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Propolis, a traditional and potentially medicinal product with several health benefits, is a beehive product with a worldwide reputation. However, despite the bioactivities reported, the low productivity and high chemical heterogeneity have been extensively hampering broader industrial uses. To assist in overcoming some of these problems, we prepared and characterized mixtures of ethanol extracts of a heterogeneous propolis sample (Pereiro) collected over a five-year period (2011\u20132015) and, additionally, we mixed two different propolis samples from distinct regions of Portugal (Pereiro and Ger\u00eas), also harvested at different times. An investigation of the antimicrobial and antioxidant properties, as well as characterization of the chemical composition of the eleven propolis blends were performed in this work. The antioxidant and antimicrobial activities of such blends of propolis samples, either from different localities and\/or different years, were maintained, or even enhanced, when a comparison of the individual extracts was conducted. The differences in the chemical composition of the original propolis samples were also diluted in the mixtures. The results reemphasize the great potential of propolis and suggest that mixing different samples, regardless of provenance or harvesting date, can contribute to propolis standardization while simultaneously increasing its availability and adding value to this beehive byproduct.<\/jats:p>","DOI":"10.3390\/antibiotics11091181","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T23:53:21Z","timestamp":1661990001000},"page":"1181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?"],"prefix":"10.3390","volume":"11","author":[{"given":"Marta","family":"Peixoto","sequence":"first","affiliation":[{"name":"Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Ana Sofia","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"CITAB, Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"CBMA, Centre of Molecular and Environmental Biology, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-8248","authenticated-orcid":false,"given":"Ana","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"CITAB, Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"CBMA, Centre of Molecular and Environmental Biology, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-8925","authenticated-orcid":false,"given":"Rui","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"CITAB, Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"CBMA, Centre of Molecular and Environmental Biology, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-8634","authenticated-orcid":false,"given":"Cristina","family":"Almeida-Aguiar","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"CITAB, Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"CBMA, Centre of Molecular and Environmental Biology, University of Minho, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","first-page":"137","article-title":"Quality criteria for propolis standardization","volume":"44","author":"Stan","year":"2011","journal-title":"Sci. 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