{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T10:22:16Z","timestamp":1776594136461,"version":"3.51.2"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["08\/57800-0; 16\/24360-4"],"award-info":[{"award-number":["08\/57800-0; 16\/24360-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Scholarship"],"award-info":[{"award-number":["Scholarship"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Grape pomace retains polyphenols in the peels and in the seeds after winemaking, which is indicative of the high valorization potential of this industrial waste. There is strong evidence that phenolics are robust antioxidants and confer photoprotection; thus, it is rational to apply these active compounds from winemaking waste to sunscreens, in order to increase UV protection. Despite the importance of this class of cosmetics to public health, more efficacious strategies are still needed to overcome the problems caused by the photoinstability of some UV filters. The hydroethanolic extract of Vitis vinifera L. grapes was obtained by percolation and then lyophilized. Six formulations were developed: Type I\u2014cosmetic base and UV filters; Type II\u2014cosmetic base and extract; and Type III\u2014cosmetic base, extract and UV filters. Each formulation was prepared in the pHs 5 and 7. The antioxidant activities of the samples were measured by DPPH\u2022 and expressed in Trolox\u00ae equivalents (TE), and their photostability and in vitro sun protection factor (SPF) were analyzed by diffuse reflectance spectrophotometry. The anti-radical efficiencies observed in the formulations with grape extract were: (II) 590.12 \u00b1 0.01 \u03bcmol TE g\u22121 at pH 5 and 424.51 \u00b1 0.32 \u03bcmol TE g\u22121 at pH 7; (III) 550.88 \u00b1 0.00 \u03bcmol TE g\u22121 at pH 5 and 429.66 \u00b1 0.10 \u03bcmol TE g\u22121, at pH 7, demonstrating that the UV filters, butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl 4-aminobenzoic acid had no influence on this effect. The photoprotective efficacy and the photostability of formulation III containing the extract and UV filters at pH 5 suggested that a synergism between the active molecules provided an 81% increase in SPF. Additionally, this was the only sample that maintained a broad spectrum of protection after irradiation. These results confirmed that the grape pomace extract has multifunctional potential for cosmetic use, mainly in sunscreens, granting them superior performance.<\/jats:p>","DOI":"10.3390\/antiox8110530","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T06:52:36Z","timestamp":1573109556000},"page":"530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The Synergistic Behavior of Antioxidant Phenolic Compounds Obtained from Winemaking Waste\u2019s Valorization, Increased the Efficacy of a Sunscreen System"],"prefix":"10.3390","volume":"8","author":[{"given":"Alexandra","family":"Hubner","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Fl\u00e1via","family":"Sobreira","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Alberto","family":"Vetore Neto","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Claudin\u00e9ia Aparecida Sales de Oliveira","family":"Pinto","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Michelli Ferrera","family":"Dario","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Ingrit Elida Collantes","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda Qu\u00edmica y T\u00eaxtil\/Facultad de Ciencias, Universidad Nacional de Ingenier\u00eda, Lima 15333, Peru"}]},{"given":"Felipe Rebello","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-6213","authenticated-orcid":false,"given":"Catarina","family":"Rosado","sequence":"additional","affiliation":[{"name":"CBIOS \u2013 Universidade Lus\u00f3fona\u2019s Research Center for Biosciences and Health Technologies, Lisbo 1749-024, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"given":"Elfriede Marianne","family":"Bacchi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo\/SP 05508-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cavalcante, C.M. 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