{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:00:22Z","timestamp":1769608822271,"version":"3.49.0"},"reference-count":83,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCTES","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\/MCTES","award":["P222RT0117"],"award-info":[{"award-number":["P222RT0117"]}]},{"name":"FCT\/MCTES","award":["PICT(2020)\/1602"],"award-info":[{"award-number":["PICT(2020)\/1602"]}]},{"name":"FCT\/MCTES","award":["323RT0142"],"award-info":[{"award-number":["323RT0142"]}]},{"name":"Ibero-American Program on Science and Technology","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Ibero-American Program on Science and Technology","award":["P222RT0117"],"award-info":[{"award-number":["P222RT0117"]}]},{"name":"Ibero-American Program on Science and Technology","award":["PICT(2020)\/1602"],"award-info":[{"award-number":["PICT(2020)\/1602"]}]},{"name":"Ibero-American Program on Science and Technology","award":["323RT0142"],"award-info":[{"award-number":["323RT0142"]}]},{"name":"Agency for the Scientific and Technological Promotion","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Agency for the Scientific and Technological Promotion","award":["P222RT0117"],"award-info":[{"award-number":["P222RT0117"]}]},{"name":"Agency for the Scientific and Technological Promotion","award":["PICT(2020)\/1602"],"award-info":[{"award-number":["PICT(2020)\/1602"]}]},{"name":"Agency for the Scientific and Technological Promotion","award":["323RT0142"],"award-info":[{"award-number":["323RT0142"]}]},{"name":"Ibero-American Program of Science and Technology for Development","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Ibero-American Program of Science and Technology for Development","award":["P222RT0117"],"award-info":[{"award-number":["P222RT0117"]}]},{"name":"Ibero-American Program of Science and Technology for Development","award":["PICT(2020)\/1602"],"award-info":[{"award-number":["PICT(2020)\/1602"]}]},{"name":"Ibero-American Program of Science and Technology for Development","award":["323RT0142"],"award-info":[{"award-number":["323RT0142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>In recent years, consumers have been increasingly interested in natural, healthier, functional foods, with a focus on sea-based products such as algae. Bifurcaria bifurcata (BB) is a macroalga that belongs to the Phaeophyceae class. These brown algae are recognized as the source of bioactive molecules of great interest to the pharmaceutical and nutraceutical industries. The present work applied response surface methodology to optimize the microwave-assisted extraction of the poorly studied algae. The optimization variables were time, pressure, and solvent composition (ethanol\/water) and the response parameters selected were yield, total phenolic and flavonoid content, and the antioxidant profile by evaluating DPPH\u2022+, ABTS\u2022+ scavenging activity, and \u03b2-carotene discoloration capacity. The results obtained reveal remarkable bioactivity of the crude extract of BB with positive results as an antioxidant and antimicrobial agent. Furthermore, the BB extract\u2019s capacity to inhibit enzymes related to neurodegenerative diseases and its anti-inflammatory and anti-proliferation activity open the possibility of future food or pharmaceutical applications.<\/jats:p>","DOI":"10.3390\/antiox13101189","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:09:52Z","timestamp":1727683792000},"page":"1189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimization and Bioactive Evaluation of Bifurcaria bifurcata Antioxidant-Rich Extracts for Functional Food and Pharmaceutical Applications"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-360X","authenticated-orcid":false,"given":"Aurora","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"},{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7856","authenticated-orcid":false,"given":"Maria","family":"Carpena","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-9334","authenticated-orcid":false,"given":"Lucia","family":"Cassani","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"}]},{"given":"Clara","family":"Grosso","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3709","authenticated-orcid":false,"given":"Paula","family":"Garcia-Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9737","authenticated-orcid":false,"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"}]},{"given":"Maria Fatima","family":"Barroso","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-0054","authenticated-orcid":false,"given":"Miguel A.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, 36310 Vigo, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2174\/138527281807140515154116","article-title":"Bioproducts from Seaweeds: A Review with Special Focus on the Iberian Peninsula","volume":"18","author":"Cardoso","year":"2014","journal-title":"Curr. 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