{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:19:15Z","timestamp":1774613955522,"version":"3.50.1"},"reference-count":73,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Acute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. Twenty-nine patients with biliary AP and 11 healthy controls were enrolled in this study. We analyzed several inflammatory biomarkers, multifactorial scores, reactive oxygen species (ROS), antioxidants defenses, and the plasma metabolome of biliary AP and healthy controls. Hepcidin (1.00), CRP (0.94), and SIRI (0.87) were the most accurate serological biomarkers of AP severity. OS played a pivotal role in the initial phase of AP, with significant changes in ROS and antioxidant defenses relating to AP severity. Phenylalanine (p &lt; 0.05), threonine (p &lt; 0.05), and lipids (p &lt; 0.01) showed significant changes in AP severity. The role of hepcidin and SIRI were confirmed as new prognostic biomarkers of biliary AP. OS appears to have a role in the onset and progression of the AP process. Overall, this study identified several metabolites that may predict the onset and progression of biliary AP severity, constituting the first metabonomic study in the field of biliary AP.<\/jats:p>","DOI":"10.3390\/antiox10060988","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T13:29:58Z","timestamp":1624282198000},"page":"988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees of Biliary Acute Pancreatitis Severity"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-1024","authenticated-orcid":false,"given":"Pedro","family":"Silva-Vaz","sequence":"first","affiliation":[{"name":"Health Sciences Research Centre, University of Beira Interior (CICS-UBI), 6200-506 Covilh\u00e3, Portugal"},{"name":"General Surgery Department, Hospital Amato Lusitano, Unidade Local de Sa\u00fade de Castelo Branco, 6000-085 Castelo Branco, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"Clinical Academic Centre of Beiras (CACB), 6200-506 Covilh\u00e3, Portugal"}]},{"given":"Ivana","family":"Jarak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-2051","authenticated-orcid":false,"given":"Lu\u00eds","family":"Rato","sequence":"additional","affiliation":[{"name":"Health School of the Polytechnic of Guarda, 6300-559 Guarda, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"QOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-306X","authenticated-orcid":false,"given":"Sara","family":"Morgado-Nunes","sequence":"additional","affiliation":[{"name":"Clinical Academic Centre of Beiras (CACB), 6200-506 Covilh\u00e3, Portugal"},{"name":"Polytechnic Institute of Castelo Branco, Escola Superior de Gest\u00e3o, 6000-084 Castelo Branco, Portugal"}]},{"given":"Aida","family":"Paulino","sequence":"additional","affiliation":[{"name":"General Surgery Department, Hospital Amato Lusitano, Unidade Local de Sa\u00fade de Castelo Branco, 6000-085 Castelo Branco, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"Clinical Academic Centre of Beiras (CACB), 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-5912","authenticated-orcid":false,"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre, University of Beira Interior (CICS-UBI), 6200-506 Covilh\u00e3, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"Clinical Academic Centre of Beiras (CACB), 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"CNC.IBILI Consortium\/Center for Innovation Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-561 Coimbra, Portugal"}]},{"given":"Jos\u00e9 Guilherme","family":"Tralh\u00e3o","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"CNC.IBILI Consortium\/Center for Innovation Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-561 Coimbra, Portugal"},{"name":"Surgery Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Faculty of Medicina, University Hospital, 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-7871","authenticated-orcid":false,"given":"Ana Margarida","family":"Abrantes","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicina, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"CNC.IBILI Consortium\/Center for Innovation Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-561 Coimbra, 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