{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:30:54Z","timestamp":1774269054908,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["UIDP\/0436\/2020"],"award-info":[{"award-number":["UIDP\/0436\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.<\/jats:p>","DOI":"10.3390\/antiox12020337","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-5030","authenticated-orcid":false,"given":"Davide","family":"Liberti","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-2297","authenticated-orcid":false,"given":"Paola","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy"}]},{"given":"Enrica","family":"Giustino","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-1715","authenticated-orcid":false,"given":"Luigi","family":"D\u2019Elia","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-646X","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Silva","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-855X","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Barreira","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-0576","authenticated-orcid":false,"given":"Daria Maria","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.egypro.2017.03.177","article-title":"Some Promising Microalgal Species for Commercial Applications: A Review","volume":"110","author":"Mobin","year":"2017","journal-title":"Energy Procedia"},{"key":"ref_2","unstructured":"Alam, F., Date, A., Rasjidin, R., Mobin, S.M.A., Moria, H., and Baqui, A. 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