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Therefore, the improvement of the actual surveillance methods and the discovery of alternative approaches with novel modes of action is vital to overcome the threats created by the emergence of such resistances. Light therapy modalities represent a viable and effective alternative to the conventional antimicrobial treatment and can be preponderant in the control of HAIs, even against multidrug resistant organisms (MDROs). This review will initially focus on the actual state of HAIs and MDROs and which methods are currently available to fight them, which is followed by the exploration of antimicrobial photodynamic therapy (aPDT) and antimicrobial blue light therapy (aBLT) as alternative approaches to control microorganisms involved in HAIs. The advantages and drawbacks of BLT relatively to aPDT and conventional antimicrobial drugs as well as its potential applications to destroy microorganisms in the healthcare setting will also be discussed.<\/jats:p>","DOI":"10.3390\/antibiotics8020058","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:22:35Z","timestamp":1557400955000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Blue Light Disinfection in Hospital Infection Control: Advantages, Drawbacks, and Pitfalls"],"prefix":"10.3390","volume":"8","author":[{"given":"Jo\u00e3o","family":"Cabral","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Porto Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Rodrigues","family":"AG","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Porto Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, 4200-450 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"ref_1","unstructured":"Kasper, D.L., Fauci, A.S., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. 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