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Since the discovery of the first UV filter, nearly 30 filters have become commercially available. Over the years, innovation and regulatory updates have driven their use by the cosmetic industry. This work aimed to characterize commercial sunscreens and unveil the main trends by analyzing the labels of 444 sunscreen formulations that are currently being marketed. Avobenzone, octocrylene, and bis-ethylhexyloxyphenol methoxyphenyl triazine were the three UV filters with the highest usage frequencies (&gt;40%). Emulsified preparations and sprays were the preferred forms, while the most frequent SPF was 50+. Differences were noted between adult and children\u2019s sunscreens, namely the higher usage of inorganic filters for the latter. Over the past few years, the five most used UV filters remained the same, but octocrylene, ethylhexyl salicylate, and nano methylene bis-benzotriazolyl tetramethylbutylphenol had decreased usage. An increasing tendency towards the use of the inorganic UV filter titanium oxide was also observed. Overall, this study characterized the true market impact of approved UV filters and how the market has evolved over recent years. This insight can help pave the way for the design of new UV filters and is helpful for the assessment of environmental risks.<\/jats:p>","DOI":"10.3390\/app122312003","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T04:34:52Z","timestamp":1669264492000},"page":"12003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Recent Trends on UV filters"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-9750","authenticated-orcid":false,"given":"Ana","family":"Jesus","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"In\u00eas","family":"Augusto","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Joana","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-4672","authenticated-orcid":false,"given":"Em\u00edlia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical and Organic Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\u2014Interdisciplinar Centre of Marine and Environmental Research, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-1779","authenticated-orcid":false,"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical and Organic Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\u2014Interdisciplinar Centre of Marine and Environmental Research, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6754","authenticated-orcid":false,"given":"Maria T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, Portugal"},{"name":"Center for Neurosciences and Cell Biology, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-8397","authenticated-orcid":false,"given":"Jos\u00e9 M. Sousa","family":"Lobo","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-048X","authenticated-orcid":false,"given":"Isabel F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","unstructured":"Shaath, N. (2005). Sunscreens: Regulations and Commercial Development, Taylor & Francis. [3rd ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jsps.2019.08.003","article-title":"Sunscreen products: Rationale for use, formulation development and regulatory considerations","volume":"27","author":"Geoffrey","year":"2019","journal-title":"Saudi Pharm. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Abiola, T.T., Whittock, A.L., and Stavros, V.G. (2020). Unravelling the Photoprotective Mechanisms of Nature-Inspired Ultraviolet Filters Using Ultrafast Spectroscopy. Molecules, 25.","DOI":"10.3390\/molecules25173945"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1011-1344(01)00202-0","article-title":"The historical aspects of sunscreens","volume":"64","author":"Urbach","year":"2001","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/jocd.14004","article-title":"History of sunscreen: An updated view","volume":"20","author":"Ma","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_6","first-page":"101","article-title":"Sonnenbrand und Sonnenbraunung","volume":"6","author":"Hausser","year":"1927","journal-title":"Wiss. Veraffentlichungen Siemens-Konzerns"},{"key":"ref_7","unstructured":"L\u2019Oreal (2022, January 06). Garnier Ambre Solaire. Available online: https:\/\/www.loreal.com\/it-it\/italy\/press-release\/group\/garnier-ambre-solaire\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jps.3030371111","article-title":"Sunscreen Compounds","volume":"37","author":"Kumler","year":"1948","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1440-0960.1999.00319.x","article-title":"Historical perspective: The PABA story","volume":"40","author":"Macki","year":"1999","journal-title":"Australas. J. Dermatol."},{"key":"ref_10","unstructured":"(2022, April 20). Commission Directive 2008\/123\/EC of 18 December 2008 Amending Council Directive 76\/768\/EEC, Concerning Cosmetic Products, for the Purpose of Adapting Annexes II and VII Thereto to Technical Progress, Available online: https:\/\/www.legislation.gov.uk\/eudr\/2008\/123\/contents."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1001\/jama.1969.03160390039008","article-title":"Early Destructive Effect of Sunlight on Human Skin","volume":"210","author":"Kligman","year":"1969","journal-title":"J. Am. Med. Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-4362.1983.tb03378.x","article-title":"A Survey of Ultraviolet Absorbers in Commercially Available Sun Products","volume":"22","author":"Roelandts","year":"1983","journal-title":"Int. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chisvert, A., and Salvador, A. (2018). Ultraviolet Filters in Cosmetics: Regulatory Aspects and Analytical Methods. Analysis of Cosmetic Products, Elsevier. [2nd ed.].","DOI":"10.1016\/B978-0-444-63508-2.00005-9"},{"key":"ref_14","unstructured":"(2022, January 06). Regulation (EC) n\u00b01223\/2009 of the European Parliament and of the Council: Current Consolidated Version (01\/03\/2022). 2022, Official Journal of the European Union. 02009R1223\u2014EN\u201403.12.2020\u2014025.001\u2014(1\u2013389). Available online: https:\/\/www.google.com.hk\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwimro215MX7AhUUslYBHficAmwQFnoECA0QAQ&url=https%3A%2F%2Feur-lex.europa.eu%2Flegal-content%2FEN%2FTXT%2FPDF%2F%3Furi%3DCELEX%3A02009R1223-20201203%26rid%3D3&usg=AOvVaw0EQqca4O9KBjZxFMiFsLy0."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00244-007-9072-7","article-title":"Cellular and stress protein responses to the UV filter 3-benzylidene camphor in the amphipod crustacean Gammarus fossarum (Koch 1835)","volume":"54","author":"Scheil","year":"2008","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0773.2002.t01-3-910403.x","article-title":"The Chemical UV-Filter 3-Benzylidene Camphor Causes an Oestrogenic Effect in an in vivo Fish Assay","volume":"91","author":"Holbech","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jesus, A., Sousa, E., Cruz, M.T., Cidade, H., Lobo, J.M.S., and Almeida, I.F. (2022). UV Filters: Challenges and Prospects. Pharmaceuticals, 15.","DOI":"10.3390\/ph15030263"},{"key":"ref_18","unstructured":"(2010). Cosmetics\u2014Sun Protection Test Methods\u2014In Vivo Determination of the Sun Protection Factor (SPF) (Standard No. ISO 24444:2010)."},{"key":"ref_19","unstructured":"(2019). Cosmetics\u2014Sun Protection Test Methods\u2014In Vivo Determination of the Sun Protection Factor (SPF) (Standard No. ISO 24444:2019)."},{"key":"ref_20","unstructured":"(2012). Determination of Sunscreen UVA Photoprotection In Vitro (Standard No. ISO 24443:2012)."},{"key":"ref_21","unstructured":"(2021). Cosmetics\u2014Determination of Sunscreen UVA Photoprotection In Vitro (Standard No. ISO 24443:2021)."},{"key":"ref_22","unstructured":"(2011). Cosmetics\u2014Sun Protection Test Methods\u2014In Vivo Determination of Sunscreen UVA Protection (Standard No. ISO 24442:2011)."},{"key":"ref_23","first-page":"199","article-title":"Formulation of sunscreens for optimal efficacy","volume":"71","author":"Moyal","year":"2020","journal-title":"J. Cosmet. Sci."},{"key":"ref_24","unstructured":"Dahmane, R., Pandel, R., Trebse, P., and Poljsak, B. (2015). The role of sun exposure in skin aging. Sun Exposure: Risk Factors, Protection Practices and Health Effects, Nova Science Publishers, Inc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Bonda, C.A., and Lott, D. (2016). Sunscreen photostability. Principles and Practice of Photoprotection, Springer International Publishing.","DOI":"10.1007\/978-3-319-29382-0_14"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1523-1747.1999.00721.x","article-title":"Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation","volume":"113","author":"Stenhagen","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/acs.chemrestox.0c00461","article-title":"Benzophenone Accumulates over Time from the Degradation of Octocrylene in Commercial Sunscreen Products","volume":"34","author":"Downs","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1039\/d0pp00335b","article-title":"Insights into the stabilization of photolabile UV-absorbers in sunscreens","volume":"19","author":"Herzog","year":"2020","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_29","unstructured":"Wolverton, S.E., and Wu, J.J. (2020). Comprehensive Dermatologic Drug Therapy, Elsevier. [4th ed.]."},{"key":"ref_30","unstructured":"(2022, January 06). Regulation (EC) n\u00b0 1223\/2009 of the European Parliament and of the Council: Current Consolidated Version (01\/10\/2021), Official Journal of the European Union L.342\/59-209. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/ALL\/?uri=celex%3A32009R1223."},{"key":"ref_31","unstructured":"Fabian, F. (2022, January 06). BASF Pushes UV Filter Production Capacities. Available online: https:\/\/www.basf.com\/global\/en\/media\/news-releases\/2019\/12\/p-19-422.html."},{"key":"ref_32","unstructured":"Whitehouse, L. (2022, January 06). Nano-Sized UV Filter Passes EU Cosmetic Regulation 2018. Available online: https:\/\/www.cosmeticsdesign-europe.com\/Article\/2018\/08\/03\/Nano-sized-UV-filter-passes-EU-Cosmetic-Regulation."},{"key":"ref_33","unstructured":"(2022, January 06). BASF Gains EU Approval of Nano-Sized UV Filter in Cosmetics 2018. Available online: https:\/\/www.basf.com\/global\/en\/media\/news-releases\/2018\/07\/p-18-276.html."},{"key":"ref_34","unstructured":"(2022, January 06). EU Updates the Use of Nano Titanium Dioxide in Cosmetics with a Warning. Available online: https:\/\/www.sgs.com\/en\/news\/2019\/12\/safeguards-17919-eu-updates-the-use-of-nano-titanium-dioxide-in-cosmetics-with-warning."},{"key":"ref_35","unstructured":"Scientific Committee on Consumer Safety (SCCS) (2016). Opinion on Additional Coatings for Titanium Dioxide (Nano Form) as UV-Filter in Dermally Applied Cosmetic Products, Unit C2, European Commission Health and Food Safety. Preliminary Version SCCS\/1580\/16."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1529-8019.2007.00150.x","article-title":"Update on photoprotection","volume":"20","author":"Palm","year":"2007","journal-title":"Dermatol. Ther."},{"key":"ref_37","unstructured":"Mendrok-Edinger, C. (2021, November 15). The Quest for Avobenzone Stabilizers and Sunscreen Photostability. Available online: https:\/\/www.cosmeticsandtoiletries.com\/formulas-products\/sun-care\/article\/21836968\/the-quest-for-avobenzone-stabilizers-and-sunscreen-photostability."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejps.2014.12.007","article-title":"Combination of retinyl palmitate and UV-filters: Phototoxic risk assessment based on photostability and in vitro and in vivo phototoxicity assays","volume":"68","author":"Benevenuto","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/jocd.13694","article-title":"A short review of alternative ingredients and technologies of inorganic UV filters","volume":"20","author":"Nery","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0781.2010.00494.x","article-title":"Photoallergic contact dermatitis","volume":"26","author":"Kerr","year":"2010","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/phpp.12171","article-title":"Factors that influence sunscreen application thickness and potential preservative exposure","volume":"31","author":"Novick","year":"2015","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cod.13777","article-title":"Ultraviolet filters in sunscreens and cosmetic products\u2014A market survey","volume":"85","author":"Chaiyabutr","year":"2021","journal-title":"Contact Dermat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1248\/jhs.51.48","article-title":"Estrogenic and Anti-Androgenic Activities of Benzophenones in Human Estrogen and Androgen Receptor Mediated Mammalian Reporter Gene Assays","volume":"51","author":"Kawamura","year":"2005","journal-title":"J. Health Sci."},{"key":"ref_44","unstructured":"(2022, May 20). Methylene Bis-Benzotriazolyl Tetramethylbutylphenol. Available online: https:\/\/incidecoder.com\/ingredients\/methylene-bis-benzotriazolyl-tetramethylbutylphenol."},{"key":"ref_45","unstructured":"Scientific Committee on Consumer Safety (2022, April 20). Opinion on 2,2\u2032-Methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3tetramethylbutyl)phenol) (Nano Form): Submission III, COLIPA S79, European Commission 2018, SCCS\/1546\/15. Available online: https:\/\/data.europa.eu\/doi\/10.2875\/101475."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cod.12159","article-title":"Contact allergy to Tinosorb(R) M: Recommendations for diagnostic improvement","volume":"70","author":"Hissink","year":"2014","journal-title":"Contact Dermat."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/cod.12037","article-title":"Photopatch testing: Recommendations for a European photopatch test baseline series","volume":"68","author":"Goncalo","year":"2013","journal-title":"Contact Dermat."}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/12\/23\/12003\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:52Z","timestamp":1760145952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/12\/23\/12003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":47,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["app122312003"],"URL":"https:\/\/doi.org\/10.3390\/app122312003","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}