{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:15:50Z","timestamp":1768626950291,"version":"3.49.0"},"reference-count":97,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANTREPRENORDOC, in the framework of Human Resources Development Operational Programme 2014-2020, financed from the European Social Fund :","award":["36355\/23.05.2019 HRD OP \/380\/6\/13 \u2013 SMIS Code: 123847."],"award-info":[{"award-number":["36355\/23.05.2019 HRD OP \/380\/6\/13 \u2013 SMIS Code: 123847."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory effect on wheat seed germination by evaluating the most sensitive physiological parameters (Germination %, Germination index, Vigor index) and using confocal laser scanning microscopy images. The analyzed extracts were found to have high antifungal activity against Candida glabrata with MIC values of 1.717 \u00b5g\/mL for leaf and 1.935 \u00b5g\/mL for root. The antitumor activity of the both extracts against A2780\/A2780cisR ovarian, LNCaP prostate and MCF-7 breast cancer cells was promising with IC50 values ranging from 23\u2013274 \u00b5g\/mL for leaf and 18\u2013152 \u00b5g\/mL for root, and the combination of N. alba extracts with cisplatin showed a synergistic effect (coefficient of drug interaction &lt;1). The antioxidant properties were assessed by \u03b2-carotene bleaching, ABTS and FRAP assays and cyclic voltammetry. Quercetin, the most prominent antioxidant, was quantified in very good yields by spectroelectrochemical assay.<\/jats:p>","DOI":"10.3390\/antibiotics9010007","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"7","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-3877","authenticated-orcid":false,"given":"Mihaela","family":"Cudalbeanu","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-5370","authenticated-orcid":false,"given":"Bianca","family":"Furdui","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-4291","authenticated-orcid":false,"given":"Geta","family":"C\u00e2r\u00e2c","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"given":"Vasilica","family":"Barbu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, Department of Food Science, Food Engineering, Biotechnology and Aquaculture, \u2018\u2018Dun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-0818","authenticated-orcid":false,"given":"Alina Viorica","family":"Iancu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Department of Morphological and Functional Sciences, \u2018\u2018Dun\u0103rea de Jos\u201d University of Galati, 800008 Romania, 47 Domneasc\u0103 Street, 8000008 Galati, Romania"}]},{"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia e Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, University of Lisbon, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge Humberto","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"IBB-Institute of Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior T\u00e9cnico, University of Lisbon, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-9169","authenticated-orcid":false,"given":"S\u00edlvia Andreia","family":"Sousa","sequence":"additional","affiliation":[{"name":"IBB-Institute of Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior T\u00e9cnico, University of Lisbon, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-0931","authenticated-orcid":false,"given":"Rodica Mihaela","family":"Dinica","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.1016\/j.matpr.2018.04.163","article-title":"Artocarpus altilis extract effect on cervical cancer cells","volume":"5","author":"Jamil","year":"2018","journal-title":"Mater. 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