{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:28:57Z","timestamp":1775600937891,"version":"3.50.1"},"reference-count":77,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>The scientific community is paying increasing attention to plant waste valorization, and also to \u201cgreener\u201d practices in the agriculture, food and cosmetic sectors. In this context, unused forest biomass (e.g., leaves, seed cones, branches\/twigs, bark and sapwood) of Cryptomeria japonica, a commercially important tree throughout Asia and the Azores Archipelago (Portugal), is currently waste\/by-products of wood processing that can be converted into eco-friendly and high added-value products, such as essential oils (EOs), with social, environmental and economic impacts. Plant-derived EOs are complex mixtures of metabolites, mostly terpenes and terpenoids, with valuable bioactivities (e.g., antioxidant, anti-inflammatory, anticancer, neuroprotective, antidepressant, antimicrobial, antiviral and pesticide), which can find applications in several industries, such as pharmaceutical, medical, aromatherapy, food, cosmetic, perfumery, household and agrochemical (e.g., biopesticides), with manifold approaches. The EOs components are also of value for taxonomic investigations. It is known that the variation in EOs chemical composition and, consequently, in their biological activities and commercial use, is due to different exogenous and endogenous factors that can lead to ecotypes or chemotypes in the same plant species. The present paper aims to provide an overview of the chemical composition, biological properties and proposals of valorization of C. japonica EO from several countries, and also to indicate gaps in the current knowledge.<\/jats:p>","DOI":"10.3390\/app112311097","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T02:46:08Z","timestamp":1637721968000},"page":"11097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Variations in Essential Oil Chemical Composition and Biological Activities of Cryptomeria japonica (Thunb. ex L.f.) D. Don from Different Geographical Origins\u2014A Critical Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-0828","authenticated-orcid":false,"given":"Ana","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Physics, Chemistry and Engineering, Faculty of Science and Technology, University of Azores, 9500-321 Ponta Delgada, S\u00e3o Miguel, Azores, Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-6237","authenticated-orcid":false,"given":"Filipe","family":"Arruda","sequence":"additional","affiliation":[{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"},{"name":"Department of Biology, Faculty of Science and Technology, University of Azores, 9500-321 Ponta Delgada, S\u00e3o Miguel, Azores, Portugal"}]},{"given":"Jorge","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Engineering, Faculty of Science and Technology, University of Azores, 9500-321 Ponta Delgada, S\u00e3o Miguel, Azores, Portugal"},{"name":"Biotechnology Centre of Azores (CBA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"}]},{"given":"Jos\u00e9","family":"Baptista","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Engineering, Faculty of Science and Technology, University of Azores, 9500-321 Ponta Delgada, S\u00e3o Miguel, Azores, Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"}]},{"given":"Jo\u00e3o","family":"Madruga","sequence":"additional","affiliation":[{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"},{"name":"Department of Agricultural Sciences, University of the Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-8729","authenticated-orcid":false,"given":"Elisabete","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Engineering, Faculty of Science and Technology, University of Azores, 9500-321 Ponta Delgada, S\u00e3o Miguel, Azores, Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of Azores, 9700-042 Angra do Hero\u00edsmo, Terceira, Azores, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","first-page":"133","article-title":"Essential oils and their application in food safety","volume":"5","author":"Akash","year":"2021","journal-title":"Front. Sustain. Food Syst."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological effects of essential oils\u2014A review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_3","first-page":"179","article-title":"Bioinsecticides based on plant essential oils: A short overview","volume":"75","author":"Isman","year":"2020","journal-title":"Z. Nat. C"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sharmeen, J.B., Mahomoodally, F.M., Zengin, G., and Maggi, F. (2021). Essential oils as natural sources of fragrance compounds for cosmetics and cosmeceuticals. Molecules, 26.","DOI":"10.3390\/molecules26030666"},{"key":"ref_5","first-page":"56","article-title":"Taxodiaceae","volume":"Volume 4","author":"Raven","year":"1999","journal-title":"Flora of China"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/treephys\/24.11.1203","article-title":"Growth and transpiration of Japanese cedar (Cryptomeria japonica) and Hinoki cypress (Chamaecyparis obtusa) seedlings in response to soil water content","volume":"24","author":"Nagakura","year":"2004","journal-title":"Tree Physiol."},{"key":"ref_7","unstructured":"Preedy, V.R. (2016). Cedar (Cryptomeria japonica) Oils. Essential Oils in Food Preservation, Flavor and Safety, Academic Press. [1st ed.]."},{"key":"ref_8","first-page":"199","article-title":"Esp\u00e9cies Florestais das Ilhas\u2014A\u00e7ores","volume":"Volume 6","author":"Silva","year":"2007","journal-title":"\u00c1rvores e Florestas de Portugal"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41598-020-80688-1","article-title":"Identification and genetic diversity analysis of a male-sterile gene (MS1) in Japanese cedar (Cryptomeria japonica D. Don)","volume":"11","author":"Hasegawa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1021\/jf0484529","article-title":"Chemical composition and antifungal activity of essential oils from different tissues of Japanese Cedar (Cryptomeria japonica)","volume":"53","author":"Cheng","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","first-page":"7","article-title":"Chemical composition of Cryptomeria japonica leaf oil from Nepal","volume":"3","author":"Satyal","year":"2015","journal-title":"Am. J. Essent. Oil Nat. Prod."},{"key":"ref_12","first-page":"63","article-title":"Compositions and antioxidant activities of essential oils of different tissues from Cryptomeria japonica D. Don","volume":"32","author":"Ho","year":"2010","journal-title":"Q. J. Chin. For."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10086-018-1773-1","article-title":"Profiling of volatile compounds from five interior decoration timbers in Taiwan using TD\/GC\u2013MS\/FID","volume":"64","author":"Chung","year":"2018","journal-title":"J. Wood Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fbioe.2020.00563","article-title":"Natural macromolecules as carriers for essential oils: From extraction to biomedical application","volume":"8","author":"Stevanovic","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.foreco.2008.08.008","article-title":"Eucalyptus essential oil as a natural pesticide","volume":"256","author":"Batish","year":"2008","journal-title":"For. Ecol. Manag."},{"key":"ref_16","first-page":"e00239","article-title":"Phytochemical activity and role of botanical pesticides in pest management for sustainable agricultural crop production","volume":"7","author":"Lengai","year":"2020","journal-title":"Sci. Afr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/1756-3305-7-426","article-title":"Larvicidal efficacy of Cryptomeria japonica leaf essential oils against Anopheles gambiae","volume":"7","author":"Mdoe","year":"2014","journal-title":"Parasites Vectors"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/10412905.2015.1045993","article-title":"Evaporation of volatiles from essential oils of Japanese conifers enhances antifungal activity","volume":"27","author":"Kusumoto","year":"2015","journal-title":"J. Essent. Oil Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Palermo, D., Giunti, G., Laudani, F., Palmeri, V., and Campolo, O. (2021). Essential oil-based nano-biopesticides: Formulation and bioactivity against the confused flour beetle Tribolium confusum. Sustainability, 13.","DOI":"10.3390\/su13179746"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.indcrop.2017.08.016","article-title":"Deterpenation of Origanum majorana L. essential oil by reduced pressure steam distillation","volume":"109","author":"Salha","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.biortech.2007.11.060","article-title":"Variations in insecticidal activity and chemical compositions of leaf essential oils from Cryptomeria japonica at different ages","volume":"100","author":"Cheng","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s10086-011-1209-7","article-title":"Inhibition activity of essential oils obtained from Japanese trees against Skeletonema costatum","volume":"57","author":"Tsuruta","year":"2011","journal-title":"J. Wood Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.foodres.2018.06.036","article-title":"Extraction of biactive compounds and essential oils from mediterranean herbs by conventional and green innovative techniques: A review","volume":"113","author":"Giacometti","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_24","first-page":"461","article-title":"Supercritical CO2 extraction of essential oils from Chamaecyparis obtusa","volume":"5","author":"Jin","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s41207-019-0122-0","article-title":"Process-intensified waste valorization and environmentally friendly D-limonene extraction","volume":"4","author":"Lopresto","year":"2019","journal-title":"Euro-Mediterr. J. Environ. Integr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/cbdv.201500186","article-title":"Chemical Profile and Antioxidant properties of extracts and essential oils from Citrus \u00d7 limon (L.) Burm. cv. Femminello Comune","volume":"13","author":"Loizzo","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.indcrop.2011.04.016","article-title":"Comparative analysis of essential oil components of two Cryptomeria species from China","volume":"34","author":"Xie","year":"2011","journal-title":"Ind. Crop. Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.atmosenv.2015.09.046","article-title":"Monitoring the dynamic emission of biogenic volatile organic compounds from Cryptomeria japonica by enclosure measurement","volume":"122","author":"Lin","year":"2015","journal-title":"Atmos. Environ. X"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/ja02260a021","article-title":"The essential oil of sugi (Cryptomeria japonica) leaves","volume":"38","author":"Uchida","year":"1916","journal-title":"J. Am. Chem. Soc."},{"key":"ref_30","first-page":"164","article-title":"Chemical and antimicrobial properties of essential oils from three coniferous trees Abies koreana, Cryptomeria japonica, and Torreya nucifera","volume":"50","author":"Oh","year":"2007","journal-title":"Appl. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10086-014-1445-8","article-title":"Acaricidal activity of components of Cryptomeria japonica against spider mites","volume":"61","author":"Yamashita","year":"2015","journal-title":"J. Wood Sci."},{"key":"ref_32","first-page":"1785","article-title":"Essential oil characterization of two Azorean Cryptomeria japonica populations and their biological evaluations","volume":"8","author":"Moiteiro","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1080\/14786419.2017.1285299","article-title":"Chemical compositions of essential oils of five introduced conifers in Corsica","volume":"31","author":"Garcia","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s10086-006-0806-3","article-title":"Essential oil from the leaves of Cryptomeria japonica acts as a silverfish (Lepisma saccharina) repellent and insecticide","volume":"52","author":"Wang","year":"2006","journal-title":"J. Wood Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11127","DOI":"10.1021\/jf9024486","article-title":"Repellency of essential oils of Cryptomeria japonica (Pinaceae) against adults of the mosquitoes Aedes aegypti and Aedes albopictus (Diptera:Culicidae)","volume":"57","author":"Gu","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/cbdv.201100243","article-title":"Chemical composition and antitermitic activity against Coptotermes formosanus Shiraki of Cryptomeria japonica leaf essential oil","volume":"9","author":"Cheng","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ptr.1864","article-title":"Chemical composition and antimicrobial activity of the essential oil of Cryptomeria japonica","volume":"21","author":"Cha","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_38","first-page":"61","article-title":"Cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and LPS-induced nitric oxide and pro-inflammatory cytokine production","volume":"58","author":"Yoon","year":"2009","journal-title":"Pol. J. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/ics.12069","article-title":"Whitening and antioxidant activities of bornyl acetate and nezukol fractionated from Cryptomeria japonica essential oil","volume":"35","author":"Kim","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_40","first-page":"719","article-title":"Chemical composition and termiticidal activity of essential oils from different tissues of Chinese cedar (Cryptomeria fortunei)","volume":"9","author":"Xie","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/02773813.2015.1057648","article-title":"Multiple uses of essential oil and by-products from various parts of the Yakushima native cedar (Cryptomeria japonica)","volume":"36","author":"Nakagawa","year":"2016","journal-title":"J. Wood Chem. Technol."},{"key":"ref_42","first-page":"285","article-title":"The diterpene hydrocarbons in the leaves of Cryptomeria japonica","volume":"58","author":"Yasue","year":"1976","journal-title":"J. Jpn. For. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1466401","DOI":"10.1080\/23311843.2018.1466401","article-title":"Growth-inhibitory components in Sugi (Cryptomeria japonica) extracts active against Microcystis aeruginosa","volume":"4","author":"Suzuki","year":"2018","journal-title":"Cogent Environ. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s00344-015-9546-1","article-title":"A century of gibberellin research","volume":"34","author":"Hedden","year":"2015","journal-title":"J. Plant Growth Regul."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1016\/j.biortech.2007.07.038","article-title":"Larvicidal activity of tectoquinone isolated from red heartwood-type Cryptomeria japonica against two mosquito species","volume":"99","author":"Cheng","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.indcrop.2011.10.023","article-title":"Chemical variation in essential oil of Cryptomeria fortunei from various areas of China","volume":"36","author":"Xie","year":"2012","journal-title":"Ind. Crop. Prod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.chemosphere.2004.10.048","article-title":"Seasonal variations of monoterpene emissions from coniferous trees of different ages in Korea","volume":"59","author":"Kim","year":"2005","journal-title":"Chemosphere"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Bang, K.W., Lewis, G., and Villas-Boas, S.G. (2020). Leptospermum scoparium (M\u0101nuka) and Cryptomeria japonica (Sugi) leaf essential oil seasonal chemical variation and their effect on antimicrobial activity. Preprints, 2020080623.","DOI":"10.20944\/preprints202008.0623.v1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.foodcont.2010.02.003","article-title":"Antimicrobial herb and spice compounds in food","volume":"21","author":"Tajkarimi","year":"2010","journal-title":"Food Control"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4014\/jmb.0803.191","article-title":"Comparison of chemical compositions and antimicrobial activities of essential oils from three conifer trees; Pinus densiflora, Cryptomeria japonica, and Chamaecyparis obtusa","volume":"19","author":"Lee","year":"2009","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s10086-005-0793-9","article-title":"Antimicrobial activity of heartwood components of sugi (Cryptomeria japonica) against several fungi and bacteria","volume":"52","author":"Matsushita","year":"2006","journal-title":"J. Wood Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yap, P.S.X., Yusoff, K., Lim, S.-H.E., Chong, C.-M., and Lai, K.-S. (2021). Membrane disruption properties of essential oils\u2014A double-edged sword?. Processes, 9.","DOI":"10.3390\/pr9040595"},{"key":"ref_53","first-page":"1163","article-title":"Antifungal properties of Japanese cedar essential oil from waste wood chips made from used sake barrels","volume":"5","author":"Takao","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s10086-019-1787-3","article-title":"Isolation of diterpenoids from sugi wood-drying byproducts and their bioactivities","volume":"65","author":"Tsujimura","year":"2019","journal-title":"J. Wood Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.watres.2007.07.008","article-title":"Antibacterial activities of plant essential oils against Legionella pneumophila","volume":"42","author":"Chang","year":"2008","journal-title":"Water Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00226-014-0644-1","article-title":"Bioactivity and characterization of exudates from Cryptomeria japonica bark","volume":"48","author":"Cheng","year":"2014","journal-title":"Wood Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0031-9422(95)00269-D","article-title":"Flavonoids and lignans from leaves of Cryptomeria japonica","volume":"40","author":"Su","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0960-8524(03)00008-7","article-title":"Bioactivity of selected plant essential oils against the yellow fever mosquito Aedes aegypti larvae","volume":"89","author":"Cheng","year":"2003","journal-title":"Bioresour. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00436-009-1550-6","article-title":"Mosquito larvicidal activities of extractives from black heartwood-type Cryptomeria japonica","volume":"105","author":"Gu","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.biortech.2006.01.006","article-title":"Anti-termitic activities of essential oils from coniferous trees against Coptotermes formosanus","volume":"98","author":"Cheng","year":"2007","journal-title":"Bioresour. Technol."},{"key":"ref_61","unstructured":"Arruda, F. (2019). Bio-Valoriza\u00e7\u00e3o de Res\u00edduos de Cryptomeria japonica por Obten\u00e7\u00e3o do \u00d3leo Essencial e de Extratos Org\u00e2nicos e Determina\u00e7\u00e3o das suas Propriedades Biol\u00f3gicas. [Master\u2019s Thesis, Universidade dos A\u00e7ores]."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.vetpar.2009.04.003","article-title":"Evidence of Fasciola hepatica infection in Radix peregra and a mollusc of the family Succineidae in Ireland","volume":"163","author":"Relf","year":"2009","journal-title":"Vet. Parasitol."},{"key":"ref_63","unstructured":"Rodrigues, A. (2019). Composi\u00e7\u00e3o Qu\u00edmica e Atividades Biol\u00f3gicas dos Metabolitos Secund\u00e1rios de Cryptomeria japonica (L.f.) D.Don Sobre a Lagarta da Pastagem Pseudaletia unipuncta Haworth (Lepidoptera: Noctuidae). [Master\u2019s Thesis, Universidade dos A\u00e7ores]."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/13416979.2020.1747150","article-title":"Growth-inhibitory activity of components in Cryptomeria japonica leaves against Robinia pseudoacacia","volume":"25","author":"Tanaka","year":"2020","journal-title":"J. For. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1126\/science.291.5511.2141","article-title":"Defensive function of herbivore-induced plant volatile emissions in nature","volume":"291","author":"Kessler","year":"2001","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10086-008-0984-2","article-title":"Neuropharmacological activities of phytoncide released from Cryptomeria japonica","volume":"55","author":"Cheng","year":"2009","journal-title":"J. Wood Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2220\/biomedres.39.241","article-title":"Inhalation of Japanese cedar (Cryptomeria japonica) wood odor causes psychological relaxation after monotonous work among female participants","volume":"39","author":"Matsubara","year":"2018","journal-title":"Biomed. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10086-008-1001-5","article-title":"Evaluation of dried-wood odors: Comparison between analytical and sensory data on odors from dried sugi (Cryptomeria japonica) wood","volume":"55","author":"Ohira","year":"2009","journal-title":"J. Wood Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12199-018-0700-9","article-title":"Gender differences in the psychophysiological effects induced by VOCs emitted from Japanese cedar (Cryptomeria japonica)","volume":"23","author":"Matsubara","year":"2018","journal-title":"Environ. Health Prev. Med."},{"key":"ref_70","first-page":"81","article-title":"Antitussive effects of several volatile oils, especially of cedar leaf oil in guinea pig","volume":"39","author":"Misawa","year":"1990","journal-title":"Pharmacometrics"},{"key":"ref_71","first-page":"250","article-title":"The effect of steam inhalation of volatile oils on the output and composition of respiratory tract fluid","volume":"163","author":"Boyd","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10086-006-0824-1","article-title":"Screening of extracts of Japanese woods for melanin biosynthesis inhibition","volume":"53","author":"Shimizu","year":"2007","journal-title":"J. Wood Sci."},{"key":"ref_73","first-page":"1337","article-title":"Biological activities of extracts from different parts of Cryptomeria japonica","volume":"11","author":"Horiba","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"ref_74","first-page":"803","article-title":"Anti-cholinesterase activity of crude drugs selected from the ingredients of incense sticks and heartwood of Chamaecyparis obtusa","volume":"13","author":"Murata","year":"2018","journal-title":"Nat. Prod. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.3390\/molecules20047329","article-title":"Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: A systematic review","volume":"20","author":"Freires","year":"2015","journal-title":"Molecules"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.3390\/molecules17043890","article-title":"Essential oil from Cryptomeria japonica induces apoptosis in human oral epidermoid carcinoma cells via mitochondrial stress and activation of caspases","volume":"17","author":"Cha","year":"2012","journal-title":"Molecules"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1248\/bpb.23.595","article-title":"Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica","volume":"23","author":"Matsunaga","year":"2000","journal-title":"Biol. Pharm. Bull."}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/23\/11097\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:34:37Z","timestamp":1760168077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/11\/23\/11097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":77,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["app112311097"],"URL":"https:\/\/doi.org\/10.3390\/app112311097","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}