{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:33:09Z","timestamp":1776738789789,"version":"3.51.2"},"reference-count":216,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["UB-GRP-66-1444"],"award-info":[{"award-number":["UB-GRP-66-1444"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["3277"],"award-info":[{"award-number":["3277"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES)","award":["0001052"],"award-info":[{"award-number":["0001052"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["UB-GRP-66-1444"],"award-info":[{"award-number":["UB-GRP-66-1444"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["3277"],"award-info":[{"award-number":["3277"]}]},{"name":"Deanship of Scientific Research at University of Bisha","award":["0001052"],"award-info":[{"award-number":["0001052"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["UB-GRP-66-1444"],"award-info":[{"award-number":["UB-GRP-66-1444"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["3277"],"award-info":[{"award-number":["3277"]}]},{"name":"European Union under the National Recovery and Resilience Plan (NRRP)","award":["0001052"],"award-info":[{"award-number":["0001052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Citrus fruits occupy an important position in the context of the fruit trade, considering that both fresh fruits and processed products are produced on a large scale. Citrus fruits are recognized as an essential component of the human diet, thanks to their high content of beneficial nutrients such as vitamins, minerals, terpenes, flavonoids, coumarins and dietary fibers. Among these, a wide range of positive biological activities are attributed to terpenes and flavonoids derivatives. In this review, a list of bibliographic reports (from 2015 onwards) on the phytochemical composition, beneficial effects and potential applications of citrus fruits and their by-products is systematically summarized. In detail, information regarding the nutraceutical and medicinal value closely linked to the presence of numerous bioactive metabolites and their growing use in the food industry and food packaging, also considering any technological strategies such as encapsulation to guarantee their stability over time, were evaluated. In addition, since citrus fruit, as well as its by-products, are interesting alternatives for the reformulation of natural cosmetic products, the sector of the cosmetic industry is also explored. More in-depth knowledge of the latest information in this field will contribute to future conscious use of citrus fruits.<\/jats:p>","DOI":"10.3390\/antiox12020481","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T03:41:17Z","timestamp":1676346077000},"page":"481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The Chemical Variability, Nutraceutical Value, and Food-Industry and Cosmetic Applications of Citrus Plants: A Critical Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-5532","authenticated-orcid":false,"given":"Anis","family":"Ben Hsouna","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, B.P \u201c1177\u201d, Sfax 3018, Tunisia"},{"name":"Department of Environmental Sciences and Nutrition, Higher Institute of Applied Sciences and Technology of Mahdia, University of Monastir, Monastir 5000, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-1056","authenticated-orcid":false,"given":"Carmen","family":"Sadaka","sequence":"additional","affiliation":[{"name":"Madison, WI 53704, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-871X","authenticated-orcid":false,"given":"Ivana","family":"Generali\u0107 Mekini\u0107","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Biotechnology, Faculty of Chemistry and Technology, University of Split, R. Bo\u0161kovi\u0107a 35, HR-21000 Split, Croatia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-4492","authenticated-orcid":false,"given":"Jaroslava","family":"\u0160varc-Gaji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-0041","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-5801","authenticated-orcid":false,"given":"Simone","family":"Morais","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9211","authenticated-orcid":false,"given":"Manuela M.","family":"Moreira","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"given":"Eduarda","family":"Ferreira","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-6851","authenticated-orcid":false,"given":"Giorgia","family":"Spigno","sequence":"additional","affiliation":[{"name":"DiSTAS, Department for Sustainable Food Process, Universit\u00e0 Cattolica del Sacro Cuore, 29122 Piacenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-0132","authenticated-orcid":false,"given":"Tanja","family":"Brezo-Borjan","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-7423","authenticated-orcid":false,"given":"Boutheina Ben","family":"Akacha","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, B.P \u201c1177\u201d, Sfax 3018, Tunisia"}]},{"given":"Rania Ben","family":"Saad","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax, B.P \u201c1177\u201d, Sfax 3018, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-4743","authenticated-orcid":false,"given":"Wissem","family":"Mnif","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences at Bisha, University of Bisha, P.O. 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