{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:49:15Z","timestamp":1774417755729,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Response surface methodology (RSM) was used to optimize the extraction of phenolics from pericap of Myrtus communis using ultrasound-assisted extraction (UAE). The results were compared with those obtained by microwave-assisted extraction (MAE) and conventional solvent extraction (CSE) methods. The individual compounds of the optimized extract obtained by UAE were identified by ultra-high-performance liquid chromatography coupled with diode array detection and electrospray ionization mass spectrometry (UHPLC-DAD-ESI-MSn). The yield of total phenolic compounds (TPC) was affected more significantly by ethanol concentration, irradiation time, liquid solvent-to-solid ratio (p &lt; 0.0001) and amplitude (p = 0.0421) and optimal parameters conditions set by the RSM model were 70% (v\/v), 7.5 min and 30%, respectively. The experimental yield of TPC (241.66 \u00b1 12.77 mg gallic acid equivalent\/g dry weight) confirmed the predicted value (235.52 \u00b1 9.9 mg gallic acid equivalent\/g dry weight), allowing also to confirm the model validity. Under optimized conditions, UAE was more efficient than MAE and CSE in extracting antioxidants, which comprised mostly myricetin glycosides. Globally, the present work demonstrated that, compared to MAE and CSE, UAE is an efficient method for phenolic extraction from M. communis pericarp, enabling to reduce the working time and the solvent consumption.<\/jats:p>","DOI":"10.3390\/antiox8070205","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T12:11:17Z","timestamp":1562069477000},"page":"205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Optimization of Ultrasound-Assisted Extraction of Polyphenols from Myrtus communis L. Pericarp"],"prefix":"10.3390","volume":"8","author":[{"given":"Nadia","family":"Bouaoudia-Madi","sequence":"first","affiliation":[{"name":"Laboratoire de Biomath\u00e9matiques, Biophysique, Biochimie, et Scientom\u00e9trie (L3BS), Facult\u00e9 des Sciences de la Natureet de la Vie, Universit\u00e9 de Bejaia, 06000 Bejaia, Algeria"}]},{"given":"Lila","family":"Boulekbache-Makhlouf","sequence":"additional","affiliation":[{"name":"Laboratoire de Biomath\u00e9matiques, Biophysique, Biochimie, et Scientom\u00e9trie (L3BS), Facult\u00e9 des Sciences de la Natureet de la Vie, Universit\u00e9 de Bejaia, 06000 Bejaia, Algeria"}]},{"given":"Khodir","family":"Madani","sequence":"additional","affiliation":[{"name":"Laboratoire de Biomath\u00e9matiques, Biophysique, Biochimie, et Scientom\u00e9trie (L3BS), Facult\u00e9 des Sciences de la Natureet de la Vie, Universit\u00e9 de Bejaia, 06000 Bejaia, Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M.S.","family":"Silva","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Sofiane","family":"Dairi","sequence":"additional","affiliation":[{"name":"Laboratoire de Biomath\u00e9matiques, Biophysique, Biochimie, et Scientom\u00e9trie (L3BS), Facult\u00e9 des Sciences de la Natureet de la Vie, Universit\u00e9 de Bejaia, 06000 Bejaia, Algeria"},{"name":"Facult\u00e9 des Sciences de la Nature et de la Vie, Universit\u00e9 de Jijel, 18000 Jijel, Algeria"}]},{"given":"Sonia","family":"Oukhmanou\u2013Bensidhoum","sequence":"additional","affiliation":[{"name":"Laboratoire de Biomath\u00e9matiques, Biophysique, Biochimie, et Scientom\u00e9trie (L3BS), Facult\u00e9 des Sciences de la Natureet de la Vie, Universit\u00e9 de Bejaia, 06000 Bejaia, Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-737X","authenticated-orcid":false,"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"ref_1","first-page":"231","article-title":"Analisie prospettive economiche dell\u2019utilizzazionze industriale del mirto","volume":"12","author":"Nuvoli","year":"1996","journal-title":"Riv. 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