{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:12:03Z","timestamp":1768878723305,"version":"3.49.0"},"reference-count":168,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["SFRH\/BD\/139319\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139319\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["SFRH\/BD\/116794\/2016"],"award-info":[{"award-number":["SFRH\/BD\/116794\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["2020.07672.BD"],"award-info":[{"award-number":["2020.07672.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT), Portugal","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["SFRH\/BD\/139319\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139319\/2018"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["SFRH\/BD\/116794\/2016"],"award-info":[{"award-number":["SFRH\/BD\/116794\/2016"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["2020.07672.BD"],"award-info":[{"award-number":["2020.07672.BD"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"National Funds via FCT (Foundation for Science and Technology)","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"COMPETE-FEDER","award":["SFRH\/BD\/139319\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139319\/2018"]}]},{"name":"COMPETE-FEDER","award":["SFRH\/BD\/116794\/2016"],"award-info":[{"award-number":["SFRH\/BD\/116794\/2016"]}]},{"name":"COMPETE-FEDER","award":["2020.07672.BD"],"award-info":[{"award-number":["2020.07672.BD"]}]},{"name":"COMPETE-FEDER","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}]},{"name":"COMPETE-FEDER","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"COMPETE-FEDER","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"COMPETE-FEDER","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Photodynamic therapy (PDT) in small animals\u2019 oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compounds without toxicity per se. When subjected to a specific wavelength, the photosensitizers are activated, triggering the production of reactive oxygen species (ROS) that lead to cell death. Additionally, antiangiogenic effects and immune stimulation may also be elicited. PDT is minimally invasive, non-toxic, and does not induce carcinogenic or mutagenic side effects. Thus, it is safe for non-neoplastic tissues compared with other neoplasms treatment modalities. This review describes the applications of PDT in the cancer treatment of small animals, particularly dogs and cats, focusing on the respective photosensitizers and treatment protocols used in trials in this therapeutic modality.<\/jats:p>","DOI":"10.3390\/app122312276","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:38:50Z","timestamp":1669793930000},"page":"12276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oncological Applications of Photodynamic Therapy in Dogs and Cats"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-3891","authenticated-orcid":false,"given":"Tarc\u00edsio Guerra","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Institute for Advanced Studies and Research (IIFA), University of \u00c9vora, 7002-554 \u00c9vora, Portugal"},{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 \u00c9vora, Portugal"},{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-4323","authenticated-orcid":false,"given":"Karla Menezes","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Institute for Advanced Studies and Research (IIFA), University of \u00c9vora, 7002-554 \u00c9vora, Portugal"},{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 \u00c9vora, Portugal"},{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-5417","authenticated-orcid":false,"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal"}]},{"given":"Ricardo","family":"Teixo","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-859X","authenticated-orcid":false,"given":"Beatriz","family":"Serambeque","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-7702","authenticated-orcid":false,"given":"Fernando Capela e","family":"Silva","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 \u00c9vora, Portugal"},{"name":"Department of Medical and Health Sciences, School of Health and Human Development, University of \u00c9vora, 7000-671 \u00c9vora, Portugal"}]},{"given":"Nuno","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 \u00c9vora, Portugal"},{"name":"Department of Veterinary Medicine, School of Sciences and Technology, University of \u00c9vora, 7004-516 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-6007","authenticated-orcid":false,"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5326\/JAAHA-MS-6570","article-title":"2016 AAHA Oncology Guidelines for Dogs and Cats","volume":"52","author":"Biller","year":"2016","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_2","unstructured":"Villalobos, A., and Kaplan, L. (2017). Canine and Feline Geriatric Oncology, Blackwell Publishing Ltd."},{"key":"ref_3","first-page":"30","article-title":"The incidence and structure of neoplasms in animals in Dnipro city","volume":"6","author":"Lieshchova","year":"2018","journal-title":"Sci. Technol. Bull. SRC Biosaf. Environ. Control AIC"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/a-0806-6366","article-title":"Radiation therapy planning using MRI-CT fusion in dogs and cats with brain tumors","volume":"47","author":"Buchholz","year":"2019","journal-title":"Tier\u00e4rztliche Prax. Ausgabe K Kleintiere\/Heimtiere"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Meuten, D.J. (2016). Tumors in Domestic Animals, John Wiley & Sons. [5th ed.].","DOI":"10.1002\/9781119181200"},{"key":"ref_6","first-page":"147","article-title":"Canine geriatrics and management of neoplastic diseases: Review","volume":"12","author":"Moreira","year":"2018","journal-title":"Pubvet"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Buchholz, J. (2016). Clinical Applications of Cancer PDT. Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice, Springer International Publishing.","DOI":"10.1007\/978-3-319-45007-0_10"},{"key":"ref_8","first-page":"401","article-title":"Interstitial Photoradiation Therapy for Primary Solid Tumors in Pet Cats and Dogs","volume":"41","author":"Dougherty","year":"1981","journal-title":"CANCER Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nascimento, C.L., Sellera, F.P., and Ribeiro, M.S. (2016). How to Enter PDT in Clinical Practice?. Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice, Springer International Publishing.","DOI":"10.1007\/978-3-319-45007-0_8"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2017.11.012","article-title":"Photodynamic therapy and diagnosis: Principles and comparative aspects","volume":"233","author":"Dobson","year":"2018","journal-title":"Vet. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Plekhova, N., Shevchenko, O., Korshunova, O., Stepanyugina, A., Tananaev, I., and Apanasevich, V. (2022). Development of Novel Tetrapyrrole Structure Photosensitizers for Cancer Photodynamic Therapy. Bioengineering, 9.","DOI":"10.3390\/bioengineering9020082"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112051","DOI":"10.1016\/j.jphotobiol.2020.112051","article-title":"Perspectives of photodynamic therapy in biotechnology","volume":"213","author":"Couto","year":"2020","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1039\/D0MD00433B","article-title":"Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer","volume":"12","author":"Pereira","year":"2021","journal-title":"RSC Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.7150\/ijbs.58773","article-title":"Application of phototherapeutic-based nanoparticles in colorectal cancer","volume":"17","author":"Yan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Guimar\u00e3es, T.G., Menezes Cardoso, K., Tralh\u00e3o, P., Marto, C.M., Alexandre, N., Botelho, M.F., and Laranjo, M. (2021). Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats. Bioengineering, 8.","DOI":"10.3390\/bioengineering8120225"},{"key":"ref_16","first-page":"002367722110393","article-title":"Evaluation of eye melanoma treatments in rabbits: A systematic review","volume":"56","author":"Marto","year":"2021","journal-title":"Lab. Anim."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Winifred Nompumelelo Simelane, N., and Abrahamse, H. (2021). Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212405"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/1098612X17752196","article-title":"Evaluation of long-term outcome and prognostic factors of feline squamous cell carcinomas treated with photodynamic therapy using liposomal phosphorylated meta-tetra(hydroxylphenyl)chlorine","volume":"20","author":"Flickinger","year":"2018","journal-title":"J. Feline Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic therapy of cancer: An update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s43046-021-00093-1","article-title":"Implications of photodynamic cancer therapy: An overview of PDT mechanisms basically and practically","volume":"33","author":"Sobhani","year":"2021","journal-title":"J. Egypt. Natl. Canc. Inst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12935-019-0815-0","article-title":"The role of photodynamic therapy on multidrug resistant breast cancer","volume":"19","author":"Aniogo","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Algorri, J.F., Ochoa, M., Rold\u00e1n-Varona, P., Rodr\u00edguez-Cobo, L., and L\u00f3pez-Higuera, J.M. (2021). Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review. Cancers, 13.","DOI":"10.3390\/cancers13143484"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic Therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ejmech.2017.12.093","article-title":"Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins","volume":"146","author":"Pereira","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10555-014-9544-y","article-title":"Retinoblastoma: Might photodynamic therapy be an option?","volume":"34","author":"Teixo","year":"2015","journal-title":"Cancer Metastasis Rev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, F., Qin, Y., and Feng, X. (2021). Advances in the Genetically Engineered KillerRed for Photodynamic Therapy Applications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810130"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.survophthal.2015.05.004","article-title":"Clinical use of photodynamic therapy in ocular tumors","volume":"60","author":"Cerman","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/php.12952","article-title":"Apoptosis, Paraptosis and Autophagy: Death and Survival Pathways Associated with Photodynamic Therapy","volume":"95","author":"Kessel","year":"2019","journal-title":"Photochem. Photobiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/med.20121","article-title":"Combination of photodynamic therapy and immunomodulation: Current status and future trends","volume":"28","author":"Qiang","year":"2008","journal-title":"Med. Res. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00018-009-0016-4","article-title":"The effect of photodynamic therapy on tumor angiogenesis","volume":"66","author":"Bhuvaneswari","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e001481","DOI":"10.1136\/jitc-2020-001481","article-title":"In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis","volume":"9","author":"Kim","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"691697","DOI":"10.3389\/fchem.2021.691697","article-title":"Photodynamic Therapy\u2014Current Limitations and Novel Approaches","volume":"9","author":"Gunaydin","year":"2021","journal-title":"Front. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2217\/fon.13.176","article-title":"Photodynamic therapy: Oncologic horizons","volume":"10","author":"Allison","year":"2014","journal-title":"Futur. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ejmech.2015.08.059","article-title":"Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cells","volume":"103","author":"Pereira","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12156-008-0081-1","article-title":"A look at clinical applications and developments of photodynamic therapy","volume":"2","author":"Serra","year":"2008","journal-title":"Oncol. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/php.13219","article-title":"Light Sources and Dosimetry Techniques for Photodynamic Therapy","volume":"96","author":"Kim","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pdpdt.2019.05.026","article-title":"Photodynamic therapy for cutaneous hemangiosarcoma in dogs","volume":"27","author":"Rocha","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"594491","DOI":"10.3389\/fbioe.2020.594491","article-title":"Recent Advances in Self-Exciting Photodynamic Therapy","volume":"8","author":"Blum","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"916","DOI":"10.7150\/thno.4571","article-title":"Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics","volume":"2","author":"Josefsen","year":"2012","journal-title":"Theranostics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7150\/thno.8070","article-title":"Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy","volume":"4","author":"Rong","year":"2014","journal-title":"Theranostics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/vop.12484","article-title":"Iridociliary cysts masquerading as neoplasia in cats: A morphologic review of 14 cases","volume":"21","author":"Fragola","year":"2018","journal-title":"Vet. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1590\/0001-3765201820170811","article-title":"Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives","volume":"90","author":"Gomes","year":"2018","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pdpdt.2011.10.001","article-title":"mTHPC\u2014A drug on its way from second to third generation photosensitizer?","volume":"9","author":"Senge","year":"2012","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-3164.2009.00743.x","article-title":"Hematoporphyrin-based photodynamic therapy for cutaneous squamous cell carcinoma in cats","volume":"20","author":"Ferreira","year":"2009","journal-title":"Vet. Dermatol."},{"key":"ref_45","first-page":"310","article-title":"Basic Concepts and Applications of Porphyrins, Chlorins and Phthalocyanines as Photosensitizers in Photonic Therapies","volume":"7","author":"Brocksom","year":"2015","journal-title":"Rev. Virtual Qu\u00edmica"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40824-018-0140-z","article-title":"Clinical development of photodynamic agents and therapeutic applications","volume":"22","author":"Baskaran","year":"2018","journal-title":"Biomater. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/00029330-200605020-00009","article-title":"Photodynamic therapy for malignant and non-malignant diseases: Clinical investigation and application","volume":"119","author":"Jian","year":"2006","journal-title":"Chin. Med. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1751-1097.2011.00986.x","article-title":"Temoporfin (Foscan\u00ae, 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin)-A Second-generation Photosensitizer","volume":"87","author":"Senge","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotochemrev.2011.06.001","article-title":"Current states and future views in photodynamic therapy","volume":"12","author":"Yano","year":"2011","journal-title":"J. Photochem. Photobiol. C Photochem. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1470-2045(04)01529-3","article-title":"The present and future role of photodynamic therapy in cancer treatment","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yano, T., Minamide, T., Takashima, K., Nakajo, K., Kadota, T., and Yoda, Y. (2021). Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132785"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0169-5002(03)00242-3","article-title":"Phase II clinical study of photodynamic therapy using mono-l-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung","volume":"42","author":"Kato","year":"2003","journal-title":"Lung Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1556-0864(15)31616-6","article-title":"Photodynamic Therapy (PDT) for Lung Cancers","volume":"1","author":"Usuda","year":"2006","journal-title":"J. Thorac. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1039\/b712847a","article-title":"ALA and its clinical impact, from bench to bedside","volume":"7","author":"Krammer","year":"2008","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Bartosi\u0144ska, J., Szczepanik-Ku\u0142ak, P., Raczkiewicz, D., Niewiedzio\u0142, M., Gerkowicz, A., Kowalczuk, D., Kwa\u015bny, M., and Krasowska, D. (2022). Topical Photodynamic Therapy with Different Forms of 5-Aminolevulinic Acid in the Treatment of Actinic Keratosis. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020346"},{"key":"ref_56","first-page":"E53","article-title":"Photodynamic Therapy with 5-aminolevulinic Acid 10% Gel and Red Light for the Treatment of Actinic Keratosis, Nonmelanoma Skin Cancers, and Acne: Current Evidence and Best Practices","volume":"14","author":"Zeitouni","year":"2021","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"112244","DOI":"10.1016\/j.jphotobiol.2021.112244","article-title":"Photodynamic therapy of cutaneous T-cell lymphoma cell lines mediated by 5-aminolevulinic acid and derivatives","volume":"221","author":"Vallecorsa","year":"2021","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pdpdt.2017.06.004","article-title":"Accumulation of porphyrins in Propionibacterium acnes by 5-aminolevulinic acid and its esters","volume":"19","author":"Ogata","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pdpdt.2006.05.002","article-title":"A clinical review of PDT for cutaneous malignancies","volume":"3","author":"Allison","year":"2006","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_60","first-page":"1117","article-title":"Recurrence analysis of intraoperative acridine orange-photodynamic therapy for dogs with intranasal tumors","volume":"62","author":"Maruo","year":"2021","journal-title":"Can. Vet. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1039\/D0TB00991A","article-title":"Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment","volume":"8","author":"Zhang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1038\/s41598-022-06000-5","article-title":"BODIPY nanoparticles functionalized with lactose for cancer-targeted and fluorescence imaging-guided photodynamic therapy","volume":"12","author":"Mai","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114612","DOI":"10.1016\/j.bios.2022.114612","article-title":"Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence\/photoacoustic dual-modal imaging and photothermal cancer therapy","volume":"216","author":"Kwon","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hamblin, M.R., and Sabino, C.P. (2016). Photosensitizers. Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice, Springer International Publishing.","DOI":"10.1007\/978-3-319-45007-0_3"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/10611860701498252","article-title":"Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation","volume":"15","author":"Iyer","year":"2007","journal-title":"J. Drug Target."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"van Straten, D., Mashayekhi, V., de Bruijn, H., Oliveira, S., and Robinson, D. (2017). Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions. Cancers, 9.","DOI":"10.3390\/cancers9020019"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/tcr.201600121","article-title":"Photodynamic Therapy: Past, Present and Future","volume":"17","author":"Chilakamarthi","year":"2017","journal-title":"Chem. Rec."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/vco.12213","article-title":"Photodynamic detection of canine mammary gland tumours after oral administration of 5-aminolevulinic acid","volume":"15","author":"Osaki","year":"2017","journal-title":"Vet. Comp. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.trsl.2015.12.001","article-title":"Evaluation of intraoperative fluorescence imaging\u2013guided surgery in cancer-bearing dogs: A prospective proof-of-concept phase II study in 9 cases","volume":"170","author":"Cabon","year":"2016","journal-title":"Transl. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2109111","DOI":"10.1002\/adma.202109111","article-title":"A Facile, Protein-Derived Supramolecular Theranostic Strategy for Multimodal-Imaging-Guided Photodynamic and Photothermal Immunotherapy In Vivo","volume":"34","author":"Cheng","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Osaki, T., Yokoe, I., Sunden, Y., Ota, U., Ichikawa, T., Imazato, H., Ishii, T., Takahashi, K., Ishizuka, M., and Tanaka, T. (2019). Efficacy of 5-Aminolevulinic Acid in Photodynamic Detection and Photodynamic Therapy in Veterinary Medicine. Cancers, 11.","DOI":"10.3390\/cancers11040495"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fonc.2019.00423","article-title":"The Role of 5-ALA in Low-Grade Gliomas and the Influence of Antiepileptic Drugs on Intraoperative Fluorescence","volume":"9","author":"Goryaynov","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.2147\/OTT.S97030","article-title":"Clinical utility of 5-aminolevulinic acid HCl to better visualize and more completely remove gliomas","volume":"9","author":"Adamson","year":"2016","journal-title":"Onco. Targets. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1021\/acsmedchemlett.6b00476","article-title":"Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents","volume":"8","author":"Pereira","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"112468","DOI":"10.1016\/j.ejmech.2020.112468","article-title":"Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer","volume":"200","author":"Laranjo","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/chem.201904257","article-title":"Manipulating Charge-Transfer States in BODIPYs: A Model Strategy to Rapidly Develop Photodynamic Theragnostic Agents","volume":"26","author":"Maroto","year":"2020","journal-title":"Chem.\u2014A Eur. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110891","DOI":"10.1016\/j.msec.2020.110891","article-title":"BSA-capped gold nanoclusters as potential theragnostic for skin diseases: Photoactivation, skin penetration, in vitro, and in vivo toxicity","volume":"112","author":"Lillo","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Cheli, R., Addis, F., Mortellaro, C.M., Fonda, D., Andreoni, A., and Cubeddu, R. (1984). HpD Phototherapy on Spontaneous Tumors in Dog and Cat. Porphyrins in Tumor Phototherapy, Springer.","DOI":"10.1007\/978-1-4684-4721-7_29"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0304-3835(87)90205-9","article-title":"Photodynamic therapy of spontaneous animal tumors using the active component of hematoporphyrin derivative (DHE) as photosensitizing drug: Clincal results","volume":"38","author":"Cheli","year":"1987","journal-title":"Cancer Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/lsm.1900110210","article-title":"Photodynamic therapy of the canine peritoneum: Normal tissue response to intraperitoneal and intravenous photofrin followed by 630 nm light","volume":"11","author":"Tochner","year":"1991","journal-title":"Lasers Surg. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/lsm.1900130306","article-title":"Comparative study between pulsed and continuous wave lasers for Photofrin\u00ae photodynamic therapy","volume":"13","author":"Panjehpour","year":"1993","journal-title":"Lasers Surg. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/lsm.22781","article-title":"Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs","volume":"50","author":"Musani","year":"2018","journal-title":"Lasers Surg. Med."},{"key":"ref_83","unstructured":"O\u2019Brien, S.J., Dederich, D.N., Wigdor, H., and Trent, A.M. (1991). Use of Chloro-Aluminum Sulfonated Phthalocyanine as a Photosensitizer in the Treatment of Malignant Tumors in Dogs and Cats, International Society for Optics and Photonics."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2460\/ajvr.68.4.399","article-title":"Phase I clinical trial of the use of zinc phthalocyanine tetrasulfonate as a photosensitizer for photodynamic therapy in dogs","volume":"68","author":"Hooser","year":"2007","journal-title":"Am. J. Vet. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1939-1676.2008.0186.x","article-title":"Photodynamic Therapy of Superficial Nasal Planum Squamous Cell Carcinomas in Cats: 55 Cases","volume":"22","author":"Bexfield","year":"2008","journal-title":"J. Vet. Intern. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1748-5827.2001.tb01796.x","article-title":"Photodynamic therapy of feline superficial squamous cell carcinoma using topical 5-aminolaevulinic acid","volume":"42","author":"Stell","year":"2001","journal-title":"J. Small Anim. Pract."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2460\/ajvr.2003.64.131","article-title":"Phototoxic effects of 635-nm light on canine transitional cell carcinoma cells incubated with 5-aminolevulinic acid","volume":"64","author":"Ridgway","year":"2003","journal-title":"Am. J. Vet. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1096-9101(1996)18:2<139::AID-LSM3>3.0.CO;2-T","article-title":"Dosimetry model for photodynamic therapy with topically administered photosensitizers","volume":"18","author":"Svaasand","year":"1996","journal-title":"Lasers Surg. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.pdpdt.2013.05.009","article-title":"Veterinary photodynamic therapy: A review","volume":"10","author":"Buchholz","year":"2013","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"180","DOI":"10.31533\/pubvet.v16n06a1129.1-4","article-title":"Photodynamic Therapy in Veterinary Medicine: Applications in dogs and cats","volume":"16","author":"Moreira","year":"2022","journal-title":"Pubvet"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.36440\/recmvz.v12i1.23097","article-title":"Terapia fotodin\u00e2mica: Revis\u00e3o de literatura","volume":"12","author":"Sellera","year":"2014","journal-title":"Rev. Educ. Contin. Med. Veterin\u00e1ria Zootec. Do CRMV-SP"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1751-1097.1999.tb03332.x","article-title":"Toxicology of a boronated porphyrin in dogs","volume":"69","author":"Tibbitts","year":"1999","journal-title":"Photochem. Photobiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1939-1676.2007.tb03020.x","article-title":"Photodynamic therapy of feline cutaneous squamous cell carcinoma using a newly developed liposomal photosensitizer: Preliminary results concerning drug safety and efficacy","volume":"21","author":"Buchholz","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"ref_94","first-page":"340","article-title":"A History of Photodynamic Therapy","volume":"61","author":"Daniell","year":"1991","journal-title":"ANZ J. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1476-5829.2003.00010.x","article-title":"Preclinical evaluation of 5-aminolevulinic acid-based photodynamic therapy for canine transitional cell carcinoma","volume":"1","author":"Lucroy","year":"2003","journal-title":"Vet. Comp. Oncol."},{"key":"ref_96","first-page":"2207","article-title":"Photodynamic therapy of naturally occurring tumors in animals using a novel benzophenothiazine photosensitizer","volume":"4","author":"Frimberger","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Correia, J.H., Rodrigues, J.A., Pimenta, S., Dong, T., and Yang, Z. (2021). Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13091332"},{"key":"ref_98","unstructured":"Laranjo, M. (2014). Fotossensibilizadores Para Terapia e Imagem em Oncologia, University of Coimbra."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1021\/cr900263j","article-title":"New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging","volume":"110","author":"Kobayashi","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/clm.1996.14.305","article-title":"Photodynamic Therapy in Veterinary Medicine: Current Status and Implications for Applications in Human Disease","volume":"14","author":"Lucroy","year":"1996","journal-title":"J. Clin. Laser Med. Surg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0304-3835(84)90062-4","article-title":"Hematoporphyrin derivative photochemotherapy of spontaneous animal tumors: Clinical results with optimized drug dose","volume":"23","author":"Cheli","year":"1984","journal-title":"Cancer Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5326\/15473317-36-3-257","article-title":"Photodynamic therapy as a treatment for esophageal squamous cell carcinoma in a dog","volume":"36","author":"Jacobs","year":"2000","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1939-1676.2003.tb02440.x","article-title":"Photodynamic Therapy for Prostatic Carcinoma in a Dog","volume":"17","author":"Lucroy","year":"2003","journal-title":"J. Vet. Intern. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tvjl.2007.08.001","article-title":"Preliminary results of intraoperative photodynamic therapy with 5-aminolevulinic acid in dogs with prostate carcinoma","volume":"178","author":"Klem","year":"2008","journal-title":"Vet. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1439-0442.2006.00802.x","article-title":"Clinical Pharmacokinetics of Anti-angiogenic Photodynamic Therapy with Benzoporphyrin Derivative Monoacid Ring-A in Dogs Having Naturally Occurring Neoplasms","volume":"53","author":"Osaki","year":"2006","journal-title":"J. Vet. Med. Ser. A"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1292\/jvms.71.125","article-title":"Efficacy of Antivascular Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid Ring A (BPD-MA) in 14 Dogs with Oral and Nasal Tumors","volume":"71","author":"Osaki","year":"2009","journal-title":"J. Vet. Med. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tvjl.2003.07.001","article-title":"Fluorescence detection of a new photosensitizer, PAD-S31, in tumour tissues and its use as a photodynamic treatment for skin tumours in dogs and a cat: A preliminary report","volume":"167","author":"Tanabe","year":"2004","journal-title":"Vet. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/jsap.12667","article-title":"Endoscopic photodynamic therapy using talaporfin sodium for recurrent intranasal carcinomas after radiotherapy in three dogs","volume":"59","author":"Ishigaki","year":"2018","journal-title":"J. Small Anim. Pract."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1939-1676.2003.tb02509.x","article-title":"Photodynamic Therapy for the Treatment of Intranasal Tumors in 3 Dogs and 1 Cat","volume":"17","author":"Lucroy","year":"2003","journal-title":"J. Vet. Intern. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1096-9101(1997)20:2<202::AID-LSM12>3.0.CO;2-H","article-title":"Photodynamic therapy of facial squamous cell carcinoma in cats using a new photosensitizer","volume":"20","author":"Magne","year":"1997","journal-title":"Lasers Surg. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1476-5810.2004.00052.x","article-title":"Non-coherent light for photodynamic therapy of superficial tumours in animals","volume":"2","author":"Reeds","year":"2004","journal-title":"Vet. Comp. Oncol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1054\/bjoc.1999.1094","article-title":"Treatment of canine oral squamous cell carcinomas with photodynamic therapy","volume":"82","author":"McCaw","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/jnci\/83.1.18","article-title":"Photodynamic Therapy of Spontaneous Cancers in Felines, Canines, and Snakes With Chloro-aluminium Sulfonated Phthalocyanine","volume":"83","author":"Roberts","year":"1991","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-3164.1998.00071.x","article-title":"Photodynamic therapy response in cats with cutaneous squamous cell carcinoma as a function of fluence","volume":"9","author":"Hahn","year":"1998","journal-title":"Vet. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1158\/1078-0432.CCR-05-0490","article-title":"Optimizing Photodynamic Therapy: In vivo Pharmacokinetics of Liposomal meta -(Tetrahydroxyphenyl)Chlorin in Feline Squamous Cell Carcinoma","volume":"11","author":"Buchholz","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/lsm.20282","article-title":"Changes in vascularity and blood volume as a result of photodynamic therapy can be assessed with power Doppler ultrasonography","volume":"38","author":"Ohlerth","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"ref_117","first-page":"1232","article-title":"Intraoperative acridine orange photodynamic therapy and cribriform electron-beam irradiation for canine intranasal tumors: A pilot study","volume":"56","author":"Maruo","year":"2015","journal-title":"Can. Vet. J."},{"key":"ref_118","first-page":"509","article-title":"Intraoperative acridine orange photodynamic therapy and cribriform electron-beam irradiation for canine intranasal carcinomas: 14 cases","volume":"60","author":"Maruo","year":"2019","journal-title":"Can. Vet. J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1572-1000(06)00036-6","article-title":"Photodynamic therapy of diseased bone","volume":"3","author":"Bisland","year":"2006","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/s11999-008-0678-5","article-title":"Treatment of canine osseous tumors with photodynamic therapy: A pilot study","volume":"467","author":"Burch","year":"2009","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/lsm.1081","article-title":"Treatment of canine hemangiopericytomas with photodynamic therapy","volume":"29","author":"McCaw","year":"2001","journal-title":"Lasers Surg. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4142\/jvs.2014.15.1.117","article-title":"Photodynamic hyperthermal chemotherapy with indocyanine green: A novel cancer therapy for 16 cases of malignant soft tissue sarcoma","volume":"15","author":"Onoyama","year":"2014","journal-title":"J. Vet. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8275935","DOI":"10.1155\/2019\/8275935","article-title":"Photodynamic Surgery for Feline Injection-Site Sarcoma","volume":"2019","author":"Martano","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_124","first-page":"269","article-title":"Threshold dose of three photosensitizers in dogs with spontaneous tumors","volume":"4","author":"Gloi","year":"2003","journal-title":"Vet. Ther."},{"key":"ref_125","first-page":"181","article-title":"Marginal Resection and Acridine Orange Photodynamic Therapy in a Cat with Recurrent Cutaneous Malignant Melanoma","volume":"12","author":"Hori","year":"2014","journal-title":"Int. J. Appl. Res. Vet. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/lsm.20177","article-title":"Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer","volume":"36","author":"Huang","year":"2005","journal-title":"Lasers Surg. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pdpdt.2012.05.003","article-title":"2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies","volume":"10","author":"Laranjo","year":"2013","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_128","first-page":"204","article-title":"Ocular ultrasonography as a diagnostic tool in the Veterinary Medicine","volume":"10","author":"Perlmann","year":"2012","journal-title":"Rev. Cient\u00edfica Med. Veterin\u00e1ria\u2014Pequenos Animais Animais Estima\u00e7\u00e3o"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3171\/jns.1993.79.4.0562","article-title":"The role of photodynamic therapy in posterior fossa brain tumors","volume":"79","author":"Whelan","year":"1993","journal-title":"J. Neurosurg."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0016-5107(93)70265-5","article-title":"A centering balloon for photodynamic therapy of esophageal cancer tested in a canine model","volume":"39","author":"Overholt","year":"1993","journal-title":"Gastrointest. Endosc."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/lsm.1900140109","article-title":"Photodynamic therapy for esophageal cancer using a 180\u00b0 windowed esophageal balloon","volume":"14","author":"Overholt","year":"1994","journal-title":"Lasers Surg. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1096-9101(1996)18:3<248::AID-LSM5>3.0.CO;2-S","article-title":"Balloon photodynamic therapy of esophageal cancer: Effect of increasing balloon size","volume":"18","author":"Overholt","year":"1996","journal-title":"Lasers Surg. Med."},{"key":"ref_133","first-page":"27","article-title":"Sequential whole bladder photodynamic therapy treatments: A preclinical study","volume":"3","author":"Nseyo","year":"1997","journal-title":"Urol. Oncol. Semin. Orig. Investig."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/1096-9101(1994)14:2<118::AID-LSM1900140204>3.0.CO;2-5","article-title":"Intrathoracic photodynamic therapy: A canine normal tissue tolerance study and early clinical experience","volume":"14","author":"Tochner","year":"1994","journal-title":"Lasers Surg. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1349-7006.1995.tb03045.x","article-title":"Novel After-loading Interstitial Photodynamic Therapy of Canine Transmissible Sarcoma with Photofrin II and Excimer Dye Laser","volume":"86","author":"Hashimoto","year":"1995","journal-title":"Jpn. J. Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archotol.1987.01860080060017","article-title":"Thermal Effects of Photodynamic Therapy on the Larynx: Experimental Study","volume":"113","author":"Abramson","year":"1987","journal-title":"Arch. Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1046\/j.1464-410X.1997.00460.x","article-title":"Interstitial photodynamic therapy in the canine prostate","volume":"80","author":"Lee","year":"1997","journal-title":"BJU Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1097-0045(19970701)32:2<89::AID-PROS3>3.0.CO;2-A","article-title":"Interstitial photodynamic therapy in the canine prostate with disulfonated aluminum phthalocyanine and 5-aminolevulinic acid-induced protoporphyrin IX","volume":"32","author":"Chang","year":"1997","journal-title":"Prostate"},{"key":"ref_139","first-page":"158","article-title":"Biological responses of dog prostate and adjacent structures after meso-tetra-(m-hydroxyphenyl) chlorin and aluminum disulfonated phthalocyanine based photodynamic therapy","volume":"23","author":"Chang","year":"1999","journal-title":"Proc. Natl. Sci. Counc. Repub. China. B"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"028002","DOI":"10.1117\/1.JBO.21.2.028002","article-title":"Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model","volume":"21","author":"Swartling","year":"2016","journal-title":"J. Biomed. Opt."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/lsm.10014","article-title":"Photodynamic therapy using Verteporfin (benzoporphyrin derivative monoacid ring A, BPD-MA) and 630 nm laser light in canine esophagus","volume":"30","author":"Panjehpour","year":"2002","journal-title":"Lasers Surg. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/php.13247","article-title":"Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative-Mediated Intraperitoneal Photodynamic Therapy in a Canine Model","volume":"96","author":"Cramer","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Horimatsu, T., Muto, M., Yoda, Y., Yano, T., Ezoe, Y., Miyamoto, S., and Chiba, T. (2012). Tissue Damage in the Canine Normal Esophagus by Photoactivation with Talaporfin Sodium (Laserphyrin): A Preclinical Study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038308"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jss.2006.01.020","article-title":"Photodynamic Therapy with Motexafin Lutetium for Rectal Cancer: A Preclinical Model in the Dog","volume":"135","author":"Ross","year":"2006","journal-title":"J. Surg. Res."},{"key":"ref_145","first-page":"374","article-title":"Preclinical evaluation of motexafin lutetium-mediated intraperitoneal photodynamic therapy in a canine model","volume":"7","author":"Griffin","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref_146","first-page":"651","article-title":"Photodynamic therapy in the canine prostate using motexafin lutetium","volume":"7","author":"Hsi","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1562\/0031-8655(2003)0770081IVOPON2.0.CO2","article-title":"In vivo Optical Properties of Normal Canine Prostate at 732 nm Using Motexafin Lutetium-mediated Photodynamic Therapy","volume":"77","author":"Zhu","year":"2007","journal-title":"Photochem. Photobiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/lsm.20341","article-title":"Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer","volume":"38","author":"Du","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2460\/ajvr.1999.60.11.1364","article-title":"Preclinical study in cats of the pro-photosensitizer 5-aminolevulinic acid","volume":"60","author":"Lucroy","year":"1999","journal-title":"Am. J. Vet. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1562\/0031-8655(2002)076<0438:PSINCP>2.0.CO;2","article-title":"Preclinical Studies in Normal Canine Prostate of a Novel Palladium-Bacteriopheophorbide (WST09) Photosensitizer for Photodynamic Therapy of Prostate Cancer","volume":"76","author":"Chen","year":"2002","journal-title":"Photochem. Photobiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1089\/pho.2005.23.172","article-title":"Effects of Photodynamic Therapy on Peripheral Nerve: In Situ Compound-Action Potentials Study in a Canine Model","volume":"23","author":"Dole","year":"2005","journal-title":"Photomed. Laser Surg."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.juro.2011.03.039","article-title":"Preclinical Study of the Novel Vascular Occluding Agent, WST11, for Photodynamic Therapy of the Canine Prostate","volume":"186","author":"Chevalier","year":"2011","journal-title":"J. Urol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.yrtph.2006.06.006","article-title":"Intravenous repeated-dose toxicity study of ZnPcS2P2-based-photodynamic therapy in beagle dogs","volume":"47","author":"Liu","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0022-5347(05)66416-6","article-title":"Studies of tin ethyl etiopurpurin photodynamic therapy of the canine prostate","volume":"165","author":"Selman","year":"2001","journal-title":"J. Urol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-5347(01)66012-9","article-title":"Transperineal photodynamic ablation of the canine prostate","volume":"156","author":"Selman","year":"1996","journal-title":"J. Urol."},{"key":"ref_156","first-page":"287","article-title":"Spatial distribution of liposome encapsulated tin etiopurpurin dichloride (SnET2) in the canine prostate: Implications for computer simulation of photodynamic therapy","volume":"11","author":"Aniola","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pdpdt.2010.03.003","article-title":"Lipophilic photosensitizer administration via the prostate arteries for photodynamic therapy of the canine prostate","volume":"7","author":"Xiao","year":"2010","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1039\/c4pp00463a","article-title":"A safety study of a novel photosensitizer, sinoporphyrin sodium, for photodynamic therapy in Beagle dogs","volume":"14","author":"Lin","year":"2015","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Osaki, T., Hibino, S., Yokoe, I., Yamaguchi, H., Nomoto, A., Yano, S., Mikata, Y., Tanaka, M., Kataoka, H., and Okamoto, Y. (2019). A Basic Study of Photodynamic Therapy with Glucose-Conjugated Chlorin e6 Using Mammary Carcinoma Xenografts. Cancers, 11.","DOI":"10.3390\/cancers11050636"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000028802","article-title":"Preclinical Evaluation of Benzoporphyrin Derivative Combined with a Light-Emitting Diode Array for Photodynamic Therapy of Brain Tumors","volume":"30","author":"Schmidt","year":"1999","journal-title":"Pediatr. Neurosurg."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tvjl.2010.05.013","article-title":"Apoptosis induced by hematoporphyrin monomethyl ether combined with He\u2013Ne laser irradiation in vitro on canine breast cancer cells","volume":"188","author":"Liu","year":"2011","journal-title":"Vet. J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pdpdt.2013.03.005","article-title":"Effect of hematoporphyrin monomethyl ether-mediated PDT on the mitochondria of canine breast cancer cells","volume":"10","author":"Li","year":"2013","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4142\/jvs.2016.17.2.235","article-title":"Hematoporphyrin monomethyl ether combined with He-Ne laser irradiation-induced apoptosis in canine breast cancer cells through the mitochondrial pathway","volume":"17","author":"Li","year":"2016","journal-title":"J. Vet. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1166\/jbn.2012.1378","article-title":"Aluminum-Chloride-Phthalocyanine Encapsulated in Liposomes: Activity Against Naturally Occurring Dog Breast Cancer Cells","volume":"8","author":"Rocha","year":"2012","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1021\/acsomega.0c06316","article-title":"Maltotriose\u2013Chlorin e6 Conjugate Linked via Tetraethyleneglycol as an Advanced Photosensitizer for Photodynamic Therapy. Synthesis and Antitumor Activities against Canine and Mouse Mammary Carcinoma Cells","volume":"6","author":"Narumi","year":"2021","journal-title":"ACS Omega"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10103-021-03324-y","article-title":"Efficacy of 5-aminolevulinic acid-based photodynamic therapy in different subtypes of canine mammary gland cancer cells","volume":"37","author":"Turna","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Osaki, T., Kunisue, N., Ota, U., Imazato, H., Ishii, T., Takahashi, K., Ishizuka, M., Tanaka, T., and Okamoto, Y. (2021). Mechanism of Differential Susceptibility of Two (Canine Lung Adenocarcinoma) Cell Lines to 5-Aminolevulinic Acid-Mediated Photodynamic Therapy. Cancers, 13.","DOI":"10.3390\/cancers13164174"},{"key":"ref_168","first-page":"92","article-title":"Chlorins in Photodynamic Therapy\u2014Synthesis and applications","volume":"1","author":"Calvete","year":"2009","journal-title":"Rev. Virtual Qu\u00edmica"}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/12\/23\/12276\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:32Z","timestamp":1760146232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/12\/23\/12276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":168,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["app122312276"],"URL":"https:\/\/doi.org\/10.3390\/app122312276","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}