{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:46:42Z","timestamp":1774324002050,"version":"3.50.1"},"reference-count":148,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia, Portugal","award":["2022.04526.PTDC. FCT 2023"],"award-info":[{"award-number":["2022.04526.PTDC. FCT 2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The indolamine hormone melatonin, also known as N-acetyl-5-methoxytrypamine, is frequently associated with circadian rhythm regulation. Light can suppress melatonin secretion, and photoperiod regulates melatonin levels by promoting its production and secretion at night in response to darkness. This hormone is becoming more and more understood for its functions as an immune-modulatory, anti-inflammatory, and antioxidant hormone. Melatonin may have a major effect on several diabetes-related disturbances, such as hormonal imbalances, oxidative stress, sleep disturbances, and mood disorders, according to recent research. This has raised interest in investigating the possible therapeutic advantages of melatonin in the treatment of diabetic complications. In addition, several studies have described that melatonin has been linked to the development of diabetes, cancer, Alzheimer\u2019s disease, immune system disorders, and heart diseases. In this review, we will highlight some of the functions of melatonin regarding vascular biology.<\/jats:p>","DOI":"10.3390\/antiox13060747","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:27:19Z","timestamp":1718861239000},"page":"747","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Melatonin and Vascular Function"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8911-6612","authenticated-orcid":false,"given":"Leandro","family":"Mendes","sequence":"first","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-2385","authenticated-orcid":false,"given":"Marcelo","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-2977","authenticated-orcid":false,"given":"Cristina M.","family":"Sena","sequence":"additional","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1080\/13813455.2020.1770799","article-title":"Physiological and Pharmacological Perspectives of Melatonin","volume":"128","author":"Samanta","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/1570159X14666161228122115","article-title":"Melatonin: Pharmacology, Functions and Therapeutic Benefits","volume":"15","author":"Tordjman","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal Melatonin: Sources, Regulation, and Potential Functions","volume":"71","author":"Escames","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vasey, C., McBride, J., and Penta, K. (2021). Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin. Nutrients, 13.","DOI":"10.3390\/nu13103480"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.32794\/mr11250011","article-title":"Mitochondria: The Birth Place, Battle Ground and the Site of Melatonin Metabolism in Cells","volume":"2","author":"Tan","year":"2019","journal-title":"Melatonin Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","article-title":"Melatonin\u2014A Pleiotropic, Orchestrating Regulator Molecule","volume":"93","author":"Hardeland","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.bbadis.2013.08.006","article-title":"Endothelial Dysfunction\u2014A Major Mediator of Diabetic Vascular Disease","volume":"1832","author":"Sena","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","article-title":"Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies","volume":"73","author":"Xu","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rita, R. (2013). Vascular Endothelial Cells and Dysfunctions Role of Melatonin. Front. Biosci., E5.","DOI":"10.2741\/E601"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tan, D.-X., Reiter, R.J., Zimmerman, S., and Hardeland, R. (2023). Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light. Biology, 12.","DOI":"10.3390\/biology12010089"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chen, D., Zhang, T., and Lee, T.H. (2020). Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases. Biomolecules, 10.","DOI":"10.3390\/biom10081158"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fendo.2019.00249","article-title":"Melatonin Synthesis and Function: Evolutionary History in Animals and Plants","volume":"10","author":"Zhao","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-079X.2011.00856.x","article-title":"A Survey of Molecular Details in the Human Pineal Gland in the Light of Phylogeny, Structure, Function and Chronobiological Diseases","volume":"51","author":"Stehle","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Minich, D.M., Henning, M., Darley, C., Fahoum, M., Schuler, C.B., and Frame, J. (2022). Is Melatonin the \u201cNext Vitamin D\u201d?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients, 14.","DOI":"10.3390\/nu14193934"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpsychores.2016.05.005","article-title":"Physiological Melatonin Levels in Healthy Older People: A Systematic Review","volume":"86","author":"Scholtens","year":"2016","journal-title":"J. Psychosom. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"888319","DOI":"10.3389\/fcvm.2022.888319","article-title":"Evidence for the Benefits of Melatonin in Cardiovascular Disease","volume":"9","author":"Tobeiha","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hardeland, R. (2019). Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051223"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1742-1241.2006.01191.x","article-title":"Melatonin: Therapeutic and Clinical Utilization","volume":"61","author":"Altun","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1196\/annals.1356.028","article-title":"Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ","volume":"1057","author":"SCHOMERUS","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","first-page":"115","article-title":"Molecular Components and Mechanism of Adrenergic Signal Transduction in Mammalian Pineal Gland: Regulation of Melatonin Synthesis","volume":"43","author":"Gupta","year":"2005","journal-title":"Indian J. Exp. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mel\u00e9ndez-Fern\u00e1ndez, O.H., Liu, J.A., and Nelson, R.J. (2023). Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043392"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fmed.2020.00226","article-title":"Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19","volume":"7","author":"Reiter","year":"2020","journal-title":"Front. Med"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., and Xu, B. (2018). Mitochondria: Central Organelles for Melatonin\u2032s Antioxidant and Anti-Aging Actions. Molecules, 23.","DOI":"10.3390\/molecules23020509"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an Antioxidant: Under Promises but over Delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"18886","DOI":"10.3390\/molecules201018886","article-title":"Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism","volume":"20","author":"Tan","year":"2015","journal-title":"Molecules"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/ehjcvp\/pvv037","article-title":"Melatonin Has Multiorgan Effects","volume":"2","author":"Opie","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113239","DOI":"10.1016\/j.psychres.2020.113239","article-title":"Clarifying the Role of Sleep in Depression: A Narrative Review","volume":"291","author":"Monti","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Markus, R.P., Sousa, K.S., da Silveira Cruz-Machado, S., Fernandes, P.A., and Ferreira, Z.S. (2021). Possible Role of Pineal and Extra-Pineal Melatonin in Surveillance, Immunity, and First-Line Defense. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212143"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.3390\/ijms14048638","article-title":"Melatonin: Buffering the Immune System","volume":"14","author":"Lardone","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_30","first-page":"30","article-title":"Melatonin and Effects on The Immune System","volume":"4","author":"Tutuncu","year":"2021","journal-title":"Int. J. Vet. Anim. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cruciani, S., Garroni, G., Pala, R., Barcessat, A.R.P., Facchin, F., Ventura, C., Fozza, C., and Maioli, M. (2022). Melatonin Finely Tunes Proliferation and Senescence in Hematopoietic Stem Cells. Eur. J. Cell Biol., 101.","DOI":"10.1016\/j.ejcb.2022.151251"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lalanne, S., Fougerou-Leurent, C., Anderson, G.M., Schroder, C.M., Nir, T., Chokron, S., Delorme, R., Claustrat, B., Bellissant, E., and Kermarrec, S. (2021). Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031490"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","article-title":"Functional MT1 and MT2 Melatonin Receptors in Mammals","volume":"27","author":"Dubocovich","year":"2005","journal-title":"Endocrine"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Nikolaev, G., Robeva, R., and Konakchieva, R. (2021). Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010471"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","article-title":"MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective","volume":"56","author":"Liu","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kopustinskiene, D.M., and Bernatoniene, J. (2021). Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020129"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e12641","DOI":"10.1111\/jpi.12641","article-title":"Melatonin MT1 and MT2 Receptor ERK Signaling Is Differentially Dependent on Gi\/o and Gq\/11 Proteins","volume":"68","author":"Chen","year":"2020","journal-title":"J. Pineal Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ma, H., Kang, J., Fan, W., He, H., and Huang, F. (2021). Ror: Nuclear Receptor for Melatonin or Not?. Molecules, 26.","DOI":"10.3390\/molecules26092693"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(00)80350-5","article-title":"Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock","volume":"19","author":"Liu","year":"1997","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"H670","DOI":"10.1152\/ajpheart.00710.2010","article-title":"Melatonin Differentially Affects Vascular Blood Flow in Humans","volume":"300","author":"Cook","year":"2011","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1111\/bph.13950","article-title":"Melatonin Receptors: Molecular Pharmacology and Signalling in the Context of System Bias","volume":"175","author":"Cecon","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sena, C.M. (2024). Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020284"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Queiroz, M., Leandro, A., Azul, L., Figueirinha, A., Sei\u00e7a, R., and Sena, C.M. (2021). Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413671"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1124\/jpet.110.174482","article-title":"MT2 Receptors Mediate the Inhibitory Effects of Melatonin on Nitric Oxide-Induced Relaxation of Porcine Isolated Coronary Arteries","volume":"336","author":"Tunstall","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s40618-023-02102-7","article-title":"In-Vitro Antiplatelet Effect of Melatonin in Healthy Individuals and Patients with Type 2 Diabetes Mellitus","volume":"46","author":"Lauko","year":"2023","journal-title":"J. Endocrinol. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.mce.2013.11.016","article-title":"Melatonin and Its Atheroprotective Effects: A Review","volume":"382","author":"Favero","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jpi.12161","article-title":"Melatonin Receptor-mediated Protection against Myocardial Ischemia\/Reperfusion Injury: Role of SIRT1","volume":"57","author":"Yu","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/07853890903485748","article-title":"Beneficial Effects of Melatonin in Cardiovascular Disease","volume":"42","author":"Reiter","year":"2010","journal-title":"Ann. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1081\/CBI-120025245","article-title":"Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms","volume":"20","author":"Hardeland","year":"2003","journal-title":"Chronobiol. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative Stress and Reactive Oxygen Species in Endothelial Dysfunction Associated with Cardiovascular and Metabolic Diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vascul. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tox.2010.04.008","article-title":"Melatonin: Action as Antioxidant and Potential Applications in Human Disease and Aging","volume":"278","author":"Collin","year":"2010","journal-title":"Toxicology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.117.07802","article-title":"Oxidative Stress, Inflammation, and Vascular Aging in Hypertension","volume":"70","author":"Guzik","year":"2017","journal-title":"Hypertension"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis","volume":"120","author":"Xia","year":"2017","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0304-4165(98)00099-3","article-title":"Scavenging of Reactive Oxygen Species by Melatonin","volume":"1425","author":"Zang","year":"1998","journal-title":"Biochim. Biophys. Acta (BBA)\u2014General. Subj."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1385\/ENDO:27:2:119","article-title":"Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance","volume":"27","author":"Hardeland","year":"2005","journal-title":"Endocrine"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/jpi.12132","article-title":"A Review of Metal-catalyzed Molecular Damage: Protection by Melatonin","volume":"56","author":"Romero","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fphys.2014.00377","article-title":"Melatonin Reduces Lipid Peroxidation and Membrane Viscosity","volume":"5","author":"Reiter","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Chitimus, D.M., Popescu, M.R., Voiculescu, S.E., Panaitescu, A.M., Pavel, B., Zagrean, L., and Zagrean, A.-M. (2020). Melatonin\u2019s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease. Biomolecules, 10.","DOI":"10.3390\/biom10091211"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physiol.00011.2014","article-title":"Melatonin: Exceeding Expectations","volume":"29","author":"Reiter","year":"2014","journal-title":"Physiology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"122361","DOI":"10.1016\/j.lfs.2023.122361","article-title":"Melatonin Prevents Overproduction of Reactive Oxygen Species and Vascular Dysfunction Induced by Cyclophosphamide","volume":"338","author":"Pimenta","year":"2024","journal-title":"Life Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ren, B.-C., Zhang, W., Zhang, W., Ma, J.-X., Pei, F., and Li, B.-Y. (2021). Melatonin Attenuates Aortic Oxidative Stress Injury and Apoptosis in STZ-Diabetes Rats by Notch1\/Hes1 Pathway. J. Steroid Biochem. Mol. Biol., 212.","DOI":"10.1016\/j.jsbmb.2021.105948"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/07315724.2003.10719272","article-title":"Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention","volume":"22","author":"Padayatty","year":"2003","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: Beneficial Effects from a Mechanistic Perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"821824","DOI":"10.3389\/fnut.2021.821824","article-title":"Melatonin, Zinc, and Vitamin C: Potential Adjuvant Treatment for COVID-19 Patients","volume":"8","author":"Borges","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1007\/s11033-020-05607-z","article-title":"Melatonin and Vitamin E Alleviate Homocysteine-induced Oxidative Injury and Apoptosis in Endothelial Cells","volume":"47","author":"Aykutoglu","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.jacc.2022.09.048","article-title":"Micronutrient Supplementation to Reduce Cardiovascular Risk","volume":"80","author":"An","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/156720205774962656","article-title":"The Emerging Role of Coenzyme Q-10 in Aging, Neurodegeneration, Cardiovascular Disease, Cancer and Diabetes Mellitus","volume":"2","author":"Dhanasekaran","year":"2005","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gutierrez-Mariscal, F.M., Arenas-de Larriva, A.P., Limia-Perez, L., Romero-Cabrera, J.L., Yubero-Serrano, E.M., and L\u00f3pez-Miranda, J. (2020). Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217870"},{"key":"ref_70","first-page":"155","article-title":"Glutathione: Systemic Protectant against Oxidative and Free Radical Damage","volume":"2","author":"Kidd","year":"1997","journal-title":"Altern. Med. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e12676","DOI":"10.1111\/jpi.12676","article-title":"Melatonin Restores Neutrophil Functions and Prevents Apoptosis amid Dysfunctional Glutathione Redox System","volume":"69","author":"NaveenKumar","year":"2020","journal-title":"J. Pineal Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"105912","DOI":"10.1016\/j.phrs.2021.105912","article-title":"Management of Inflammation in Cardiovascular Diseases","volume":"173","author":"Goswami","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Del Pinto, R., and Ferri, C. (2018). Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123701"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in Obesity, Diabetes, and Related Disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Poznyak, A., Grechko, A.V., Poggio, P., Myasoedova, V.A., Alfieri, V., and Orekhov, A.N. (2020). The Diabetes Mellitus\u2013Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051835"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.2337\/db06-1662","article-title":"Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy","volume":"56","author":"Westermann","year":"2007","journal-title":"Diabetes"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M.G., Rizzo, V., Curr\u00f2, M., Ientile, R., and Caccamo, D. (2020). Is Melatonin the Cornucopia of the 21st Century?. Antioxidants, 9.","DOI":"10.3390\/antiox9111088"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e12525","DOI":"10.1111\/jpi.12525","article-title":"Melatonin and Inflammation\u2014Story of a Double-Edged Blade","volume":"65","author":"Hardeland","year":"2018","journal-title":"J. Pineal Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood-2005-09-3691","article-title":"Melatonin Suppresses Macrophage Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by Inhibiting P52 Acetylation and Binding","volume":"108","author":"Deng","year":"2006","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"175965","DOI":"10.1016\/j.ejphar.2023.175965","article-title":"Melatonin Ameliorates Atherosclerosis by Suppressing S100a9-Mediated Vascular Inflammation","volume":"957","author":"Chen","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e12698","DOI":"10.1111\/jpi.12698","article-title":"Melatonin Attenuates Diabetic Cardiomyopathy and Reduces Myocardial Vulnerability to Ischemia-reperfusion Injury by Improving Mitochondrial Quality Control: Role of SIRT6","volume":"70","author":"Yu","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_82","first-page":"70","article-title":"Melatonin and Tumeric Ameliorate Aging-Induced Changes: Implication of Immunoglobulins, Cytokines, DJ-1\/NRF2 and Apoptosis Regulation","volume":"10","author":"Ismail","year":"2018","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Ortiz, M., Sayed, R.K.A., Fern\u00e1ndez-Mart\u00ednez, J., Cionfrini, A., Aranda-Mart\u00ednez, P., Escames, G., de Haro, T., and Acu\u00f1a-Castroviejo, D. (2020). Melatonin\/Nrf2\/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants, 9.","DOI":"10.3390\/antiox9121187"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sayed, R.K.A., Fern\u00e1ndez-Ortiz, M., Rahim, I., Fern\u00e1ndez-Mart\u00ednez, J., Aranda-Mart\u00ednez, P., Rusanova, I., Mart\u00ednez-Ruiz, L., Alsaadawy, R.M., Escames, G., and Acu\u00f1a-Castroviejo, D. (2021). The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage. Antioxidants, 10.","DOI":"10.3390\/antiox10081269"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fct.2019.04.049","article-title":"Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats via Induction of Anti-Aging Protein, Klotho","volume":"129","author":"Ko","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/mutage\/geaa017","article-title":"Melatonin Supplementation over Different Time Periods until Ageing Modulates Genotoxic Parameters in Mice","volume":"35","author":"Damiani","year":"2020","journal-title":"Mutagenesis"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Zhang, X., Zheng, Y., Wang, Z., Gan, J., Yu, B., Lu, B., and Jiang, X. (2023). Melatonin as a Therapeutic Agent for Alleviating Endothelial Dysfunction in Cardiovascular Diseases: Emphasis on Oxidative Stress. Biomed. Pharmacother., 167.","DOI":"10.1016\/j.biopha.2023.115475"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.lfs.2018.03.035","article-title":"Involvement of the Nitric Oxide in Melatonin-Mediated Protection against Injury","volume":"200","author":"Fan","year":"2018","journal-title":"Life Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12967-023-04361-7","article-title":"Targeting Oxidative Stress as a Preventive and Therapeutic Approach for Cardiovascular Disease","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1034\/j.1600-079X.2001.310313.x","article-title":"Melatonin Protects against Oxidized Low-density Lipoprotein-induced Inhibition of Nitric Oxide Production in Human Umbilical Artery","volume":"31","author":"Wakatsuki","year":"2001","journal-title":"J. Pineal Res."},{"key":"ref_91","first-page":"1","article-title":"Melatonin Attenuates Ox-LDL-Induced Endothelial Dysfunction by Reducing ER Stress and Inhibiting JNK\/Mff Signaling","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jpi.12085","article-title":"Melatonin Ameliorates Vascular Endothelial Dysfunction, Inflammation, and Atherosclerosis by Suppressing the TLR4\/NF-\u03baB System in High-fat-fed Rabbits","volume":"55","author":"Hu","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-079X.2011.00892.x","article-title":"Synergism between Melatonin and Atorvastatin against Endothelial Cell Damage Induced by Lipopolysaccharide","volume":"51","author":"Dayoub","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/hr.2016.103","article-title":"Effect of Long-Term Treatment with Melatonin on Vascular Markers of Oxidative Stress\/Inflammation and on the Anticontractile Activity of Perivascular Fat in Aging Mice","volume":"40","author":"Favero","year":"2017","journal-title":"Hypertens. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e12710","DOI":"10.1111\/jpi.12710","article-title":"Melatonin Reverses the Loss of the Anticontractile Effect of Perivascular Adipose Tissue in Obese Rats","volume":"70","author":"Gonzaga","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Franco, C., Sciatti, E., Favero, G., Bonomini, F., Vizzardi, E., and Rezzani, R. (2022). Essential Hypertension and Oxidative Stress: Novel Future Perspectives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214489"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/hr.2014.99","article-title":"Relationship between Melatonin Secretion and Nighttime Blood Pressure in Elderly Individuals with and without Antihypertensive Treatment: A Cross-Sectional Study of the HEIJO-KYO Cohort","volume":"37","author":"Obayashi","year":"2014","journal-title":"Hypertens. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0002-9149(99)00112-5","article-title":"Effects of Melatonin on Vascular Reactivity, Catecholamine Levels, and Blood Pressure in Healthy Men","volume":"83","author":"Arangino","year":"1999","journal-title":"Am. J. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.amjhyper.2004.06.009","article-title":"Treatment by -Acetylcysteine and Melatonin Increases Cardiac Baroreflex and Improves Antioxidant Reserve","volume":"17","author":"Girouard","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"ref_100","first-page":"311","article-title":"Acute Effects of Oral Melatonin Administration on Arterial Distensibility, as Determined by Carotid-Femoral Pulse Wave Velocity, in Healthy Young Men","volume":"11","author":"Yildiz","year":"2006","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10157-017-1505-7","article-title":"Melatonin Ameliorates Intrarenal Renin\u2013Angiotensin System in a 5\/6 Nephrectomy Rat Model","volume":"22","author":"Ishigaki","year":"2018","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"13A","DOI":"10.1067\/mhj.2001.114368","article-title":"Acute Effects of Melatonin Administration on Cardiovascular Autonomic Regulation in Healthy Men","volume":"141","author":"Nishiyama","year":"2001","journal-title":"Am. Heart J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1113\/jphysiol.2003.043182","article-title":"Melatonin Attenuates the Sympathetic Nerve Responses to Orthostatic Stress in Humans","volume":"551","author":"Ray","year":"2003","journal-title":"J. Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-079X.2010.00835.x","article-title":"Melatonin Treatment Improves Blood Pressure, Lipid Profile, and Parameters of Oxidative Stress in Patients with Metabolic Syndrome","volume":"50","author":"Poliwczak","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Nduhirabandi, F., and Maarman, G. (2018). Melatonin in Heart Failure: A Promising Therapeutic Strategy?. Molecules, 23.","DOI":"10.3390\/molecules23071819"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2007.01.035","article-title":"The Effect of N-Acetylcysteine and Melatonin in Adult Spontaneously Hypertensive Rats with Established Hypertension","volume":"561","author":"Zicha","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-079X.1997.tb00297.x","article-title":"Potentially Beneficial Cardiovascular Effects of Melatonin Administration in Women","volume":"22","author":"Cagnacci","year":"1997","journal-title":"J. Pineal Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"R335","DOI":"10.1152\/ajpregu.1998.274.2.R335","article-title":"Influences of Melatonin Administration on the Circulation of Women","volume":"274","author":"Cagnacci","year":"1998","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/jpi.12067","article-title":"Melatonin Ameliorates Endothelial Dysfunction, Vascular Inflammation, and Systemic Hypertension in Rats with Chronic Intermittent Hypoxia","volume":"55","author":"Hung","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3892\/ijmm.2021.4928","article-title":"Role of the Central Renin-angiotensin System in Hypertension (Review)","volume":"47","author":"Su","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/jpi.12071","article-title":"Melatonin Ameliorates Angiotensin II-induced Vascular Endothelial Damage via Its Antioxidative Properties","volume":"55","author":"Nakao","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/hr.2013.20","article-title":"Nocturnal Urinary Melatonin Excretion Is Associated with Non-Dipper Pattern in Elderly Hypertensives","volume":"36","author":"Obayashi","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/1074248416660622","article-title":"Melatonin and Human Cardiovascular Disease","volume":"22","author":"BaHammam","year":"2017","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-2265.2001.01204.x","article-title":"Effect of Exogenous Melatonin on Vascular Reactivity and Nitric Oxide in Postmenopausal Women: Role of Hormone Replacement Therapy","volume":"54","author":"Cagnacci","year":"2001","journal-title":"Clin. Endocrinol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0079-6123(08)81008-4","article-title":"Melatonin: A Multitasking Molecule","volume":"Volume 181","author":"Reiter","year":"2010","journal-title":"Progress in Brain Research"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"147916412092058","DOI":"10.1177\/1479164120920582","article-title":"Diabetes and Atherothrombosis: The Circadian Rhythm and Role of Melatonin in Vascular Protection","volume":"17","author":"Otamas","year":"2020","journal-title":"Diab. Vasc. Dis. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0167-5273(02)00461-8","article-title":"Decreased Nocturnal Synthesis of Melatonin in Patients with Coronary Artery Disease","volume":"89","author":"Yaprak","year":"2003","journal-title":"Int. J. Cardiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.11.003","article-title":"Elevated Levels of Oxidized Low-Density Lipoprotein and Impaired Nocturnal Synthesis of Melatonin in Patients with Myocardial Infarction","volume":"180","author":"Vargas","year":"2005","journal-title":"Atherosclerosis"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1001\/jama.2013.2710","article-title":"Melatonin Secretion and the Incidence of Type 2 Diabetes","volume":"309","author":"McMullan","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/2359-3997000000098","article-title":"The Role of Melatonin in Diabetes: Therapeutic Implications","volume":"59","author":"Sharma","year":"2015","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1034\/j.1600-079X.2000.290302.x","article-title":"Low Urinary 6-sulphatoxymelatonin Levels in Patients with Coronary Artery Disease","volume":"29","author":"Girotti","year":"2000","journal-title":"J. Pineal Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse Metabolic and Cardiovascular Consequences of Circadian Misalignment","volume":"106","author":"Scheer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-079X.2007.00499.x","article-title":"Oral Melatonin Reduces Blood Coagulation Activity: A Placebo-controlled Study in Healthy Young Men","volume":"44","author":"Wirtz","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0002-8703(99)70390-X","article-title":"Circadian Variation and Triggering of Acute Coronary Events","volume":"137","author":"Muller","year":"1999","journal-title":"Am. Heart J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MBC.0b013e3281139c67","article-title":"Relation of Autonomic Activity to Plasminogen Activator Inhibitor-1 Plasma Concentration and the Role of Body Mass Index","volume":"18","author":"Nelesen","year":"2007","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-079X.1993.tb00501.x","article-title":"Inhibitory Effect of Melatonin on Platelet Activation Induced by Collagen and Arachidonic Acid","volume":"14","author":"Kornblihtt","year":"1993","journal-title":"J. Pineal Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e12438","DOI":"10.1111\/jpi.12438","article-title":"Melatonin Suppresses Platelet Activation and Function against Cardiac Ischemia\/Reperfusion Injury via PPAR \u03b3\/ FUNDC1\/Mitophagy Pathways","volume":"63","author":"Zhou","year":"2017","journal-title":"J. Pineal Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2013.07.053","article-title":"Melatonin Elevates Apoptosis in Human Platelets via ROS Mediated Mitochondrial Damage","volume":"438","author":"Girish","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14712\/fb2009055020045","article-title":"Oxidized-LDL and Fe3+\/Ascorbic Acid-Induced Oxidative Modifications and Phosphatidylserine Exposure in Human Platelets Are Reduced by Melatonin","volume":"55","author":"Sener","year":"2009","journal-title":"Folia Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00415-020-10381-w","article-title":"Effect of Melatonin Supplementation on Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"269","author":"Fatemeh","year":"2022","journal-title":"J. Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00394-019-02123-0","article-title":"Melatonin Supplementation and Pro-Inflammatory Mediators: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"59","author":"Zarezadeh","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2021.01.034","article-title":"Anti-Inflammatory Effects of Melatonin: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"93","author":"Cho","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1016\/j.clnu.2021.06.007","article-title":"Effects of Melatonin Supplementation on Diabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"40","author":"Delpino","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.amjhyper.2005.05.008","article-title":"Prolonged Melatonin Administration Decreases Nocturnal Blood Pressure in Women","volume":"18","author":"Cagnacci","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2147\/VHRM.S24603","article-title":"Effect of Melatonin on Nocturnal Blood Pressure: Meta-Analysis of Randomized Controlled Trials","volume":"7","author":"Laudon","year":"2011","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"103026","DOI":"10.1016\/j.ctim.2024.103026","article-title":"Effects of Melatonin on Blood Pressure, Arterial Stiffness and Quality of Life in Postmenopausal Women: A Randomized Controlled Trial","volume":"81","author":"Amstrup","year":"2024","journal-title":"Complement. Ther. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","article-title":"The Safety of Melatonin in Humans","volume":"36","author":"Andersen","year":"2016","journal-title":"Clin. Drug Investig."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Andersen, L.P.H., Werner, M.U., Rosenkilde, M.M., Harps\u00f8e, N.G., Fuglsang, H., Rosenberg, J., and G\u00f6genur, I. (2016). Pharmacokinetics of Oral and Intravenous Melatonin in Healthy Volunteers. BMC Pharmacol. Toxicol., 17.","DOI":"10.1186\/s40360-016-0052-2"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00228-015-1873-4","article-title":"Clinical Pharmacokinetics of Melatonin: A Systematic Review","volume":"71","author":"Andersen","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s11845-021-02828-4","article-title":"Dietary Supplements, Cytochrome Metabolism, and Pharmacogenetic Considerations","volume":"191","author":"Matura","year":"2022","journal-title":"Ir. J. Med. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e12374","DOI":"10.1111\/jpi.12374","article-title":"Effect of Intravenous and Intracoronary Melatonin as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-elevation Myocardial Infarction: Results of the Melatonin Adjunct in the Acute MyocaRdial Infarction Treated with Angioplasty Trial","volume":"62","author":"Azpeitia","year":"2017","journal-title":"J. Pineal Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","article-title":"Critical Issues for the Translation of Cardioprotection","volume":"120","author":"Heusch","year":"2017","journal-title":"Circ. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fphys.2018.00528","article-title":"Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?","volume":"9","author":"Jiki","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"101431","DOI":"10.1016\/j.smrv.2021.101431","article-title":"Pharmacokinetics of Exogenous Melatonin in Relation to Formulation, and Effects on Sleep: A Systematic Review","volume":"57","author":"Moroni","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"107011","DOI":"10.1016\/j.phrs.2023.107011","article-title":"Effect of Oral Melatonin Treatment on Insulin Resistance and Diurnal Blood Pressure Variability in Night Shift Workers. A Double-Blind, Randomized, Placebo-Controlled Study","volume":"199","author":"Hannemann","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2021.05.034","article-title":"Sleep Timing and the Circadian Clock in Mammals: Past, Present and the Road Ahead","volume":"126","author":"Sanchez","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-physiol-021115-105102","article-title":"Endocrine Effects of Circadian Disruption","volume":"78","author":"Bedrosian","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ctim.2018.11.003","article-title":"Adverse Events Associated with Oral Administration of Melatonin: A Critical Systematic Review of Clinical Evidence","volume":"42","author":"Foley","year":"2019","journal-title":"Complement. Ther. 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