{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:34:02Z","timestamp":1764225242763,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The potential bioactivity of dietary and medicinal endemic Helichrysum plants from Madeira Archipelago was explored, for the first time, in order to supply new information for the general consumer. In vitro antioxidant properties were investigated using DPPH, ABTS\u2022+, FRAP and \u03b2-Carotene assays, and the total phenolic content (TPC) and total flavonoid content (TFC) were also determined. Although the results generally showed a large variation among the three analyzed plants, the methanolic extracts showed the highest antioxidant capacity. Exception is made for H. devium n-hexane extract that showed good radical scavenger capacity associated to compounds with good reducing properties. In the Artemia salina toxicity assay and antimycobaterial activity, H. devium was the most potent plant with the lowest LD50 at 216.7 \u00b1 10.4 and MIC \u2264 50 \u03bcg\u00b7mL\u22121. Chemometric evaluation (Principal Component Analysis\u2014PCA) showed close interdependence between the ABTS, TPC and TFC methods and allowed to group H. devium samples.<\/jats:p>","DOI":"10.3390\/antiox3040713","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T10:32:28Z","timestamp":1414751548000},"page":"713-729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Antioxidant Capacity, Cytotoxicity and Antimycobacterial Activity of Madeira Archipelago Endemic Helichrysum Dietary and Medicinal Plants"],"prefix":"10.3390","volume":"3","author":[{"given":"Sandra","family":"Gouveia-Figueira","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica da Madeira, CCCEE, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, piso 0, Funchal 9000-390, Portugal"},{"name":"Department of Chemistry, Ume\u00e5 University, Ume\u00e5 SE-901 87, Sweden"},{"name":"Department of Pharmacology and Clinical Neuroscience, Ume\u00e5 University,  Ume\u00e5 SE-901 87, Sweden"}]},{"given":"Carla","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica da Madeira, CCCEE, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, piso 0, Funchal 9000-390, Portugal"}]},{"given":"Maria","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica da Madeira, CCCEE, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, piso 0, Funchal 9000-390, Portugal"}]},{"given":"Ana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Unidade de Geologia Marinha, Laborat\u00f3rio Nacional de Energia e Geologia, I.P.,  Estrada da Portela, Zambujal\u2014Alfragide Apartado 7586, Amadoram 2720-866, Portugal"}]},{"given":"Malin","family":"Nording","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ume\u00e5 University, Ume\u00e5 SE-901 87, Sweden"}]},{"given":"Paula","family":"Castilho","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica da Madeira, CCCEE, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, piso 0, Funchal 9000-390, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1570-0232(04)00764-0","article-title":"Separation Procedures for Naturally Occurring Antioxidant Phytochemicals","volume":"812","author":"Tsao","year":"2004","journal-title":"J. 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