{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:21:35Z","timestamp":1774945295070,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/04462\/2013"],"award-info":[{"award-number":["UID\/Multi\/04462\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011310","name":"Rural and Environment Science and Analytical Services Division","doi-asserted-by":"publisher","award":["FP7-KBBE-2010-4265942"],"award-info":[{"award-number":["FP7-KBBE-2010-4265942"]}],"id":[{"id":"10.13039\/100011310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-\u03b1, and intracellular superoxide via NF-\u03baB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammation<\/jats:p>","DOI":"10.3390\/antiox9100970","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T10:18:00Z","timestamp":1602497880000},"page":"970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-5362","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Garcia","sequence":"first","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), apartado 12, 2781-901 Oeiras, Portugal"},{"name":"ITQB, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-4395","authenticated-orcid":false,"given":"Teresa Faria","family":"Pais","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), apartado 12, 2781-901 Oeiras, Portugal"},{"name":"Instituto Gulbenkian de Ci\u00eancia (IGC), Rua Quinta Grande, 2780-156 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-1768","authenticated-orcid":false,"given":"Paula","family":"Pinto","sequence":"additional","affiliation":[{"name":"ITQB, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"Instituto Polit\u00e9cnico de Santar\u00e9m, Escola Superior Agr\u00e1ria, Qta do Galinheiro, 2001-904 Santar\u00e9m, Portugal"},{"name":"Life Quality Research Centre (CIEQV), IPSantar\u00e9m\/IPLeiria, 2040-413 Rio Maior, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9926-4206","authenticated-orcid":false,"given":"Gary","family":"Dobson","sequence":"additional","affiliation":[{"name":"Plant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0124","authenticated-orcid":false,"given":"Gordon J.","family":"McDougall","sequence":"additional","affiliation":[{"name":"Plant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-4265","authenticated-orcid":false,"given":"Derek","family":"Stewart","sequence":"additional","affiliation":[{"name":"Plant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UK"},{"name":"School of Engineering and Physical Sciences, Institute of Mechanical, Process and Energy Engineering, Heriot-Watt University, Edinburg EH14 4AS, Scotland, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5809-1924","authenticated-orcid":false,"given":"Cl\u00e1udia Nunes","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), apartado 12, 2781-901 Oeiras, Portugal"},{"name":"ITQB, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School\/\/Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 130, 1169-056 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biochi.2018.05.015","article-title":"Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling","volume":"155","author":"Fernandes","year":"2018","journal-title":"Biochimie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/glia.20928","article-title":"Innate immunity and neuroinflammation in the CNS: The role of microglia in toll-like receptor-mediated neuronal injury","volume":"58","author":"Lehnardt","year":"2010","journal-title":"Glia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: The good, the bad, and the inflamed","volume":"11","author":"Cherry","year":"2014","journal-title":"J. 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