{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:28:12Z","timestamp":1773516492002,"version":"3.50.1"},"reference-count":173,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health from Portugal\u2014HfPT","award":["C630926586-00465198"],"award-info":[{"award-number":["C630926586-00465198"]}]},{"name":"PRR\u2014Plano de Recupera\u00e7\u00e3o e Resili\u00eancia","award":["C630926586-00465198"],"award-info":[{"award-number":["C630926586-00465198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>It is acknowledged that humans have a diverse and abundant microbial community known as the human microbiome. Nevertheless, our comprehension of the numerous functions these microorganisms have in human health is still in its early stages. Microorganisms belonging to the human microbiome typically coexist with their host, but in certain situations, they can lead to diseases. They are found in several areas of the human body in healthy individuals. The microbiome is highly diverse, and its composition varies depending on the body site. It primarily comprises bacteria that are crucial for upholding a state of well-being and equilibrium. The microbiome\u2019s influence on atopic dermatitis development was, therefore, analyzed. The importance of maintaining a balanced and functional commensal microbiota, as well as the use of prebiotics and probiotics in the prevention and treatment of atopic dermatitis were also explored. The skin microbiome\u2019s association with atopic dermatitis will allow for a better understanding of pathogenesis and also exploring new therapeutic approaches, making the skin microbiome an increasingly relevant therapeutic target.<\/jats:p>","DOI":"10.3390\/app131810540","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T21:08:36Z","timestamp":1695330516000},"page":"10540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Overview of the Relevance of Human Gut and Skin Microbiome in Disease: The Influence on Atopic Dermatitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-106X","authenticated-orcid":false,"given":"Maria Pia","family":"Ferraz","sequence":"first","affiliation":[{"name":"Departamento de Engenharia Metal\u00fargica e de Materiais, Faculdade de Engenharia da Universidade do Porto, 4200-465 Porto, Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"INEB\u2014Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, 4200-135 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mayocp.2013.10.011","article-title":"A clinician\u2019s primer on the role of the microbiome in human health and disease","volume":"89","author":"Khanna","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41430-021-00991-6","article-title":"Role of the gut microbiome in chronic diseases: A narrative review","volume":"76","author":"Vijay","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1002\/cphy.c210052","article-title":"Microbiome in Colonic Carcinogenesis","volume":"13","author":"Sun","year":"2023","journal-title":"Compr. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"McDonald, D., Birmingham, A., and Knight, R. (2015). Context and the human microbiome. Microbiome, 3.","DOI":"10.1186\/s40168-015-0117-2"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gupta, V.K., Paul, S., and Dutta, C. (2017). Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01162"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2019.01.001","article-title":"Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle","volume":"176","author":"Pasolli","year":"2019","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"ref_9","first-page":"708","article-title":"The gut microbiota, a new cardiovascular risk factor?","volume":"46","author":"Duboc","year":"2017","journal-title":"Presse Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCGENETICS.114.000219","article-title":"Does our gut microbiome predict cardiovascular risk? A review of the evidence from metabolomics","volume":"8","author":"Griffin","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Griffiths, K., Aggarwal, B.B., Singh, R.B., Buttar, H.S., Wilson, D., and De Meester, F. (2016). Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention. Diseases, 4.","DOI":"10.3390\/diseases4030028"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hrestak, D., Matijasic, M., Cipcic Paljetak, H., Ledic Drvar, D., Ljubojevic Hadzavdic, S., and Peric, M. (2022). Skin Microbiota in Atopic Dermatitis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073503"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1174331","DOI":"10.3389\/fmed.2023.1174331","article-title":"Gut microbiota and atopic dermatitis: A two-sample Mendelian randomization study","volume":"10","author":"Xue","year":"2023","journal-title":"Front. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40257-019-00467-1","article-title":"The Microbiome and Atopic Dermatitis: A Review","volume":"20","author":"Pothmann","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jdv.19125","article-title":"Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review","volume":"37","author":"Connetable","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mazur, M., Tomczak, H., Lodyga, M., Plagens-Rotman, K., Merks, P., and Czarnecka-Operacz, M. (2023). The Intestinal and Skin Microbiome in Patients with Atopic Dermatitis and Their Influence on the Course of the Disease: A Literature Review. Healthcare, 11.","DOI":"10.3390\/healthcare11050766"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13073-021-01007-5","article-title":"Population study of the gut microbiome: Associations with diet, lifestyle, and cardiometabolic disease","volume":"13","author":"Walker","year":"2021","journal-title":"Genome. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/acs.chemrev.2c00431","article-title":"Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies","volume":"123","author":"Aggarwal","year":"2023","journal-title":"Chem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tig.2012.09.005","article-title":"Biodiversity and functional genomics in the human microbiome","volume":"29","author":"Morgan","year":"2013","journal-title":"Trends. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3389\/fimmu.2020.00700","article-title":"Microbiome Composition and Its Impact on the Development of Allergic Diseases","volume":"11","author":"Peroni","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Willis, J.R., and Gabaldon, T. (2020). The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020308"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/dna.2009.0874","article-title":"The oral microbiota: Living with a permanent guest","volume":"28","author":"Avila","year":"2009","journal-title":"DNA Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tim.2005.09.006","article-title":"Oral microbial communities in sickness and in health","volume":"13","author":"Jenkinson","year":"2005","journal-title":"Trends Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1462-2920.12502","article-title":"Oral cavity contains distinct niches with dynamic microbial communities","volume":"17","author":"Xu","year":"2015","journal-title":"Environ. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.33073\/pjm-2014-018","article-title":"The oral microbiome in dental caries","volume":"63","author":"Struzycka","year":"2014","journal-title":"Pol. J. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, J.S., Chu, C.H., and Yu, O.Y. (2022). Oral Microbiome and Dental Caries Development. Dent. J., 10.","DOI":"10.3390\/dj10100184"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zheng, L., Cao, T., Xiong, P., Ma, Y., Wei, L., and Wang, J. (2023). Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1081629"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2231-0762.151956","article-title":"Biofilm in endodontics: A review","volume":"5","author":"Jhajharia","year":"2015","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hao, Y., Zeng, Z., Peng, X., Ai, P., Han, Q., Ren, B., Li, M., Wang, H., Zhou, X., and Zhou, X. (2022). The human oral-nasopharynx microbiome as a risk screening tool for nasopharyngeal carcinoma. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1013920"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wang, J., Feng, J., Zhu, Y., Li, D., Wang, J., and Chi, W. (2022). Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.931065"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Morrison, A.G., Sarkar, S., Umar, S., Lee, S.T.M., and Thomas, S.M. (2023). The Contribution of the Human Oral Microbiome to Oral Disease: A Review. Microorganisms, 11.","DOI":"10.3390\/microorganisms11020318"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.cll.2014.08.004","article-title":"The oral microbiome and oral cancer","volume":"34","author":"Wang","year":"2014","journal-title":"Clin. Lab. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nearing, J.T., DeClercq, V., and Langille, M.G.I. (2023). Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer. NPJ Biofilms Microbiomes, 9.","DOI":"10.1038\/s41522-023-00391-7"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Smedra, A., and Berent, J. (2023). The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach. Biomolecules, 13.","DOI":"10.3390\/biom13050815"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1144021","DOI":"10.3389\/fonc.2023.1144021","article-title":"Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis","volume":"13","author":"Thu","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: From microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11906-017-0725-2","article-title":"Oral Microbiome and Nitric Oxide: The Missing Link in the Management of Blood Pressure","volume":"19","author":"Bryan","year":"2017","journal-title":"Curr. Hypertens Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: Consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1469-0691.2010.03410.x","article-title":"Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins","volume":"17","author":"Jourdain","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Jourdain, S., Dreze, P.A., Vandeven, J., Verhaegen, J., Van Melderen, L., and Smeesters, P.R. (2011). Sequential multiplex PCR assay for determining capsular serotypes of colonizing S. pneumoniae. BMC Infect. Dis., 11.","DOI":"10.1186\/1471-2334-11-100"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3345\/cep.2020.01452","article-title":"Effects of nasopharyngeal microbiota in respiratory infections and allergies","volume":"64","author":"Kang","year":"2021","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2012.03.010","article-title":"The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites","volume":"129","author":"Ursell","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021115-105238","article-title":"The Microbiome and the Respiratory Tract","volume":"78","author":"Dickson","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.meegid.2011.03.022","article-title":"Skin microbiota: Microbial community structure and its potential association with health and disease","volume":"11","author":"Rosenthal","year":"2011","journal-title":"Infect Genet. Evol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Santiago-Rodriguez, T.M., Le Francois, B., Macklaim, J.M., Doukhanine, E., and Hollister, E.B. (2023). The Skin Microbiome: Current Techniques, Challenges, and Future Directions. Microorganisms, 11.","DOI":"10.3390\/microorganisms11051222"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.cell.2016.04.008","article-title":"Temporal Stability of the Human Skin Microbiome","volume":"165","author":"Oh","year":"2016","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Skowron, K., Bauza-Kaszewska, J., Kraszewska, Z., Wiktorczyk-Kapischke, N., Grudlewska-Buda, K., Kwiecinska-Pirog, J., Walecka-Zacharska, E., Radtke, L., and Gospodarek-Komkowska, E. (2021). Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms, 9.","DOI":"10.3390\/microorganisms9030543"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1101\/gr.191320.115","article-title":"The intersection of microbiome and host at the skin interface: Genomic- and metagenomic-based insights","volume":"25","author":"Grice","year":"2015","journal-title":"Genome Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1171700","article-title":"Topographical and temporal diversity of the human skin microbiome","volume":"324","author":"Grice","year":"2009","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1038\/jid.2011.168","article-title":"Diversity of the human skin microbiome early in life","volume":"131","author":"Capone","year":"2011","journal-title":"J. Invest Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/gm378","article-title":"Shifts in human skin and nares microbiota of healthy children and adults","volume":"4","author":"Oh","year":"2012","journal-title":"Genome. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2165\/00128071-200203070-00001","article-title":"Cosmetics: What is their influence on the skin microflora?","volume":"3","author":"Holland","year":"2002","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tim.2013.10.001","article-title":"Structure and function of the human skin microbiome","volume":"21","author":"Schommer","year":"2013","journal-title":"Trends Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kim, G., Kim, M., Kim, M., Park, C., Yoon, Y., Lim, D.H., Yeo, H., Kang, S., Lee, Y.G., and Beak, N.I. (2021). Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome. Commun. Biol., 4.","DOI":"10.1038\/s42003-020-01619-4"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.0607077104","article-title":"Molecular analysis of human forearm superficial skin bacterial biota","volume":"104","author":"Gao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/pde.13955","article-title":"Skin microbiota: Friend or foe in pediatric skin health and skin disease","volume":"36","author":"Schneider","year":"2019","journal-title":"Pediatr. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1000081107","article-title":"Succession of microbial consortia in the developing infant gut microbiome","volume":"108","author":"Koenig","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/jvim.14875","article-title":"The Gastrointestinal Microbiome: A Review","volume":"32","author":"Barko","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1055\/s-0042-1760678","article-title":"A Brief History of Microbial Study and Techniques for Exploring the Gastrointestinal Microbiome","volume":"36","author":"Sidebottom","year":"2023","journal-title":"Clin. Colon. Rectal. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Cheng, S., Zou, H., Han, Z., Xie, T., Zhang, B., Dai, D., Yin, X., Liang, Y., and Kou, Y. (2023). Correlation of the gut microbiome and immune-related adverse events in gastrointestinal cancer patients treated with immune checkpoint inhibitors. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1099063"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1053\/j.gastro.2011.02.011","article-title":"Development of the human gastrointestinal microbiota and insights from high-throughput sequencing","volume":"140","author":"Blaser","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1536\/ihj.16-414","article-title":"Gut Microbiota and Coronary Artery Disease","volume":"57","author":"Yamashita","year":"2016","journal-title":"Int. Heart J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jare.2022.06.008","article-title":"Gut microbiota combined with metabolites reveals unique features of acute myocardial infarction patients different from stable coronary artery disease","volume":"46","author":"Dong","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1753-4887.2010.00365.x","article-title":"Fermentation potential of the gut microbiome: Implications for energy homeostasis and weight management","volume":"69","author":"Arora","year":"2011","journal-title":"Nutr. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","article-title":"The role of the gut microbiota in nutrition and health","volume":"9","author":"Flint","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"k2179","DOI":"10.1136\/bmj.k2179","article-title":"Role of the gut microbiota in nutrition and health","volume":"361","author":"Valdes","year":"2018","journal-title":"BMJ"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1031502","DOI":"10.3389\/fnut.2022.1031502","article-title":"Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health","volume":"9","author":"Wan","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_75","first-page":"71","article-title":"Gut microbiota: Next frontier in understanding human health and development of biotherapeutics","volume":"5","author":"Prakash","year":"2011","journal-title":"Biologics"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1590\/2359-3997000000029","article-title":"Translational research into gut microbiota: New horizons on obesity treatment: Updated 2014","volume":"59","author":"Tsukumo","year":"2015","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2007.11.059","article-title":"Microbial influences in inflammatory bowel diseases","volume":"134","author":"Sartor","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00248-013-0192-5","article-title":"Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods","volume":"65","author":"Delgado","year":"2013","journal-title":"Microb. Ecol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tim.2014.03.001","article-title":"Phylogeny, culturing, and metagenomics of the human gut microbiota","volume":"22","author":"Walker","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Turroni, F., Ozcan, E., Milani, C., Mancabelli, L., Viappiani, A., van Sinderen, D., Sela, D.A., and Ventura, M. (2015). Glycan cross-feeding activities between bifidobacteria under in vitro conditions. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01030"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Riviere, A., Selak, M., Lantin, D., Leroy, F., and De Vuyst, L. (2016). Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00979"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Fakharian, F., Thirugnanam, S., Welsh, D.A., Kim, W.K., Rappaport, J., Bittinger, K., and Rout, N. (2023). The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071849"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1469-0691.2012.03861.x","article-title":"Spatial and temporal variability of the human microbiota","volume":"18","author":"Parfrey","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrurol.2014.361","article-title":"The microbiome of the urinary tract\u2014A role beyond infection","volume":"12","author":"Whiteside","year":"2015","journal-title":"Nat. Rev. Urol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Kim, D.S., and Lee, J.W. (2023). Urinary Tract Infection and Microbiome. Diagnostics, 13.","DOI":"10.3390\/diagnostics13111921"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.coi.2010.06.008","article-title":"Microbiota-stimulated immune mechanisms to maintain gut homeostasis","volume":"22","author":"Chung","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e01283-01214","DOI":"10.1128\/mBio.01283-14","article-title":"The female urinary microbiome: A comparison of women with and without urgency urinary incontinence","volume":"5","author":"Pearce","year":"2014","journal-title":"mBio"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Karstens, L., Asquith, M., Davin, S., Stauffer, P., Fair, D., Gregory, W.T., Rosenbaum, J.T., McWeeney, S.K., and Nardos, R. (2016). Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?. Front. Cell. Infect. Microbiol., 6.","DOI":"10.3389\/fcimb.2016.00078"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Mestrovic, T., Matijasic, M., Peric, M., Cipcic Paljetak, H., Baresic, A., and Verbanac, D. (2020). The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010007"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Ling, Z., Kong, J., Liu, F., Zhu, H., Chen, X., Wang, Y., Li, L., Nelson, K.E., Xia, Y., and Xiang, C. (2010). Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-488"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Walther-Antonio, M.R., Jeraldo, P., Berg Miller, M.E., Yeoman, C.J., Nelson, K.E., Wilson, B.A., White, B.A., Chia, N., and Creedon, D.J. (2014). Pregnancy\u2019s stronghold on the vaginal microbiome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098514"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ijpo.12217","article-title":"The prenatal gut microbiome: Are we colonized with bacteria in utero?","volume":"12","author":"Walker","year":"2017","journal-title":"Pediatr. Obes."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Senn, V., Bassler, D., Choudhury, R., Scholkmann, F., Righini-Grunder, F., Vuille-Dit-Bile, R.N., and Restin, T. (2020). Microbial Colonization From the Fetus to Early Childhood-A Comprehensive Review. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.573735"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/NNR.0000000000000133","article-title":"The Infant Microbiome: Implications for Infant Health and Neurocognitive Development","volume":"65","author":"Yang","year":"2016","journal-title":"Nurs. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/1040841X.2021.1905606","article-title":"Sneathia: An emerging pathogen in female reproductive disease and adverse perinatal outcomes","volume":"47","author":"Theis","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"104074","DOI":"10.1016\/j.jff.2020.104074","article-title":"Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health","volume":"72","author":"Walsh","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_98","first-page":"26050","article-title":"The composition of the gut microbiota throughout life, with an emphasis on early life","volume":"26","author":"Rodriguez","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/WOX.0b013e3182784ee0","article-title":"Clinical Use of Probiotics in Pediatric Allergy (CUPPA): A World Allergy Organization Position Paper","volume":"5","author":"Fiocchi","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Smythe, P., and Wilkinson, H.N. (2023). The Skin Microbiome: Current Landscape and Future Opportunities. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043950"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13568-020-01066-8","article-title":"Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis","volume":"10","author":"Bajinka","year":"2020","journal-title":"AMB Express"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/ismej.2011.212","article-title":"The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates","volume":"6","author":"Zoetendal","year":"2012","journal-title":"ISME J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/1535370219898407","article-title":"Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet","volume":"245","author":"Qiu","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/cea.13533","article-title":"High-fat diet-induced obesity worsens TH2 immune response and immunopathologic characteristics in murine model of eosinophilic oesophagitis","volume":"50","author":"Silva","year":"2020","journal-title":"Clin. Exp. Allergy"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/ismej.2012.27","article-title":"Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations","volume":"6","author":"Zhang","year":"2012","journal-title":"ISME J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.physbeh.2016.04.029","article-title":"Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?","volume":"164","author":"Nettleton","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13073-016-0295-y","article-title":"The influence of a short-term gluten-free diet on the human gut microbiome","volume":"8","author":"Bonder","year":"2016","journal-title":"Genome Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"178.e171","DOI":"10.1016\/j.cmi.2015.10.003","article-title":"The influence of non-steroidal anti-inflammatory drugs on the gut microbiome","volume":"22","author":"Rogers","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1053\/j.gastro.2015.06.043","article-title":"Proton Pump Inhibitors Alter Specific Taxa in the Human Gastrointestinal Microbiome: A Crossover Trial","volume":"149","author":"Freedberg","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41467-019-14177-z","article-title":"Impact of commonly used drugs on the composition and metabolic function of the gut microbiota","volume":"11","author":"Collij","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ni, Q., Zhang, P., Li, Q., and Han, Z. (2022). Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases. Front. Cell. Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.849985"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00430-013-0305-2","article-title":"Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: A working hypothesis","volume":"202","author":"Bellavia","year":"2013","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/ncomms3163","article-title":"Structural modulation of gut microbiota in life-long calorie-restricted mice","volume":"4","author":"Zhang","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2016.07.008","article-title":"Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial","volume":"24","author":"Reijnders","year":"2016","journal-title":"Cell. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11882-015-0567-4","article-title":"The role of the skin microbiome in atopic dermatitis","volume":"15","author":"Williams","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/jdv.18178","article-title":"Requirements and expectations of high-quality biomarkers for atopic dermatitis and psoriasis in 2021-a two-round Delphi survey among international experts","volume":"36","author":"Ziehfreund","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"adv5671","DOI":"10.2340\/actadv.v103.5671","article-title":"Effects of Early Emollient Use in Children at High Risk of Atopic Dermatitis: A German Pilot Study","volume":"103","author":"Harder","year":"2023","journal-title":"Acta Derm. Venereol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s13555-022-00850-7","article-title":"Similarities and Differences in the Perception of Atopic Dermatitis Burden Between Patients, Caregivers, and Independent Physicians (AD-GAP Survey)","volume":"13","author":"Paller","year":"2023","journal-title":"Dermatol. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13223-018-0281-6","article-title":"Atopic dermatitis","volume":"14","author":"Kapur","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.alit.2021.07.003","article-title":"Subtypes of atopic dermatitis: From phenotype to endotype","volume":"71","author":"Tokura","year":"2022","journal-title":"Allergol. Int."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Blicharz, L., Rudnicka, L., Czuwara, J., Waskiel-Burnat, A., Goldust, M., Olszewska, M., and Samochocki, Z. (2021). The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis-An Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168403"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41435-021-00133-9","article-title":"Mechanisms of microbe-immune system dialogue within the skin","volume":"22","author":"Lunjani","year":"2021","journal-title":"Genes. Immun."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kim, K., Kim, H., and Sung, G.Y. (2022). An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042116"},{"key":"ref_125","first-page":"11","article-title":"Antimicrobial peptides in human skin disease","volume":"18","author":"Yamasaki","year":"2008","journal-title":"Eur. J. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1111\/bjd.15409","article-title":"Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis","volume":"177","author":"Li","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_127","first-page":"435","article-title":"Pathogenic role of the staphylococcal accessory gene regulator quorum sensing system in atopic dermatitis","volume":"13","author":"Tamai","year":"2023","journal-title":"Front. Cell Infect. Mi"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Ring, J., Ring, J., Przybilla, B., and Ruzicka, T. (2006). Handbook of Atopic Eczema, Springer. [2nd ed.].","DOI":"10.1007\/3-540-29856-8"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaci.2018.11.015","article-title":"The microbiome in patients with atopic dermatitis","volume":"143","author":"Paller","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1038\/s41467-019-12253-y","article-title":"Microbe-host interplay in atopic dermatitis and psoriasis","volume":"10","author":"Fyhrquist","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_131","first-page":"98","article-title":"Atopic dermatitis: Recent insight on pathogenesis and novel therapeutic target","volume":"34","author":"Banderali","year":"2016","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4168\/aair.2020.12.2.322","article-title":"Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant","volume":"12","author":"Park","year":"2020","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jaci.2017.11.045","article-title":"Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type","volume":"141","author":"Lee","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Yap, G.C., Loo, E.X., Aw, M., Lu, Q., Shek, L.P., and Lee, B.W. (2014). Molecular analysis of infant fecal microbiota in an Asian at-risk cohort-correlates with infant and childhood eczema. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-166"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/imr.12556","article-title":"The nutrition-gut microbiome-physiology axis and allergic diseases","volume":"278","author":"McKenzie","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ejcn.2012.126","article-title":"Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: A randomized controlled trial","volume":"66","author":"Jones","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1017\/S000711451200373X","article-title":"Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults","volume":"109","author":"Fuentes","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Lau, K., Srivatsav, V., Rizwan, A., Nashed, A., Liu, R., Shen, R., and Akhtar, M. (2017). Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases. Nutrients, 9.","DOI":"10.3390\/nu9080859"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.anaerobe.2010.03.005","article-title":"Effect of apple intake on fecal microbiota and metabolites in humans","volume":"16","author":"Shinohara","year":"2010","journal-title":"Anaerobe"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/mnfr.201200122","article-title":"Marie Menard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: Effects on inflammation and apoptosis","volume":"56","author":"Femia","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1136\/gutjnl-2012-303304","article-title":"Insight into the prebiotic concept: Lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women","volume":"62","author":"Dewulf","year":"2013","journal-title":"Gut"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1574-6941.12186","article-title":"Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro","volume":"87","author":"Scott","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.3390\/nu7063959","article-title":"Apples and cardiovascular health\u2014Is the gut microbiota a core consideration?","volume":"7","author":"Koutsos","year":"2015","journal-title":"Nutrients"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1007\/s00253-016-7351-9","article-title":"Inulin-type fructan fermentation by bifidobacteria depends on the strain rather than the species and region in the human intestine","volume":"100","author":"Selak","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"368736","DOI":"10.1155\/2015\/368736","article-title":"Harnessing the Microbiome to Enhance Cancer Immunotherapy","volume":"2015","author":"Nelson","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1089\/chi.2015.0194","article-title":"Relative Abundance in Bacterial and Fungal Gut Microbes in Obese Children: A Case Control Study","volume":"13","author":"Borgo","year":"2017","journal-title":"Child Obes."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.phrs.2018.11.042","article-title":"Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition","volume":"139","author":"Hu","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3389\/fimmu.2019.01341","article-title":"Fecal Microbial Transplantation and Its Potential Application in Cardiometabolic Syndrome","volume":"10","author":"Leshem","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s12276-022-00728-w","article-title":"Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q\/TNF-related protein 9 genetic deficiency","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fphar.2012.00171","article-title":"Probiotic therapy as a novel approach for allergic disease","volume":"3","author":"Toh","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_152","first-page":"926","article-title":"Prebiotics and probiotics in atopic dermatitis","volume":"18","author":"Rusu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3920\/BM2013.0040","article-title":"Impact of prebiotics and probiotics on skin health","volume":"5","author":"Tester","year":"2014","journal-title":"Benef. Microbes"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jamapediatrics.2015.3943","article-title":"Synbiotics for Prevention and Treatment of Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials","volume":"170","author":"Chang","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapediatrics.2015.4406","article-title":"Examining the Evidence for Using Synbiotics to Treat or Prevent Atopic Dermatitis","volume":"170","author":"Tang","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000501636","article-title":"Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 \u00d7 2 Factorial, Randomized, Non-Treatment Controlled Trial","volume":"180","author":"Dissanayake","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"G315","DOI":"10.1152\/ajpgi.00265.2006","article-title":"The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells","volume":"292","author":"Keller","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.det.2017.02.006","article-title":"An Update on the Pathophysiology of Atopic Dermatitis","volume":"35","author":"Malik","year":"2017","journal-title":"Dermatol. Clin."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40257-018-0404-3","article-title":"Probiotic Supplementation for Prevention of Atopic Dermatitis in Infants and Children: A Systematic Review and Meta-analysis","volume":"20","author":"Li","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Alam, M.J., Xie, L., Yap, Y.A., Marques, F.Z., and Robert, R. (2022). Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies. Pathogens, 11.","DOI":"10.3390\/pathogens11060642"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Shimamori, Y., Mitsunaka, S., Yamashita, H., Suzuki, T., Kitao, T., Kubori, T., Nagai, H., Takeda, S., and Ando, H. (2020). Staphylococcal Phage in Combination with Staphylococcus Epidermidis as a Potential Treatment for Staphylococcus Aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants. Viruses, 13.","DOI":"10.3390\/v13010007"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000473872","article-title":"Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases","volume":"9","author":"Totte","year":"2017","journal-title":"Case Rep. Dermatol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jaci.2019.05.020","article-title":"Endolysin treatment against Staphylococcus aureus in adults with atopic dermatitis: A randomized controlled trial","volume":"144","author":"Totte","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4168\/aair.2023.15.3.271","article-title":"The Effect of Prebiotics on Atopic Dermatitis","volume":"15","author":"Ahn","year":"2023","journal-title":"Allergy Asthma Immun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1002\/jsfa.12582","article-title":"Fructo-oligofructose ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions and psychiatric comorbidities in mice","volume":"103","author":"Chen","year":"2023","journal-title":"J. Sci. Food Agr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/ddg.15120","article-title":"Meta-analysis on preventive and therapeutic effects of probiotic supplementation in infant atopic dermatitis","volume":"21","author":"Steinhoff","year":"2023","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"131","DOI":"10.24425\/pjvs.2023.145014","article-title":"Clinical effects of combined Lactobacillus paracasei and kestose on canine atopic dermatitis","volume":"26","author":"Kawano","year":"2023","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4168\/aair.2022.14.5.549","article-title":"Bifidobacterium longum and Galactooligosaccharide Improve Skin Barrier Dysfunction and Atopic Dermatitis-like Skin","volume":"14","author":"Kim","year":"2022","journal-title":"Allergy Asthma Immun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.1002\/iid3.636","article-title":"Synbiotic containing extensively hydrolyzed formula improves gastrointestinal and atopic symptom severity, growth, caregiver quality of life, and hospital-related healthcare use in infants with cow\u2019s milk allergy","volume":"10","author":"Hubbard","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Effendi, R.M.R.A., Anshory, M., Kalim, H., Dwiyana, R.F., Suwarsa, O., Pardo, L.M., Nijsten, T.E.C., and Thio, H.B. (2022). Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases. Microorganisms, 10.","DOI":"10.3390\/microorganisms10122382"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.alit.2021.11.001","article-title":"Skin microbiome of atopic dermatitis","volume":"71","author":"Koh","year":"2022","journal-title":"Allergol. Int."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13555-020-00352-4","article-title":"A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review","volume":"10","author":"Wan","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Panthee, B., Gyawali, S., Panthee, P., and Techato, K. (2022). Environmental and Human Microbiome for Health. Life, 12.","DOI":"10.3390\/life12030456"}],"container-title":["Applied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3417\/13\/18\/10540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:55:12Z","timestamp":1760129712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3417\/13\/18\/10540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":173,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["app131810540"],"URL":"https:\/\/doi.org\/10.3390\/app131810540","relation":{},"ISSN":["2076-3417"],"issn-type":[{"value":"2076-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}