{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:54:07Z","timestamp":1768834447689,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["778168"],"award-info":[{"award-number":["778168"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Centro de Qu\u00edmica Estrutural","award":["778168"],"award-info":[{"award-number":["778168"]}]},{"name":"Centro de Qu\u00edmica Estrutural","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Centro de Qu\u00edmica Estrutural","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Centro de Qu\u00edmica Estrutural","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["778168"],"award-info":[{"award-number":["778168"]}]},{"name":"Institute of Molecular Sciences","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Institute of Molecular Sciences","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This work investigates the prospects for exploitation of Gnaphalium viscosum (Kunth) abundant but with limited applications till present biomass. The feasibility of traditional techniques (two-phase solvent, and the benchmark Soxhlet extraction) and supercritical extraction without\/with a cosolvent at T = 40\u201360 \u00b0C and p = 30\u201350 MPa was examined to explore the possibility of recovering phytochemicals from G. viscosum leaves, flowers and stems. The efficiency of the techniques was assessed and compared based on yield, influence of solvents used, total phenolic content and antioxidant activity of the extracts. Phenolics of different complexities were identified and quantified by applying LC (LC\u2013MS\/MS, and LC\u2013HRAM), while the fatty acid profile was determined by GC\u2013FID. The results of this extensive study demonstrated the huge valorization potential and prospects of G. viscosum, since highly potent antioxidants such as kaempferol, kaempferol-3-O-\u03b2-d-glucoside (astragalin), and chlorogenic acid were ascertained in considerable amounts. Furthermore, for the first time, the presence of leontopodic acid, a greatly substituted derivative of glucaric acid, was detected in the species.<\/jats:p>","DOI":"10.3390\/antiox11122495","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T06:58:29Z","timestamp":1671433109000},"page":"2495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of Gnaphalium viscosum (Kunth) Valorization Prospects: Sustainable Recovery of Antioxidants by Different Techniques"],"prefix":"10.3390","volume":"11","author":[{"given":"Stanislava","family":"Boyadzhieva","sequence":"first","affiliation":[{"name":"Institute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-0864","authenticated-orcid":false,"given":"Jose A. P.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Instituto Superior de Engenharia de Lisboa, Instituto Polit\u00e9cnico de Lisboa, Rua Conselheiro Em\u00eddio Navarro 1, 1959-007 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-2921","authenticated-orcid":false,"given":"Massimiliano","family":"Errico","sequence":"additional","affiliation":[{"name":"Department of Green Technology, Faculty of Engineering, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}]},{"given":"H. Elizabeth","family":"Reynel-Avilla","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Aguascalientes, Aguascalientes 20256, Mexico"},{"name":"CONACYT, Ciudad de M\u00e9xico 03940, Mexico"}]},{"given":"Dragomir S.","family":"Yankov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-3539","authenticated-orcid":false,"given":"Adrian","family":"Bonilla-Petriciolet","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Aguascalientes, Aguascalientes 20256, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-8183","authenticated-orcid":false,"given":"Roumiana P.","family":"Stateva","sequence":"additional","affiliation":[{"name":"Institute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.3390\/molecules18078298","article-title":"The genus Gnaphalium L. 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