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LISBOA-01-0145-FEDER-022125"],"award-info":[{"award-number":["RNEM\u2014Portuguese Mass Spectrometry Network, ref. LISBOA-01-0145-FEDER-022125"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Gas-phase experiments, using electrospray ionization quadrupole ion trap mass spectrometry (ESI-QIT\/MS), were conducted to probe basic interactions of the uranyl(VI) ion, UO22+, with selected natural amino acids, namely, L-cysteine (Cys), L-histidine (His), and L-aspartic acid (Asp), which strongly bind to metal ions. The simplest amino acid, glycine (Gly), was also studied for comparison. Cys, His, and Asp have additional potentially coordinating groups beyond the amino and carboxylic acid functional groups, specifically thiol in Cys, imidazole in His, and a second carboxylate in Asp. Gas-phase experiments comprised collision-induced dissociation (CID) of uranyl\u2013amino acid complexes and competitive CID to assess the relative binding strength of different amino acids in the same uranyl complex. Reactivity of selected uranyl\u2013amino acid complexes with water provided further insights into relative stabilities. In positive ion mode, CID and ensuing reactions with water suggested that uranyl\u2013neutral AA binding strength decreased in the order His &gt; Asp &gt; Cys &gt; Gly, which is similar to amino acid proton affinities. In negative ion mode, CID revealed a decreasing dissociation tendency in the order Gly &gt;&gt; His \u2248 Cys &gt; Asp, presumably reflecting a reverse enhanced binding to uranyl of the doubly deprotonated amino acids formed in CID.<\/jats:p>","DOI":"10.3390\/app13063834","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T02:59:26Z","timestamp":1679021966000},"page":"3834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Examining Interactions of Uranyl(VI) Ions with Amino Acids in the Gas Phase"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-2657","authenticated-orcid":false,"given":"Ana F.","family":"Lucena","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-6627","authenticated-orcid":false,"given":"Leonor","family":"Maria","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]},{"given":"John K.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-057X","authenticated-orcid":false,"given":"Joaquim","family":"Mar\u00e7alo","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 2695-066 Bobadela, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106107","DOI":"10.1016\/j.envint.2020.106107","article-title":"Emerging health risks and underlying toxicological mechanisms of uranium contamination: Lessons from the past two decades","volume":"145","author":"Ma","year":"2020","journal-title":"Environ. 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Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20480","DOI":"10.1021\/acs.inorgchem.2c03185","article-title":"Optimized Coordination of Uranyl in Engineered Calmodulin Site 1 Provides a Subnanomolar Affinity for Uranyl and a Strong Uranyl versus Calcium Selectivity","volume":"61","author":"Pardoux","year":"2022","journal-title":"Inorg. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1002\/chem.201605481","article-title":"Cyclic Phosphopeptides to Rationalize the Role of Phosphoamino Acids in Uranyl Binding to Biological Targets","volume":"23","author":"Starck","year":"2017","journal-title":"Chem.\u2014A Eur. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1039\/C3MT00269A","article-title":"Characterization of UO22+binding to osteopontin, a highly phosphorylated protein: Insights into potential mechanisms of uranyl accumulation in bones","volume":"6","author":"Qi","year":"2014","journal-title":"Metallomics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1039\/c3mt20237b","article-title":"Receptor recognition of transferrin bound to lanthanides and actinides: A discriminating step in cellular acquisition of f-block metals","volume":"5","author":"Deblonde","year":"2013","journal-title":"Metallomics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ccr.2019.01.006","article-title":"Coordination chemistry of f-block metal ions with ligands bearing bio-relevant functional groups","volume":"386","author":"Schaper","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ccr.2011.08.015","article-title":"Advances in the investigation of dioxouranium(VI) complexes of interest for natural fluids","volume":"256","author":"Berto","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1039\/c0ja00223b","article-title":"Radionuclide speciation: A key point in the field of nuclear toxicology studies","volume":"26","author":"Bresson","year":"2011","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ccr.2005.09.010","article-title":"Uranium(VI) bio-coordination chemistry from biochemical, solution and protein structural data","volume":"250","author":"Huang","year":"2006","journal-title":"Coord. Chem. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.addr.2015.06.009","article-title":"Novel drug delivery systems for actinides (uranium and plutonium) decontamination agents","volume":"90","author":"Fattal","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1524\/ract.2013.2047","article-title":"Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation","volume":"101","author":"Deblonde","year":"2013","journal-title":"Radiochim. Acta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/01.HP.0000326345.41816.c2","article-title":"Taylor lecture: The quest for therapeutic actinide chelators","volume":"95","author":"Durbin","year":"2008","journal-title":"Health Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1021\/cr990114x","article-title":"Rational Design of Sequestering Agents for Plutonium and Other Actinides","volume":"103","author":"Gorden","year":"2003","journal-title":"Chem. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"122403","DOI":"10.1016\/j.saa.2023.122403","article-title":"A novel fluorescence sensor for uranyl ion detection based on a dansyl-modified peptide","volume":"292","author":"Zhang","year":"2023","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trac.2019.04.026","article-title":"Sensors for determination of uranium: A review","volume":"118","author":"Wu","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/acs.inorgchem.5b02379","article-title":"Thermodynamic and Structural Investigation of Synthetic Actinide\u2013Peptide Scaffolds","volume":"55","author":"Safi","year":"2016","journal-title":"Inorg. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nchem.1856","article-title":"A protein engineered to bind uranyl selectively and with femtomolar affinity","volume":"6","author":"Zhou","year":"2014","journal-title":"Nat. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17484","DOI":"10.1021\/ja5087563","article-title":"UO22+ Uptake by Proteins: Understanding the Binding Features of the Super Uranyl Binding Protein and Design of a Protein with Higher Affinity","volume":"136","author":"Odoh","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16566","DOI":"10.1002\/chem.201404546","article-title":"Engineering Short Peptide Sequences for Uranyl Binding","volume":"20","author":"Lebrun","year":"2014","journal-title":"Chem.\u2014A Eur. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aca.2010.11.050","article-title":"A review on the interrogation of peptide\u2013metal interactions using electrospray ionization-mass spectrometry","volume":"686","author":"Carlton","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/ar0302843","article-title":"A Thermodynamic \u201cVocabulary\u201d for Metal Ion Interactions in Biological Systems","volume":"37","author":"Rodgers","year":"2004","journal-title":"Acc. Chem. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1021\/acs.chemrev.5b00688","article-title":"Cationic Noncovalent Interactions: Energetics and Periodic Trends","volume":"116","author":"Rodgers","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/mas.20215","article-title":"Vibrational spectroscopy of bare and solvated ionic complexes of biological relevance","volume":"28","author":"Polfer","year":"2009","journal-title":"Mass Spectrom. Rev."},{"key":"ref_28","first-page":"183","article-title":"Spectroscopy of Metal-Ion Complexes with Peptide-Related Ligands","volume":"Volume 364","author":"Rijs","year":"2015","journal-title":"Gas-Phase IR Spectroscopy and Structure of Biological Molecules"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1002\/chem.201705692","article-title":"Infrared Multiphoton Dissociation Spectroscopy with Free-Electron Lasers: On the Road from Small Molecules to Biomolecules","volume":"24","year":"2018","journal-title":"Chem.\u2014A Eur. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1021\/jasms.2c00079","article-title":"Potassium Binding Interactions with Aliphatic Amino Acids: Thermodynamic and Entropic Effects Analyzed via a Guided Ion Beam and Computational Study","volume":"33","author":"Jones","year":"2022","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_31","unstructured":"(2023, February 26). IAEA Live Chart of Nuclides. Available online: https:\/\/www-nds.iaea.org\/relnsd\/vcharthtml\/VChartHTML.html."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijms.2007.02.018","article-title":"Gas-phase acidities of the 20 protein amino acids","volume":"267","author":"Jones","year":"2007","journal-title":"Int. J. Mass Spectrom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1103\/PhysRevA.55.2036","article-title":"High-resolution threshold photodetachment spectroscopy of OH\u2212","volume":"55","author":"Smith","year":"1997","journal-title":"Phys. Rev. A"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/mas.20070","article-title":"Electrospray mass spectrometry (ESI-MS) in the study of metal\u2013ligand solution equilibria","volume":"25","author":"Bombi","year":"2006","journal-title":"Mass Spectrom. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1021\/ic900575r","article-title":"Can Electrospray Mass Spectrometry Quantitatively Probe Speciation? Hydrolysis of Uranyl Nitrate Studied by Gas-Phase Methods","volume":"48","author":"Tsierkezos","year":"2009","journal-title":"Inorg. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.aca.2010.08.023","article-title":"A review of recent trends in electrospray ionisation\u2013mass spectrometry for the analysis of metal\u2013organic ligand complexes","volume":"678","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"625945","DOI":"10.3389\/fchem.2020.625945","article-title":"Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry","volume":"8","author":"Indelicato","year":"2021","journal-title":"Front. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Haynes, W.M., Lide, D.R., and Bruno, T.J. (2017). CRC Handbook of Chemistry and Physics, CRC Press. [97th ed.].","DOI":"10.1201\/9781315380476"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jasms.2010.01.021","article-title":"Variable denticity in carboxylate binding to the uranyl coordination complexes","volume":"21","author":"Groenewold","year":"2010","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/(SICI)1096-9888(199605)31:5<500::AID-JMS327>3.0.CO;2-Q","article-title":"Fragmentation Reactions of Protonated \u03b1-Amino Acids","volume":"31","author":"Dookeran","year":"1996","journal-title":"J. Mass Spectrom."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1387-3806(99)00225-0","article-title":"Fragmentation mechanisms of \u03b1-amino acids protonated under electrospray ionization: A collisional activation and ab initio theoretical study","volume":"195\u2013196","author":"Rogalewicz","year":"2000","journal-title":"Int. J. Mass Spectrom."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1038\/s41598-019-42777-8","article-title":"Revisiting Fragmentation Reactions of Protonated \u03b1-Amino Acids by High-Resolution Electrospray Ionization Tandem Mass Spectrometry with Collision-Induced Dissociation","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Armentrout, P.B. (2021). Energetics and mechanisms for decomposition of cationized amino acids and peptides explored using guided ion beam tandem mass spectrometry. Mass Spectrom. Rev., 1\u201326.","DOI":"10.1002\/mas.21723"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/ar500377u","article-title":"Gas Phase Studies of the Pesci Decarboxylation Reaction: Synthesis, Structure, and Unimolecular and Bimolecular Reactivity of Organometallic Ions","volume":"48","author":"Rijs","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1021\/acs.organomet.6b00079","article-title":"Synthesis and Hydrolysis of Uranyl, Neptunyl, and Plutonyl Gas-Phase Complexes Exhibiting Discrete Actinide\u2013Carbon Bonds","volume":"35","author":"Dau","year":"2016","journal-title":"Organometallics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s13361-019-02179-6","article-title":"Gas-Phase Deconstruction of UO22+: Mass Spectrometry Evidence for Generation of [OUVICH]+ by Collision-Induced Dissociation of [UVIO2(C\u2261CH)]+","volume":"30","author":"Tatosian","year":"2019","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20073","DOI":"10.1039\/D1CP03092B","article-title":"Mass spectrometric and theoretical study on the formation of uranyl hydride from uranyl carboxylate","volume":"23","author":"Xiong","year":"2021","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1021\/acs.jpca.5b01445","article-title":"Gas-Phase Reactions of Molecular Oxygen with Uranyl(V) Anionic Complexes\u2014Synthesis and Characterization of New Superoxides of Uranyl(VI)","volume":"119","author":"Lucena","year":"2015","journal-title":"J. Phys. Chem. A"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1021\/ja0573209","article-title":"Binding of Molecular O2 to Di- and Triligated [UO2]+","volume":"128","author":"Groenewold","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1021\/jp804202q","article-title":"Two-Electron Three-Centered Bond in Side-On (\u03b72) Uranyl(V) Superoxo Complexes","volume":"112","author":"Bryantsev","year":"2008","journal-title":"J. Phys. Chem. A"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1021\/jp807651c","article-title":"Addition of H2O and O2 to Acetone and Dimethylsulfoxide Ligated Uranyl(V) Dioxocations","volume":"113","author":"Leavitt","year":"2009","journal-title":"J. Phys. Chem. A"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1021\/ic3001625","article-title":"Gas-Phase Uranyl, Neptunyl, and Plutonyl: Hydration and Oxidation Studied by Experiment and Theory","volume":"51","author":"Rios","year":"2012","journal-title":"Inorg. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1063\/1.556018","article-title":"Evaluated Gas Phase Basicities and Proton Affinities of Molecules: An Update","volume":"27","author":"Hunter","year":"1998","journal-title":"J. Phys. Chem. Ref. 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