{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:50:02Z","timestamp":1770709802281,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/MULTI\/04349\/2019"],"award-info":[{"award-number":["UID\/MULTI\/04349\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04565\/2020"],"award-info":[{"award-number":["UIDP\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UI\/BD\/152244\/2021"],"award-info":[{"award-number":["UI\/BD\/152244\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UID\/MULTI\/04349\/2019"],"award-info":[{"award-number":["UID\/MULTI\/04349\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UIDP\/04565\/2020"],"award-info":[{"award-number":["UIDP\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Research Unit Institute for Bioengineering and Biosciences\u2014iBB","doi-asserted-by":"publisher","award":["UI\/BD\/152244\/2021"],"award-info":[{"award-number":["UI\/BD\/152244\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UID\/MULTI\/04349\/2019"],"award-info":[{"award-number":["UID\/MULTI\/04349\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UIDP\/04565\/2020"],"award-info":[{"award-number":["UIDP\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","doi-asserted-by":"publisher","award":["UI\/BD\/152244\/2021"],"award-info":[{"award-number":["UI\/BD\/152244\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UID\/MULTI\/04349\/2019"],"award-info":[{"award-number":["UID\/MULTI\/04349\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UIDP\/04565\/2020"],"award-info":[{"award-number":["UIDP\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"J.P.C.","doi-asserted-by":"publisher","award":["UI\/BD\/152244\/2021"],"award-info":[{"award-number":["UI\/BD\/152244\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The cytotoxic activity of four sets of camphorimine complexes based on the Cu(I), Cu(II), Ag(I), and Au(I) metal sites were assessed against the cisplatin-sensitive A2780 and OVCAR3 ovarian cancer cells. The results showed that the gold complexes were ca. one order of magnitude more active than the silver complexes, which in turn were ca. one order of magnitude more active than the copper complexes. An important finding was that the cytotoxic activity of the Ag(I) and Au(I) camphorimine complexes was higher than that of cisplatin. Another relevant aspect was that the camphorimine complexes did not interact significantly with DNA, in contrast with cisplatin. The cytotoxic activity of the camphorimine complexes displayed a direct relationship with the cellular uptake by OVCAR3 cells, as ascertained by PIXE (particle-induced X-ray emission). The levels of ROS (reactive oxygen species) formation exhibited an inverse relationship with the reduction potentials for the complexes with the same metal, as assessed by cyclic voltammetry. In order to gain insight into the toxicity of the complexes, their cytotoxicity toward nontumoral cells (HDF and V79 fibroblasts) was evaluated. The in vivo cytotoxicity of complex 5 using the nematode Caenorhabditis elegans was also assessed. The silver camphorimine complexes displayed the highest selectivity coefficients (activity vs. toxicity).<\/jats:p>","DOI":"10.3390\/antibiotics11081010","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T21:11:05Z","timestamp":1658956265000},"page":"1010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tuning the Biological Activity of Camphorimine Complexes through Metal Selection"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-1146","authenticated-orcid":false,"given":"Joana P.","family":"Costa","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-2603","authenticated-orcid":false,"given":"Teresa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"IBB\u2014Instituto de Bioengenharia e Bioci\u00eancias, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal"}]},{"given":"Maria S.","family":"Martins","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"},{"name":"Departamento de F\u00edsica, NOVA School of Science and Technology FCT NOVA, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"given":"M. Fernanda N. N.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-676X","authenticated-orcid":false,"given":"Joana R.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, IBB\u2014Institute for Bioengineering and Biosciences, Associate Laboratory, i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge H.","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, IBB\u2014Institute for Bioengineering and Biosciences, Associate Laboratory, i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-1273","authenticated-orcid":false,"given":"Rafaela A. L.","family":"Silva","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-603X","authenticated-orcid":false,"given":"Joana F.","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-5019","authenticated-orcid":false,"given":"Lu\u00eds M. C.","family":"Alves","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]},{"given":"In\u00eas","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"},{"name":"Departamento de F\u00edsica, NOVA School of Science and Technology FCT NOVA, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-0328","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Cruz","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, NOVA School of Science and Technology FCT NOVA, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5299","authenticated-orcid":false,"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[{"name":"C2TN\u2014Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/carcin\/bgp263","article-title":"The global burden of cancer: Priorities for prevention","volume":"31","author":"Thun","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)90327-0","article-title":"Conventional cancer therapy: Promise broken or promise delayed","volume":"351","author":"Tannock","year":"1998","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.3390\/cancers3033279","article-title":"Assessment of the Evolution of Cancer Treatment Therapies","volume":"3","author":"Arruebo","year":"2011","journal-title":"Cancers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejmech.2017.04.007","article-title":"Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives","volume":"142","author":"Rilak","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: The first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1021\/acs.chemrev.8b00685","article-title":"Introduction: Metals in Medicine","volume":"119","author":"Franz","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: Molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","article-title":"Cisplatin and beyond: Molecular mechanisms of action and drug resistance development in cancer chemotherapy","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4155\/fmc-2018-0248","article-title":"Metal-based antitumor compounds: Beyond cisplatin","volume":"11","author":"Simpson","year":"2019","journal-title":"Future Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.drudis.2009.09.003","article-title":"Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs","volume":"14","author":"Sadler","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4155\/fmc-2017-0317","article-title":"Anticancer metallodrugs: Where is the next cisplatin?","volume":"10","author":"Hanif","year":"2018","journal-title":"Future Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.2174\/092986710793213751","article-title":"Copper Compounds in Cancer Chemotherapy","volume":"17","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1040-8428(01)00221-9","article-title":"Vanadium in cancer treatment","volume":"42","author":"Evangelou","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/DDDT.S119488","article-title":"Metal complexes in cancer therapy\u2014An update from drug design perspective","volume":"11","author":"Ndagi","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.2147\/DDDT.S275007","article-title":"Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives","volume":"14","author":"Lee","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_16","first-page":"487","article-title":"Beyond Platinums: Gold Complexes as Anticancer Agents","volume":"34","author":"Nardon","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: Opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ygyno.2015.06.005","article-title":"Long-Term Mortality Among Women with Epithelial Ovarian Cancer","volume":"138","author":"Dinkelspiel","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Arora, M., Talhouk, A., McAlpine, J.N., Law, M.R., and Hanley, G.E. (2018). Long-term mortality among women with epithelial ovarian cancer: A population-based study in British Columbia, Canada. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4970-9"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJWH.S197604","article-title":"Ovarian cancer in the world: Epidemiology and risk factors","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1758834010361333","article-title":"Practical considerations in ovarian cancer chemotherapy","volume":"2","author":"Cristea","year":"2010","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jinorgbio.2016.11.003","article-title":"Synthesis of Ag(I) camphor sulphonylimine complexes and assessment of their cytotoxic properties against cisplatin-resistant A2780cisR and A2780 cell lines","volume":"166","author":"Cardoso","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jinorgbio.2018.08.011","article-title":"Search for cytotoxic compounds against ovarian cancer cells: Synthesis, characterization and assessment of the activity of new camphor carboxylate and camphor carboxamide silver complexes","volume":"188","author":"Carvalho","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/cr900223a","article-title":"In Situ Imaging of Metals in Cells and Tissues","volume":"109","author":"McRae","year":"2009","journal-title":"Chem. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"041102","DOI":"10.1063\/1.4971414","article-title":"High-resolution fast ion microscopy of single whole biological cells","volume":"3","author":"Bettiol","year":"2016","journal-title":"Appl. Phys. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1039\/C4MT00105B","article-title":"Imaging of intracellular metal partitioning in marine diatoms exposed to metal pollution: Consequences to cellular toxicity and metal fate in the environment","volume":"6","author":"Godinho","year":"2014","journal-title":"Metallomics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jinorgbio.2017.05.011","article-title":"New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation","volume":"174","author":"Ribeiro","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"110791","DOI":"10.1016\/j.jinorgbio.2019.110791","article-title":"Ag(I) camphor complexes: Antimicrobial activity by design","volume":"199","author":"Carvalho","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a-Mor\u00e1n, O.A., Villarreal, M.L., \u00c1lvarez-Berber, L., Meneses-Acosta, A., and Rodr\u00edguez-L\u00f3pez, V. (2016). Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from bursera fagaroides var. fagaroides on breast cancer cell lines. Molecules, 21.","DOI":"10.3390\/molecules21081013"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"110904","DOI":"10.1016\/j.jinorgbio.2019.110904","article-title":"On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities","volume":"202","author":"Sousa","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/9781782622208-00001","article-title":"Overview of Reactive Oxygen Species","volume":"Volume 1","author":"Krumova","year":"2016","journal-title":"Singlet Oxygen: Applications in Biosciences and Nanosciences"},{"key":"ref_32","first-page":"5381692","article-title":"Understanding of ROS-inducing strategy in anticancer therapy","volume":"18","author":"Kim","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: The bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(96)00251-X","article-title":"The superoxide production mediated by the redox cycling of xenobiotics in rat brain microsomes is dependent on their reduction potential","volume":"725","author":"Livertoux","year":"1996","journal-title":"Brain Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1039\/B922209J","article-title":"Exploring the Cellular Accumulation of Metal Complexes","volume":"39","author":"Puckett","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9417","DOI":"10.1039\/c2dt30217a","article-title":"Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?","volume":"41","author":"Davis","year":"2012","journal-title":"Dalton Trans."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/pola.25866","article-title":"Electronic structure and properties of camphorimine Cu(I) coordination polymers","volume":"50","author":"Fernandes","year":"2012","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.poly.2014.11.020","article-title":"Insight into the cytotoxicity of polynuclear Cu(I) camphor complexes","volume":"87","author":"Fernandes","year":"2015","journal-title":"Polyhedron"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Costa, J.P., Pinheiro, M.J.F., Sousa, S.A., Botelho do Rego, A.M., Marques, F., Oliveira, M.C., Leit\u00e3o, J.H., Mira, N., and Carvalho, M.F.N.N. (2019). Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains. Antibiotics, 8.","DOI":"10.3390\/antibiotics8030144"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Costa, J.P., Sousa, S.A., Galv\u00e3o, A.M., Mata, J.M., Leit\u00e3o, J.H., and Carvalho, M.F.N.N. (2021). Key Parameters on the Antibacterial Activity of Silver Camphor Complexes. Antibiotics, 10.","DOI":"10.3390\/antibiotics10020135"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Costa, J.P., Sousa, S.A., Soeiro, C., Leit\u00e3o, J.H., Galv\u00e3o, A.M., Marques, F., and Carvalho, M.F.N.N. (2021). Synthesis and Characterization of Camphorimine Au(I) Complexes with a Remarkable High Antibacterial Activity towards B. contaminans and P. aeruginosa. Antibiotics, 10.","DOI":"10.3390\/antibiotics10101272"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1021\/ic00104a042","article-title":"Synthesis, Structure and Electrochemistry of Palladium Complexes with Camphor-Derived Chiral Ligands","volume":"33","author":"Carvalho","year":"1994","journal-title":"Inorg. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Armarego, W.L.F., and Chai, C.L.L. (2008). Purification of Laboratory Chemicals, Elsevier Inc.. [6th ed.].","DOI":"10.1016\/B978-1-85617-567-8.50012-3"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110779","DOI":"10.1016\/j.jinorgbio.2019.110779","article-title":"Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells","volume":"199","author":"Rivas","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"110727","DOI":"10.1016\/j.jinorgbio.2019.110727","article-title":"Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes","volume":"198","author":"Matos","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/10715761003709802","article-title":"2\u2032,7\u2032-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy","volume":"44","author":"Chen","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_48","first-page":"e61122","article-title":"Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay","volume":"159","author":"Borges","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Cudalbeanu, M., Peitinho, D., Silva, F., Marques, R., Pinheiro, T., Ferreira, A., Marques, F., Paulo, A., Soeiro, C.F., and Sousa, S.A. (2021). Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties. Nanomaterials, 11.","DOI":"10.3390\/nano11061562"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/jemt.20402","article-title":"Nuclear microscopy: A tool for and percutaneous absorption imaging elemental distribution in vivo","volume":"70","author":"Alves","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"ref_51","unstructured":"(2022, May 29). Oxford Microbeams Ltd. Available online: http:\/\/www.microbeams.co.uk\/."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The Genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.scitotenv.2014.09.094","article-title":"Suitability of a Saccharomyces cerevisiae-based assay to assess the toxicity of pyrimethanil sprayed soils via surface runoff: Comparison with standard aquatic and soil toxicity assays","volume":"505","author":"Gil","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ijantimicag.2017.03.002","article-title":"Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives","volume":"49","author":"Alves","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Nuez-Martinez, M., Pinto, C.I.G., Guerreiro, J.F., Mendes, F., Marques, F., Mu\u00f1oz-Juan, A., Xavier, J.A.M., Laromaine, A., Bitonto, V., and Protti, N. (2021). Cobaltabis(dicarbollide) ([o-COSAN]\u2212) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma. Cancers, 13.","DOI":"10.3390\/cancers13246367"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/8\/1010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:57:23Z","timestamp":1760140643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/8\/1010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["antibiotics11081010"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11081010","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]}}}