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These bioactive compounds have been the focus of considerable research due to their antioxidant, anti-inflammatory, and photoprotective properties. In this review, the current state of the art in the encapsulation of carotenoids and coenzyme Q10 in lipid nanoparticles to improve their bioavailability, chemical stability, and skin absorption is discussed. Additionally, the main findings are highlighted on the cytotoxic and photoprotective effects of these systems in the skin.<\/jats:p>","DOI":"10.3390\/antiox10071034","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:24:57Z","timestamp":1624832697000},"page":"1034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-915X","authenticated-orcid":false,"given":"Luciana","family":"de Souza Guedes","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-871X","authenticated-orcid":false,"given":"Renata Miliani","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"given":"N\u00e1dia A.","family":"Bou-Chacra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-8510","authenticated-orcid":false,"given":"Maria Val\u00e9ria Robles","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-6213","authenticated-orcid":false,"given":"Catarina","family":"Rosado","sequence":"additional","affiliation":[{"name":"CBIOS, Universidade Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/ics.12316","article-title":"Plant-based active photoprotectants for sunscreens","volume":"38","author":"Cefali","year":"2016","journal-title":"Int. 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