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Conventional polyphenol extraction techniques are based on the use of solvents that are harmful to health and to the environment, creating a demand for sustainable complementary initiatives that mitigate part of the environmental effects and offer consumer safety. Current advances in these technologies allow for the recovery of valuable antioxidants from winemaking by-products free of hazardous solvents, biocompatible, and in compliance with international sustainable development guidelines. Nanotechnology has gained prominence in the development of green technologies to reduce or eliminate toxic agents and improve the stability and bioavailability of waste polyphenols. These efforts have led to the application of bioactive compounds from wine by-products in the development of more efficacious sunscreens, as a skin protection approach, and improvements in the antioxidant effectiveness of nanocarriers with potential use in the promotion of cutaneous health. We aimed to present different extraction and encapsulation technologies for biologically active compounds from wine by-products (Vitis vinifera L.). We also focused on a particular application of such compounds towards the development of value-added skin protection products aligned with a sustainable circular economy.<\/jats:p>","DOI":"10.3390\/app13169068","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T12:45:53Z","timestamp":1691498753000},"page":"9068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Technological Aspects and Potential Cutaneous Application of Wine Industry By-Products"],"prefix":"10.3390","volume":"13","author":[{"given":"Alexandra de Almeida","family":"H\u00fcbner","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"given":"Michelle Maria Gon\u00e7alves Bar\u00e3o","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-5148","authenticated-orcid":false,"given":"Daniel Pecoraro","family":"Demarque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-6213","authenticated-orcid":false,"given":"Catarina","family":"Rosado","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona\u2019s Research Center for Biosciences and Health Technologies, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-8510","authenticated-orcid":false,"given":"Maria Val\u00e9ria Robles","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"given":"Irene Satiko","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-900, Brazil"}]},{"given":"Fabiana Vieira Lima Solino","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Pharmacy, Federal University of Esp\u00edrito Santo, S\u00e3o Mateus 29932-540, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"ref_1","unstructured":"International Organization of Vine and Wine (2023). 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