{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:46:41Z","timestamp":1776206801461,"version":"3.50.1"},"reference-count":195,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.<\/jats:p>","DOI":"10.3390\/app10030947","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:28:31Z","timestamp":1580729311000},"page":"947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":186,"title":["Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-9797","authenticated-orcid":false,"given":"Bahare","family":"Salehi","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-1668","authenticated-orcid":false,"given":"Elena","family":"Azzini","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina, 546-00178 Roma, Italy"}]},{"given":"Paolo","family":"Zucca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-2188","authenticated-orcid":false,"given":"Elena","family":"Maria Varoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Milan State University, 20142 Milan, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-8991","authenticated-orcid":false,"given":"Nanjangud","family":"V. Anil Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-9040","authenticated-orcid":false,"given":"Luciana","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-4272","authenticated-orcid":false,"given":"Elisa","family":"Panzarini","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-2219","authenticated-orcid":false,"given":"Jovana","family":"Rajkovic","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-3527","authenticated-orcid":false,"given":"Patrick","family":"Valere Tsouh Fokou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde 812, Cameroon"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-5241","authenticated-orcid":false,"given":"Ilaria","family":"Peluso","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina, 546-00178 Roma, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-0852","authenticated-orcid":false,"given":"Abhay","family":"Prakash Mishra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, H.N.B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand 246174, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-9790","authenticated-orcid":false,"given":"Manisha","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar, Garhwal, Uttarakhand 246174, India"}]},{"given":"Youssef","family":"El Rayess","sequence":"additional","affiliation":[{"name":"Department Agricultural and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Jounieh B.P. 446, Lebanon"}]},{"given":"Marc","family":"El Beyrouthy","sequence":"additional","affiliation":[{"name":"Department Agricultural and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Jounieh B.P. 446, Lebanon"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-0528","authenticated-orcid":false,"given":"William","family":"N. Setzer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-4981","authenticated-orcid":false,"given":"Letizia","family":"Polito","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine-DIMES General Pathology Section, Via San Giacomo, 14, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-1236","authenticated-orcid":false,"given":"Marcello","family":"Iriti","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-6838","authenticated-orcid":false,"given":"Antoni","family":"Sureda","sequence":"additional","affiliation":[{"name":"Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands &amp; Health Research Institute of the Balearic Islands (IdISBa), E-07122 Palma, Balearic Islands, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, E- 07122 Palma, Balearic Islands, Spain"}]},{"given":"Maria","family":"Magdalena Quetglas-Llabr\u00e9s","sequence":"additional","affiliation":[{"name":"Research Group in Community Nutrition and Oxidative Stress, University of Balearic Islands &amp; Health Research Institute of the Balearic Islands (IdISBa), E-07122 Palma, Balearic Islands, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile"},{"name":"Unidad de Desarrollo Tecnol\u00f3gico, Universidad de Concepci\u00f3n UDT, Concepcion 4070386, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"}]},{"given":"Mehdi","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, Kerman University of Medical Sciences, Kerman 7616913555, Iran"}]},{"given":"Leticia","family":"M. Estevinho","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, School of Agriculture of the Polytechnic Institute of Bragan\u00e7a (ESA-IPB), Campus de Santa Apol\u00f3nia, 5301-854 Bragan\u00e7a, Portugal"},{"name":"CIMO, Mountain Research Center, Polytechnic Institute of Bragan\u00e7a, Campus Santa Apol\u00f3nia, 5301-855 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.3390\/molecules15107313","article-title":"Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties","volume":"15","author":"Dai","year":"2010","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14715\/cmb\/2018.64.8.9","article-title":"In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir","volume":"64","author":"Salehi","year":"2018","journal-title":"Cell. Mol. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life","volume":"141","author":"Halliwell","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1105\/tpc.105.033589","article-title":"Redox Homeostasis and Antioxidant Signaling: A Metabolic Interface between Stress Perception and Physiological Responses","volume":"17","author":"Foyer","year":"2005","journal-title":"Plant Cell"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Salehi, B., Martorell, M., Arbiser, J.L., Sureda, A., Martins, N., Maurya, P.K., Sharifi-Rad, M., Kumar, P., and Sharifi-Rad, J. (2018). Antioxidants: Positive or Negative Actors?. Biomolecules, 8.","DOI":"10.3390\/biom8040124"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116607","DOI":"10.1016\/j.lfs.2019.116607","article-title":"Targeting of oxidative stress and inflammation through ROS\/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation","volume":"232","author":"Abtahi","year":"2019","journal-title":"Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7150\/ijbs.12096","article-title":"Significance of antioxidant potential of plants and its relevance to therapeutic applications","volume":"11","author":"Kasote","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: Antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1079\/095442200108729016","article-title":"Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants","volume":"13","author":"Duthie","year":"2000","journal-title":"Nutr. Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40279-014-0151-4","article-title":"Polyphenol supplementation: Benefits for exercise performance or oxidative stress?","volume":"44","author":"Myburgh","year":"2014","journal-title":"Sport Med."},{"key":"ref_12","first-page":"174","article-title":"Antioxidants, oxidative damage and oxygen deprivation stress: A review","volume":"91","author":"Blokhina","year":"2002","journal-title":"Ann. Bot."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/9780470319444.ch7","article-title":"Flavonoids: A Re-Run of the carotenoids story?","volume":"282","author":"Halliwell","year":"2007","journal-title":"Novartis Found Symp."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ajcn\/74.4.418","article-title":"Flavonoids: A review of probable mechanisms of action and potential applications","volume":"74","author":"Nijveldt","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/mnfr.200900039","article-title":"Tannins: Current knowledge of food sources, intake, bioavailability and biological effects","volume":"53","author":"Serrano","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.plaphy.2010.08.016","article-title":"Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants","volume":"48","author":"Gill","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/plants4030393","article-title":"Senescence, Stress, and Reactive Oxygen Species","volume":"4","author":"Jajic","year":"2015","journal-title":"Plants"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/jn\/137.8.1951","article-title":"Anthocyanins Inhibit Nuclear Factor-\u03baB Activation in Monocytes and Reduce Plasma Concentrations of Pro-Inflammatory Mediators in Healthy Adults","volume":"137","author":"Karlsen","year":"2007","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1021\/jf000766i","article-title":"Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radical\u2019s, and singlet oxygen","volume":"48","author":"Wang","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1158\/1055-9965.EPI-15-0053","article-title":"Carotenoid intake from natural sources and head and neck cancer: A systematic review and meta-analysis of epidemiological studies","volume":"24","author":"Leoncini","year":"2015","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000355849","article-title":"Vitamin A and carotenoids and the risk of parkinson\u2019s disease: A systematic review and meta-analysis","volume":"42","author":"Takeda","year":"2014","journal-title":"Neuroepidemiology"},{"key":"ref_22","first-page":"1143","article-title":"da C.P.; Teodoro, A.J.; Lotsch, P.F.; Granjeiro, J.M.; Borojevic, R. Anticancer properties of carotenoids in prostate cancer. A review","volume":"30","author":"Soares","year":"2015","journal-title":"Histol. Histopathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.maturitas.2013.10.004","article-title":"Nutrition and breast cancer","volume":"77","author":"Romieu","year":"2014","journal-title":"Maturitas"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Battelli, M.G., Polito, L., Bortolotti, M., and Bolognesi, A. (2016). Xanthine oxidoreductase-derived reactive species: Physiological and pathological effects. Oxid. Med. Cell. Longev., 3527579.","DOI":"10.1155\/2016\/3527579"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/cam4.601","article-title":"Xanthine oxidoreductase in cancer: More than a differentiation marker","volume":"5","author":"Battelli","year":"2016","journal-title":"Cancer Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.bbadis.2014.05.022","article-title":"Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme","volume":"1842","author":"Battelli","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1749-6632.2000.tb06182.x","article-title":"Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future","volume":"899","author":"Gutteridge","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/01.mco.0000247478.79779.8f","article-title":"Rationale and impact of vitamin C in clinical nutrition","volume":"9","author":"McGregor","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2008.01.028","article-title":"Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?","volume":"476","author":"Halliwell","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bors, W., Heller, W., Michel, C., and Saran, M. (1990). Radical chemistry of flavonoid antioxidants. Antioxidants in Therapy and Preventative Medicine, Springer.","DOI":"10.1007\/978-1-4684-5730-8_25"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0891-5849(99)00187-2","article-title":"Antioxidant capacity of flavanols and gallate esters: Pulse radiolysis studies","volume":"27","author":"Bors","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodchem.2011.04.079","article-title":"Bin Antioxidant capacities and total phenolic contents of 62 fruits","volume":"129","author":"Fu","year":"2011","journal-title":"Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1021\/jf991072g","article-title":"Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippophae rhamnoides L.) during maturation","volume":"48","author":"Gao","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1269\/jrr.08096","article-title":"Radioprotective Properties of Polyphenols from Phyllanthus amarus Linn","volume":"50","author":"Londhe","year":"2009","journal-title":"J. Radiat. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/14786410500378494","article-title":"Antioxidant galloylated flavonol glycosides from Calliandra haematocephala","volume":"20","author":"Moharram","year":"2006","journal-title":"Nat. Prod. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and prooxidant properties of flavonoids","volume":"82","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.foodchem.2005.05.042","article-title":"A DFT study of the reactivity of OH groups in quercetin and taxifolin antioxidants: The specificity of the 3-OH site","volume":"97","author":"Trouillas","year":"2006","journal-title":"Food Chem."},{"key":"ref_39","first-page":"318","article-title":"da R.; Medina-Remon, A.; von Poser, G.; Lamuela-Raventos, R.M.; Eifler-Lima, V.L.; Garcia, S.C. The Antioxidant Activity of Coumarins and Flavonoids","volume":"13","author":"Bubols","year":"2013","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/092986707780090954","article-title":"SAR and QSAR of the Antioxidant Activity of Flavonoids","volume":"14","author":"Amic","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9636","DOI":"10.3390\/molecules16119636","article-title":"A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives","volume":"16","author":"Moalin","year":"2011","journal-title":"Molecules"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.foodchem.2013.03.072","article-title":"Bond dissociation free energy as a general parameter for flavonoid radical scavenging activity","volume":"141","year":"2013","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1385\/CBB:35:2:141","article-title":"Repair of oxidative DNA damage: Mechanisms and functions","volume":"35","author":"Lu","year":"2001","journal-title":"Cell Biochem. Biophys."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/nar\/gki192","article-title":"Preferential binding and structural distortion by Fe2+at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences","volume":"33","author":"Rai","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/np9904509","article-title":"Flavonoids as antioxidants","volume":"63","author":"Pietta","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12013-009-9043-x","article-title":"A review of the antioxidant mechanisms of polyphenol compounds related to iron binding","volume":"53","author":"Perron","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/np970237h","article-title":"Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers","volume":"61","author":"Cos","year":"1998","journal-title":"J. Nat. Prod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-291X(02)00442-4","article-title":"Molecular modeling of flavonoids that inhibits xanthine oxidase","volume":"294","author":"Lin","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(02)02192-1","article-title":"Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids","volume":"451","author":"Nijveldt","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mrfmmm.2004.01.015","article-title":"Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription","volume":"551","author":"Needs","year":"2004","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00011-009-0037-3","article-title":"Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease","volume":"58","author":"Villares","year":"2009","journal-title":"Inflamm. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/abbi.1997.0455","article-title":"Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides","volume":"349","author":"Tsushida","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(02)01621-0","article-title":"Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action","volume":"65","author":"Sadik","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.2174\/0929867323666160725091915","article-title":"Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme","volume":"23","author":"Batteli","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.freeradbiomed.2007.02.017","article-title":"Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin","volume":"42","author":"Tanigawa","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jnutbio.2010.02.008","article-title":"Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: Role of miR-155","volume":"22","author":"Loboda","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1167\/iovs.10-5775","article-title":"Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19\/HPV-16 cells","volume":"52","author":"Miyamoto","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fct.2014.07.038","article-title":"The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway","volume":"72","author":"Saw","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/tx060157q","article-title":"Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression","volume":"19","author":"Boerboom","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/carcin\/13.4.605","article-title":"Activities of flavonoids for the cleavage of DNA in the presence of cu(II): Correlation with generation of active oxygen species","volume":"13","author":"Ahmad","year":"1992","journal-title":"Carcinogenesis"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.freeradbiomed.2005.06.025","article-title":"Potential markers of oxidative stress in stroke","volume":"39","author":"Cherubini","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","article-title":"Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships","volume":"22","author":"Cao","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4161\/oxim.2.4.9112","article-title":"Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure","volume":"2","author":"Flora","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.abb.2010.06.013","article-title":"The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention","volume":"501","author":"Lambert","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0891-5849(99)00167-7","article-title":"Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with \u03b1-linolenic acid","volume":"27","author":"Sugihara","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_67","unstructured":"Yordi, E.G., P\u00e9rez, E.M., Matos, M.J., and Villares, E.U. (2012). Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity Relationship Evidence. Nutrition, Well-Being and Health, IntechOpen Limited."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"135","DOI":"10.12688\/f1000research.2-135.v1","article-title":"Pro-oxidant activity of dietary chemopreventive agents: An under-appreciated anti-cancer property","volume":"2","author":"Azmi","year":"2013","journal-title":"F1000Research"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ijbiomac.2017.08.049","article-title":"Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention","volume":"106","author":"Arif","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1055\/s-0028-1088302","article-title":"Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals","volume":"74","author":"Surh","year":"2008","journal-title":"Planta Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1271\/bbb.67.2632","article-title":"Production of Hydrogen Peroxide by Polyphenols and Polyphenol-rich Beverages under Quasi -physiological Conditions","volume":"67","author":"Akagawa","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0006-291X(03)00655-7","article-title":"Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines","volume":"304","author":"Chai","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.freeradbiomed.2006.03.002","article-title":"Flavonoid-induced glutathione depletion: Potential implications for cancer treatment","volume":"41","author":"Kachadourian","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40495-015-0017-y","article-title":"Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol\/3,3\u2032-Diindolylmethane: Antioxidative Stress\/Inflammation, Nrf2, Epigenetics\/Epigenomics and In Vivo Cancer Chemopreventive Efficacy","volume":"1","author":"Fuentes","year":"2015","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/j.seminoncol.2015.09.013","article-title":"Frugal chemoprevention: Targeting Nrf2 with foods rich in sulforaphane","volume":"43","author":"Yang","year":"2016","journal-title":"Semin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/tx900148k","article-title":"Catechol type polyphenol is a potential modifier of protein sulfhydryls: Development and application of a new probe for understanding the dietary polyphenol actions","volume":"22","author":"Ishii","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","article-title":"Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG","volume":"46","author":"Na","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/toxsci\/kfu080","article-title":"Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids","volume":"140","author":"Copple","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.redox.2014.11.012","article-title":"The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2\/Keap1 pathway activation in ovarian carcinoma cell lines","volume":"4","author":"Sirota","year":"2015","journal-title":"Redox Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1073\/pnas.1002890107","article-title":"Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia","volume":"107","author":"Wu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1073\/pnas.0603290103","article-title":"Dynamic redox control of NF- B through glutaredoxin-regulated S-glutathionylation of inhibitory B kinase beta","volume":"103","author":"Reynaert","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bcp.2014.08.004","article-title":"Vanden Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKK\u03b2","volume":"91","author":"Heyninck","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/carcin\/bgq099","article-title":"Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-\u03baB activation and cyclooxygenase-2 expression in human breast epithelial cells: Cysteine 179 of IKK\u03b2 as a potential target","volume":"31","author":"Son","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11906-010-0103-9","article-title":"Oxidative stress and vascular function: Implications for pharmacologic treatments","volume":"12","author":"Weseler","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_86","first-page":"192","article-title":"M\u00e9todos para medir el da\u00f1o oxidativo","volume":"29","author":"Gastell","year":"2000","journal-title":"Rev. Cuba. Med. Mil."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: A Theory based on Free Radical and Radiation Chemestry","volume":"11","author":"Harman","year":"1956","journal-title":"J Gerontol."},{"key":"ref_88","first-page":"20","article-title":"Molecular mechanisms of aging: The role of oxidative stress and epigenetic modifications","volume":"32","author":"Aitbaev","year":"2019","journal-title":"Adv. Gerontol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"551","DOI":"10.12965\/jer.1836268.134","article-title":"Role of exercise in age-related sarcopenia","volume":"14","author":"Yoo","year":"2018","journal-title":"J Exerc. Rehabil."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0022-3859.33869","article-title":"The oxidative hypothesis of senescence","volume":"53","author":"Gilca","year":"2007","journal-title":"J. Postgrad. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/271028","article-title":"The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: The great exploration","volume":"2012","author":"Hutcheson","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Milisav, I., Ribari, S., and Poljsak, B. (2018). Antioxidant Vitamins and Ageing, Springer.","DOI":"10.1007\/978-981-13-2835-0_1"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: Mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/ajcn\/68.5.1081","article-title":"Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables","volume":"68","author":"Cao","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1021\/jf072505f","article-title":"Berry fruit supplementation and the aging brain","volume":"56","author":"Lau","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/jf025993u","article-title":"Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits","volume":"51","author":"Seeram","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1080\/14786410802267643","article-title":"Protective role of tea catechins on erythrocytes subjected to oxidative stress during human aging","volume":"23","author":"Maurya","year":"2009","journal-title":"Nat. Prod. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4161\/cc.7.8.5740","article-title":"Resveratrol: A multitargeted agent for age-associated chronic diseases","volume":"7","author":"Harikumar","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Springer, M., and Moco, S. (2019). Resveratrol and Its Human Metabolites\u2014Effects on Metabolic Health and Obesity. Nutrients, 11.","DOI":"10.3390\/nu11010143"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0006-8993(02)03543-6","article-title":"Resveratrol protects against global cerebral ischemic injury in gerbils","volume":"958","author":"Wang","year":"2002","journal-title":"Brain Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2174\/1389450117666161005150650","article-title":"Cardioprotective Effects of the Polyphenol Hydroxytyrosol from Olive Oil","volume":"18","author":"Tejada","year":"2017","journal-title":"Curr Drug Targets"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/jn\/138.8.1411","article-title":"Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells","volume":"138","author":"Fabiani","year":"2008","journal-title":"J. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00054747","article-title":"Oxygen-derived free radicals and myocardial reperfusion injury: An overview","volume":"5","author":"Bolli","year":"1991","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1300\/J133v03n03_04","article-title":"Evidence for grape, wine and tea polyphenols as modulators of atherosclerosis and ischemic heart disease in humans","volume":"3","author":"Dubick","year":"2001","journal-title":"J. Nutraceuticals Funct. Med. Foods"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"154295","DOI":"10.1155\/2014\/154295","article-title":"Effect of centella asiatica on oxidative stress and lipid metabolism in hyperlipidemic animal models","volume":"2014","author":"Zhao","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1248\/cpb.55.337","article-title":"Convallasaponin A, a New 5\u03b2-Spirostanol Triglycoside from the Rhizomes of Convallaria majalis","volume":"55","author":"Higano","year":"2007","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/iub.47","article-title":"Resveratrol: One molecule, many targets","volume":"60","author":"Pirola","year":"2008","journal-title":"IUBMB Life"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1039\/C3FO60539F","article-title":"Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models","volume":"5","author":"Arce","year":"2014","journal-title":"Food Funct."},{"key":"ref_111","unstructured":"da Chunga, A.P. (2006). Digitalis purpurea, Digitalis lanata. Plantas e Produtos Vegetais em Fitoterapia, Funda\u00e7\u00e3o Calouste Gulbenkian."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev.nutr.21.1.381","article-title":"Inhibition of Carcinogenesis by Dietary Polyphenolic Compounds","volume":"21","author":"Yang","year":"2001","journal-title":"Ann. Rev. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1079\/NRR19940011","article-title":"Anticarcinogenic Factors in Plant Foods: A New Class of Nutrients?","volume":"7","author":"Johnson","year":"1994","journal-title":"Nutr. Res. Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/0973-1296.80667","article-title":"Isolation of biologically active constituents from Moringa peregrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt","volume":"7","author":"Ezzat","year":"2011","journal-title":"Pharmacogn. Mag."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1159\/000320570","article-title":"Reference profile correlation reveals estrogen-like trancriptional activity of curcumin","volume":"26","author":"Bachmeier","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Senft, C., Polacin, M., Priester, M., Seifert, V., K\u00f6gel, D., and Weissenberger, J. (2010). The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-491"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/1476-4598-9-285","article-title":"Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2","volume":"9","author":"Xu","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_119","first-page":"166","article-title":"Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis","volume":"2","author":"Acharya","year":"2010","journal-title":"Recent Patents Food Nutr. Agric."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/cncr.24699","article-title":"Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes","volume":"116","author":"Das","year":"2010","journal-title":"Cancer"},{"key":"ref_121","first-page":"4025","article-title":"Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin","volume":"29","author":"Hsieh","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s12272-009-1917-3","article-title":"Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells","volume":"32","author":"Qiao","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e12822","DOI":"10.1111\/jfbc.12822","article-title":"Inhibitory effect of black tea (Camellia sinensis) theaflavins and thearubigins against HCT 116 colon cancer cells and HT 460 lung cancer cells","volume":"43","author":"Imran","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bcp.2008.10.035","article-title":"Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4). Protein kinase modulation and reactive oxygen species generation","volume":"77","author":"Aller","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2174\/187152012803833026","article-title":"Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability","volume":"12","author":"Wang","year":"2012","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_126","first-page":"641","article-title":"Role of medicinal plants in oxidative stress and cancer","volume":"2","author":"Ahmed","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.bbagen.2014.05.017","article-title":"Diabetes, oxidative stress and therapeutic strategies","volume":"1840","author":"Rochette","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Salehi, B., Ata, A., Kumar, N.V.A., Sharopov, F., Ram\u00edrez-Alarc\u00f3n, K., Ruiz-Ortega, A., Ayatollahi, S.A., Fokou, P.V.T., Kobarfard, F., and Zakaria, Z.A. (2019). Antidiabetic potential of medicinal plants and their active components. Biomolecules, 9.","DOI":"10.3390\/biom9100551"},{"key":"ref_129","first-page":"706","article-title":"Diabetes Mellitus and its herbal treatment","volume":"3","author":"Amartya","year":"2012","journal-title":"Int. J. Res. Pharm. Biomed. Sci."},{"key":"ref_130","first-page":"727","article-title":"The role of Acacia Arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats","volume":"34","author":"Hegazy","year":"2013","journal-title":"Saudi Med. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2165\/00002512-200118090-00004","article-title":"Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment","volume":"18","author":"Halliwell","year":"2001","journal-title":"Drugs Aging"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1389557515666150401111410","article-title":"Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities","volume":"15","author":"Benard","year":"2015","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S2225-4110(16)30119-5","article-title":"The magic velvet bean of mucuna pruriens","volume":"2","author":"Lampariello","year":"2012","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.3390\/molecules15053517","article-title":"Neuroprotective herbs and foods from different traditional medicines and diets","volume":"15","author":"Iriti","year":"2010","journal-title":"Molecules"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1745-7254.2005.00019.x","article-title":"Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress","volume":"26","author":"Chen","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1055\/s-2001-16488","article-title":"Neurotrophic and neuroprotective actions of ginsenosides Rb1and Rg1","volume":"67","author":"Rudakewich","year":"2001","journal-title":"Planta Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-0-387-46401-5_8","article-title":"Neuroprotective effects of curcumin","volume":"595","author":"Cole","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"594657","DOI":"10.1100\/2012\/594657","article-title":"Noni juice improves serum lipid profiles and other risk markers in cigarette smokers","volume":"2012","author":"Wang","year":"2012","journal-title":"Sci. World J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1139\/cjpp-2016-0062","article-title":"Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate cardiometabolic risk factors","volume":"94","author":"Babish","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3109\/09637486.2015.1093610","article-title":"Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome","volume":"66","author":"Silveira","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1089\/jmf.2014.0171","article-title":"Beneficial Effects of Polyphenol-Rich Chokeberry Juice Consumption on Blood Pressure Level and Lipid Status in Hypertensive Subjects","volume":"18","author":"Kardum","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1089\/jmf.2015.3488","article-title":"Combined Supplementation with Grape Pomace and Omija Fruit Ethanol Extracts Dose-Dependently Improves Body Composition, Plasma Lipid Profiles, Inflammatory Status, and Antioxidant Capacity in Overweight and Obese Subjects","volume":"19","author":"Han","year":"2016","journal-title":"J. Med. Food"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3109\/09637486.2014.898256","article-title":"Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption","volume":"65","author":"Ivanova","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3945\/jn.115.222414","article-title":"Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women","volume":"146","author":"Dostal","year":"2016","journal-title":"J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mnfr.201300751","article-title":"Effects of single dose and regular intake of green tea (Camellia sinensis) on DNA damage, DNA repair, and heme oxygenase-1 expression in a randomized controlled human supplementation study","volume":"58","author":"Ho","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1590\/1516-3180.2015.01702312","article-title":"The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia","volume":"134","author":"Argani","year":"2016","journal-title":"Sao Paulo Med. J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5935\/0101-2800.20140071","article-title":"Effects of grape powder supplementation on inflammatory and antioxidant markers in hemodialysis patients: A randomized double-blind study","volume":"36","author":"Janiques","year":"2014","journal-title":"J. Bras. Nefrol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ptr.5537","article-title":"Cardioprotective Efficacy of Red Wine Extract of Onion in Healthy Hypercholesterolemic Subjects","volume":"30","author":"Chiu","year":"2016","journal-title":"Phyther. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1017\/S0007114515002950","article-title":"Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: A randomised double-blinded placebo-controlled cross-over trial","volume":"114","author":"Burak","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/acs.jafc.6b04701","article-title":"Dietary wolfberry extract modifies oxidative stress by controlling the expression of inflammatory mrnas in overweight and hypercholesterolemic subjects: A randomized, double-blind, placebo-controlled trial","volume":"65","author":"Lee","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3923\/pjbs.2012.742.747","article-title":"Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension","volume":"15","author":"Verma","year":"2012","journal-title":"Pakistan J. Biol. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3109\/19390211.2015.1120842","article-title":"Antioxidant Activity of Heracleum persicum Fruit Extract: Evidence from a Randomized Controlled Trial","volume":"13","author":"Panahi","year":"2016","journal-title":"J. Diet. Suppl."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8361493","DOI":"10.1155\/2017\/8361493","article-title":"A Chilean Berry Concentrate Protects against Postprandial Oxidative Stress and Increases Plasma Antioxidant Activity in Healthy Humans","volume":"2017","author":"Urquiaga","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.nutres.2014.07.002","article-title":"Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females","volume":"34","author":"McAnulty","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1089\/jmf.2014.0103","article-title":"Effects of Pomegranate Extract Supplementation on Cardiovascular Risk Factors and Physical Function in Hemodialysis Patients","volume":"18","author":"Wu","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00394-015-1011-1","article-title":"The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults","volume":"55","author":"Allsopp","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/mutage\/geu022","article-title":"Redox-linked effects of green tea on DNA damage and repair, and influence of microsatellite polymorphism in HMOX-1: Results of a human intervention trial","volume":"30","author":"Choi","year":"2015","journal-title":"Mutagenesis"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/jcim-2014-0021","article-title":"The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes","volume":"12","author":"Shidfar","year":"2015","journal-title":"J. Complement. Integr. Med."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Kaatabi, H., Bamosa, A.O., Badar, A., Al-Elq, A., Abou-Hozaifa, B., Lebda, F., Al-Khadra, A., and Al-Almaie, S. (2015). Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0113486"},{"key":"ref_160","first-page":"85","article-title":"Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects","volume":"26","author":"Mesaik","year":"2013","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jep.2014.04.051","article-title":"Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial","volume":"154","author":"Seo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.arr.2011.11.005","article-title":"Of mice and men: The benefits of caloric restriction, exercise, and mimetics","volume":"11","author":"Mercken","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_164","first-page":"149","article-title":"Natural Products in the Promotion of Healthspan and Longevity","volume":"3","author":"Fuentes","year":"2019","journal-title":"Clin. Pharmacol. Transl. Med."},{"key":"ref_165","first-page":"293916","article-title":"Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men","volume":"1","author":"Esposito","year":"2011","journal-title":"Cardiol. Res. Pract."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1017\/S0007114511002078","article-title":"Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)","volume":"106","author":"Buckland","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MOL.0000000000000044","article-title":"Dietary patterns, Mediterranean diet, and cardiovascular disease","volume":"25","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.18632\/oncotarget.13553","article-title":"Impact of Mediterranean diet on metabolic syndrome, cancer and longevity","volume":"8","author":"Noce","year":"2017","journal-title":"Oncotarget"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ejcn.2014.230","article-title":"Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factors","volume":"69","author":"Pes","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0007114518002593","article-title":"Mediterranean diet and its components in relation to all-cause mortality: Meta-analysis","volume":"120","author":"Eleftheriou","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.3390\/nu7095353","article-title":"Food habits, lifestyle factors and mortality among oldest old Chinese: The Chinese longitudinal healthy longevity survey (CLHLS)","volume":"7","author":"Shi","year":"2015","journal-title":"Nutrients"},{"key":"ref_172","first-page":"96","article-title":"Hunza\u2014A Healthy and a Long Living People","volume":"15","author":"Vlahchev","year":"2002","journal-title":"Asklepii"},{"key":"ref_173","unstructured":"Schmid, A. (2016). The Dom of Hunza (Northern Areas of Pakistan). Disappearing Peoples?, Routledge."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1055\/s-0030-1270524","article-title":"The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans","volume":"43","author":"Zarse","year":"2011","journal-title":"Horm. Metab. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.freeradbiomed.2012.08.594","article-title":"Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans","volume":"53","author":"Shukla","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5214\/ans.0972.7531.200106","article-title":"Withania somnifera root extract extends lifespan of Caenorhabditis elegans","volume":"20","author":"Kumar","year":"2013","journal-title":"Ann. Neurosci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10522-013-9487-7","article-title":"Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies","volume":"15","author":"Lee","year":"2014","journal-title":"Biogerontology"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Zamberlan, D.C., Amaral, G.P., Arantes, L.P., Machado, M.L., Mizdal, C.R., Campos, M.M.A., and Soares, F.A.A. (2016). Rosmarinus officinalis L. increases caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz. J. Med. Biol. Res., 49.","DOI":"10.1590\/1414-431x20165235"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1039\/C8FO01680A","article-title":"Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans","volume":"9","author":"Wang","year":"2018","journal-title":"Food Funct."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/jphp.12979","article-title":"Antiageing properties of Damaurone D in Caenorhabditis elegans","volume":"70","author":"Kim","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"108647","DOI":"10.1016\/j.cbpc.2019.108647","article-title":"Betula utilis extract prolongs life expectancy, protects against amyloid-\u03b2 toxicity and reduces Alpha Synuclien in Caenorhabditis elegans via DAF-16 and SKN-1","volume":"228","author":"Pandey","year":"2020","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1096\/fj.15-282061","article-title":"The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogaster","volume":"30","author":"Piegholdt","year":"2016","journal-title":"FASEB J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.phymed.2017.07.009","article-title":"Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis","volume":"33","author":"Chatzigeorgiou","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/rej.2017.2023","article-title":"Ilex paraguariensis extends lifespan and increases an ability to resist environmental stresses in drosophila","volume":"21","author":"Niraula","year":"2018","journal-title":"Rejuvenation Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exger.2018.09.014","article-title":"Skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson\u2019s disease through activation of mitophagy","volume":"113","author":"Wu","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"6726874","DOI":"10.1155\/2018\/6726874","article-title":"Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington\u2019s Disease","volume":"2018","author":"Arabit","year":"2018","journal-title":"Biomed Res. Int."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41467-019-08555-w","article-title":"The flavonoid 4,4\u2032-dimethoxychalcone promotes autophagy-dependent longevity across species","volume":"10","author":"Zimmermann","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Bedmar, Z., Demyda-Peyr\u00e1s, S., Merinas-Amo, T., and Del R\u00edo-Celestino, M. (2019). Nutraceutic potential of two allium species and their distinctive organosulfur compounds: A multi-assay evaluation. Foods, 8.","DOI":"10.3390\/foods8060222"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.biopha.2007.05.007","article-title":"Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol","volume":"61","author":"Tomobe","year":"2007","journal-title":"Biomed. Pharmacother."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11357-012-9489-4","article-title":"Dietary resveratrol prevents Alzheimer\u2019s markers and increases life span in SAMP8","volume":"35","author":"Porquet","year":"2013","journal-title":"Age (Omaha)"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jep.2017.03.050","article-title":"Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose \/NaNO2","volume":"203","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2018.08.008","article-title":"Protective effects of Withania somnifera extract in SOD1 G93A mouse model of amyotrophic lateral sclerosis","volume":"309","author":"Dutta","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"9134","DOI":"10.1038\/s41598-019-45600-6","article-title":"Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract","volume":"9","author":"Aires","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Pan, M.H., Wu, J.C., Ho, C.T., and Badmaev, V. (2017). Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function. J. Complement. Integr. Med., 14.","DOI":"10.1515\/jcim-2015-0107"},{"key":"ref_195","first-page":"3614960","article-title":"Antidepressant and Antiaging Effects of A\u00e7a\u00ed (Euterpe oleracea Mart.) in Mice","volume":"2019","author":"Arrifano","year":"2019","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/10\/3\/947\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:53:46Z","timestamp":1760172826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/10\/3\/947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":195,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["app10030947"],"URL":"https:\/\/doi.org\/10.3390\/app10030947","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,1]]}}}