{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:17:07Z","timestamp":1773076627138,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national funds","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"national funds","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"national funds","award":["5537 DRI"],"award-info":[{"award-number":["5537 DRI"]}]},{"name":"national funds","award":["S\u00e9rvia 2020\/21"],"award-info":[{"award-number":["S\u00e9rvia 2020\/21"]}]},{"name":"national funds","award":["7747845"],"award-info":[{"award-number":["7747845"]}]},{"name":"Portuguese-Serbia Bilateral Cooperation","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Portuguese-Serbia Bilateral Cooperation","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Portuguese-Serbia Bilateral Cooperation","award":["5537 DRI"],"award-info":[{"award-number":["5537 DRI"]}]},{"name":"Portuguese-Serbia Bilateral Cooperation","award":["S\u00e9rvia 2020\/21"],"award-info":[{"award-number":["S\u00e9rvia 2020\/21"]}]},{"name":"Portuguese-Serbia Bilateral Cooperation","award":["7747845"],"award-info":[{"award-number":["7747845"]}]},{"name":"Science Fund of the Republic of Serbia","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Science Fund of the Republic of Serbia","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Science Fund of the Republic of Serbia","award":["5537 DRI"],"award-info":[{"award-number":["5537 DRI"]}]},{"name":"Science Fund of the Republic of Serbia","award":["S\u00e9rvia 2020\/21"],"award-info":[{"award-number":["S\u00e9rvia 2020\/21"]}]},{"name":"Science Fund of the Republic of Serbia","award":["7747845"],"award-info":[{"award-number":["7747845"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study aims to validate a new cosmetic ingredient from Salicornia ramosissima S J. Woods through in vitro and ex vivo assays. The halophyte extracts were obtained by subcritical water extraction (SWE) at different temperatures (110, 120, 140, 160 and 180 \u00b0C). The antioxidant\/radical scavenging activities and the phenolic profile were screened for all extracts. The optimal extract was assessed in keratinocytes and fibroblasts, while permeation assays were performed in Franz cells. The inhibitory activity of hyaluronidase and elastase was also evaluated. The sample extracted at 180 \u00b0C presented the highest phenolic content (1739.28 mg\/100 g of dry weight (dw)). Despite not being efficient in the sequestration of ABTS\u2022+, this extract scavenged the DPPH\u2022 (IC50 = 824.57 \u00b5g\/mL). The scavenging capacity of superoxide (O2\u2022\u2212) and hypochlorous acid (HOCl) was also considerable (respectively, IC50 = 158.87 \u00b5g\/mL and IC50 = 5.80 \u00b5g\/mL). The cell viability assays confirmed the absence of negative effects on keratinocytes, while the fibroblasts\u2019 viability slightly decreased. The ex vivo permeation of rutin, quercetin and syringic acid after 24 h was, respectively, 11, 20 and 11%. Additionally, the extract showed a good elastase and hyaluronidase inhibitory activity. The results obtained support the S. ramosissima bioactivity as a cosmetic ingredient.<\/jats:p>","DOI":"10.3390\/antiox11122449","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T02:59:01Z","timestamp":1670900341000},"page":"2449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Salicornia ramosissima: A New Green Cosmetic Ingredient with Promising Skin Effects"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-4440","authenticated-orcid":false,"given":"Ana","family":"Correia","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV\u2014Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-9816","authenticated-orcid":false,"given":"Ana Margarida","family":"Silva","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV\u2014Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9211","authenticated-orcid":false,"given":"Manuela M.","family":"Moreira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV\u2014Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"given":"Miguel","family":"Salazar","sequence":"additional","affiliation":[{"name":"Agro-On\/RiaFresh\u2014Verduras da Ria Formosa, S\u00edtio do Besouro, 8005-421 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-4492","authenticated-orcid":false,"given":"Jaroslava","family":"\u0160varc-Gaji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-0132","authenticated-orcid":false,"given":"Tanja","family":"Brezo-Borjan","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-4889","authenticated-orcid":false,"given":"Maria de la Luz","family":"C\u00e1diz-Gurrea","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s\/n, E-18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-5338","authenticated-orcid":false,"given":"Antonio Segura","family":"Carretero","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s\/n, E-18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-6401","authenticated-orcid":false,"given":"Francesca","family":"Loschi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6953","authenticated-orcid":false,"given":"Stefano","family":"Dall\u2019Acqua","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV\u2014Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-0041","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV\u2014Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tifs.2021.03.012","article-title":"Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries","volume":"117","author":"Carpena","year":"2021","journal-title":"Trends Food Sci. 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