{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:05:15Z","timestamp":1770905115189,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund (ERDF)","award":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["SFRH\/BPD\/99219\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/99219\/2013"]}]},{"name":"European Regional Development Fund (ERDF)","award":["SFRH\/BD\/148263\/2019"],"award-info":[{"award-number":["SFRH\/BD\/148263\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BPD\/99219\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/99219\/2013"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/148263\/2019"],"award-info":[{"award-number":["SFRH\/BD\/148263\/2019"]}]},{"name":"FCT post-doctoral fellowship","award":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"]}]},{"name":"FCT post-doctoral fellowship","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"FCT post-doctoral fellowship","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"FCT post-doctoral fellowship","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"FCT post-doctoral fellowship","award":["SFRH\/BPD\/99219\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/99219\/2013"]}]},{"name":"FCT post-doctoral fellowship","award":["SFRH\/BD\/148263\/2019"],"award-info":[{"award-number":["SFRH\/BD\/148263\/2019"]}]},{"name":"FCT fellowship","award":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"]}]},{"name":"FCT fellowship","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"FCT fellowship","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"FCT fellowship","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"FCT fellowship","award":["SFRH\/BPD\/99219\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/99219\/2013"]}]},{"name":"FCT fellowship","award":["SFRH\/BD\/148263\/2019"],"award-info":[{"award-number":["SFRH\/BD\/148263\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Soluble A\u03b21\u201342 oligomers (A\u03b2O) are formed in the early stages of Alzheimer\u2019s disease (AD) and were previously shown to trigger enhanced Ca2+ levels and mitochondrial dysfunction via the activation of N-methyl-D-aspartate receptors (NMDAR). Src kinase is a ubiquitous redox-sensitive non-receptor tyrosine kinase involved in the regulation of several cellular processes, which was demonstrated to have a reciprocal interaction towards NMDAR activation. However, little is known about the early-stage mechanisms associated with A\u03b2O-induced neurodysfunction involving Src. Thus, in this work, we analysed the influence of brief exposure to oligomeric A\u03b21\u201342 on Src activation and related mechanisms involving mitochondria and redox changes in mature primary rat hippocampal neurons. Data show that brief exposure to A\u03b2O induce H2O2-dependent Src activation involving different cellular events, including NMDAR activation and mediated intracellular Ca2+ rise, enhanced cytosolic and subsequent mitochondrial H2O2 levels, accompanied by mild mitochondrial fragmentation. Interestingly, these effects were prevented by Src inhibition, suggesting a feedforward modulation. The current study supports a relevant role for Src kinase activation in promoting the loss of postsynaptic glutamatergic synapse homeostasis involving cytosolic and mitochondrial ROS generation after brief exposure to A\u03b2O. Therefore, restoring Src activity can constitute a protective strategy for mitochondria and related hippocampal glutamatergic synapses.<\/jats:p>","DOI":"10.3390\/antiox12091770","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:36:45Z","timestamp":1694932605000},"page":"1770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uncovering the Early Events Associated with Oligomeric A\u03b2-Induced Src Activation"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9623-5012","authenticated-orcid":false,"given":"Sandra I.","family":"Mota","sequence":"first","affiliation":[{"name":"CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"IIIUC-Institute of Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-7894","authenticated-orcid":false,"given":"L\u00edgia","family":"F\u00e3o","sequence":"additional","affiliation":[{"name":"CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-4658","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Coelho","sequence":"additional","affiliation":[{"name":"CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-3776","authenticated-orcid":false,"given":"A. Cristina","family":"Rego","sequence":"additional","affiliation":[{"name":"CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4103\/1673-5374.332127","article-title":"Amyloid-Beta Peptide and Tau Protein Crosstalk in Alzheimer\u2019s Disease","volume":"17","author":"Roda","year":"2022","journal-title":"Neural. Regen. 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