{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:11:49Z","timestamp":1774332709495,"version":"3.50.1"},"reference-count":99,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Thymus genus comprises numerous species that are particularly abundant in the West Mediterranean region. A growing body of evidence suggests that many of these species are a rich source of bioactive compounds, including phenolic compounds such as rosmarinic acid, salvianolic acids and luteolin glycosides, able to render them potential applications in a range of industrial fields. This review collects the most relevant studies focused on the antioxidant, anti-inflammatory and anti-cancer of phenolic-rich extracts from Thymus plants, highlighting correlations made by the authors with respect to the main phenolic players in such activities.<\/jats:p>","DOI":"10.3390\/antiox9090814","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T08:53:43Z","timestamp":1598950423000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Health-Promoting Effects of Thymus Phenolic-Rich Extracts: Antioxidant, Anti-inflammatory and Antitumoral Properties"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-1617","authenticated-orcid":false,"given":"Andrea F.","family":"Afonso","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Public Health Laboratory of Bragan\u00e7a, Local Health Unit, Rua Eng. Adelino Amaro da Costa, 5300-146 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-3134","authenticated-orcid":false,"given":"Ol\u00edvia R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-737X","authenticated-orcid":false,"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"ref_1","unstructured":"Stahl-Biskup, E., and S\u00e1ez, F. (2002). The History, Botany and Taxonomy of the Genus Thymus. Thyme, the Genus Thymus, Taylor & Francis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2174\/1573411011309030008","article-title":"Overview on Mentha and Thymus Polyphenols","volume":"9","author":"Pereira","year":"2013","journal-title":"Curr. Anal. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bse.2007.08.009","article-title":"Chemical characterisation of wild populations of Thymus from different climatic regions in southeast Spain","volume":"36","author":"Horwath","year":"2008","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403950","DOI":"10.1155\/2015\/403950","article-title":"Antioxidant and anticholinesterase potential of six thymus species","volume":"2015","author":"Kindl","year":"2015","journal-title":"Evidence-based Complement. Altern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/14756366.2014.930453","article-title":"Antibacterial, antioxidant and hypoglycaemic effects of Thymus capitatus (L.) Hoffmanns. et Link leaves\u2019 fractions","volume":"30","author":"Iauk","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ozkan, G., Kamiloglu, S., Ozdal, T., Boyacioglu, D., and Capanoglu, E. (2016). Potential use of Turkish medicinal plants in the treatment of various diseases. Molecules, 21.","DOI":"10.3390\/molecules21030257"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: An overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kubatka, P., Uramova, S., Kello, M., Kajo, K., Samec, M., Jasek, K., Vybohova, D., Liskova, A., Mojzis, J., and Adamkov, M. (2019). Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma In Vivo and In Vitro. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071749"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.indcrop.2013.10.006","article-title":"Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils","volume":"52","author":"Ferreira","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12016","DOI":"10.3390\/molecules200712016","article-title":"Studies on Chemical Composition, Antimicrobial and Antioxidant Activities of Five Thymus vulgaris L. Essential Oils","volume":"20","author":"Grulova","year":"2015","journal-title":"Molecules"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.2174\/138161208786404218","article-title":"Portuguese Thymbra and Thymus species volatiles: chemical composition and biological activities","volume":"14","author":"Figueiredo","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1541-4337.2011.00156.x","article-title":"Natural Antioxidants: Sources, Compounds, Mechanisms of Action, and Potential Applications","volume":"10","author":"Brewer","year":"2011","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/joim.12055","article-title":"The role of mitochondrial DNA mutations and free radicals in disease and ageing","volume":"273","author":"Lagouge","year":"2013","journal-title":"J. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10522-018-9747-7","article-title":"Polyphenols protect against age-associated apoptosis in female rat cochleae","volume":"19","author":"Cuadrado","year":"2018","journal-title":"Biogerontology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4330\/wjc.v6.i6.462","article-title":"Antioxidants, inflammation and cardiovascular disease","volume":"6","author":"Mangge","year":"2014","journal-title":"World J. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lin, D., Xiao, M., Zhao, J., Li, Z., Xing, B., Li, X., Kong, M., Li, L., Zhang, Q., and Liu, Y. (2016). An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes. Molecules, 21.","DOI":"10.3390\/molecules21101374"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9175806","DOI":"10.1155\/2017\/9175806","article-title":"Epigenetics and Oxidative Stress in Aging","volume":"2017","author":"Calabria","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_20","unstructured":"Atta-ur-Rahman, F. (2016). The Anti-inflammatory Potential of Flavonoids: Mechanistic Aspects. Studies in Natural Products Chemistry, Elsevier."},{"key":"ref_21","unstructured":"Goldsby, R.A., Kindt, T.J., Osborne, B.A., and Kuby, J. (2007). Leukocyte Migration and Inflammation. Kuby Immunology, W.H. Freeman and Company. [6th ed.]."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.31254\/phyto.2014.3303","article-title":"COX and LOX inhibitory potential of Abroma augusta and Desmodium gangeticum","volume":"3","author":"Bisht","year":"2014","journal-title":"J. Phytopharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/ard.62.6.501","article-title":"Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs","volume":"62","author":"Lajeunesse","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ginwala, R., Bhavsar, R., Chigbu, D.G.I., and Jain, P. (2019). Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin. Antioxidants, 8.","DOI":"10.3390\/antiox8020035"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1158\/1078-0432.CCR-12-1554","article-title":"Molecular pathways: Inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target","volume":"19","author":"Grimm","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ars.2016.6850","article-title":"Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers","volume":"26","author":"Cheng","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.bjc.6606010","article-title":"The role of microRNAs in liver cancer progression","volume":"104","author":"Huang","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1440-1681.2009.05245.x","article-title":"MicroRNAs and apoptosis: Implications in the molecular therapy of human disease","volume":"36","author":"Yang","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.mrrev.2012.05.002","article-title":"The secret life of Bcl-2: Apoptosis-independent inhibition of DNA repair by Bcl-2 family members","volume":"751","author":"Laulier","year":"2012","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"893247","DOI":"10.1155\/2014\/893247","article-title":"Proapoptotic and antiproliferative effects of Thymus caramanicus on human breast cancer cell line (MCF-7) and its interaction with anticancer drug vincristine","volume":"2014","author":"Falahi","year":"2014","journal-title":"Evidence-based Complement. Altern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wang, W.-H., Hsuan, K.-Y., Chu, L.-Y., Lee, C.-Y., Tyan, Y.-C., Chen, Z.-S., and Tsai, W.-C. (2017). Anticancer effects of Salvia miltiorrhiza alcohol extract on oral squamous carcinoma cells. Evidence-based Complement. Altern. Med., 2017.","DOI":"10.1155\/2017\/5364010"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2016.12.051","article-title":"Apoptosis induced by the methanol extract of Salvia miltiorrhiza Bunge in non-small cell lung cancer through PTEN-mediated inhibition of PI3K\/Akt pathway","volume":"200","author":"Ye","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_33","first-page":"1103","article-title":"Anti-Inflammatory Plant Natural Products for Cancer Therapy","volume":"76","author":"Aravindaram","year":"2010","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.bcp.2010.06.050","article-title":"Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy","volume":"80","author":"Cerella","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/1750-3841.12101","article-title":"Dietary bioactive compounds and their health implications","volume":"78","author":"Liu","year":"2013","journal-title":"J. Food Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.biocel.2013.10.004","article-title":"Flavonoids as prospective compounds for anti-cancer therapy","volume":"45","author":"Ravishankar","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.indcrop.2014.11.029","article-title":"Contribution of the main polyphenols of Thymus mastichina subsp: mastichina to its antioxidant properties","volume":"66","author":"Sponza","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1556\/AChrom.28.2016.2.7","article-title":"A Comparison of Antioxidant, Antibacterial, and Anticancer Activity of the Selected Thyme Species by Means of Hierarchical Clustering and Principal Component Analysis","volume":"28","author":"Pytlakowska","year":"2016","journal-title":"Acta Chromatogr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fbp.2010.04.008","article-title":"A review of the antioxidant potential of medicinal plant species","volume":"89","author":"Krishnaiah","year":"2011","journal-title":"Food Bioprod. Process."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Afonso, A.F., Pereira, O.R., Neto, R.T., Silva, A.M.S., and Cardoso, S.M. (2017). Health-promoting effects of Thymus herba-barona, Thymus pseudolanuginosus, and Thymus caespititius decoctions. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091879"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Afonso, A.F., Pereira, O.R., V\u00e1lega, M., Silva, A.M.S., and Cardoso, S.M. (2018). Metabolites and biological activities of Thymus zygis, Thymus pulegioides, and Thymus fragrantissimus grown under organic cultivation. Molecules, 23.","DOI":"10.3390\/molecules23071514"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.phytochem.2014.08.015","article-title":"Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties","volume":"107","author":"Galasso","year":"2014","journal-title":"Phytochemistry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.apjtb.2015.05.011","article-title":"Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties","volume":"5","author":"Khouya","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.indcrop.2015.01.064","article-title":"A detailed study on the chemical and biological profiles of essential oil and methanol extract of Thymus nummularius (Anzer tea): Rosmarinic acid","volume":"67","author":"Ertas","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-019-2556-y","article-title":"Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas","volume":"19","author":"Rezzoug","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109500","DOI":"10.1016\/j.foodres.2020.109500","article-title":"Thymus algeriensis Bioss & Reut: Relationship of phenolic compounds composition with in vitro\/in vivo antioxidant and antibacterial activity","volume":"136","author":"Righi","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bse.2017.12.009","article-title":"Variation of phenolic constituents of Tunisian Thymus capitatus (L.) Hoff. et Link. populations","volume":"77","author":"Jaouadi","year":"2018","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jaouadi, R., Silva, A.M.S., Boussaid, M., Yahia, I.B.H., Cardoso, S.M., and Zaouali, Y. (2019). Differentiation of phenolic composition among tunisian Thymus algeriensis boiss. Et reut. (Lamiaceae) populations: Correlation to bioactive activities. Antioxidants, 8.","DOI":"10.3390\/antiox8110515"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.indcrop.2010.11.012","article-title":"Biological activities of extracts of plants grown in Portugal","volume":"33","author":"Albano","year":"2011","journal-title":"Ind. Crops Prod."},{"key":"ref_50","first-page":"62","article-title":"Analysis of phenolic compounds in Greek plants of Lamiaceae family by HPLC","volume":"6","author":"Skendi","year":"2017","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"127362","DOI":"10.1016\/j.foodchem.2020.127362","article-title":"Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species","volume":"331","author":"Taghouti","year":"2020","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jff.2013.03.014","article-title":"Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells","volume":"5","author":"Pereira","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.lwt.2009.09.024","article-title":"Lamiaceae often used in Portuguese folk medicine as a source of powerful antioxidants: Vitamins and phenolics","volume":"43","author":"Barros","year":"2010","journal-title":"LWT Food Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Taghouti, M., Martins-Gomes, C., Sch\u00e4fer, J., Santos, J.A., Bunzel, M., Nunes, F.M., and Silva, A.M. (2020). Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition. Antioxidants, 9.","DOI":"10.3390\/antiox9010034"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/ejlt.201000368","article-title":"Lipophilic and hydrophilic antioxidants, lipid peroxidation inhibition and radical scavenging activity of two Lamiaceae food plants","volume":"112","author":"Fernandes","year":"2010","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ustuner, O., Anlas, C., Bakirel, T., Ustun-alkan, F., Sigirci, B.D., Ak, S., Akpulat, H.A., Donmez, C., and Koca-caliskan, U. (2019). In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas. Molecules, 24.","DOI":"10.3390\/molecules24183353"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.foodres.2015.07.005","article-title":"1H NMR based metabolic profiling of eleven Algerian aromatic plants and evaluation of their antioxidant and cytotoxic properties","volume":"76","author":"Brahmi","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"22736","DOI":"10.1007\/s11356-019-05562-8","article-title":"The remedial effect of Thymus vulgaris extract against lead toxicity-induced oxidative stress, hepatorenal damage, immunosuppression, and hematological disorders in rats","volume":"26","author":"Refaat","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.foodchem.2013.04.089","article-title":"Effects of Salvia officinalis and Thymus vulgaris on oxidant-induced DNA damage and antioxidant status in HepG2 cells","volume":"141","author":"Kozics","year":"2013","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Silva, A.M., Martins-Gomes, C., Souto, E.B., Sch\u00e4fer, J., Santos, J.A., Bunzel, M., and Nunes, F.M. (2020). Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities. Antioxidants, 9.","DOI":"10.3390\/antiox9060482"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1039\/C8FO00456K","article-title":"Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds","volume":"9","author":"Taghouti","year":"2018","journal-title":"Food Funct."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Hmidani, A., Dine, E., Bouhlali, T., Khouya, T., and Ramchoun, M. (2019). Antioxidant, anti-inflammatory and anticoagulant activities of three Thymus species grown in southeastern Morocco. Futur. J. Pharm. Sci., 5.","DOI":"10.1186\/s43094-019-0005-x"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.sajb.2019.01.005","article-title":"Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas","volume":"121","author":"Khouya","year":"2019","journal-title":"South African J. Bot."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.3390\/molecules18067253","article-title":"Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease","volume":"18","author":"Debnath","year":"2013","journal-title":"Molecules"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/138955709787001712","article-title":"Distribution and Biological Activities of the Flavonoid Luteolin","volume":"9","year":"2009","journal-title":"Mini-Reviews Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Leyva-Lopez, N., Gutierrez-Grijalva, E.P., Ambriz-Perez, D.L., and Basilio Heredia, J. (2016). Flavonoids as cytokine modulators: A possible therapy for inflammation-related diseases. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060921"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Azab, A., Nassar, A., and Azab, A.N. (2016). Anti-inflammatory activity of natural products. Molecules, 21.","DOI":"10.3390\/molecules21101321"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Sobeh, M., Rezq, S., Cheurfa, M., Abdelfattah, M.A.O., Rashied, R.M.H., El-Shazly, A.M., Yasri, A., Wink, M., and Mahmoud, M.F. (2020). Thymus algeriensis and Thymus fontanesii: Chemical composition, in vivo antiinflammatory, pain killing and antipyretic activities: A comprehensive comparison. Biomolecules, 10.","DOI":"10.3390\/biom10040599"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jff.2018.02.012","article-title":"Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss","volume":"43","author":"Taghouti","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s11694-018-9967-1","article-title":"In vitro and In vivo biological activities and phenolic characterization of Thymus praecox subsp. skorpilii var. skorpilii","volume":"13","author":"Rayaman","year":"2019","journal-title":"J. Food Meas. Charact."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"627843","DOI":"10.1155\/2012\/627843","article-title":"An investigation of the relationship between the anti-inflammatory activity, polyphenolic content, and antioxidant activities of cooked and in vitro digested culinary herbs","volume":"2012","author":"Chohan","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.archoralbio.2017.06.031","article-title":"Thymus vulgaris L. extract has antimicrobial and anti-inflammatory effects in the absence of cytotoxicity and genotoxicity","volume":"82","author":"Martins","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s10753-017-0728-9","article-title":"Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses through the Inhibition of TLR4 and CD14 Expression and NF-kappaB and NLRP3 Inflammasome Activation","volume":"41","author":"Wei","year":"2018","journal-title":"Inflammation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2018.01.042","article-title":"Ethyl rosmarinate inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in alveolar macrophages","volume":"824","author":"Thammason","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2174\/138920009787846369","article-title":"Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways","volume":"10","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.3892\/etm.2016.3854","article-title":"Anti-inflammatory effects of luteolin on experimental autoimmune thyroiditis in mice","volume":"12","author":"Xia","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10753-017-0700-8","article-title":"Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice","volume":"41","author":"Jiang","year":"2018","journal-title":"Inflammation"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1124\/jpet.111.190736","article-title":"Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities","volume":"341","author":"Joe","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"142087","DOI":"10.1155\/2012\/142087","article-title":"Animal models as tools to investigate antidiabetic and anti-inflammatory plants","volume":"2012","author":"Eddouks","year":"2012","journal-title":"Evidence-based Complement. Altern. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.biopha.2018.08.078","article-title":"Biomedicine & Pharmacotherapy Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations","volume":"109","author":"Mahmoodi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.12659\/MSM.898177","article-title":"Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice","volume":"22","author":"Xin","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"451682","DOI":"10.5402\/2011\/451682","article-title":"Effect of rosmarinic and caffeic acids on inflammatory and nociception process in rats","volume":"2011","author":"Gamaro","year":"2011","journal-title":"ISRN Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.phymed.2018.01.001","article-title":"Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects","volume":"40","author":"Rahbardar","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_84","first-page":"1","article-title":"Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-\u03baB and STAT3 activation","volume":"7","author":"Jin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.21873\/invivo.11583","article-title":"Apigenin Exerts Anti-inflammatory Effects in an Experimental Model of Acute Pancreatitis by Down-regulating TNF-\u03b1","volume":"33","author":"Charalabopoulos","year":"2019","journal-title":"In Vivo"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"564927","DOI":"10.1155\/2012\/564927","article-title":"Anticancer activity of certain herbs and spices on the cervical epithelial carcinoma (HeLa) cell line","volume":"2012","author":"Berrington","year":"2012","journal-title":"Evidence-based Complement. Altern. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_88","first-page":"1491","article-title":"Thymus mastichina: Chemical Constituents and their Anti-cancer Activity","volume":"7","author":"Gordo","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.foodchem.2013.03.090","article-title":"Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells","volume":"141","author":"Berdowska","year":"2013","journal-title":"Food Chem."},{"key":"ref_90","first-page":"22","article-title":"Antioxidant Potential of Four Species of Natural Product and Therapeutic Strategies for Cancer through Suppression of Viability in the Human Multiple Myeloma Cell Line U266","volume":"32","author":"Fatma","year":"2019","journal-title":"Biomed. Environ. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2017.03.035","article-title":"Flavone polyphenols dominate in Thymus schimperi Ronniger: LC\u2013ESI\u2013MS\/MS characterization and study of anti-proliferative effects of plant extract on AGS and HepG2 cancer cells","volume":"1053","author":"Desta","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1080\/01635581.2012.719658","article-title":"Effects of Thymus serpyllum Extract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells","volume":"64","author":"Bozkurt","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1021\/jf100082p","article-title":"Polyphenolic compounds from Salvia species protect cellular DNA from oxidation and stimulate DNA repair in cultured human cells","volume":"58","author":"Ramos","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1039\/C8FO00568K","article-title":"Thymus lanceolatus ethanolic extract protects human cells from t-BHP induced oxidative damage","volume":"9","author":"Caprioli","year":"2018","journal-title":"Food Funct."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/jmf.2013.3121","article-title":"Thymus vulgaris (Thyme) Inhibits Proliferation, Adhesion, Migration, and Invasion of Human Colorectal Cancer Cells","volume":"18","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fonc.2014.00131","article-title":"Orchestration of angiogenesis by immune cells","volume":"4","author":"Bruno","year":"2014","journal-title":"Front Oncol"},{"key":"ref_97","first-page":"2441","article-title":"Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family","volume":"18","author":"Abdallah","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Jaksevicius, A., Carew, M., Mistry, C., Modjtahedi, H., and Opara, E.I. (2017). Inhibitory effects of culinary herbs and spices on the growth of HCA-7 colorectal cancer cells and their COX-2 expression. Nutrients, 9.","DOI":"10.3390\/nu9101051"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s13197-017-2965-1","article-title":"Potential use of deodorised water extracts: Polyphenol-rich extract of Thymus pannonicus as a chemopreventive agent","volume":"55","author":"Drobac","year":"2018","journal-title":"J. Food Sci. Technol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/9\/814\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:38Z","timestamp":1760177138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/9\/814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":99,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["antiox9090814"],"URL":"https:\/\/doi.org\/10.3390\/antiox9090814","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}