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Hydroalcoholic extracts from the dried biomass were subjected to sequential liquid\u2013liquid partitions, affording five different fractions (F1\u2013F5). Their cosmetic potential was assessed through a set of in vitro assays concerning their antioxidant, photoprotective, and healing properties. Additionally, their cytotoxicity in HaCaT cells and their capacity to induce inflammation in RAW 264.7 cells were also evaluated. As a proof-of-concept, O\/W emulsions were prepared, and emulsion stability was assessed by optical microscopy, droplet size analysis, centrifugation tests, and rheology analysis. Furthermore, in vivo tests were conducted with the final formulation to assess its antioxidant capacity. At subtoxic concentrations, the most lipophilic fraction has provided photoprotection against UV light-induced photooxidation in HaCaT cells. This was conducted together with the aqueous fraction, which also displayed healing capacities. Regarding the physical and stability assays, the best performance was achieved with the formulation containing 1% aqueous extract, which exhibited water retention and antioxidant properties in the in vivo assay. In summary, Gelidium corneum displayed itself as a potential source of bioactive ingredients with multitarget properties for dermatological use.<\/jats:p>","DOI":"10.3390\/antiox12091684","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:47:26Z","timestamp":1693306046000},"page":"1684","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Insights into the Dermocosmetic Potential of the Red Seaweed Gelidium corneum"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-2564","authenticated-orcid":false,"given":"Margarida","family":"Matias","sequence":"first","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"},{"name":"LIFE-Health and Bioscience Research Institute, Technological University of Shannon, Moylish Park, V94 E8YF Limerick, Ireland"}]},{"given":"Alice","family":"Martins","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-2127","authenticated-orcid":false,"given":"Celso","family":"Alves","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-1699","authenticated-orcid":false,"given":"Joana","family":"Silva","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-3111","authenticated-orcid":false,"given":"Susete","family":"Pinteus","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"}]},{"given":"Manuel","family":"Fitas","sequence":"additional","affiliation":[{"name":"PhD Trials, Avenida Maria Helena Vieira da Silva, n\u00b0 24 A, 1750-182 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5723-0750","authenticated-orcid":false,"given":"Pedro","family":"Pinto","sequence":"additional","affiliation":[{"name":"PhD Trials, Avenida Maria Helena Vieira da Silva, n\u00b0 24 A, 1750-182 Lisboa, Portugal"},{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-5622","authenticated-orcid":false,"given":"Joana","family":"Marto","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-7991","authenticated-orcid":false,"given":"Helena","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"given":"Patrick","family":"Murray","sequence":"additional","affiliation":[{"name":"LIFE-Health and Bioscience Research Institute, Technological University of Shannon, Moylish Park, V94 E8YF Limerick, Ireland"}]},{"given":"Rui","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre and ARNET-Aquatic Research Network, Escola Superior de Turismo e Tecnologia do Mar, Polytechnic of Leiria, 2520-630 Peniche, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zappelli, C., Barbulova, A., Apone, F., and Colucci, G. (2016). Effective Active Ingredients Obtained through Biotechnology. Cosmetics, 3.","DOI":"10.3390\/cosmetics3040039"},{"key":"ref_2","unstructured":"Galanakis, C.M. (2017). Handbook of Grape Processing By-Products, Elsevier Inc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.phymed.2011.10.003","article-title":"Bioactive Compounds from Natural Resources against Skin Aging","volume":"19","author":"Mukherjee","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.algal.2017.05.019","article-title":"Cosmetic Attributes of Algae\u2014A Review","volume":"25","author":"Ariede","year":"2017","journal-title":"Algal Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.fsc.2018.06.002","article-title":"How to Use Oral and Topical Cosmeceuticals to Prevent and Treat Skin Aging","volume":"26","author":"Baumann","year":"2018","journal-title":"Facial Plast."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"a015370","DOI":"10.1101\/cshperspect.a015370","article-title":"Natural and Sun-Induced Aging of Human Skin","volume":"5","author":"Rittie","year":"2015","journal-title":"Cold Spring Harb."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/jid.2013.9","article-title":"UVB-Induced Melanocyte Proliferation in Neonatal Mice Driven by CCR2-Independent Recruitment of Ly6clowMHCIIhi Macrophages","volume":"133","author":"Handoko","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1871528113666140522112003","article-title":"Inflammaging in Skin and Other Tissues\u2014The Roles of Complement System and Macrophage","volume":"13","author":"Zhuang","year":"2014","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1089\/15230860260220175","article-title":"Oxidative Stress and Its Role in Skin Disease","volume":"4","author":"Trouba","year":"2002","journal-title":"Antioxid Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101036","DOI":"10.1016\/j.arr.2020.101036","article-title":"Biomarkers, Oxidative Stress and Autophagy in Skin Aging","volume":"59","author":"Gu","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gomez-Zavaglia, A., Prieto Lage, M.A., Jimenez-Lopez, C., Mejuto, J.C., and Simal-Gandara, J. (2019). The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value. Antioxidants, 8.","DOI":"10.3390\/antiox8090406"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-3040.2010.02268.x","article-title":"Integrative Analysis of Metabolite and Transcript Abundance during the Short-Term Response to Saline and Oxidative Stress in the Brown Alga Ectocarpus Siliculosus: Abiotic Stress Response in Ectocarpus Siliculosus","volume":"34","author":"Dittami","year":"2011","journal-title":"Plant Cell Environ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3389\/fphar.2018.00777","article-title":"From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds","volume":"9","author":"Alves","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jesumani, V., Du, H., Aslam, M., Pei, P., and Huang, N. (2019). Potential Use of Seaweed Bioactive Compounds in Skincare\u2014A Review. Mar. Drugs, 17.","DOI":"10.3390\/md17120688"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Vega, J., Schneider, G., Moreira, B.R., Herrera, C., Bonomi-Barufi, J., and Figueroa, F.L. (2021). Mycosporine-Like Amino Acids from Red Macroalgae: UV-Photoprotectors with Potential Cosmeceutical Applications. Appl. Sci., 11.","DOI":"10.3390\/app11115112"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Geraldes, V., and Pinto, E. (2021). Mycosporine-Like Amino Acids (MAAs): Biology, Chemistry and Identification Features. Pharmaceuticals, 14.","DOI":"10.3390\/ph14010063"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10126-019-09905-x","article-title":"Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum","volume":"21","author":"Dobretsov","year":"2019","journal-title":"Mar. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101956","DOI":"10.1016\/j.algal.2020.101956","article-title":"Photoprotection Properties of Marine Photosynthetic Organisms Grown in High Ultraviolet Exposure Areas: Cosmeceutical Applications","volume":"49","author":"Schneider","year":"2020","journal-title":"Algal Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Vega, J., Bonomi-Barufi, J., G\u00f3mez-Pinchetti, J.L., and Figueroa, F.L. (2020). Cyanobacteria and Red Macroalgae as Potential Sources of Antioxidants and UV Radiation-Absorbing Compounds for Cosmeceutical Applications. Mar. Drugs, 18.","DOI":"10.3390\/md18120659"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Castej\u00f3n, N., Parailloux, M., Izdebska, A., Lobinski, R., and Fernandes, S.C.M. (2021). Valorization of the Red Algae Gelidium Sesquipedale by Extracting a Broad Spectrum of Minor Compounds Using Green Approaches. Mar. Drugs, 19.","DOI":"10.3390\/md19100574"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Matias, M., Pinteus, S., Martins, A., Silva, J., Alves, C., Mouga, T., Gaspar, H., and Pedrosa, R. (2022). Gelidiales Are Not Just Agar\u2014Revealing the Antimicrobial Potential of Gelidium corneum for Skin Disorders. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040481"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.foodchem.2016.09.067","article-title":"Cytoprotective Effect of Seaweeds with High Antioxidant Activity from the Peniche Coast (Portugal)","volume":"218","author":"Pinteus","year":"2017","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Silva, J., Alves, C., Freitas, R., Martins, A., Pinteus, S., Ribeiro, J., Gaspar, H., Alfonso, A., and Pedrosa, R. (2019). Antioxidant and Neuroprotective Potential of the Brown Seaweed Bifurcaria bifurcata in an in Vitro Parkinson\u2019s Disease Model. Mar. Drugs, 17.","DOI":"10.3390\/md17020085"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/jf0305231","article-title":"Extending Applicability of the Oxygen Radical Absorbance Capacity (ORAC\u2212Fluorescein) Assay","volume":"52","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.fct.2006.02.002","article-title":"Antioxidant and Antiproliferative Activities of Extracts from a Variety of Edible Seaweeds","volume":"44","author":"Yuan","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Marto, J., Neves, \u00c2., Gon\u00e7alves, L., Pinto, P., Almeida, C., and Sim\u00f5es, S. (2018). Rice Water: A Traditional Ingredient with Anti-Aging Efficacy. Cosmetics, 5.","DOI":"10.3390\/cosmetics5020026"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2478\/v10102-009-0022-2","article-title":"Inhibition of Nitric Oxide Production in Lipopolysaccharide-Activated RAW 264.7 Macrophages by Jeju Plant Extracts","volume":"2","author":"Yang","year":"2009","journal-title":"Interdiscip. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.indcrop.2017.09.033","article-title":"Cynara scolymus L.: A Promising Mediterranean Extract for Topical Anti-Aging Prevention","volume":"109","author":"Marques","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nunes, A., Gon\u00e7alves, L., Marto, J., Martins, A.M., Silva, A.N., Pinto, P., Martins, M., Fraga, C., and Ribeiro, H.M. (2021). Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13040465"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jcis.2018.12.098","article-title":"Role of Particles in the Rheology of Solid-Stabilized High Internal Phase Emulsions","volume":"540","author":"Kaganyuk","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jcis.2020.04.105","article-title":"Polymeric-Nanofluids Stabilized Emulsions: Interfacial versus Bulk Rheology","volume":"576","author":"Kamkar","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"ref_32","unstructured":"Larson, R.G. (1999). Topics in Chemical Engineering, Oxford University Press."},{"key":"ref_33","unstructured":"Brummer, R. (2006). Springer Laboratory Manuals in Polymer Science, Springer."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Semenzato, A., Costantini, A., Meloni, M., Maramaldi, G., Meneghin, M., and Baratto, G. (2018). Formulating O\/W Emulsions with Plant-Based Actives: A Stability Challenge for an Effective Product. Cosmetics, 5.","DOI":"10.3390\/cosmetics5040059"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jcis.2005.04.044","article-title":"Rheological Characterization of Polysaccharide\u2013Surfactant Matrices for Cosmetic O\/W Emulsions","volume":"290","author":"Bais","year":"2005","journal-title":"J. Colloid Interface Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1111\/j.1750-3841.2009.01352.x","article-title":"Correlations of Antioxidant Activity against Phenolic Content Revisited: A New Approach in Data Analysis for Food and Medicinal Plants","volume":"74","year":"2009","journal-title":"J. Food Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-food-032818-121401","article-title":"Source, Extraction, Characterization, and Applications of Novel Antioxidants from Seaweed","volume":"10","author":"Jacobsen","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Cavaco, M., Duarte, A., Freitas, M.V., Afonso, C., Bernardino, S., Pereira, L., Martins, M., and Mouga, T. (2021). Seasonal Nutritional Profile of Gelidium corneum (Rhodophyta, Gelidiaceae) from the Center of Portugal. Foods, 10.","DOI":"10.3390\/foods10102394"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s41208-019-00181-z","article-title":"Commercial Red Seaweed in Portugal (Gelidium sesquipedale and Pterocladiella capillacea, Florideophyceae): Going beyond a Single-Purpose Product Approach by Valorizing Bioactivity","volume":"36","author":"Matos","year":"2020","journal-title":"Thalassas"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s10811-014-0438-8","article-title":"Phenolic Profiles, Antioxidant Capacity, and Acetylcholinesterase Inhibitory Activity of Eight South African Seaweeds","volume":"27","author":"Rengasamy","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.biotechadv.2011.05.016","article-title":"Algal Chemodiversity and Bioactivity: Sources of Natural Variability and Implications for Commercial Application","volume":"29","author":"Stengel","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Cotas, J., Leandro, A., Monteiro, P., Pacheco, D., Figueirinha, A., Gon\u00e7alves, A.M.M., Da Silva, G.J., and Pereira, L. (2020). Seaweed Phenolics: From Extraction to Applications. Mar. Drugs, 18.","DOI":"10.3390\/md18080384"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10715762.2017.1355550","article-title":"Marine Algae as Attractive Source to Skin Care","volume":"51","author":"Berthon","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.procbio.2019.03.023","article-title":"R-Phycoerythrin, R-Phycocyanin and ABE Production from Gelidium amansii by Clostridium acetobutylicum","volume":"81","author":"Sukwong","year":"2019","journal-title":"Process Biochem."},{"key":"ref_45","unstructured":"Pangestuti, R., and Kurnianto, D. (2017). Seaweed Polysaccharides, Elsevier."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/07388551.2018.1503995","article-title":"Algal Polysaccharides: Potential Bioactive Substances for Cosmeceutical Applications","volume":"39","author":"Kim","year":"2019","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ribeiro, D., Carvalho J\u00fanior, A., Vale De Macedo, G., Chagas, V., Silva, L., Cutrim, B., Santos, D., Soares, B., Zagmignan, A., and De Miranda, R. (2019). Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials. Biomolecules, 10.","DOI":"10.3390\/biom10010063"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"108863","DOI":"10.1016\/j.matdes.2020.108863","article-title":"Bio-Multifunctional Alginate\/Chitosan\/Fucoidan Sponges with Enhanced Angiogenesis and Hair Follicle Regeneration for Promoting Full-Thickness Wound Healing","volume":"193","author":"Hao","year":"2020","journal-title":"Mater. Des."},{"key":"ref_49","first-page":"47","article-title":"The living stratum corneum: Implications for cosmetic formulation","volume":"106","author":"Jass","year":"1991","journal-title":"Cosmet. Toilet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0022-2275(20)41978-9","article-title":"Regulation of epidermal sphingolipid synthesis by permeability barrier function","volume":"32","author":"Holleran","year":"1991","journal-title":"J. Lipid Res."},{"key":"ref_51","unstructured":"Mitsui, T. (1997). New Cosmetic Science, Elsevier Science."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.2174\/1381612825666190521120051","article-title":"Recent Advances in the Use of Algal Polysaccharides for Skin Wound Healing","volume":"25","author":"Kumar","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_53","unstructured":"Salvador, A., and Pascual-Mart\u00ed, M.C. (2005). Encyclopedia of Analytical Science, Elsevier."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijbiomac.2013.03.001","article-title":"Chemical Composition and Moisture-Absorption\/Retention Ability of Polysaccharides Extracted from Five Algae","volume":"57","author":"Wang","year":"2013","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/9\/1684\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:41:31Z","timestamp":1760128891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/9\/1684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["antiox12091684"],"URL":"https:\/\/doi.org\/10.3390\/antiox12091684","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]}}}