{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:51:00Z","timestamp":1762869060587,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"CICS-UBI projects","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020","UIDP\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Portuguese Foundation for Science and Technology\/MCTES","award":["UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020","UIDP\/00709\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress has a fundamental role in the pathophysiology of various conditions, like infertility. This case-control study was performed to assess the potential role of CYP19A1, GSTM1, and GSTT1 in modifying individual predisposition to female infertility. Genotyping of 201 women with established infertility and 161 fertile female controls was performed, and statistical associations were analyzed. For carriers of GSTM1 null genotype along with CYP19A1 C allele, there is a significant association with female infertility risk (OR 7.023; 95% CI (3.627\u201313.601; p &lt; 0.001), and, also for carriers of GSTT1 null genotype along with the CYP19A1 TC\/CC genotype (OR 24.150; 95% CI (11.148\u201352.317; p &lt; 0.001). A positive association with female infertility risk for carriers of the C allele in CYP19A1 and null genotypes in GTSM1 (OR 11.979; 95% CI (4.570\u201331.400; p &lt; 0.001) or GSTT1 (OR 13.169; 95% CI (4.518\u201338.380; p &lt; 0.001) was found. When both GSTs are deleted, the risk of developing female infertility is significant, independently of the CYP19A1 genotype; when all the presumed high-risk genotypes are present, we found a significant association with female infertility risk (OR 47,914; 95% CI (14,051\u2013163,393; p &lt; 0.001).<\/jats:p>","DOI":"10.3390\/antiox12040940","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:45:32Z","timestamp":1681706732000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CYP19A1 TC\/CC Polymorphism, along with Deletion of GSTM1 and GSTT1 Genes, Strongly Influences Female Infertility Risk"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-2489","authenticated-orcid":false,"given":"Maria Manuel","family":"Casteleiro Alves","sequence":"first","affiliation":[{"name":"Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior (UBI), 6201-506 Covilh\u00e3, Portugal"},{"name":"Assisted Reproduction Laboratory of Academic Hospital of Cova da Beira (CHUCB), 6200-251 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-0765","authenticated-orcid":false,"given":"Micaela","family":"Almeida","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior (UBI), 6201-506 Covilh\u00e3, Portugal"}]},{"given":"Ant\u00f3nio H\u00e9lio","family":"Oliani","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior (UBI), 6201-506 Covilh\u00e3, Portugal"},{"name":"Assisted Reproduction Laboratory of Academic Hospital of Cova da Beira (CHUCB), 6200-251 Covilh\u00e3, Portugal"},{"name":"Department of Obstetrics and Gynecology, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-1645","authenticated-orcid":false,"given":"Luiza","family":"Breitenfeld","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior (UBI), 6201-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-665X","authenticated-orcid":false,"given":"Ana Cristina","family":"Ramalhinho","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior (UBI), 6201-506 Covilh\u00e3, Portugal"},{"name":"Assisted Reproduction Laboratory of Academic Hospital of Cova da Beira (CHUCB), 6200-251 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6249536","DOI":"10.1155\/2018\/6249536","article-title":"The Role of Oxidative Stress, Selected Metals, and Parameters of the Immune System in Male Fertility","volume":"2018","author":"Dobrakowski","year":"2018","journal-title":"Oxidative Med. 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