{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:55:56Z","timestamp":1761519356582,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/143226\/2019"],"award-info":[{"award-number":["SFRH\/BD\/143226\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Background: we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of exercise training on cardiac function and circulating biomarkers outcomes among women with breast cancer (BC) receiving anthracycline or trastuzumab-containing therapy. Methods: PubMed, EMBASE, Cochrane Library, Web of Science and Scopus were searched. The primary outcome was change on left ventricular ejection fraction (LVEF). Secondary outcomes included diastolic function, strain imaging and circulating biomarkers. Results: Four RCTs were included, of those three were conducted during anthracycline and one during trastuzumab, involving 161 patients. All trials provided absolute change in LVEF (%) after a short to medium-term of treatment exposure (\u22646 months). Pooled data revealed no differences in LVEF in the exercise group versus control [mean difference (MD): 2.07%; 95% CI: \u22120.17 to 4.34]. Similar results were observed by pooling data from the three RCTs conducted during anthracycline. Data from trials that implemented interventions with \u226536 exercise sessions (n = 3) showed a significant effect in preventing LVEF decline favoring the exercise (MD: 3.25%; 95% CI: 1.20 to 5.31). No significant changes were observed on secondary outcomes. Conclusions: exercise appears to have a beneficial effect in mitigating LVEF decline and this effect was significant for interventions with \u226536 exercise sessions.<\/jats:p>","DOI":"10.3390\/app11188336","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T10:12:03Z","timestamp":1631095923000},"page":"8336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Pedro","family":"Antunes","sequence":"first","affiliation":[{"name":"Research Center in Sport Sciences, Health and Human Development, CIDESD, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-2577","authenticated-orcid":false,"given":"Dulce","family":"Esteves","sequence":"additional","affiliation":[{"name":"Research Center in Sport Sciences, Health and Human Development, CIDESD, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4851","authenticated-orcid":false,"given":"C\u00e9lia","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Center of Mathematics and Applications, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}]},{"given":"Anabela","family":"Amarelo","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Medical Oncology, Centro Hospitalar Vila Nova de Gaia\/Espinho, 4400-129 Vila Nova de Gaia, Portugal"}]},{"given":"Jos\u00e9","family":"Fonseca-Moutinho","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-8084","authenticated-orcid":false,"given":"Vera","family":"Afreixo","sequence":"additional","affiliation":[{"name":"CIDMA\u2014Center for Research and Development in Mathematics and Applications, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Henrique","family":"Costa","sequence":"additional","affiliation":[{"name":"Psychiatry and Mental Health Department, Centro Hospitalar de Set\u00fabal, 2190-446 Set\u00fabal, Portugal"}]},{"given":"Alberto","family":"Alves","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia\u2014ISMAI, 4475-690 Maia, Portugal"}]},{"given":"Ana","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Medical Oncology, Centro Hospitalar Vila Nova de Gaia\/Espinho, 4400-129 Vila Nova de Gaia, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. 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Dis."}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/18\/8336\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:58Z","timestamp":1760165938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/18\/8336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":56,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["app11188336"],"URL":"https:\/\/doi.org\/10.3390\/app11188336","relation":{},"ISSN":["2076-3417"],"issn-type":[{"type":"electronic","value":"2076-3417"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}