{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:20:18Z","timestamp":1768828818601,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020, UIDP\/50011\/2020 & LA\/P\/0006\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020, UIDP\/50011\/2020 & LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["REF-168-89-ARH\/2018"],"award-info":[{"award-number":["REF-168-89-ARH\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["UIDB\/50008\/2020-UIDP\/50008\/2020"],"award-info":[{"award-number":["UIDB\/50008\/2020-UIDP\/50008\/2020"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Diamond-based electrodes and biosensors are interesting in analytics because of their particular set of properties, namely: large potential window, chemical inertness, low baseline current, stability, and transparency. Diamond-based electrodes and biosensors were shown to detect biological molecules such as neurotransmitters and proteins, respectively. In this review, we summarise the different types of diamond electrodes and biosensors based on their type of detection (electrochemical or optical), functionalisation, and target analyte. The last section presents a discussion on the different analytical responses obtained with electrodes or biosensors, according to the type of analyte. Electrodes work quite well for detecting small molecules with redox properties, whereas biosensors are more suited for detecting molecules with a high molecular weight, such as DNA and proteins.<\/jats:p>","DOI":"10.3390\/app12063000","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:34:13Z","timestamp":1647401653000},"page":"3000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diamonds for Life: Developments in Sensors for Biomolecules"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-6172","authenticated-orcid":false,"given":"N\u00e1dia E.","family":"Santos","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Departamento de Eletr\u00f3nica, Telecomunica\u00e7\u00f5es e Inform\u00e1tica, Instituto de Telecomunica\u00e7\u00f5es, Universidade de Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-9736","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Figueira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Miguel","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-5645","authenticated-orcid":false,"given":"Filipe A. Almeida","family":"Paz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-970X","authenticated-orcid":false,"given":"Susana Santos","family":"Braga","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9271-207X","authenticated-orcid":false,"given":"Joana C.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Departamento de Eletr\u00f3nica, Telecomunica\u00e7\u00f5es e Inform\u00e1tica, Instituto de Telecomunica\u00e7\u00f5es, Universidade de Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1088\/0022-3727\/40\/20\/S21","article-title":"Diamond for bio-sensor applications","volume":"40","author":"Nebel","year":"2007","journal-title":"J. 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