{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:11:20Z","timestamp":1777461080776,"version":"3.51.4"},"reference-count":55,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Planes Nacionales","award":["I+D+iI2008\u20132011\/2013\u20132016"],"award-info":[{"award-number":["I+D+iI2008\u20132011\/2013\u20132016"]}]},{"name":"Planes Nacionales","award":["PI19\/00478"],"award-info":[{"award-number":["PI19\/00478"]}]},{"name":"Planes Nacionales","award":["REIPI RD12\/0015\/0013"],"award-info":[{"award-number":["REIPI RD12\/0015\/0013"]}]},{"name":"Planes Nacionales","award":["REIPI RD16\/0016\/0010"],"award-info":[{"award-number":["REIPI RD16\/0016\/0010"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["I+D+iI2008\u20132011\/2013\u20132016"],"award-info":[{"award-number":["I+D+iI2008\u20132011\/2013\u20132016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00478"],"award-info":[{"award-number":["PI19\/00478"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["REIPI RD12\/0015\/0013"],"award-info":[{"award-number":["REIPI RD12\/0015\/0013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["REIPI RD16\/0016\/0010"],"award-info":[{"award-number":["REIPI RD16\/0016\/0010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa, Ministerio de Econom\u00eda y Competitividad, Spanish Network for Research in Infectious Diseases","award":["I+D+iI2008\u20132011\/2013\u20132016"],"award-info":[{"award-number":["I+D+iI2008\u20132011\/2013\u20132016"]}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa, Ministerio de Econom\u00eda y Competitividad, Spanish Network for Research in Infectious Diseases","award":["PI19\/00478"],"award-info":[{"award-number":["PI19\/00478"]}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa, Ministerio de Econom\u00eda y Competitividad, Spanish Network for Research in Infectious Diseases","award":["REIPI RD12\/0015\/0013"],"award-info":[{"award-number":["REIPI RD12\/0015\/0013"]}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa, Ministerio de Econom\u00eda y Competitividad, Spanish Network for Research in Infectious Diseases","award":["REIPI RD16\/0016\/0010"],"award-info":[{"award-number":["REIPI RD16\/0016\/0010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The emergence and spread of multidrug-resistant bacteria are a global concern. The lack of new antibiotics in the pipeline points to the need for developing new strategies. In this sense, gold(III) complexes (G3Cs) could be a promising alternative due to their recently described antibacterial activity. The aim of this study was to evaluate the antimicrobial activity of G3Cs alone and in combination with colistin against pathogenic bacteria from veterinary sources. Minimal inhibitory concentration (MIC) values were determined by broth microdilution and compared with clinically relevant antibiotics. Antibiofilm activity was determined by crystal violet staining. Combinations of selected G3Cs with colistin and cytotoxicity in commercial human cell lines were evaluated. Four and seven G3Cs showed antibacterial effect against Gram-negative and Gram-positive strains, respectively, with this activity being higher among Gram-positive strains. The G3Cs showed antibiofilm activity against Gram-negative species at concentrations similar or one to four folds higher than the corresponding MICs. Combination of G3Cs with colistin showed a potential synergistic antibacterial effect reducing concentrations and toxicity of both agents. The antimicrobial and antibiofilm activity, the synergistic effect when combined with colistin and the in vitro toxicity suggest that G3Cs would provide a new therapeutic alternative against multidrug-resistant bacteria from veterinary origin.<\/jats:p>","DOI":"10.3390\/antibiotics11121728","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T04:28:57Z","timestamp":1669868937000},"page":"1728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Gold(III) Complexes Activity against Multidrug-Resistant Bacteria of Veterinary Significance"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-0717","authenticated-orcid":false,"given":"Carlos","family":"Ratia","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic\u2014Universitat de Barcelona, 08036 Barcelona, Spain"}]},{"given":"Sara","family":"Sueiro","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic\u2014Universitat de Barcelona, 08036 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-0034","authenticated-orcid":false,"given":"Raquel G.","family":"Soengas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Universidad de Oviedo, Juli\u00e1n Claver\u00eda 7, 33006 Oviedo, Spain"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Iglesias","sequence":"additional","affiliation":[{"name":"\u00c1rea de Qu\u00edmica Org\u00e1nica, Centro de Investigaci\u00f3n CIAIMBITAL, Universidad de Almer\u00eda, 04120 Almer\u00eda, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1786-0157","authenticated-orcid":false,"given":"Fernando","family":"L\u00f3pez-Ortiz","sequence":"additional","affiliation":[{"name":"\u00c1rea de Qu\u00edmica Org\u00e1nica, Centro de Investigaci\u00f3n CIAIMBITAL, Universidad de Almer\u00eda, 04120 Almer\u00eda, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-105X","authenticated-orcid":false,"given":"Sara Mar\u00eda","family":"Soto","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic\u2014Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref_1","unstructured":"European Commission (2017, June 15). 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