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soil degradation is occurring at unprecedented rates, not only as an indirect effect of climate change (CC) but also due to intensified agricultural practices which affect soil properties and biodiversity. Therefore, understanding the impacts of CC and soil degradation on plant physiology is crucial for the sustainable development of mitigation strategies to prevent crop productivity losses. The amino acid proline has long been recognized for playing distinct roles in plant cells undergoing osmotic stress. Due to its osmoprotectant and redox-buffering ability, a positive correlation between proline accumulation and plants\u2019 tolerance to abiotic stress has been pointed out in numerous reviews. Indeed, proline quantification is used systematically by plant physiologists as an indicator of the degree of tolerance and a measurement of the antioxidant potential in plants under stressful conditions. Moreover, the exogenous application of proline has been shown to increase resilience to several stress factors, including those related to soil degradation such as salinity and exposure to metals and xenobiotics. However, recent data from several studies often refer to proline accumulation as a signal of stress sensitivity with no clear correlation with improved antioxidant activity or higher stress tolerance, including when proline is used exogenously as a stress reliever. Nevertheless, endogenous proline levels are strongly modified by these stresses, proving its involvement in plant responses. Hence, one main question arises\u2014is proline augmentation always a sign of improved stress resilience? From this perspective, the present review aims to provide a more comprehensive understanding of the implications of proline accumulation in plants under abiotic stress induced by soil degradation factors, reinforcing the idea that proline quantification should not be employed as a sole indicator of stress sensitivity or resilience but rather complemented with further biochemical and physiological endpoints.<\/jats:p>","DOI":"10.3390\/antiox12030666","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T05:01:12Z","timestamp":1678251672000},"page":"666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Accumulation of Proline in Plants under Contaminated Soils\u2014Are We on the Same Page?"],"prefix":"10.3390","volume":"12","author":[{"given":"Sofia","family":"Spormann","sequence":"first","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Pedro","family":"Nadais","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Filipa","family":"Sousa","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Mafalda","family":"Pinto","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-1393","authenticated-orcid":false,"given":"Maria","family":"Martins","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-3596","authenticated-orcid":false,"given":"Bruno","family":"Sousa","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5243","authenticated-orcid":false,"given":"Fernanda","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-2024","authenticated-orcid":false,"given":"Cristiano","family":"Soares","sequence":"additional","affiliation":[{"name":"GreenUPorto-Sustainable Agrifood Production Research Centre & Inov4Agro, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s13593-016-0350-5","article-title":"Cultivars to Face Climate Change Effects on Crops and Weeds: A Review","volume":"36","author":"Korres","year":"2016","journal-title":"Agron. Sustain. Dev."},{"key":"ref_2","first-page":"635","article-title":"Examining Plant Physiological Responses to Climate Change through an Evolutionary Lens","volume":"172","author":"Becklin","year":"2016","journal-title":"Plant Physiol."},{"key":"ref_3","unstructured":"FAO (2017). FAO Strategy on Climate Change, FAO."},{"key":"ref_4","unstructured":"FAO (2018, January 2\u201314). FAO\u2019s Work on Climate Change. Proceedings of the United Nations Climate Change Conference 2018, Food and Agriculture Organization of the United Nations, Katowice, Poland."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"110697","DOI":"10.1016\/j.envres.2020.110697","article-title":"Arable Lands under the Pressure of Multiple Land Degradation Processes. A Global Perspective","volume":"194","author":"Patriche","year":"2021","journal-title":"Environ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111736","DOI":"10.1016\/j.jenvman.2020.111736","article-title":"Soil Salinity under Climate Change: Challenges for Sustainable Agriculture and Food Security","volume":"280","author":"Mukhopadhyay","year":"2021","journal-title":"J. Environ. Manag."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1002\/ldr.4056","article-title":"Climate Change-Triggered Land Degradation and Planetary Health: A Review","volume":"32","author":"Talukder","year":"2021","journal-title":"Land Degrad. Dev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/ppl.12812","article-title":"Enhancing the Abiotic Stress Tolerance of Plants: From Chemical Treatment to Biotechnological Approaches","volume":"164","author":"Nguyen","year":"2018","journal-title":"Physiol. Plant"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hossain, A., Skalicky, M., Brestic, M., Maitra, S., Alam, M.A., Syed, M.A., Hossain, J., Sarkar, S., Saha, S., and Bhadra, P. (2021). Consequences and Mitigation Strategies of Abiotic Stresses in Wheat (Triticum aestivum L.) under the Changing Climate. Agronomy, 11.","DOI":"10.3390\/agronomy11020241"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hosseinifard, M., Stefaniak, S., Javid, M.G., Soltani, E., Wojtyla, \u0141., and Garnczarska, M. (2022). Contribution of Exogenous Proline to Abiotic Stresses Tolerance in Plants: A Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095186"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/aab.12482","article-title":"Biostimulants Enhance Growth and Drought Tolerance in Arabidopsis thaliana and Exhibit Chemical Priming Action","volume":"174","author":"Fleming","year":"2019","journal-title":"Ann. Appl. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.4161\/psb.21949","article-title":"Role of Proline under Changing Environments: A Review","volume":"7","author":"Hayat","year":"2012","journal-title":"Plant Signal. Behav."},{"key":"ref_13","unstructured":"Dar, M.I., Naikoo, M.I., Rehman, F., Naushin, F., and Khan, F.A. (2015). Osmolytes and Plants Acclimation to Changing Environment: Emerging Omics Technologies, Springer."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18782\/2320-7051.6032","article-title":"Specific Role of Proline Against Heavy Metals Toxicity in Plants","volume":"5","author":"Aslam","year":"2017","journal-title":"Int. J. Pure Appl. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/plb.13363","article-title":"Proline, a Multifaceted Signalling Molecule in Plant Responses to Abiotic Stress: Understanding the Physiological Mechanisms","volume":"24","author":"Ghosh","year":"2022","journal-title":"Plant Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/jxb\/erj073","article-title":"The Significance of Amino Acids and Amino Acid-Derived Molecules in Plant Responses and Adaptation to Heavy Metal Stress","volume":"57","author":"Sharma","year":"2006","journal-title":"J. Exp. Bot."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"EL-Bauome, H.A., Abdeldaym, E.A., Abd El-Hady, M.A.M., Darwish, D.B.E., Alsubeie, M.S., El-Mogy, M.M., Basahi, M.A., Al-Qahtani, S.M., Al-Harbi, N.A., and Alzuaibr, F.M. (2022). Exogenous Proline, Methionine, and Melatonin Stimulate Growth, Quality, and Drought Tolerance in Cauliflower Plants. Agriculture, 12.","DOI":"10.3390\/agriculture12091301"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e0140","DOI":"10.1199\/tab.0140","article-title":"Proline Metabolism and Its Implications for Plant-Environment Interaction","volume":"8","author":"Verslues","year":"2010","journal-title":"Arab. Book"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tplants.2009.11.009","article-title":"Proline: A Multifunctional Amino Acid","volume":"15","author":"Szabados","year":"2010","journal-title":"Trends Plant Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tplants.2021.07.009","article-title":"Proline Metabolism as Regulatory Hub","volume":"27","author":"Alvarez","year":"2022","journal-title":"Trends Plant Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2970249","article-title":"The Structure and Function of Proline-Rich Regions in Proteins","volume":"297","author":"Williamson","year":"1994","journal-title":"Biochem. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4161\/psb.4.11.9797","article-title":"Proline Accumulation in Plants: Not Only Stress","volume":"4","author":"Mattioli","year":"2009","journal-title":"Plant Signal. Behav."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3389\/fpls.2020.565134","article-title":"Differential Contribution of P5CS Isoforms to Stress Tolerance in Arabidopsis","volume":"11","author":"Funck","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e02952","DOI":"10.1016\/j.heliyon.2019.e02952","article-title":"Regulation of L-Proline Biosynthesis, Signal Transduction, Transport, Accumulation and Its Vital Role in Plants during Variable Environmental Conditions","volume":"5","author":"Meena","year":"2019","journal-title":"Heliyon"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00425-006-0429-3","article-title":"Two Tobacco Proline Dehydrogenases Are Differentially Regulated and Play a Role in Early Plant Development","volume":"225","author":"Ribarits","year":"2007","journal-title":"Planta"},{"key":"ref_26","unstructured":"Szepesi, \u00c1., and Sz\u0151ll\u0151si, R. (2018). Plant Metabolites and Regulation under Environmental Stress, Academic Press."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/pce.12157","article-title":"Is Proline Accumulation per Se Correlated with Stress Tolerance or Is Proline Homeostasis a More Critical Issue?","volume":"37","author":"Sreenivasulu","year":"2014","journal-title":"Plant Cell Environ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.plaphy.2014.04.007","article-title":"How Reactive Oxygen Species and Proline Face Stress Together","volume":"80","author":"Rejeb","year":"2014","journal-title":"Plant Physiol. Biochem."},{"key":"ref_29","unstructured":"Heuer, B. (2016). Handbook of Plant and Crop Stress, CRC Press. [3rd ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00726-008-0061-6","article-title":"Proline Accumulation in Plants: A Review","volume":"35","author":"Verbruggen","year":"2008","journal-title":"Amino Acids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1089\/ars.2012.5074","article-title":"Proline Mechanisms of Stress Survival","volume":"19","author":"Liang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_32","first-page":"544","article-title":"Role of Proline in Cell Wall Synthesis and Plant Development and Its Implications in Plant Ontogeny","volume":"6","author":"Kumari","year":"2015","journal-title":"Front. Plant Sci."},{"key":"ref_33","unstructured":"Hare, P.D., and Cress, W.A. (1997). Metabolic Implications of Stress-Induced Proline Accumulation in Plants, Kluwer Academic Publishers."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10535-015-0549-3","article-title":"Proline: A Key Player in Plant Abiotic Stress Tolerance","volume":"59","author":"Kaur","year":"2015","journal-title":"Biol. Plant"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-319-96190-3_2","article-title":"Soil Salinity: Historical Perspectives and a World Overview of the Problem","volume":"2018","author":"Shahid","year":"2018","journal-title":"Guidel. Salin. Assess. Mitig. Adapt. Using Nucl. Relat. Tech."},{"key":"ref_36","first-page":"1","article-title":"Present Scenario of Global Salt Affected Soils, Its Management and Importance of Salinity Research","volume":"1","author":"Hossain","year":"2019","journal-title":"Int. Res. J. Biol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1007\/s11356-014-3739-1","article-title":"Effect of Salinity Stress on Plants and Its Tolerance Strategies: A Review","volume":"22","author":"Parihar","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11738-019-3004-9","article-title":"Different Proline Responses of Two Algerian Durum Wheat Cultivars to in Vitro Salt Stress","volume":"42","author":"Ami","year":"2020","journal-title":"Acta Physiol. Plant"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11484","DOI":"10.1021\/jf901490f","article-title":"Saline Water Irrigation Effects on Antioxidant Defense System and Proline Accumulation in Leaves and Roots of Field-Grown Olive","volume":"57","author":"Sensoy","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hnilickova, H., Kraus, K., Vachova, P., and Hnilicka, F. (2021). Salinity Stress Affects Photosynthesis, Malondialdehyde Formation, and Proline Content in Portulaca oleracea L.. Plants, 10.","DOI":"10.3390\/plants10050845"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/01904167.2013.867980","article-title":"Effects of Salinity Stress on Physiological Performance of Various Wheat and Barley Cultivars","volume":"37","author":"Izadi","year":"2014","journal-title":"J. Plant Nutr."},{"key":"ref_42","first-page":"835","article-title":"Seed Germination, Antioxidant Enzymes Activity and Proline Content in Medicinal Plant Tagetes minuta under Salinity Stress","volume":"154","author":"Moghaddam","year":"2019","journal-title":"Plant Biosyst. Int. J. Deal. All Asp. Plant Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s13580-020-00231-z","article-title":"Evaluation of Chlorophyll Fluorescence Parameters and Proline Content in Tomato Seedlings Grown under Different Salt Stress Conditions","volume":"61","author":"Shin","year":"2020","journal-title":"Hortic. Environ. Biotechnol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sousa, B., Rodrigues, F., Soares, C., Martins, M., Azenha, M., Lino-Neto, T., Santos, C., Cunha, A., and Fidalgo, F. (2022). Impact of Combined Heat and Salt Stresses on Tomato Plants\u2014Insights into Nutrient Uptake and Redox Homeostasis. Antioxidants, 11.","DOI":"10.3390\/antiox11030478"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jplph.2018.10.013","article-title":"Influence of the Proline Metabolism and Glycine Betaine on Tolerance to Salt Stress in Tomato (Solanum lycopersicum L.) Commercial Genotypes","volume":"231","author":"Blasco","year":"2018","journal-title":"J. Plant Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1017\/S1479262120000350","article-title":"Effects of Salinity Stress on Proline Content and Expression of \u03941-Pyrroline-5-Carboxylate Synthase and Vacuolar-Type H+ Subunit E Genes in Wheat","volume":"18","author":"Goharrizi","year":"2020","journal-title":"Plant Genet. Resour."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1134\/S1021443719040022","article-title":"Expression Profiles of P5CS and DREB2 Genes under Salt Stress in Aegilops cylindrica","volume":"66","author":"Arabbeigi","year":"2019","journal-title":"Russ. J. Plant Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.plaphy.2016.08.021","article-title":"Responses of Photosynthesis, Nitrogen and Proline Metabolism to Salinity Stress in Solanum lycopersicum under Different Levels of Nitrogen Supplementation","volume":"109","author":"Singh","year":"2016","journal-title":"Plant Physiol. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bcab.2016.05.007","article-title":"Nitrogen Modifies NaCl Toxicity in Eggplant Seedlings: Assessment of Chlorophyll a Fluorescence, Antioxidative Response and Proline Metabolism","volume":"7","author":"Singh","year":"2016","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.plaphy.2020.09.014","article-title":"Silicon Confers Cucumber Resistance to Salinity Stress through Regulation of Proline and Cytokinins","volume":"156","author":"Zhu","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3389\/fpls.2015.00792","article-title":"Proline Accumulation and Metabolism-Related Genes Expression Profiles in Kosteletzkya virginica Seedlings under Salt Stress","volume":"6","author":"Wang","year":"2015","journal-title":"Front. Plant Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.sajb.2017.06.034","article-title":"Epibrassinolide Reverses the Stress Generated by Combination of Excess Aluminum and Salt in Two Wheat Cultivars through Altered Proline Metabolism and Antioxidants","volume":"112","author":"Yusuf","year":"2017","journal-title":"S. Afr. J. Bot."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.5897\/AJB10.2269","article-title":"The Effect of NaCl on Proline Metabolism in Saussurea amara Seedlings","volume":"10","author":"Wang","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"ref_54","first-page":"955","article-title":"Real Time PCR Expression Analysis of Gene Encoding P5CS Enzyme and Proline Metabolism under NaCl Salinity in Rice","volume":"36","author":"Bagdi","year":"2015","journal-title":"J. Environ. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5483\/BMBRep.2009.42.1.028","article-title":"Proline Accumulation and Transcriptional Regulation of Proline Biothesynthesis and Degradation in Brassica napus","volume":"42","author":"Xue","year":"2009","journal-title":"BMB Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Naliwajski, M., and Sk\u0142odowska, M. (2021). The Relationship between the Antioxidant System and Proline Metabolism in the Leaves of Cucumber Plants Acclimated to Salt Stress. Cells, 10.","DOI":"10.3390\/cells10030609"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.phytochem.2017.04.016","article-title":"Evaluation of Proline Functions in Saline Conditions","volume":"140","author":"Mansour","year":"2017","journal-title":"Phytochemistry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/plb.12916","article-title":"Stress-Driven Increase in Proline Levels, and Not Proline Levels Themselves, Correlates with the Ability to Withstand Excess Salt in a Group of 17 Italian Rice Genotypes","volume":"21","author":"Forlani","year":"2019","journal-title":"Plant Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gharsallah, C., Fakhfakh, H., Grubb, D., and Gorsane, F. (2016). Effect of Salt Stress on Ion Concentration, Proline Content, Antioxidant Enzyme Activities and Gene Expression in Tomato Cultivars. AoB Plants, 8.","DOI":"10.1093\/aobpla\/plw055"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.2134\/agronj13.0569","article-title":"Selecting Alfalfa Cultivars for Salt Tolerance Based on Some Physiochemical Traits","volume":"106","author":"Ashrafi","year":"2014","journal-title":"Agron. J."},{"key":"ref_61","first-page":"281","article-title":"Performance of Some Alfalfa Cultivars under Salinity Stress Conditions","volume":"7","author":"Badran","year":"2015","journal-title":"J. Agric. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1671-2927(08)60229-1","article-title":"Changes of Proline Content, Activity, and Active Isoforms of Antioxidative Enzymes in Two Alfalfa Cultivars Under Salt Stress","volume":"8","author":"Wang","year":"2009","journal-title":"Agric. Sci. China"},{"key":"ref_63","first-page":"6937","article-title":"The Effects of Salt Stress on the Growth, Biochemical Parameter and Mineral Element Content of Some Maize (Zea mays L.) Cultivars","volume":"9","author":"Carpici","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0098-8472(01)00109-5","article-title":"Effects of Salt Stress on Growth, Inorganic Ions and Proline Accumulation in Relation to Osmotic Adjustment in Five Sugar Beet Cultivars","volume":"47","author":"Ghoulam","year":"2002","journal-title":"Environ. Exp. Bot."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s11738-013-1298-6","article-title":"Evaluation of Salinity Tolerance in Seedlings of Sugar Beet (Beta vulgaris L.) Cultivars Using Proline, Soluble Sugars and Cation Accumulation Criteria","volume":"35","author":"Wu","year":"2013","journal-title":"Acta Physiol. Plant"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10722-006-9165-6","article-title":"Proline Accumulation as a Response to Salt Stress in 30 Wheat (Triticum aestivum L.) Cultivars Differing in Salt Tolerance","volume":"54","author":"Poustini","year":"2007","journal-title":"Genet. Resour. Crop Evol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11104-012-1179-6","article-title":"Evaluation of Salt Tolerance at the Seedling Stage in Rice Genotypes by Growth Performance, Ion Accumulation, Proline and Chlorophyll Content","volume":"358","author":"Kanawapee","year":"2012","journal-title":"Plant Soil"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0176-1617(96)80193-3","article-title":"Effects of Various Salts and of Mannitol on Ion and Proline Accumulation in Relation to Osmotic Adjustment in Rice (Oryza sativa L.) Callus Cultures","volume":"149","author":"Lutts","year":"1996","journal-title":"J. Plant Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.flora.2012.03.004","article-title":"Growth Stage-Based Modulation in Antioxidant Defense System and Proline Accumulation in Two Hexaploid Wheat (Triticum aestivum L.) Cultivars Differing in Salinity Tolerance","volume":"207","author":"Ashraf","year":"2012","journal-title":"Flora Morphol. Distrib. Funct. Ecol. Plants"},{"key":"ref_70","first-page":"2707","article-title":"Enhanced Proline Synthesis May Determine Resistance to Salt Stress in Tomato Cultivars","volume":"43","author":"Ali","year":"2011","journal-title":"Pak. J. Bot."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/14620316.2013.11512989","article-title":"Exogenous Application of Proline Alleviates Salt-Induced Oxidative Stress in Phaseolus vulgaris L. Plants","volume":"88","author":"Abdelhamid","year":"2015","journal-title":"J. Hortic. Sci. Biotechnol."},{"key":"ref_72","first-page":"50","article-title":"Improvement of Salt Tolerance in Rice (\u201cOryza sativa\u201d L.) by Increasing Antioxidant Defense Systems Using Exogenous Application of Proline","volume":"10","author":"Bhusan","year":"2016","journal-title":"Aust. J. Crop Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00299-019-02382-5","article-title":"Salt Acclimation in Sorghum Plants by Exogenous Proline: Physiological and Biochemical Changes and Regulation of Proline Metabolism","volume":"38","author":"Costa","year":"2019","journal-title":"Plant Cell Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00344-018-9787-x","article-title":"Salt Tolerance Induced by Exogenous Proline in Maize Is Related to Low Oxidative Damage and Favorable Ionic Homeostasis","volume":"37","author":"Marques","year":"2018","journal-title":"J. Plant Growth Regul."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0168-9452(03)00222-X","article-title":"Influence of Exogenous Application of Proline and Glycinebetaine on Growth of Salt-Stressed Tomato Plants","volume":"165","author":"Heuer","year":"2003","journal-title":"Plant Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.envexpbot.2006.12.008","article-title":"Improved Salt Tolerance of Melon (Cucumis melo L.) by the Addition of Proline and Potassium Nitrate","volume":"60","author":"Kaya","year":"2007","journal-title":"Environ. Exp. Bot."},{"key":"ref_77","first-page":"861","article-title":"Induction of salt tolerance in wheat (Triticum aestivum L.) seedlings through exogenous application of proline","volume":"48","author":"Mahboob","year":"2016","journal-title":"Pak. J. Bot."},{"key":"ref_78","first-page":"57","article-title":"Effect of Exogenous Proline in Two Sugarcane Genotypes Grown in Vitro under Salt Stress","volume":"20","author":"Medeiros","year":"2015","journal-title":"Acta Biol\u00f3gica Colomb."},{"key":"ref_79","first-page":"246","article-title":"Exogenous Application of Proline Alleviates Salt-Induced Toxicity in Sainfoin Seedlings","volume":"27","author":"Wu","year":"2017","journal-title":"J. Anim. Plant Sci."},{"key":"ref_80","first-page":"417","article-title":"Highlighting the Mechanisms by Which Proline Can Confer Tolerance to Salt Stress in Cakile maritima","volume":"48","author":"Messedi","year":"2016","journal-title":"Pak. J. Bot."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1747-0765.2009.00412.x","article-title":"Protective Role of Proline against Salt Stress Is Partially Related to the Improvement of Water Status and Peroxidase Enzyme Activity in Cucumber","volume":"55","author":"Huang","year":"2010","journal-title":"Soil Sci. Plant Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00726-010-0677-1","article-title":"Exogenous Proline Effects on Water Relations and Ions Contents in Leaves and Roots of Young Olive","volume":"40","author":"Magdich","year":"2011","journal-title":"Amino Acids"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3906\/bot-1312-13","article-title":"Exogenous Proline and Proline-Enriched Lolium perenne Leaf Extract Protects against Phytotoxic Effects of Nickel and Salinity in Pisum Sativum by Altering Polyamine Metabolism in Leaves","volume":"38","author":"Shahid","year":"2014","journal-title":"Turk. J. Bot."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"757219","DOI":"10.1155\/2014\/757219","article-title":"Exogenous Proline and Glycine Betaine Mediated Upregulation of Antioxidant Defense and Glyoxalase Systems Provides Better Protection against Salt-Induced Oxidative Stress in Two Rice (Oryza sativa L.) Varieties","volume":"2014","author":"Hasanuzzaman","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"13413","DOI":"10.1007\/s11356-016-6533-4","article-title":"Is Foliar Spray of Proline Sufficient for Mitigation of Salt Stress in Brassica juncea Cultivars?","volume":"23","author":"Wani","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.plaphy.2019.01.002","article-title":"Epibrassinolide and Proline Alleviate the Photosynthetic and Yield Inhibition under Salt Stress by Acting on Antioxidant System in Mustard","volume":"135","author":"Wani","year":"2019","journal-title":"Plant Physiol. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11738-015-1921-9","article-title":"Exogenous Proline Reduces NaCl-Induced Damage by Mediating Ionic and Osmotic Adjustment and Enhancing Antioxidant Defense in Eurya emarginata","volume":"37","author":"Zheng","year":"2015","journal-title":"Acta Physiol. Plant"},{"key":"ref_88","first-page":"233","article-title":"Antioxidant Response of Two Salt-Stressed Barley Varieties in the Presence or Absence of Exogenous Proline","volume":"32","author":"Reza","year":"2006","journal-title":"Gen. Appl. Plant Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12298-010-0003-0","article-title":"Evidence for a Role of Exogenous Glycinebetaine and Proline in Antioxidant Defense and Methylglyoxal Detoxification Systems in Mung Bean Seedlings under Salt Stress","volume":"16","author":"Hossain","year":"2010","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10535-014-0392-y","article-title":"Applications of Ascorbic Acid or Proline Increase Resistance to Salt Stress in Barley Seedlings","volume":"58","author":"Agami","year":"2014","journal-title":"Biol. Plant"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1021\/jf9041479","article-title":"Exogenous Proline Effects on Photosynthetic Performance and Antioxidant Defense System of Young Olive Tree","volume":"58","author":"Sensoy","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3329\/pa.v27i4.32120","article-title":"Exogenous Proline Enhances Nutrient Uptake and Confers Tolerance to Salt Stress in Maize (Zea mays L.)","volume":"27","author":"Alam","year":"2016","journal-title":"Progress. Agric."},{"key":"ref_93","first-page":"300","article-title":"The Effect of Exogenous Application of Proline and Glycine Betaine on the Nodule Activity of Soybean Under Saline Condition","volume":"2","author":"Sorour","year":"2017","journal-title":"J. Agric. Biotechnol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s11738-014-1579-8","article-title":"Stress-Induced \u03941-Pyrroline-5-Carboxylate Synthetase (P5CS) Gene Confers Tolerance to Salt Stress in Transgenic Sugarcane","volume":"36","author":"Guerzoni","year":"2014","journal-title":"Acta Physiol. Plant"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fpls.2020.00046","article-title":"Proline Biosynthesis Enzyme Genes Confer Salt Tolerance to Switchgrass (Panicum virgatum L.) in Cooperation With Polyamines Metabolism","volume":"11","author":"Guan","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.plaphy.2015.05.014","article-title":"Proline Over-Accumulation Alleviates Salt Stress and Protects Photosynthetic and Antioxidant Enzyme Activities in Transgenic Sorghum [Sorghum bicolor (L.) Moench]","volume":"94","author":"Reddy","year":"2015","journal-title":"Plant Physiol. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.envexpbot.2018.12.009","article-title":"Plants Facing Oxidative Challenges\u2014A Little Help from the Antioxidant Networks","volume":"161","author":"Soares","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3389\/fpls.2017.00927","article-title":"Toward Unveiling the Mechanisms for Transcriptional Regulation of Proline Biosynthesis in the Plant Cell Response to Biotic and Abiotic Stress Conditions","volume":"8","author":"Zarattini","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"110326","DOI":"10.1016\/j.plantsci.2019.110326","article-title":"The Salt-Induced Transcription Factor GmMYB84 Confers Salinity Tolerance in Soybean","volume":"291","author":"Zhang","year":"2020","journal-title":"Plant Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.plantsci.2018.03.018","article-title":"VvWRKY30, a Grape WRKY Transcription Factor, Plays a Positive Regulatory Role under Salinity Stress","volume":"280","author":"Zhu","year":"2019","journal-title":"Plant Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/ppl.12978","article-title":"The WRKY Transcription Factor WRKY8 Promotes Resistance to Pathogen Infection and Mediates Drought and Salt Stress Tolerance in Solanum lycopersicum","volume":"168","author":"Gao","year":"2020","journal-title":"Physiol. Plant"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Liang, J., Zheng, J., Wu, Z., and Wang, H. (2020). Strawberry FaNAC2 Enhances Tolerance to Abiotic Stress by Regulating Proline Metabolism. Plants, 9.","DOI":"10.3390\/plants9111417"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.plaphy.2019.04.038","article-title":"Overexpression of the NAC Transcription Factor JUNGBRUNNEN1 (JUB1) Increases Salinity Tolerance in Tomato","volume":"140","author":"Alshareef","year":"2019","journal-title":"Plant Physiol. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1111\/febs.15157","article-title":"A BHLH Transcription Factor, MYC2, Imparts Salt Intolerance by Regulating Proline Biosynthesis in Arabidopsis","volume":"287","author":"Verma","year":"2020","journal-title":"FEBS J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"23085","DOI":"10.1038\/srep23085","article-title":"An Ethylene-Responsive Factor BpERF11 Negatively Modulates Salt and Osmotic Tolerance in Betula platyphylla","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"114463","DOI":"10.1016\/j.indcrop.2021.114463","article-title":"Overexpression of an ABA-Inducible Homeodomain-Leucine Zipper I Gene MsHB7 Confers Salt Stress Sensitivity to Alfalfa","volume":"177","author":"Li","year":"2022","journal-title":"Ind. Crops Prod."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"135196","DOI":"10.1016\/j.chemosphere.2022.135196","article-title":"Heavy Metal and Metalloid Toxicity in Horticultural Plants: Tolerance Mechanism and Remediation Strategies","volume":"303","author":"Noor","year":"2022","journal-title":"Chemosphere"},{"key":"ref_108","first-page":"299","article-title":"Proline Accumulation in Lemongrass (Cymbopogon flexuosus Stapf.) Due to Heavy Metal Stress","volume":"30","author":"Handique","year":"2009","journal-title":"J. Environ. Biol."},{"key":"ref_109","first-page":"157","article-title":"Effects of Some Heavy Metals on Content of Chlorophyll, Proline and Some Antioxidant Chemicals in Bean (Phaseolus vulgaris L.) Seedlings","volume":"47","author":"Zengin","year":"2005","journal-title":"Acta Biol. Crac. Ser. Bot."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s12298-019-00667-3","article-title":"Variations in the Antioxidant and Free Radical Scavenging under Induced Heavy Metal Stress Expressed as Proline Content in Chickpea","volume":"25","author":"Bhagyawant","year":"2019","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"10496","DOI":"10.1007\/s11356-019-04540-4","article-title":"Biogeochemical Behavior of Nickel under Different Abiotic Stresses: Toxicity and Detoxification Mechanisms in Plants","volume":"26","author":"Ameen","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s13762-019-02215-8","article-title":"Heavy Metal Stress and Responses in Plants","volume":"16","author":"Ghori","year":"2019","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10725-007-9240-9","article-title":"Differential Biochemical Responses of Wheat Shoots and Roots to Nickel Stress: Antioxidative Reactions and Proline Accumulation","volume":"54","author":"Gajewska","year":"2008","journal-title":"Plant Growth Regul."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"20408","DOI":"10.1007\/s11356-016-7230-z","article-title":"Molybdenum (Mo) Increases Endogenous Phenolics, Proline and Photosynthetic Pigments and the Phytoremediation Potential of the Industrially Important Plant Ricinus communis L. for Removal of Cadmium from Contaminated Soil","volume":"23","author":"Hadi","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s00128-019-02651-9","article-title":"EDTA-Assisted Metal Uptake in Raphanus sativus L. and Brassica oleracea L.: Assessment of Toxicity and Food Safety","volume":"103","author":"Chaturvedi","year":"2019","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envexpbot.2015.09.010","article-title":"Effect of 24-Epibrassinolide on ROS Content, Antioxidant System, Lipid Peroxidation and Ni Uptake in Solanum nigrum L. under Ni Stress","volume":"122","author":"Soares","year":"2016","journal-title":"Environ. Exp. Bot."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00709-010-0197-6","article-title":"Interactive Effect of Calcium and Gibberellin on Nickel Tolerance in Relation to Antioxidant Systems in Triticum aestivum L.","volume":"248","author":"Siddiqui","year":"2011","journal-title":"Protoplasma"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3389\/fpls.2016.00591","article-title":"Jasmonic Acid Modulates the Physio-Biochemical Attributes, Antioxidant Enzyme Activity, and Gene Expression in Glycine max under Nickel Toxicity","volume":"7","author":"Sirhindi","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2478\/v10184-012-0019-3","article-title":"Proline Enhances Antioxidative Enzyme Activity, Photosynthesis and Yield of Cicer arietinum L. Exposed to Cadmium Stress","volume":"72","author":"Hayat","year":"2013","journal-title":"Acta Bot. Croat."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-030-27423-8_4","article-title":"Exogenous Proline-Mediated Abiotic Stress Tolerance in Plants: Possible Mechanisms","volume":"2019","author":"Zouari","year":"2019","journal-title":"Osmoprotectant Mediat. Abiotic Stress Toler. Plants"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"20587","DOI":"10.1007\/s11356-017-9665-2","article-title":"Nickel Stressed Responses of Rice in Ni Subcellular Distribution, Antioxidant Production, and Osmolyte Accumulation","volume":"24","author":"Rizwan","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00344-022-10595-4","article-title":"Early Activation of Antioxidant Responses in Ni-Stressed Tomato Cultivars Determines Their Resilience Under Co-Exposure to Drought","volume":"42","author":"Spormann","year":"2022","journal-title":"J. Plant Growth Regul."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00128-013-1047-y","article-title":"Chromium Phytotoxicity in Radish (Raphanus sativus): Effects on Metabolism and Nutrient Uptake","volume":"91","author":"Tiwari","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1744-7348.2012.00575.x","article-title":"Antioxidant Responses to Water Deficit by Drought-Tolerant and -Sensitive Sugarcane Varieties","volume":"161","author":"Cia","year":"2012","journal-title":"Ann. Appl. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ecoenv.2017.05.038","article-title":"Remediation of Heavy Metal Contaminated Soils by Using Solanum nigrum: A Review","volume":"143","author":"Rizwan","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.flora.2008.03.004","article-title":"Cadmium Accumulation in Atriplex halimus Subsp. Schweinfurthii and Its Influence on Growth, Proline, Root Hydraulic Conductivity and Nutrient Uptake","volume":"204","author":"Nedjimi","year":"2009","journal-title":"Flora Morphol. Distrib. Funct. Ecol. Plants"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.envexpbot.2007.01.004","article-title":"Antioxidative Defense and Proline\/Phytochelatin Accumulation in a Newly Discovered Cd-Hyperaccumulator, Solanum nigrum L.","volume":"60","author":"Sun","year":"2007","journal-title":"Environ. Exp. Bot."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Matsunami, M., Toyofuku, K., Kimura, N., and Plants, A.O. (2020). Osmotic Stress Leads to Significant Changes in Rice Root Metabolic Profiles between Tolerant and Sensitive Genotypes. Plants, 9.","DOI":"10.3390\/plants9111503"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1399-3054.1997.tb01026.x","article-title":"Heavy Metal-Induced Accumulation of Free Proline in a Metal-Tolerant and a Nontolerant Ecotype of Silene vuigaris","volume":"101","author":"Schat","year":"1997","journal-title":"Physiol. Plant."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Sofy, M.R., Seleiman, M.F., Alhammad, B.A., Alharbi, B.M., and Mohamed, H.I. (2020). Minimizing Adverse Effects of Pb on Maize Plants by Combined Treatment with Jasmonic, Salicylic Acids and Proline. Agronomy, 10.","DOI":"10.3390\/agronomy10050699"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/17429145.2018.1437480","article-title":"The Ameliorative Effects of Exogenously Applied Proline on Physiological and Biochemical Parameters of Wheat (Triticum aestivum L.) Crop under Copper Stress Condition","volume":"13","author":"Noreen","year":"2018","journal-title":"J. Plant Interact."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ecoleng.2015.11.016","article-title":"Exogenous Proline Enhances Growth, Mineral Uptake, Antioxidant Defense, and Reduces Cadmium-Induced Oxidative Damage in Young Date Palm (Phoenix dactylifera L.)","volume":"86","author":"Zouari","year":"2016","journal-title":"Ecol. Eng."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00244-008-9226-2","article-title":"Relationship between Proline and Hg2+-Induced Oxidative Stress in a Tolerant Rice Mutant","volume":"56","author":"Wang","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.plantsci.2003.08.015","article-title":"Effects of Proline on Copper Transport in Rice Seedlings under Excess Copper Stress","volume":"166","author":"Chen","year":"2004","journal-title":"Plant Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1515\/biolog-2017-0033","article-title":"Modulation in Arsenic-Induced Lipid Catabolism in Glycine max Using Proline, 24-Epibrassinolide and Diphenylene Iodonium","volume":"72","author":"Chandrakar","year":"2017","journal-title":"Biologia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1080\/09168451.2020.1799747","article-title":"Exogenous Proline Enhances Antioxidant Enzyme Activities but Does Not Mitigate Growth Inhibition by Selenate Stress in Tobacco BY-2 Cells","volume":"84","author":"Khatun","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00299-008-0643-5","article-title":"Protective Effects of Proline against Cadmium Toxicity in Micropropagated Hyperaccumulator, Solanum nigrum L.","volume":"28","author":"Xu","year":"2009","journal-title":"Plant Cell Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ibiod.2017.06.010","article-title":"The Role of Exogenous Proline in Amelioration of Lipid Peroxidation in Rice Seedlings Exposed to Cr(VI)","volume":"123","author":"Yu","year":"2017","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wang, Y., Tan, P., Chang, L., Yue, Z., Zeng, C., Li, M., Liu, Z., Dong, X., and Yan, M. (2022). Exogenous Proline Mitigates Toxic Effects of Cadmium via the Decrease of Cadmium Accumulation and Reestablishment of Redox Homeostasis in Brassica juncea. BMC Plant Biol., 22.","DOI":"10.1186\/s12870-022-03538-4"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s42452-021-04301-4","article-title":"Phytoremediation: A Sustainable Environmental Technology for Heavy Metals Decontamination","volume":"3","author":"Nedjimi","year":"2021","journal-title":"SN Appl. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11270-019-4089-x","article-title":"Phytoremediation of Lead and Chromium Contaminated Soil Improves with the Endogenous Phenolics and Proline Production in Parthenium, Cannabis, Euphorbia, and Rumex Species","volume":"230","author":"Ullah","year":"2019","journal-title":"Water Air Soil Pollut."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s40415-016-0253-3","article-title":"Foliar Treatment with Lolium perenne (Poaceae) Leaf Extract Alleviates Salinity and Nickel-Induced Growth Inhibition in Pea","volume":"39","author":"Balal","year":"2016","journal-title":"Rev. Bras. De Bot."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ecoenv.2015.03.021","article-title":"Exogenous Proline Application Ameliorates Toxic Effects of Arsenate in Solanum melongena L. Seedlings","volume":"117","author":"Singh","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12011-010-8699-9","article-title":"Exogenous Proline Application Reduces Phytotoxic Effects of Selenium by Minimising Oxidative Stress and Improves Growth in Bean (Phaseolus vulgaris L.) Seedlings","volume":"140","author":"Aggarwal","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Hayat, K., Khan, J., Khan, A., Ullah, S., Ali, S., and Fu, Y. (2021). Ameliorative Effects of Exogenous Proline on Photosynthetic Attributes, Nutrients Uptake, and Oxidative Stresses under Cadmium in Pigeon Pea (Cajanus cajan L.). Plants, 10.","DOI":"10.3390\/plants10040796"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.sajb.2018.07.008","article-title":"Olive Trees Response to Lead Stress: Exogenous Proline Provided Better Tolerance than Glycine Betaine","volume":"118","author":"Zouari","year":"2018","journal-title":"S. Afr. J. Bot."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"40","DOI":"10.22271\/2582-3744.2020.mar.40","article-title":"Exogenous Proline and Hormone in Combination with Compost Improves Growth and Tolerance of Maize under Heavy Metal Stress","volume":"2","author":"Adejumo","year":"2020","journal-title":"Plants Environ."},{"key":"ref_148","first-page":"489","article-title":"Ameliorative Role of Pre-Sowing Proline Treatment in Coriandrum sativum L. Seedlings under Mercury Toxicity","volume":"90","author":"Kapoor","year":"2021","journal-title":"Phyton Int. J. Exp. Bot."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ecoenv.2019.02.025","article-title":"Effects of Biochar and Zeolite Soil Amendments with Foliar Proline Spray on Nickel Immobilization, Nutritional Quality and Nickel Concentrations in Wheat","volume":"173","author":"Shahbaz","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.plaphy.2019.04.025","article-title":"Interplaying Roles of Silicon and Proline Effectively Improve Salt and Cadmium Stress Tolerance in Phaseolus vulgaris Plant","volume":"139","author":"Rady","year":"2019","journal-title":"Plant Physiol. Biochem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fchem.2017.00070","article-title":"Synergistic Effects of Heavy Metals and Pesticides in Living Systems","volume":"5","author":"Singh","year":"2017","journal-title":"Front. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1000392","DOI":"10.4172\/2161-0525.1000392","article-title":"Xenobiotic Compounds Present in Soil and Water: A Review on Remediation Strategies","volume":"6","author":"Godheja","year":"2016","journal-title":"J. Environ. Anal. Toxicol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Duarte, R.M.B.O., Matos, J.T.V., and Senesi, N. (2018). Organic Pollutants in Soils. Soil Pollut. Monit. Remediat., 103\u2013126.","DOI":"10.1016\/B978-0-12-849873-6.00005-4"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.chemosphere.2016.09.053","article-title":"Ecotoxicological Relevance of Nano-NiO and Acetaminophen to Hordeum vulgare L.: Combining Standardized Procedures and Physiological Endpoints","volume":"165","author":"Soares","year":"2016","journal-title":"Chemosphere"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.envpol.2019.01.063","article-title":"Is Soil Contamination by a Glyphosate Commercial Formulation Truly Harmless to Non-Target Plants?\u2014Evaluation of Oxidative Damage and Antioxidant Responses in Tomato","volume":"247","author":"Soares","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"122871","DOI":"10.1016\/j.jhazmat.2020.122871","article-title":"Glyphosate-Dependent Effects on Photosynthesis of Solanum lycopersicum L.\u2014An Ecophysiological, Ultrastructural and Molecular Approach","volume":"398","author":"Soares","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"29130","DOI":"10.1007\/s11356-020-09136-x","article-title":"Diclofenac Shifts the Role of Root Glutamine Synthetase and Glutamate Dehydrogenase for Maintaining Nitrogen Assimilation and Proline Production at the Expense of Shoot Carbon Reserves in Solanum lycopersicum L.","volume":"27","author":"Martins","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"113762","DOI":"10.1016\/j.envpol.2019.113762","article-title":"Response of Solanum lycopersicum L. to Diclofenac\u2014Impacts on the Plant\u2019s Antioxidant Mechanisms","volume":"258","author":"Sousa","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/fes3.114","article-title":"An Efficient Antioxidant System and Heavy Metal Exclusion from Leaves Make Solanum cheesmaniae More Tolerant to Cu than Its Cultivated Counterpart","volume":"6","author":"Soares","year":"2017","journal-title":"Food Energy Secur."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jhazmat.2015.10.043","article-title":"Impact of Phosphate on Glyphosate Uptake and Toxicity in Willow","volume":"304","author":"Gomes","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s11356-010-0342-y","article-title":"Effects of Acetaminophen in Brassica juncea L. Czern.: Investigation of Uptake, Translocation, Detoxification, and the Induced Defense Pathways","volume":"17","author":"Bartha","year":"2010","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"130128","DOI":"10.1016\/j.jhazmat.2022.130128","article-title":"Ecotoxicological Relevance of Glyphosate and Flazasulfuron to Soil Habitat and Retention Functions\u2014Single vs. Combined Exposures","volume":"442","author":"Soares","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10311-020-00969-z","article-title":"Glyphosate Uptake, Translocation, Resistance Emergence in Crops, Analytical Monitoring, Toxicity and Degradation: A Review","volume":"18","author":"Singh","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.envpol.2017.11.041","article-title":"Pharmaceutical and Personal Care Products-Induced Stress Symptoms and Detoxification Mechanisms in Cucumber Plants","volume":"234","author":"Sun","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1093\/jxb\/eru269","article-title":"Alteration of Plant Physiology by Glyphosate and Its By-Product Aminomethylphosphonic Acid: An Overview","volume":"65","author":"Gomes","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fpls.2017.00207","article-title":"Glyphosate-Dependent Inhibition of Photosynthesis in Willow","volume":"8","author":"Gomes","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Soares, C., Nadais, P., Sousa, B., Pinto, E., Ferreira, I.M.P.L.V.O., Pereira, R., and Fidalgo, F. (2021). Silicon Improves the Redox Homeostasis to Alleviate Glyphosate Toxicity in Tomato Plants\u2014Are Nanomaterials Relevant?. Antioxidants, 10.","DOI":"10.3390\/antiox10081320"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Soares, C., Rodrigues, F., Sousa, B., Pinto, E., Ferreira, I.M.P.L.V.O., Pereira, R., and Fidalgo, F. (2021). Foliar Application of Sodium Nitroprusside Boosts Solanum lycopersicum L. Tolerance to Glyphosate by Preventing Redox Disorders and Stimulating Herbicide Detoxification Pathways. Plants, 10.","DOI":"10.3390\/plants10091862"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ecoenv.2017.09.020","article-title":"Biotransformation of Flubendazole and Fenbendazole and Their Effects in the Ribwort Plantain (Plantago lanceolata)","volume":"147","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"31202","DOI":"10.1007\/s11356-020-09442-4","article-title":"Pharmaceuticals in Environment: The Effect of Ivermectin on Ribwort Plantain (Plantago lanceolata L.)","volume":"27","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.scitotenv.2016.03.054","article-title":"Stress-Related Phenomena and Detoxification Mechanisms Induced by Common Pharmaceuticals in Alfalfa (Medicago sativa L.) Plants","volume":"557\u2013558","author":"Christou","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"103746","DOI":"10.1016\/j.etap.2021.103746","article-title":"Effect of Diclofenac and Naproxen and Their Mixture on Spring Barley Seedlings and Heterocypris incongruens","volume":"88","author":"Biczak","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.envpol.2018.06.037","article-title":"Can Nano-SiO2 Reduce the Phytotoxicity of Acetaminophen?\u2014A Physiological, Biochemical and Molecular Approach","volume":"241","author":"Soares","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"10815","DOI":"10.1007\/s11356-014-3059-5","article-title":"Biochemical and Standard Toxic Effects of Acetaminophen on the Macrophyte Species Lemna minor and Lemna gibba","volume":"21","author":"Nunes","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"110890","DOI":"10.1016\/j.ecoenv.2020.110890","article-title":"Responses of Hydrocharis dubia (Bl.) Backer and Trapa Bispinosa Roxb. to Tetracycline Exposure","volume":"202","author":"Liu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s10646-009-0396-0","article-title":"Fluroxypyr Triggers Oxidative Damage by Producing Superoxide and Hydrogen Peroxide in Rice (Oryza sativa)","volume":"19","author":"Wu","year":"2010","journal-title":"Ecotoxicology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.plaphy.2018.07.027","article-title":"Differential Effects of Acetophenone on Shoots\u2019 and Roots\u2019 Metabolism of Solanum nigrum L. Plants and Implications in Its Phytoremediation","volume":"130","author":"Moreira","year":"2018","journal-title":"Plant Physiol. Biochem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10646-018-1916-6","article-title":"Pesticide-Induced Oxidative Stress and Antioxidant Responses in Tomato (Solanum lycopersicum) Seedlings","volume":"27","author":"Shakir","year":"2018","journal-title":"Ecotoxicology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s42729-021-00604-y","article-title":"Exogenously Used Proline Offers Potent Antioxidative and Osmoprotective Strategies to Re-Balance Growth and Physio-Biochemical Attributes in Herbicide-Stressed Trigonella foenum-graecum","volume":"21","author":"Boulahia","year":"2021","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Shopova, E., Katerova, Z., Brankova, L., Dimitrova, L., Sergiev, I., Todorova, D., and Talaat, N.B. (2021). Modulation of Physiological Stress Response of Triticum aestivum L. to Glyphosate by Brassinosteroid Application. Life, 11.","DOI":"10.3390\/life11111156"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00299-015-1850-5","article-title":"Overexpression of D-Amino Acid Oxidase from Bradyrhizobium japonicum, Enhances Resistance to Glyphosate in Arabidopsis thaliana","volume":"34","author":"Han","year":"2015","journal-title":"Plant Cell. Rep."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jenvman.2019.04.035","article-title":"Salicylic Acid Alleviates Glyphosate-Induced Oxidative Stress in Hordeum vulgare L.","volume":"241","author":"Spormann","year":"2019","journal-title":"J. Environ. Manag."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10725-016-0223-6","article-title":"Exogenous 24-Epibrassinolide Regulates Antioxidant and Pesticide Detoxification Systems in Grapevine after Chlorothalonil Treatment","volume":"81","author":"Wang","year":"2017","journal-title":"Plant Growth Regul."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1104\/pp.122.2.357","article-title":"Hypersensitivity of an Arabidopsis Sugar Signaling Mutant toward Exogenous Proline Application","volume":"122","author":"Hellmann","year":"2000","journal-title":"Plant Physiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.sjbs.2018.03.009","article-title":"Arbuscular Mycorrhizal Fungi Regulate the Oxidative System, Hormones and Ionic Equilibrium to Trigger Salt Stress Tolerance in Cucumis sativus L.","volume":"25","author":"Hashem","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_186","first-page":"228","article-title":"Foliar Application of Auxin or Cytokinin Can Confer Salinity Stress Tolerance in Vicia faba L.","volume":"11","author":"Latef","year":"2021","journal-title":"Agronomy"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.sajb.2018.07.009","article-title":"24-Epibrassinolide Supplemented with Silicon Enhances the Photosynthetic Efficiency of Brassica juncea under Salt Stress","volume":"118","author":"Siddiqui","year":"2018","journal-title":"S. Afr. J. Bot."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1007\/s00344-022-10592-7","article-title":"Salicylic Acid Improves Nitrogen Fixation, Growth, Yield and Antioxidant Defence Mechanisms in Chickpea Genotypes Under Salt Stress","volume":"41","author":"Kaur","year":"2022","journal-title":"J. Plant Growth Regul."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00344-020-10187-0","article-title":"Exogenous Application of Melatonin Induces Tolerance to Salt Stress by Improving the Photosynthetic Efficiency and Antioxidant Defense System of Maize Seedling","volume":"40","author":"Ahmad","year":"2021","journal-title":"J. Plant Growth Regul."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13237-020-00326-z","article-title":"Exogenously Applied Selenium (Se) Mitigates the Impact of Salt Stress in Setaria italica L. and Panicum miliaceum L.","volume":"63","author":"Shah","year":"2020","journal-title":"Nucleus"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"110964","DOI":"10.1016\/j.ecoenv.2020.110964","article-title":"Different Methods of Silicon Application Attenuate Salt Stress in Sorghum and Sunflower by Modifying the Antioxidative Defense Mechanism","volume":"203","author":"Hurtado","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1271\/bbb.90244","article-title":"Exogenous Proline and Glycinebetaine Suppress Apoplastic Flow to Reduce Na+ Uptake in Rice Seedlings","volume":"73","author":"Sobahan","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_193","first-page":"93","article-title":"Induction of Salt Tolerance in Two Cultivars of Sorghum (Sorghum bicolor L.) by Exogenous Application of Proline at Seedling Stage","volume":"10","author":"Nawaz","year":"2010","journal-title":"World Appl. Sci. J."},{"key":"ref_194","first-page":"157","article-title":"Role of Exogenous Proline in Ameliorating Salt Stress at Early Stage in Two Rice Cultivars","volume":"7","author":"Deivanai","year":"2011","journal-title":"J. Stress Physiol. Biochem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s13593-011-0076-3","article-title":"Osmoregulators Proline and Glycine Betaine Counteract Salinity Stress in Canola","volume":"32","author":"Sakr","year":"2012","journal-title":"Agron. Sustain. Dev."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1271\/bbb.120233","article-title":"Effects of Exogenous Proline and Glycinebetaine on the Salt Tolerance of Rice Cultivars","volume":"76","author":"Sobahan","year":"2012","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jplph.2012.01.004","article-title":"Exogenous Proline and Trehalose Promote Recovery of Rice Seedlings from Salt-Stress and Differentially Modulate Antioxidant Enzymes and Expression of Related Genes","volume":"169","author":"Nounjan","year":"2012","journal-title":"J. Plant Physiol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"309","DOI":"10.17221\/762\/2011-PSE","article-title":"Effects of Exogenous Proline and Trehalose on Physiological Responses in Rice Seedlings during Salt-Stress and after Recovery","volume":"58","author":"Nounjan","year":"2012","journal-title":"Plant Soil Environ."},{"key":"ref_199","first-page":"1","article-title":"Effect of Seed Soaking with Exogenous Proline on Seed Germination of Rice Under Salt Stress","volume":"21","author":"Yang","year":"2014","journal-title":"J. Northeast. Agric. Univ. (Engl. Ed.)"},{"key":"ref_200","first-page":"1014","article-title":"Alleviation of Adverse Effects of Salt Stress on Soybean (Glycine max L.) by Using Osmoprotectants and Organic Nutrients","volume":"9","author":"Sorour","year":"2015","journal-title":"Int. J. Agric. Biosyst. Eng."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10725-014-9980-2","article-title":"In Vitro Rice Shoot Apices as Simple Model to Study the Effect of NaCl and the Potential of Exogenous Proline and Glutathione in Mitigating Salinity Stress","volume":"75","author":"Teh","year":"2015","journal-title":"Plant Growth Regul."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ecoenv.2016.07.028","article-title":"Sequenced Application of Ascorbate-Proline-Glutathione Improves Salt Tolerance in Maize Seedlings","volume":"133","author":"Rady","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_203","first-page":"38","article-title":"Exogenous Proline and Glycinebetaine Mitigate the Detrimental Effect of Salt Stress on Rice Plants","volume":"10","author":"Sobahan","year":"2016","journal-title":"Sci. Eng. Health Stud."},{"key":"ref_204","first-page":"2449","article-title":"Effect of Proline on Germination and Seedling Growth of Rice (Oryza sativa L.) under Salt Stress","volume":"7","author":"Singh","year":"2018","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1556\/0806.46.2018.10","article-title":"Influence of Proline Priming on Antioxidative Potential and Ionic Distribution and Its Relationship with Salt Tolerance of Wheat","volume":"46","author":"Shafiq","year":"2018","journal-title":"Cereal Res. Commun."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jplph.2009.04.002","article-title":"Exogenous Proline and Glycinebetaine Increase Antioxidant Enzyme Activities and Confer Tolerance to Cadmium Stress in Cultured Tobacco Cells","volume":"166","author":"Islam","year":"2009","journal-title":"J. Plant Physiol."},{"key":"ref_207","first-page":"129","article-title":"Effects of Exogenous Proline on the Growth of Wheat Seedlings under Cadmium Stress","volume":"24","author":"Min","year":"2013","journal-title":"Yingyong Shengtai Xuebao"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s40415-014-0089-7","article-title":"Exogenous Proline and Glycinebetaine Mitigate Cadmium Stress in Two Genetically Different Spring Wheat (Triticum aestivum L.) Cultivars","volume":"37","author":"Rasheed","year":"2014","journal-title":"Rev. Bras. Bot."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ecoenv.2016.02.024","article-title":"Impact of Proline Application on Cadmium Accumulation, Mineral Nutrition and Enzymatic Antioxidant Defense System of Olea europaea L. Cv Chemlali Exposed to Cadmium Stress","volume":"128","author":"Zouari","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_210","first-page":"221","article-title":"Exogenous Proline Application Enhances the Efficiency of Nitrogen Fixation and Assimilation in Chickpea Plants Exposed to Cadmium","volume":"39","author":"Alyemeni","year":"2016","journal-title":"Legume Res."},{"key":"ref_211","first-page":"2145","article-title":"Proline Application Triggers Temporal Redox Imbalance, but Alleviates Cadmium Stress in Wheat Seedlings","volume":"49","author":"Konotop","year":"2017","journal-title":"Pak. J. Bot."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00709-010-0178-9","article-title":"Proline Improves Copper Tolerance in Chickpea (Cicer arietinum)","volume":"245","author":"Singh","year":"2010","journal-title":"Protoplasma"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1134\/S102144371102021X","article-title":"Proline Protects Atropa belladonna Plants against Nickel Salt Toxicity","volume":"58","author":"Stetsenko","year":"2011","journal-title":"Russ. J. Plant Physiol."},{"key":"ref_214","first-page":"319","article-title":"The Effect of Common Bean (Phaseolus vulgaris L.) Seed Pretreatment with Proline and Glycine Betaine on Tolerance to Lead Stress","volume":"12","author":"Sadeghipour","year":"2019","journal-title":"Environ. Stress. Crop Sci."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jplph.2005.08.003","article-title":"Inhibition of Ribonuclease and Protease Activities in Arsenic Exposed Rice Seedlings: Role of Proline as Enzyme Protectant","volume":"163","author":"Mishra","year":"2006","journal-title":"J. Plant Physiol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11738-022-03382-x","article-title":"Salicylic Acid Alleviates Oxidative Stress and Lipid Peroxidation Caused by Clopyralid Herbicide in Indian Mustard Plants","volume":"44","author":"Ghahremani","year":"2022","journal-title":"Acta Physiol. Plant"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1016\/j.freeradbiomed.2018.04.519","article-title":"Salicylic Acid Improves the Performance of the Enzymatic Antioxidant System of Barley Exposed to Glyphosate","volume":"120","author":"Soares","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-65124-8","article-title":"Silicon Tackles Butachlor Toxicity in Rice Seedlings by Regulating Anatomical Characteristics, Ascorbate-Glutathione Cycle, Proline Metabolism and Levels of Nutrients","volume":"10","author":"Tripthi","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/666\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:47Z","timestamp":1760122247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":218,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["antiox12030666"],"URL":"https:\/\/doi.org\/10.3390\/antiox12030666","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]}}}