{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:32:15Z","timestamp":1769509935857,"version":"3.49.0"},"reference-count":18,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}]},{"DOI":"10.13039\/501100015620","name":"Institute for Bioengineering and Biosciences","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100015620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The worldwide emergence of microbial resistance to available antibiotics presents a global threat to public health and health systems. This special issue aimed to gather papers describing novel antibiotics, originating form chemical synthesis, repurposing of existent drugs, or from natural sources like plant extracts, herbs and spices. A total of 13 papers were published, covering a wide range of topic, including antimicrobial resistance surveillance studies; synthesis of novel molecules with antimicrobial activities; modification or repurposing of already existing molecules, plant-derived active extracts, and molecules; the effects of antimicrobial therapy on microbiota; and the investigation of novel formulations for human and veterinary uses. After decades of antibiotics discovery decline, antibiotics discovery is boosting. Recent developments of post genomics approaches and bioinformatics tools will most certainly turn the tide in the discovery and development of antimicrobials in this exciting field.<\/jats:p>","DOI":"10.3390\/antibiotics9080471","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T03:16:46Z","timestamp":1596424606000},"page":"471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge H.","family":"Leit\u00e3o","sequence":"first","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences; Instituto Superior T\u00e9cnico, Department of Bioengineering, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"ref_1","unstructured":"(2020, July 28). WHO Publishes List of Bacteria for which New Antibiotics Are Urgently Needed. Available online: http:\/\/www.who.int\/en\/news-room\/detail\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Folliero, V., Caputo, P., Della Rocca, M.T., Chianese, A., Galdiero, M., Iovene, M.R., Hay, C., Franci, G., and Galdiero, M. (2020). Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania \u201cLuigi Vanvitelli\u201d between 2017 and 2018. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050215"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Leit\u00e3o, J.H., Sousa, S.A., Leite, S.A., and Carvalho, M.F.N.N. (2018). Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines. Antibiotics, 7.","DOI":"10.3390\/antibiotics7030065"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Morsy, M.A., Ali, E.M., Kandeel, M., Venugopala, K.N., Nair, A.B., Greish, K., and El-Daly, M. (2020). Screening and Molecular Docking of Novel Benzothiazole Derivatives as Potential Antimicrobial Agents. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050221"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alves, L.G., Portel, J.F., Sousa, S.A., Ferreira, O., Almada, S., Silva, E.R., Martins, A.M., and Leit\u00e3o, J.H. (2019). Investigations into the Structure\/Antibacterial Activity Relationships of Cyclam and Cyclen Derivatives. Antibiotics, 8.","DOI":"10.3390\/antibiotics8040224"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Terekhov, S.S., Nazarov, A.S., Mokrushina, Y.A., Baranova, M.N., Potapova, N.A., Malakhova, M.V., Ilina, E.N., Smirnov, I.V., and Gabibov, A.G. (2020). Deep Functional Profiling Facilitates the Evaluation of the Antibacterial Potential of the Antibiotic Amicoumacin. Antibiotics, 9.","DOI":"10.3390\/antibiotics9040157"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ying, L., Zhu, H., Fosso, M.Y., Garneau-Tsodikova, S., and Fredrick, K. (2020). Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020093"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: Progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Alves Ferreira, D., Martins, L.M.D.R.S., Fernandes, A.R., and Martins, M. (2020). A Tale of Two Ends: Repurposing Metallic Compounds from Anti-Tumour Agents to Effective Antibacterial Activity. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060321"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1039\/d0mt00064g","article-title":"Gold(iii) bis(dithiolene) complexes: From molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents","volume":"12","author":"Fontinha","year":"2020","journal-title":"Metallomics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.1504022112","article-title":"Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis","volume":"112","author":"Harbut","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sadgrove, N.J., Oliveira, T.B., Khumalo, G.P., van Vuuren, S.F., and van Wyk, B.-E. (2020). Antimicrobial Isoflavones and Derivatives from Erythrina (Fabaceae): Structure Activity Perspective (Sar & Qsar) on Experimental and Mined Values Against Staphylococcus aureus. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050223"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sadgrove, N.J., Senbill, H., Van Wyk, B.-E., and Greatrex, B.W. (2020). New Labdanes with Antimicrobial and Acaricidal Activity: Terpenes of Callitris and Widdringtonia (Cupressaceae). Antibiotics, 9.","DOI":"10.3390\/antibiotics9040173"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cudalbeanu, M., Furdui, B., C\u00e2r\u00e2c, G., Barbu, V., Iancu, A.V., Marques, F., Leit\u00e3o, J.H., Sousa, S.A., and Dinica, R.M. (2020). Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts. 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