{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:36:03Z","timestamp":1776198963136,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCT","award":["FCT UID\/QUI\/00062\/2019"],"award-info":[{"award-number":["FCT UID\/QUI\/00062\/2019"]}]},{"name":"FCT\/MCT","award":["FCT UID\/AGR\/04033\/2019"],"award-info":[{"award-number":["FCT UID\/AGR\/04033\/2019"]}]},{"name":"FCT\/MEC","award":["SFRH\/BD\/107731\/2015"],"award-info":[{"award-number":["SFRH\/BD\/107731\/2015"]}]},{"name":"FCT\/MEC","award":["SFRH\/BPD\/70589\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/70589\/2010"]}]},{"name":"FCT\/MEC","award":["SFRH\/BD\/103003\/2014"],"award-info":[{"award-number":["SFRH\/BD\/103003\/2014"]}]},{"name":"FCT\/MEC","award":["PD\/BD\/114579\/2016"],"award-info":[{"award-number":["PD\/BD\/114579\/2016"]}]},{"DOI":"10.13039\/501100014717","name":"CENTRO 2020","doi-asserted-by":"publisher","award":["Project AgroForWealth: CENTRO-01-0145-FEDER-000001"],"award-info":[{"award-number":["Project AgroForWealth: CENTRO-01-0145-FEDER-000001"]}],"id":[{"id":"10.13039\/501100014717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"QREN, FEDER, COMPETE","award":["Project ProfitApple 38162"],"award-info":[{"award-number":["Project ProfitApple 38162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Apple pomace is a by-product of apple processing industries with low value and thus frequent disposal, although with valuable compounds. Acidified hot water extraction has been suggested as a clean, feasible, and easy approach for the recovery of polyphenols. This type of extraction allowed us to obtain 296 g of extract per kg of dry apple pomace, including 3.3 g of polyphenols and 281 g of carbohydrates. Ultrafiltration and solid-phase extraction using C18 cartridges of the hot water extract suggested that, in addition to the apple native polyphenols detected by ultra-high-pressure liquid chromatography coupled to a diode-array detector and mass spectrometry UHPLC-DAD-ESI-MSn, polyphenols could also be present as complexes with carbohydrates. For the water-soluble polyphenols, antioxidant and anti-inflammatory effects were observed by inhibiting chemically generated hydroxyl radicals (OH\u2022) and nitrogen monoxide radicals (NO\u2022) produced in lipopolysaccharide-stimulated macrophages. The water-soluble polyphenols, when incorporated into yogurt formulations, were not affected by fermentation and improved the antioxidant properties of the final product. This in vitro research paves the way for agro-food industries to achieve more diversified and sustainable solutions towards their main by-products.<\/jats:p>","DOI":"10.3390\/antiox8060189","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:54:31Z","timestamp":1561118071000},"page":"189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Apple Pomace Extract as a Sustainable Food Ingredient"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4647-5274","authenticated-orcid":false,"given":"Pedro A. R.","family":"Fernandes","sequence":"first","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"S\u00f3nia S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Rita","family":"Bastos","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Isabel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Center of Pharmaceutical Studies, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Maria T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Center of Pharmaceutical Studies, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Ant\u00f3nio","family":"Pinto","sequence":"additional","affiliation":[{"name":"School of Agriculture and CI&amp;DETS, Polytechnic Institute of Viseu, 3500-606 Viseu, Portugal"},{"name":"CITAB, University of Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"CERNAS, Agrarian Higher School, 3045-601 Coimbra, Portugal"}]},{"given":"Elisabete","family":"Coelho","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Cl\u00e1udia P.","family":"Passos","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8898-6342","authenticated-orcid":false,"given":"Manuel A.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-737X","authenticated-orcid":false,"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-0897","authenticated-orcid":false,"given":"Dulcineia F.","family":"Wessel","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"School of Agriculture and CI&amp;DETS, Polytechnic Institute of Viseu, 3500-606 Viseu, Portugal"},{"name":"CITAB, University of Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ifset.2012.06.002","article-title":"Dietary fibre and phytochemical characteristics of fruit and vegetable by-products and their recent applications as novel ingredients in food products","volume":"16","author":"Arendt","year":"2012","journal-title":"Innov. 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