{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:35:13Z","timestamp":1770230113084,"version":"3.49.0"},"reference-count":84,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Portuguese Foundation for Science and Technology","award":["PTDC\/CTA-AMB\/0592\/2021"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021"]}]},{"name":"The Portuguese Foundation for Science and Technology","award":["2020.04413.BD"],"award-info":[{"award-number":["2020.04413.BD"]}]},{"name":"FCT","award":["PTDC\/CTA-AMB\/0592\/2021"],"award-info":[{"award-number":["PTDC\/CTA-AMB\/0592\/2021"]}]},{"name":"FCT","award":["2020.04413.BD"],"award-info":[{"award-number":["2020.04413.BD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The increasing frequency and duration of marine heatwaves (MHWs) due to climate change pose severe threats to aquaculture, causing drastic physiological and growth impairments in farmed fish, undermining their resilience against additional environmental pressures. To ensure sustainable production that meets the global seafood demand and animal welfare standards, cost-effective and eco-friendly strategies are urgently needed. This study explored the efficacy of the red macroalga Asparagopsis taxiformis on juvenile white seabream Diplodus sargus reared under optimal conditions and upon exposure to a MHW. Fish were fed with four experimental diets (0%, 1.5%, 3% or 6% of dried powdered A. taxiformis) for a prophylactic period of 30 days (T30) and subsequently exposed to a Mediterranean category II MHW for 15 days (T53). Biometric data and samples were collected at T30, T53 and T61 (8 days post-MHW recovery), to assess performance indicators, biomarker responses and histopathological alterations. Results showed that A. taxiformis supplementation improved catalase and glutathione S-transferase activities and reduced lipid peroxidation promoted by the MHW, particularly in fish biofortified with 1.5% inclusion level. No histopathological alterations were observed after 30 days. Additionally, fish biofortified with 1.5% A. taxiformis exhibited increased citrate synthase activity and fish supplemented with 1.5% and 3% showed improved digestive enzyme activities (e.g., pepsin and trypsin activities). Overall, the present findings pointed to 1.5% inclusion as the optimal dosage for aquafeeds biofortification with A. taxiformis, and confirmed that this seaweed species is a promising cost-effective ingredient with functional properties and great potential for usage in a climate-smart context.<\/jats:p>","DOI":"10.3390\/antiox13080949","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T18:21:40Z","timestamp":1722882100000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Asparagopsis taxiformis as a Novel Antioxidant Ingredient for Climate-Smart Aquaculture: Antioxidant, Metabolic and Digestive Modulation in Juvenile White Seabream (Diplodus sargus) Exposed to a Marine Heatwave"],"prefix":"10.3390","volume":"13","author":[{"given":"Al\u00edcia","family":"Pereira","sequence":"first","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-5338","authenticated-orcid":false,"given":"Isa","family":"Marmelo","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"UCIBIO REQUIMTE, Applied Molecular Biosciences Unit, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]},{"given":"Marta","family":"Dias","sequence":"additional","affiliation":[{"name":"UCIBIO REQUIMTE, Applied Molecular Biosciences Unit, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"MARE, Marine and Environmental Sciences Centre & ARNET, Aquatic Research Infrastructure Network Associate Laboratory, Faculty of Sciences, University of Lisbon (FCUL), 1749-016 Lisbon, Portugal"},{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Ana Catarina","family":"Silva","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7212-7446","authenticated-orcid":false,"given":"Ana Catarina","family":"Grade","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"given":"Marisa","family":"Barata","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-764X","authenticated-orcid":false,"given":"Pedro","family":"Pous\u00e3o-Ferreira","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-2624","authenticated-orcid":false,"given":"Jorge","family":"Dias","sequence":"additional","affiliation":[{"name":"SPAROS Lda., \u00c1rea Empresarial de Marim, Lote C, 8700-221 Olh\u00e3o, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-9583","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Anacleto","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"MARE, Marine and Environmental Sciences Centre & ARNET, Aquatic Research Infrastructure Network Associate Laboratory, Faculty of Sciences, University of Lisbon (FCUL), 1749-016 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-745X","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Marques","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-0366","authenticated-orcid":false,"given":"M\u00e1rio S.","family":"Diniz","sequence":"additional","affiliation":[{"name":"UCIBIO REQUIMTE, Applied Molecular Biosciences Unit, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Ana Lu\u00edsa","family":"Maulvault","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Sea and Atmosphere, Avenida Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"UCIBIO REQUIMTE, Applied Molecular Biosciences Unit, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"ref_1","unstructured":"Paerl, H., and Kennish, M. 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