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The present study is dedicated to profiling cysteine metabolic pathways in NSCLC cell lines and tumor samples. This was carried out by analyzing hydrogen sulfide (H2S) and ATP levels, examining mRNA and protein expression patterns of cysteine catabolic enzymes and transporters, and conducting metabolomics analysis using nuclear magnetic resonance (NMR) spectroscopy. Selenium\u2013chrysin (SeChry) was tested as a therapeutic alternative with the aim of having an effect on cysteine catabolism and showed promising results. NSCLC cell lines presented different cysteine metabolic patterns, with A549 and H292 presenting a higher reliance on cystathionine \u03b2-synthase (CBS) and cystathionine \u03b3-lyase (CSE) to maintain H2S levels, while the PC-9 cell line presented an adaptive behavior based on the use of mercaptopyruvate sulfurtransferase (MST) and cysteine dioxygenase (CDO1), both contributing to the role of cysteine as a pyruvate source. The analyses of human lung tumor samples corroborated this variability in profiles, meaning that the expression of certain genes may be informative in defining prognosis and new targets. Heterogeneity points out individual profiles, and the identification of new targets among metabolic players is a step forward in cancer management toward personalized medicine.<\/jats:p>","DOI":"10.3390\/antiox13010051","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T09:56:27Z","timestamp":1703757387000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management toward Personalized Medicine"],"prefix":"10.3390","volume":"13","author":[{"given":"Ana","family":"Hip\u00f3lito","sequence":"first","affiliation":[{"name":"iNOVA4Health, NOVA Medical School, 1150-069 Lisbon, Portugal"},{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"given":"Cindy","family":"Mendes","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School, 1150-069 Lisbon, Portugal"},{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-7173","authenticated-orcid":false,"given":"Filipa","family":"Martins","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School, 1150-069 Lisbon, Portugal"},{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"given":"Isabel","family":"Lemos","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School, 1150-069 Lisbon, Portugal"},{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-5524","authenticated-orcid":false,"given":"In\u00eas","family":"Francisco","sequence":"additional","affiliation":[{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"given":"Fernando","family":"Cunha","sequence":"additional","affiliation":[{"name":"Pathology Department, The Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"given":"Teresa","family":"Almod\u00f4var","sequence":"additional","affiliation":[{"name":"Pneumology Department, The Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"given":"Cristina","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Molecular Pathobiology Research Unit, fromThe Portuguese Institute of Oncology (IPOLFG), 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-3552","authenticated-orcid":false,"given":"Lu\u00eds G.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Biological Technology Ant\u00f3nio Xavier (ITQB NOVA), 2780-157 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-8473","authenticated-orcid":false,"given":"Vasco D. 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Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","article-title":"Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship","volume":"83","author":"Molina","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fonc.2017.00193","article-title":"Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification","volume":"7","author":"Inamura","year":"2017","journal-title":"Front. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.trecan.2016.05.010","article-title":"Resisting Resistance: Targeted Therapies in Lung Cancer","volume":"2","author":"Lin","year":"2016","journal-title":"Trends Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/138920210793175903","article-title":"Lung Cancer: Are we up to the Challenge?","volume":"11","author":"Esposito","year":"2010","journal-title":"Curr. Genom."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer : New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_8","first-page":"1","article-title":"Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders","volume":"Volume 1219","author":"Serpa","year":"2020","journal-title":"Tumor Microenvironment"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Schiliro, C., and Firestein, B.L. (2021). Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation. Cells, 10.","DOI":"10.3390\/cells10051056"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-030-34025-4_16","article-title":"The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response","volume":"1219","author":"Mendes","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the Intersections between Metabolism and Cancer Biology","volume":"168","author":"DeBerardinis","year":"2017","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Ca\u00f1averas, J.C., and Lahoz, A. (2021). Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers. Cancers, 13.","DOI":"10.3390\/cancers13133230"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107283","DOI":"10.1016\/j.lungcan.2023.107283","article-title":"NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC","volume":"182","author":"Mendes","year":"2023","journal-title":"Lung Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00109-020-01965-0","article-title":"Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive?","volume":"98","author":"Mendes","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_15","first-page":"3930","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/0008-5472.CAN-11-2474","article-title":"Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors","volume":"72","author":"Boidot","year":"2012","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate Metabolism in Human Lung Tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Nunes, S.C., Lopes-Coelho, F., Gouveia-Fernandes, S., Ramos, C., Pereira, S.A., and Serpa, J. (2018). Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer. BMC Evol. Biol., 18.","DOI":"10.1186\/s12862-018-1214-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1038\/s41598-018-27753-y","article-title":"Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity","volume":"8","author":"Nunes","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Nunes, S.C., Ramos, C., Santos, I., Mendes, C., Silva, F., Vicente, J.B., Pereira, S.A., F\u00e9lix, A., Gon\u00e7alves, L.G., and Serpa, J. (2021). Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.722412"},{"key":"ref_22","first-page":"1440","article-title":"Glutathione Depletion Causes Cell Growth Inhibition and Enhanced Apoptosis in Pancreatic Cancer Cells","volume":"89","author":"Schnelldorfer","year":"2000","journal-title":"Cancer Interdiscip. Int. J. Am. Cancer Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/cbf.1149","article-title":"The role of glutathione in cancer","volume":"22","author":"Balendiran","year":"2004","journal-title":"Cell Biochem. Funct."},{"key":"ref_24","first-page":"4813","article-title":"HNF1\u03b2 drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)","volume":"37","author":"Nunes","year":"2015","journal-title":"Tumour Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-\u03b2-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36125","DOI":"10.1038\/srep36125","article-title":"Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics","volume":"6","author":"Szczesny","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2015.05.024","article-title":"Role of cystathionine \u03b2-synthase in human breast Cancer","volume":"86","author":"Sen","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bhattacharyya, S., Saha, S., Giri, K., Lanza, I.R., Nair, K.S., Jennings, N.B., Rodriguez-Aguayo, C., Lopez-Berestein, G., Basal, E., and Weaver, A.L. (2013). Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079167"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1667\/RR14177.1","article-title":"Radiation Exposure Promotes Hepatocarcinoma Cell Invasion through Epithelial Mesenchymal Transition Mediated by H2S\/CSE Pathway","volume":"185","author":"Pan","year":"2016","journal-title":"Radiat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine \u03b3 lyase\/hydrogen sulfide pathway in human melanoma progression","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"166.e15","DOI":"10.1016\/j.urolonc.2015.06.020","article-title":"Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladder","volume":"34","author":"Gai","year":"2016","journal-title":"Urol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hip\u00f3lito, A., Nunes, S.C., Vicente, J.B., and Serpa, J. (2020). Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer. Molecules, 25.","DOI":"10.3390\/molecules25173984"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6290931","DOI":"10.1155\/2018\/6290931","article-title":"Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology","volume":"2018","author":"Vicente","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zuhra, K., Tom\u00e9, C.S., Forte, E., Vicente, J.B., and Giuffr\u00e8, A. (2021). The multifaceted roles of sulfane sulfur species in cancer-associated processes. Biochim. Biophys. Acta Bioenerg., 1862.","DOI":"10.1016\/j.bbabio.2020.148338"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical Biology of H2S Signaling through Persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jnutbio.2003.10.005","article-title":"Regulation of cysteine dioxygenase and \u03b3-glutamylcysteine synthetase is associated with hepatic cysteine level","volume":"15","author":"Lee","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_40","first-page":"E326","article-title":"Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo","volume":"276","author":"Bella","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_41","first-page":"E144","article-title":"Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism","volume":"277","author":"Bella","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41416-020-01156-1","article-title":"Cysteine metabolic circuitries: Druggable targets in cancer","volume":"124","author":"Pereira","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.nutr.24.012003.132418","article-title":"Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine","volume":"24","author":"Stipanuk","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mnfr.201500031","article-title":"L-Cysteine metabolism and its nutritional implications","volume":"60","author":"Yin","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"38369","DOI":"10.1038\/srep38369","article-title":"rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NF\u03baB upon 5-FU treatment","volume":"6","author":"Russo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, M., Yan, J., Cao, X., Hua, P., and Li, Z. (2020). Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1\u03b1 activation. Biochem. Pharmacol., 172.","DOI":"10.1016\/j.bcp.2019.113775"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1158\/0008-5472.CAN-16-3480","article-title":"Upregulation of cystathionine-\u03b2-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis","volume":"77","author":"Phillips","year":"2017","journal-title":"Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2019.09.006","article-title":"Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG\/TYMS axis in colon cancer cells","volume":"466","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bcp.2017.10.007","article-title":"Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells","volume":"149","author":"Untereiner","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Santos, I., Ramos, C., Mendes, C., Sequeira, C.O., Tom\u00e9, C.S., Fernandes, D.G.H., Mota, P., Pires, R.F., Urso, D., and Hip\u00f3lito, A. (2019). Targeting glutathione and cystathionine \u03b2-synthase in ovarian cancer treatment by selenium\u2013chrysin polyurea dendrimer nanoformulation. Nutrients, 11.","DOI":"10.3390\/nu11102523"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The Cancer Genome Atlas Pan-Cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Borisov, V.B., and Forte, E. (2021). Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312688"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Cruz, A., Mota, P., Ramos, C., Pires, R.F., Mendes, C., Silva, J.P., Nunes, S.C., Bonif\u00e1cio, V.D.B., and Serpa, J. (2020). Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance. Antioxidants, 9.","DOI":"10.3390\/antiox9020133"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3389\/fonc.2020.00947","article-title":"Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival","volume":"10","author":"Serpa","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"972913","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"2013","author":"Traverso","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Yen, W.C., Wu, Y.H., Wu, C.C., Lin, H.R., Stern, A., Chen, S.H., Shu, J.C., and Tsun-Yee Chiu, D. (2020). Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX\/p38 MAPK\/AP-1 redox signaling. Redox Biol., 28.","DOI":"10.1016\/j.redox.2019.101363"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbcan.2019.05.006","article-title":"Gluconeogenesis in cancer cells\u2014Repurposing of a starvation-induced metabolic pathway?","volume":"1872","author":"Grasmann","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.1074\/jbc.RA117.000508","article-title":"Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice","volume":"293","author":"Zhang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"G249","DOI":"10.1152\/ajpgi.00039.2018","article-title":"Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine","volume":"315","author":"Potts","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.1424641112","article-title":"ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis","volume":"112","author":"Tsai","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e45572","DOI":"10.7554\/eLife.45572","article-title":"Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer","volume":"8","author":"Kang","year":"2019","journal-title":"eLife"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kulkarni, A., Dangat, K., Kale, A., Sable, P., Chavan-Gautam, P., and Joshi, S. (2011). Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017706"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pascale, R.M., Peitta, G., Simile, M.M., and Feo, F. (2019). Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma. Medicina, 55.","DOI":"10.3390\/medicina55060296"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.15252\/embj.201488166","article-title":"Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2","volume":"34","author":"Dann","year":"2015","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijo.2021.5183","article-title":"Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3\/P53 pathway","volume":"58","author":"Wang","year":"2021","journal-title":"Int. J. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhang, P., Li, X., He, Q., Zhang, L., Song, K., Yang, X., He, Q., Wang, Y., Hong, X., and Ma, J. (2020). TRIM21-SERPINB5 AIDS GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis. J. Biomed. Sci., 27.","DOI":"10.1186\/s12929-020-0625-7"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e139929","DOI":"10.1172\/JCI139929","article-title":"Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer","volume":"131","author":"Huang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00726-017-2490-6","article-title":"Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth","volume":"50","author":"Li","year":"2018","journal-title":"Amino Acids"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1152\/ajpendo.00006.2011","article-title":"Arginine synthesis from enteral glutamine in healthy adults in the fed state","volume":"301","author":"Tomlinson","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/ajcn\/87.5.1282","article-title":"Glutamine is an important precursor for de novo synthesis of arginine in humans","volume":"87","author":"Boelens","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1194\/jlr.M062042","article-title":"Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells","volume":"57","author":"Jeffries","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Petrella, G., Corsi, F., Ciufolini, G., Germini, S., Capradossi, F., Pelliccia, A., Torino, F., Ghibelli, L., and Cicero, D.O. (2023). Metabolic Reprogramming of Castration-Resistant Prostate Cancer Cells as a Response to Chemotherapy. Metabolites, 13.","DOI":"10.3390\/metabo13010065"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1111\/cas.14443","article-title":"Nuclear magnetic resonance-based tissue metabolomic analysis clarifies molecular mechanisms of gastric carcinogenesis","volume":"111","author":"Gu","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8","article-title":"Ketone Bodies: A Review of Physiology, Pathophysiology and Application of Monitoring to Diabetes","volume":"15","author":"Laffel","year":"1999","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1158\/1078-0432.CCR-12-0287","article-title":"Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts","volume":"19","author":"Allen","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jeelani, R., Khan, S.N., Shaeib, F., Kohan-Ghadr, H.R., Aldhaheri, S.R., Najafi, T., Thakur, M., Morris, R., and Abu-Soud, H.M. (2017). Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality. Free Radic. Biol. Med., 110.","DOI":"10.1016\/j.freeradbiomed.2017.05.006"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chien, C.H., Hsueh, W.T., Chuang, J.Y., and Chang, K.Y. (2021). Dissecting the mechanism of temozolomide resistance and its association with the regulatory roles of intracellular reactive oxygen species in glioblastoma. J. Biomed. Sci., 28.","DOI":"10.1186\/s12929-021-00717-7"},{"key":"ref_81","first-page":"7131","article-title":"Oxidative stress induced by carboplatin promotes apoptosis and inhibits migration of HN-3 cells","volume":"16","author":"He","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41419-019-2081-4","article-title":"Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells","volume":"10","author":"Kleih","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1517\/17425247.2012.665365","article-title":"Recent trends in cancer drug resistance reversal strategies using nanoparticles","volume":"9","author":"Palakurthi","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Rizzo, A., Napoli, A., Roggiani, F., Tomassetti, A., Bagnoli, M., and Mezzanzanica, D. (2018). One-Carbon Metabolism: Biological Players in Epithelial Ovarian Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072092"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"104083","DOI":"10.1016\/j.phrs.2018.11.034","article-title":"Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells","volume":"154","author":"Augsburger","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Brait, M., Ling, S., Nagpal, J.K., Chang, X., Park, H.L., Lee, J., Okamura, J., Yamashita, K., Sidransky, D., and Kim, M.S. (2012). Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044951"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Kojima, K., Nakamura, T., Ooizumi, Y., Igarashi, K., Tanaka, T., Yokoi, K., Ishii, S., Nishizawa, N., Katoh, H., and Kosaka, Y. (2019). Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211108"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1158\/1078-0432.CCR-14-2049","article-title":"Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome","volume":"21","author":"Deckers","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_89","first-page":"1","article-title":"Promoter DNA methylation of CDO1 gene and its clinical significance in esophageal squamous cell carcinoma","volume":"30","author":"Ushiku","year":"2017","journal-title":"Dis. Esophagus Off. J. Int. Soc. Dis. Esophagus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1245\/s10434-018-6865-z","article-title":"Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in Colon Cancer with Postoperative Adjuvant Chemotherapy","volume":"26","author":"Yokoi","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neo.2017.10.005","article-title":"Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells","volume":"19","author":"Hao","year":"2017","journal-title":"Neoplasia"},{"key":"ref_92","first-page":"323","article-title":"Erastin\/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2\/xCT pathway","volume":"19","author":"Li","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/carcin\/bgad020","article-title":"Inhibition of Lung Adenocarcinoma by Combinations of Sulfasalazine (SAS) and Disulfiram-copper (DSF-Cu) in Cell Line Models and Mice","volume":"44","author":"Shameem","year":"2023","journal-title":"Carcinogenesis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrd.2015.1","article-title":"Gasotransmitters in cancer: From pathophysiology to experimental therapy","volume":"15","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine \u03b2-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ascen\u00e7\u00e3o, K., and Szabo, C. (2022). Emerging roles of cystathionine \u03b2-synthase in various forms of cancer. Redox Biol., 53.","DOI":"10.1016\/j.redox.2022.102331"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/1\/51\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:43:14Z","timestamp":1760132594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/1\/51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["antiox13010051"],"URL":"https:\/\/doi.org\/10.3390\/antiox13010051","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,28]]}}}