{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:46:02Z","timestamp":1776732362220,"version":"3.51.2"},"reference-count":92,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia, Portugal","award":["IF\/00157\/2014"],"award-info":[{"award-number":["IF\/00157\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Mercury (Hg) is globally recognized as a persistent chemical contaminant that accumulates in marine biota, thus constituting an ecological hazard, as well as a health risk to seafood consumers. Climate change-related stressors may influence the bioaccumulation, detoxification, and toxicity of chemical contaminants, such as Hg. Yet, the potential interactions between environmental stressors and contaminants, as well as their impacts on marine organisms and seafood safety, are still unclear. Hence, the aim of this work was to assess the bioaccumulation of Hg and neuro-oxidative responses on the commercial flat fish species Solea senegalensis (muscle, liver, and brain) co-exposed to dietary Hg in its most toxic form (i.e., MeHg), seawater warming (\u0394T\u00b0C = +4 \u00b0C), and acidification (pCO2 = +1000 \u00b5atm, equivalent to \u0394pH = \u22120.4 units). In general, fish liver exhibited the highest Hg concentration, followed by brain and muscle. Warming enhanced Hg bioaccumulation, whereas acidification decreased this element\u2019s levels. Neuro-oxidative responses to stressors were affected by both climate change-related stressors and Hg dietary exposure. Hazard quotient (HQ) estimations evidenced that human exposure to Hg through the consumption of fish species may be aggravated in tomorrow\u2019s ocean, thus raising concerns from the seafood safety perspective.<\/jats:p>","DOI":"10.3390\/app10061993","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T09:27:41Z","timestamp":1584437261000},"page":"1993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mercury in Juvenile Solea senegalensis: Linking Bioaccumulation, Seafood Safety, and Neuro-Oxidative Responses under Climate Change-Related Stressors"],"prefix":"10.3390","volume":"10","author":[{"given":"Carolina","family":"Camacho","sequence":"first","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"},{"name":"Geobiotec-Earth Sciences Department, Faculty of Sciences and Technology, Nova University of Lisbon, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"given":"Ana Lu\u00edsa","family":"Maulvault","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"},{"name":"MARE-Marine Environmental Science Centre, Laborat\u00f3rio Mar\u00edtimo da Guia, Faculdade de Ci\u00eancias da Universidade de Lisboa, Av. Nossa Senhora do Cabo 939, 2750-374 Cascais, Portugal"}]},{"given":"Marta T.","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-598X","authenticated-orcid":false,"given":"Vera","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-4406","authenticated-orcid":false,"given":"Fab\u00edola H. S.","family":"Foga\u00e7a","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Embrapa Agroind\u00fastria de Alimentos, Avenida das Am\u00e9ricas, 29501 Guaratiba, 23020-470 Rio de Janeiro, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-764X","authenticated-orcid":false,"given":"Pedro","family":"Pous\u00e3o-Ferreira","sequence":"additional","affiliation":[{"name":"Aquaculture Research Station (EPPO), Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), 8700-305 Olh\u00e3o, Portugal"}]},{"given":"M. Leonor","family":"Nunes","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-5178","authenticated-orcid":false,"given":"Rui","family":"Rosa","sequence":"additional","affiliation":[{"name":"MARE-Marine Environmental Science Centre, Laborat\u00f3rio Mar\u00edtimo da Guia, Faculdade de Ci\u00eancias da Universidade de Lisboa, Av. Nossa Senhora do Cabo 939, 2750-374 Cascais, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-745X","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Marques","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Seafood Upgrading and Bioprospection, Portuguese Institute of Sea and Atmosphere (IPMA, I.P.), Av. Doutor Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Center of Marine Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos S\/N, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ijheh.2011.09.003","article-title":"Mercury and methylmercury concentrations in Mediterranean seafood and surface sediments, intake evaluation and risk for consumers","volume":"215","author":"Spada","year":"2012","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.envres.2015.09.016","article-title":"Toxic elements and speciation in seafood samples from different contaminated sites in Europe","volume":"143","author":"Maulvault","year":"2015","journal-title":"Environ. 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