{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:08:41Z","timestamp":1769062121168,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/QUI\/50006\/2020"],"award-info":[{"award-number":["UIDB\/QUI\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04138\/2020, PTDC\/SAU-SER\/30197\/2017LISBOA-01-0145-FEDER-030197"],"award-info":[{"award-number":["UIDP\/04138\/2020, PTDC\/SAU-SER\/30197\/2017LISBOA-01-0145-FEDER-030197"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/01146\/2015"],"award-info":[{"award-number":["IF\/01146\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>One of the new trends of personal care industry is the use of organic ingredients derived from nature, in particular, from food-processing residues with proven efficacy. Lycopene is a carotenoid responsible for the red color of several fruits, namely tomato, whose antioxidant and photoprotective effects have been studied. Methods: Lycopene-enriched extracts (LEE) were obtained from tomato waste using supercritical CO2 extraction, incorporated in microemulsions and macroemulsions for topical use, and characterized through GC-MS for the identification of volatile compounds. The aim of this work was to evaluate the impact of the presence of lycopene-enriched extracts developed emulsions through the identification of volatile compounds and by a sensory analysis to assess the odor and color perception and the acceptability of such semi-solid systems as cosmetic products. Results: Volatile compounds were identified in the extract and in the formulations containing the extract. Preliminary data show that the odor of both LEE-loaded microemulsions and LEE-loaded macroemulsions was classified as undefined. The information about the composition did not modify the odor perception but increased the acceptability of some cosmetic products. LEE conferred a yellowish color to formulations, and the information about the formulation composition increased the likelihood of different cosmetic products with this color being bought. Conclusions: The commercialization of personal care products does not only dependent on the associated organoleptic properties, but is influenced by the information about the composition, namely by the presence of an antioxidant compound.<\/jats:p>","DOI":"10.3390\/app11115120","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T21:42:06Z","timestamp":1622497326000},"page":"5120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluating the Presence of Lycopene-Enriched Extracts from Tomato on Topical Emulsions: Physico-Chemical Characterization and Sensory Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Ana","family":"Costa","sequence":"first","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-475X","authenticated-orcid":false,"given":"Marta","family":"Marques","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"given":"Franca","family":"Congiu","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-999X","authenticated-orcid":false,"given":"Alexandre","family":"Paiva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-8905","authenticated-orcid":false,"given":"Pedro","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"IBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Av. da Rep\u00fablica, Esta\u00e7\u00e3o Agron\u00f3mica, Apartado 12, 2780-901 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-4634","authenticated-orcid":false,"given":"Maria Ros\u00e1rio","family":"Bronze","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"},{"name":"IBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Av. da Rep\u00fablica, Esta\u00e7\u00e3o Agron\u00f3mica, Apartado 12, 2780-901 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-5622","authenticated-orcid":false,"given":"Joana","family":"Marto","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-7991","authenticated-orcid":false,"given":"Helena Margarida","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Sandra","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. 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J. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tifs.2019.11.015","article-title":"Feeding the skin: A new trend in food and cosmetics convergence","volume":"95","author":"Ascenso","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1900424","DOI":"10.1002\/cbdv.201900424","article-title":"Extraction of Natural Fragrance Ingredients: History Overview and Future Trends","volume":"16","author":"Burger","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Matei, F., and Zirra, D. (2019). Introduction to Biotech Entrepreneurship: From Idea to Business: A European Perspective, Springer International Publishing.","DOI":"10.1007\/978-3-030-22141-6"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109323","DOI":"10.1016\/j.lwt.2020.109323","article-title":"Lycopene in human health","volume":"127","author":"Caseiro","year":"2020","journal-title":"LWT"},{"key":"ref_8","unstructured":"(2020, October 13). YESto Website. Available online: https:\/\/yesto.com\/."},{"key":"ref_9","unstructured":"(2020, October 13). Ella Bach\u00e9 Website. Available online: www.ellabache.com."},{"key":"ref_10","unstructured":"(2020, October 13). Nature Republic Website. Available online: www.naturerepublic.com."},{"key":"ref_11","unstructured":"(2020, October 13). Haeckels Website. Available online: www.haeckels.co.uk."},{"key":"ref_12","unstructured":"(2020, October 13). Skinfood Website. Available online: www.theskinfood.us."},{"key":"ref_13","unstructured":"(2020, October 13). Garancia Website. Available online: www.garancia-beauty.com."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ics.12087","article-title":"Wrinkle reduction in post-menopausal women consuming a novel oral supplement: A double-blind placebo-controlled randomized study","volume":"36","author":"Jenkins","year":"2014","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/ics.12316","article-title":"Plant-based active photoprotectants for sunscreens","volume":"38","author":"Cefali","year":"2016","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1468-2494.2011.00668.x","article-title":"A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal-induced damages","volume":"33","author":"Tito","year":"2011","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1590\/S1516-89132013000200005","article-title":"Influence of the presence and type of fragrance on the sensory perception of cosmetic formulations","volume":"56","author":"Srebernich","year":"2013","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0950-3293(02)00014-9","article-title":"Sensory evaluation in quality control: An overview, new developments and future opportunities","volume":"13","year":"2002","journal-title":"Food Qual. Prefer."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1521-3803(199812)42:06<395::AID-FOOD395>3.3.CO;2-Z","article-title":"Characterization of aroma volatiles in tomatoes by sensory analyses","volume":"42","author":"Krumbein","year":"1998","journal-title":"Nahrung"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/1750-3841.13980","article-title":"Sensory and Flavor Characteristics of Tomato Juice from Garden Gem and Roma Tomatoes with Comparison to Commercial Tomato Juice","volume":"83","author":"Zhu","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0308-8146(94)90164-3","article-title":"Effect of storage and ripening on fresh tomato quality, Part I","volume":"49","author":"Stern","year":"1994","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Carri\u00e7o, C., Pinto, P., Gra\u00e7a, A., Gon\u00e7alves, L.M., Ribeiro, H.M., and Marto, J. (2019). Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11030131"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.supflu.2006.05.009","article-title":"Supercritical carbon dioxide extraction of carotenoids, tocopherols and sitosterols from industrial tomato by-products","volume":"40","author":"Daood","year":"2007","journal-title":"J. Supercrit Fluid"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/lipi.19790810705","article-title":"Tomato Seed Oil I Fatty Acid Composition, Stability and Hydrogenation of the Oil","volume":"81","author":"Morad","year":"1979","journal-title":"Fette Seifen Anstrichm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.indcrop.2004.11.001","article-title":"Physical, chemical and fuel related properties of tomato seed oil for evaluating its direct use in diesel engines","volume":"22","author":"Giannelos","year":"2005","journal-title":"Ind. Crops Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1021\/jf011001t","article-title":"Supercritical Fluid Extraction of Lycopene from Tomato Processing Byproducts","volume":"50","author":"Rozzi","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1021\/jf000311t","article-title":"Supercritical CO2 Extraction of \u03b2-Carotene and Lycopene from Tomato Paste Waste","volume":"48","author":"Baysal","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/pharmaceutics6010052","article-title":"Overcoming the cutaneous barrier with microemulsions","volume":"6","author":"Lopes","year":"2014","journal-title":"Pharmaceutics"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pereira, J., Gon\u00e7alves, R., Barreto, M., Dias, C., Carvalho, F., Almeida, A.J., Ribeiro, H.M., and Marto, J. (2020). Development of Gel-in-Oil Emulsions for Khellin Topical Delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050398"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/adj.12247","article-title":"Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: An in vitro study","volume":"60","author":"Randall","year":"2015","journal-title":"Aust. Dent. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/idj.12071","article-title":"Important considerations in the development of toothpaste formulations for children","volume":"63","author":"Stovell","year":"2013","journal-title":"Int. Dent. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1021\/acs.jafc.7b01108","article-title":"Characterization of Aroma-Active Compounds in Italian Tomatoes with Emphasis on New Odorants","volume":"65","author":"Kreissl","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s11694-018-9863-8","article-title":"Characterization of the key aroma compounds in tomato pastes as affected by hot and cold break process","volume":"12","author":"Kelebek","year":"2018","journal-title":"J. Food Meas. Charact."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/ffj.1811","article-title":"Aroma volatiles of tomatoes and tomato products evaluated by solid-phase microextraction","volume":"22","year":"2007","journal-title":"Flavour Fragr. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.foodchem.2014.05.147","article-title":"Characterization of the most aroma-active compounds in cherry tomato by application of the aroma extract dilution analysis","volume":"165","author":"Selli","year":"2014","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Li, J., Di, T., and Bai, J. (2019). Distribution of Volatile Compounds in Different Fruit Structures in Four Tomato Cultivars. Molecules, 24.","DOI":"10.3390\/molecules24142594"},{"key":"ref_37","unstructured":"(2020, October 09). The Good Scent Company Information System. Available online: http:\/\/www.thegoodscentscompany.com\/index.html."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2621.1970.tb04799.x","article-title":"Flavor chemistry of tomato volaties","volume":"35","author":"Kazeniac","year":"1970","journal-title":"J. Food Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0308-8146(77)90042-5","article-title":"Tomato volatile components: Effect of processing","volume":"2","author":"Sieso","year":"1977","journal-title":"Food Chem."},{"key":"ref_40","unstructured":"Crouzet, J., and Kanasawud, P. (1992). Methods in Enzymology, Academic Press."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.foodchem.2007.07.045","article-title":"Description of volatile compounds generated by the degradation of carotenoids in paprika, tomato and marigold oleoresins","volume":"106","author":"Rios","year":"2008","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chovatiya, R., and Silverberg, J.I. (2019). Pathophysiology of Atopic Dermatitis and Psoriasis: Implications for Management in Children. Children, 6.","DOI":"10.3390\/children6100108"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Clarke, S. (2008). Essential Chemistry for Aromatherapy, Churchill Livingstone. [2nd ed.].","DOI":"10.1016\/B978-0-443-10403-9.00002-9"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tifs.2005.04.004","article-title":"Not just colors-Carotenoid degradation as a link between pigmentation and aroma in tomato and watermelon fruit","volume":"16","author":"Lewinsohn","year":"2005","journal-title":"Trends Food Sci. Technol."}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/11\/5120\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:09:29Z","timestamp":1760162969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/11\/5120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":44,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["app11115120"],"URL":"https:\/\/doi.org\/10.3390\/app11115120","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]}}}