{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:08:30Z","timestamp":1774458510596,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001872","name":"Centro para el Desarrollo Tecnol\u00f3gico Industrial","doi-asserted-by":"publisher","award":["IDI-20141209"],"award-info":[{"award-number":["IDI-20141209"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This randomized double-blind and controlled single-center clinical trial was designed to evaluate the effect of a 6-week intake of a probiotic product (1 capsule\/day) vs. a placebo on an oxidative stress model of physical exercise (high intensity and duration) in male cyclists (probiotic group, n = 22; placebo, n = 21). This probiotic included three lyophilized strains (Bifidobacterium longum CECT 7347, Lactobacillus casei CECT 9104, and Lactobacillus rhamnosus CECT 8361). Study variables were urinary isoprostane, serum malondialdehyde (MDA), serum oxidized low-density lipoprotein (Ox-LDL), urinary 8-hydroxy-2\u2032-deoxiguanosine (8-OHdG), serum protein carbonyl, serum glutathione peroxidase (GPx), and serum superoxide dismutase (SOD). At 6 weeks, as compared with baseline, significant differences in 8-OHdG (\u0394 mean difference \u221210.9 (95% CI \u221214.5 to \u22127.3); p &lt; 0.001), MDA (\u0394 mean difference \u2212207.6 (95% CI \u2212349.1 to \u221266.1; p &lt; 0.05), and Ox-LDL (\u0394 mean difference \u2212122.5 (95% CI \u2212240 to \u22124.5); p &lt; 0.05) were found in the probiotic group only. Serum GPx did not increase in the probiotic group, whereas the mean difference was significant in the placebo group (477.8 (95% CI 112.5 to 843.2); p &lt; 0.05). These findings suggest an antioxidant effect of this probiotic on underlying interacting oxidative stress mechanisms and their modulation in healthy subjects. The study was registered in ClinicalTrials.gov (NCT03798821).<\/jats:p>","DOI":"10.3390\/antiox10020323","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T14:23:27Z","timestamp":1614003807000},"page":"323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Antioxidant Effect of a Probiotic Product on a Model of Oxidative Stress Induced by High-Intensity and Duration Physical Exercise"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-1344","authenticated-orcid":false,"given":"Maravillas","family":"S\u00e1nchez Macarro","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-0576","authenticated-orcid":false,"given":"Vicente","family":"\u00c1vila-Gand\u00eda","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-9075","authenticated-orcid":false,"given":"Silvia","family":"P\u00e9rez-Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-1927","authenticated-orcid":false,"given":"Fernando","family":"C\u00e1novas","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-5385","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Garc\u00eda-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"given":"Mar\u00eda Salud","family":"Abell\u00e1n-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-9477","authenticated-orcid":false,"given":"Desir\u00e9e","family":"Victoria-Montesinos","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-0470","authenticated-orcid":false,"given":"Antonio J.","family":"Luque-Rubia","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-8371","authenticated-orcid":false,"given":"Eric","family":"Climent","sequence":"additional","affiliation":[{"name":"Research and Development Department, ADM-Biopolis, ADM, Parc Cientific Universitat de Valencia, Paterna, 46980 Valencia, Spain"}]},{"given":"Salvador","family":"Genov\u00e9s","sequence":"additional","affiliation":[{"name":"Research and Development Department, ADM-Biopolis, ADM, Parc Cientific Universitat de Valencia, Paterna, 46980 Valencia, Spain"}]},{"given":"Daniel","family":"Ramon","sequence":"additional","affiliation":[{"name":"Research and Development Department, ADM-Biopolis, ADM, Parc Cientific Universitat de Valencia, Paterna, 46980 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-3573","authenticated-orcid":false,"given":"Empar","family":"Chenoll","sequence":"additional","affiliation":[{"name":"Research and Development Department, ADM-Biopolis, ADM, Parc Cientific Universitat de Valencia, Paterna, 46980 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-5502","authenticated-orcid":false,"given":"Francisco Javier","family":"L\u00f3pez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain"},{"name":"Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. 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