{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:40:25Z","timestamp":1776750025232,"version":"3.51.2"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/EMD-EMD\/29394\/2017"],"award-info":[{"award-number":["PTDC\/EMD-EMD\/29394\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04436\/2020"],"award-info":[{"award-number":["UIDB\/04436\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04436\/2020"],"award-info":[{"award-number":["UIDP\/04436\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-029394"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-029394"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>This paper presents the design, fabrication and characterization of temperature microsensors based on Resistance Temperature Detectors (RTDs) with a meander-shaped geometry. Numerical simulations were performed for studying the sensitivity of the RTDs according to their windings numbers as well as for optimizing their layout. These RTDs were fabricated using well-established microfabrication and photolithographic techniques. The fabricated sensors feature high sensitivity (0.3542 mV\/\u00b0C), linearity and reproducibility in a temperature range of 35 to 45 \u00b0C. Additionally, each sensor has a small size with a strong potential for their integration in microfluidic devices, as organ-on-a-chip, allowing the possibility for in-situ monitoring the physiochemical properties of the cellular microenvironment.<\/jats:p>","DOI":"10.3390\/app11093864","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T21:49:20Z","timestamp":1619300960000},"page":"3864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Development of Highly Sensitive Temperature Microsensors for Localized Measurements"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-808X","authenticated-orcid":false,"given":"Paulo J.","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Industrial Electronics, Microelectromechanical Systems Research Unit (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-1251","authenticated-orcid":false,"given":"V\u00e2nia C.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Industrial Electronics, Microelectromechanical Systems Research Unit (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"given":"Vitor H.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Industrial Electronics, Microelectromechanical Systems Research Unit (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-2654","authenticated-orcid":false,"given":"Raquel O.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Industrial Electronics, Microelectromechanical Systems Research Unit (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-9267","authenticated-orcid":false,"given":"Patr\u00edcia C.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Integrated Micro and Nanotechnologies, INL International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-0556","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Minas","sequence":"additional","affiliation":[{"name":"Department of Industrial Electronics, Microelectromechanical Systems Research Unit (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"ref_1","first-page":"198","article-title":"Personalised organs-on-chips: Functional testing for precision medicine","volume":"19","author":"Mummery","year":"2018","journal-title":"Lab Chip"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/17460441.2019.1551873","article-title":"Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling","volume":"14","author":"Haderspeck","year":"2019","journal-title":"Expert Opin. 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