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Quantitative motion analysis is useful for assessing motor function, including gait, in diseases affecting movement. A single markerless RGB-D camera enables 3D full-body motion capture in a less expensive and intrusive, and more portable way than multi-camera marker-based systems. In this study, we examine whether a gait analysis system based on an RGB-D camera can be used to detect significant changes in the gait of ATTRv amyloidosis patients over time, when compared with a 12-camera system. We acquired 3D data provided by both systems from six ATTRv amyloidosis patients, while performing a simple gait task, once (T0) and 18 months later (T1). A direct comparison of systems has already been conducted. In this work, however, for each patient, we investigated if the RGB-D camera system detects statistically significant differences between the two different acquisitions in a similar way to the reference system, and whether it is reliable to use during patients\u2019 follow-up. The obtained results show that the differences detected between T0 and T1 for both systems follow the same tendency for 65% of the spatiotemporal gait parameters, and for 38% of the kinematic parameters (38%). The most reliable parameters were: stride duration\/length, gait speed (and its variability), and arm\/foot swing velocity, all with an almost perfect strength of agreement.<\/jats:p>","DOI":"10.3390\/app122010203","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T22:18:13Z","timestamp":1665526693000},"page":"10203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Portable RGB-D Camera-Based System for Assessing Gait Impairment Progression in ATTRv Amyloidosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-789X","authenticated-orcid":false,"given":"Maria do Carmo","family":"Vilas-Boas","sequence":"first","affiliation":[{"name":"Faculty of Engineering (FEUP), Institute for Systems Engineering and Computers\u2014Technology and Science (INESC TEC), University of Porto, 4200-391 Porto, Portugal"},{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar do Porto, 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-7982","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Electronics, Telecommunications and Informatics, Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-3003","authenticated-orcid":false,"given":"Hugo Miguel Pereira","family":"Choupina","sequence":"additional","affiliation":[{"name":"Faculty of Engineering (FEUP), Institute for Systems Engineering and Computers\u2014Technology and Science (INESC TEC), University of Porto, 4200-391 Porto, Portugal"}]},{"given":"M\u00e1rcio Neves","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar do Porto, 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-9354","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Electronics, Telecommunications and Informatics, Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Teresa","family":"Coelho","sequence":"additional","affiliation":[{"name":"Unidade Corino de Andrade, Hospital Santo Ant\u00f3nio, Centro Hospitalar do Porto, 4099-001 Porto, Portugal"}]},{"given":"Jo\u00e3o Paulo Silva","family":"Cunha","sequence":"additional","affiliation":[{"name":"Faculty of Engineering (FEUP), Institute for Systems Engineering and Computers\u2014Technology and Science (INESC TEC), University of Porto, 4200-391 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/WCO.0000000000000288","article-title":"Sixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe: Where are we now? 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