicillin were evaluated through the disc diffusion method. Farnesol at sub-MIC was able to restore the activity of methicillin and oxacillin on the MJMC102 and MJMC111 strains, as well as two MRSA clinical isolates, and potentiated the effect of the remaining antibiotics. The results obtained demonstrate the great potential for the topical application of phytochemicals and derivatives as antibiotic resistance modifier agents to combat multidrug resistance in bacterial wound infections.<\/jats:p>","DOI":"10.3390\/antibiotics11050620","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:21:25Z","timestamp":1651652485000},"page":"620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-3276","authenticated-orcid":false,"given":"Diana","family":"Oliveira","sequence":"first","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"ALiCE\u2014Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"CIQUP\u2014Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"},{"name":"DEQ\u2014Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-6805","authenticated-orcid":false,"given":"Anabela","family":"Borges","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"ALiCE\u2014Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"DEQ\u2014Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-4965","authenticated-orcid":false,"given":"Maria J.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"CITAB\u2014Centre for the Research and Technology for Agro-Environment and Biological Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\u2014Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-4398","authenticated-orcid":false,"given":"Manuel","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"ALiCE\u2014Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"},{"name":"DEQ\u2014Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Afonso, A.C., Oliveira, D., Saavedra, M.J., Borges, A., and Sim\u00f5es, M. (2021). Biofilms in diabetic foot ulcers: Impact, risk factors and control strategies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158278"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41572-019-0092-1","article-title":"Diabetic neuropathy","volume":"5","author":"Feldman","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.dsx.2015.04.007","article-title":"Diabetic foot ulcer\u2014A review on pathophysiology, classification and microbial etiology","volume":"9","author":"Noor","year":"2015","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ramirez-Acu\u00f1a, J.M., Cardenas-Cadena, S.A., Marquez-Salas, P.A., Garza-Veloz, I., Perez-Favila, A., Cid-Baez, M.A., Flores-Morales, V., and Martinez-Fierro, M.L. (2019). Diabetic foot ulcers: Current advances in antimicrobial therapies and emerging treatments. Antibiotics, 8.","DOI":"10.3390\/antibiotics8040193"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Matta-Guti\u00e9rrez, G., Garc\u00eda-Morales, E., Garc\u00eda-\u00e1lvarez, Y., \u00c1lvaro-Afonso, F.J., Molines-Barroso, R.J., and L\u00e1zaro-Mart\u00ednez, J.L. (2021). The influence of multidrug-resistant bacteria on clinical outcomes of diabetic foot ulcers: A systematic review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091948"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4066\/AMJ.2015.2422","article-title":"Spectrum of bacteria associated with diabetic foot ulcer and biofilm formation: A prospective study","volume":"8","author":"Banu","year":"2015","journal-title":"Australas. Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Spichler, A., Hurwitz, B.L., Armstrong, D.G., and Lipsky, B.A. (2015). Microbiology of diabetic foot infections: From Louis Pasteur to \u201ccrime scene investigation\u201d. BMC Med., 13.","DOI":"10.1186\/s12916-014-0232-0"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pouget, C., Dunyach-Remy, C., Pantel, A., Schuldiner, S., Sotto, A., and Lavigne, J.P. (2020). Biofilms in diabetic foot ulcers: Significance and clinical relevance. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101580"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Borges, A., Abreu, A.C., Dias, C., Saavedra, M.J., Borges, F., and Sim\u00f5es, M. (2016). New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms. Molecules, 21.","DOI":"10.3390\/molecules21070877"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Mart\u00ednez, F.J., Barraj\u00f3n-Catal\u00e1n, E., and Micol, V. (2020). Tackling antibiotic resistance with compounds of natural origin: A comprehensive review. Biomedicines, 8.","DOI":"10.3390\/biomedicines8100405"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Alsheikh, H.M.A., Sultan, I., Kumar, V., Rather, I.A., Al-sheikh, H., Jan, A.T., and Haq, Q.M.R. (2020). Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080480"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Prakash, B., Kumar, A., Singh, P.P., and Songachan, L.S. (2020). Antimicrobial and Antioxidant Properties of Phytochemicals: Current Status and Future Perspective, Elsevier Inc.","DOI":"10.1016\/B978-0-12-818593-3.00001-4"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.phymed.2007.01.005","article-title":"Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin","volume":"14","author":"Rosato","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/14786419.2012.678351","article-title":"Chemical composition and synergistic interaction between aminoglycosides antibiotics and essential oil of Lantana montevidensis Briq","volume":"27","author":"Rodrigues","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.phymed.2009.04.004","article-title":"Synergy effects of the antibiotics gentamicin and the essential oil of Croton zehntneri","volume":"16","author":"Rodrigues","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.phymed.2013.02.013","article-title":"Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria","volume":"20","author":"Yap","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/japtr.JAPTR_366_18","article-title":"Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics","volume":"10","author":"Aouam","year":"2019","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Oliveira, D., Borges, A., Ruiz, R.M., Negr\u00edn, Z.R., Distinto, S., Borges, F., and Sim\u00f5es, M. (2021). 2-(2-Methyl-2-Nitrovinyl)Furan But Not Furvina Interfere With Staphylococcus Aureus Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid Against Biofilms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020613"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/dkg044","article-title":"A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus","volume":"51","author":"Gibbons","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1586\/eri.12.57","article-title":"Plant essential oils and their constituents in coping with multidrug-resistant bacteria","volume":"10","author":"Kon","year":"2012","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijantimicag.2011.05.005","article-title":"Essential oils from Moroccan plants as potential chemosensitisers restoring antibiotic activity in resistant Gram-negative bacteria","volume":"38","author":"Fadli","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.12659\/MSM.881760","article-title":"The inhibitory effect of Zingiber corallinum Hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity","volume":"17","author":"Yang","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1574-6968.2007.00772.x","article-title":"Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus","volume":"273","author":"Kuroda","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000064916","article-title":"Actions of farnesol and xylitol against Staphylococcus aureus","volume":"48","author":"Akiyama","year":"2002","journal-title":"Chemotherapy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jdermsci.2005.01.003","article-title":"A novel method to control the balance of skin microflora: Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin","volume":"38","author":"Masako","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chan, W.K., Tan, L.T.H., Chan, K.G., Lee, L.H., and Goh, B.H. (2016). Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules, 21.","DOI":"10.3390\/molecules21050529"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"da Cruz, R.P., de Freitas, T.S., Costa, M.D.S., Dos Santos, A.T.L., Campina, F.F., Pereira, R.L.S., Bezerra, J.W.A., Quintans-J\u00fanior, L.J., Ara\u00fajo, A.A.D.S., and De Siqueira J\u00fanior, J.P. (2020). Effect of \u03b1-bisabolol and its \u03b2-cyclodextrin complex as TetK and NorA efflux pump inhibitors in Staphylococcus aureus strains. Antibiotics, 9.","DOI":"10.3390\/antibiotics9010028"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Schroeder, M., Brooks, B.D., and Brooks, A.E. (2017). The complex relationship between virulence and antibiotic resistance. Genes, 8.","DOI":"10.3390\/genes8010039"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jgar.2020.06.010","article-title":"Relationship between virulence factors and antimicrobial resistance in Staphylococcus aureus from bovine mastitis","volume":"22","author":"Heinemann","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tim.2004.11.001","article-title":"Can laboratory reference strains mirror \u201creal-world\u201d pathogenesis?","volume":"13","author":"Fux","year":"2005","journal-title":"Trends Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mocan, A., Babot\u0103, M., Pop, A., Fize\u0219an, I., Diuzheva, A., Locatelli, M., Carradori, S., Campestre, C., Menghini, L., and Sisea, C.R. (2020). Chemical constituents and biologic activities of sage species: A comparison between salvia officinalis l., s. glutinosa l. and s. transsylvanica (schur ex griseb. & schenk) schur. Antioxidants, 9.","DOI":"10.3390\/antiox9060480"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Miklasi\u0144ska-Majdanik, M., K\u0119pa, M., Wojtyczka, R.D., Idzik, D., and W\u0105sik, T.J. (2018). Phenolic compounds diminish antibiotic resistance of Staphylococcus aureus clinical strains. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15102321"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.fct.2019.04.037","article-title":"Toxicological and pharmacologic effects of farnesol (C15H26O): A descriptive systematic review","volume":"129","author":"Bezerra","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tiv.2012.08.022","article-title":"Toxicity of terpenes on fibroblast cells compared to their hemolytic potential and increase in erythrocyte membrane fluidity","volume":"27","author":"Mendanha","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/np5008697","article-title":"(-)-\u03b1-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis","volume":"78","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_37","unstructured":"Tisserand, R., and Young, R. (2013). Essential Oil Safety: A Guide for Health Care Professionals, Elsevier Health Sciences."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijantimicag.2013.05.008","article-title":"Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model","volume":"42","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/08927014.2017.1280732","article-title":"Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes","volume":"33","author":"Borges","year":"2017","journal-title":"Biofouling"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ibiod.2018.02.004","article-title":"Effect of plant-based catecholic molecules on the prevention and eradication of Escherichia coli biofilms: A structure activity relationship study","volume":"141","author":"Baptista","year":"2019","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.diagmicrobio.2014.03.002","article-title":"Evaluation of the best method to assess antibiotic potentiation by phytochemicals against Staphylococcus aureus","volume":"79","author":"Abreu","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/5\/620\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:05:58Z","timestamp":1760137558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/5\/620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["antibiotics11050620"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11050620","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2022,5,4]]}}}