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On the other hand, its arrangement for 3D printing of cylindrical-shaped filaments containing drugs (to produce customized pharmaceuticals), is still scarce in the literature, and is currently an open field of research. One of the main challenges involves the manufacture of filaments that are flexible and functional, as their cylindrical shape (which is necessary for its use on FDM 3D printers) significantly increases the material\u2019s fragility. Thus, the objective of this work was to prepare and characterize E100\/Hesperidin (Hsp) filaments, and to study in vitro dissolution from Hsp active molecules of this unconventional polymeric matrix. The hybrid filaments were produced using a surface chemical treatment of the material resulting from a hot-melt extrusion process. The microstructural characterization of the filaments was performed using SEM, XRD, FTIR and ATR. The thermal analysis of the materials was performed using DSC, and the mechanical resistance was analyzed using flexural testing. The in vitro release profiles of the filament-arranged drug were evaluated in solutions of simulated gastro and intestinal fluids.<\/jats:p>","DOI":"10.3390\/app132011558","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:41:21Z","timestamp":1698025281000},"page":"11558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Eudragit E100\/Hesperidin 3D Printing Filaments: Preparation, Characterization, and In Vitro Release Studies"],"prefix":"10.3390","volume":"13","author":[{"given":"Pedro H. N.","family":"Cardoso","sequence":"first","affiliation":[{"name":"Research Group on Electrospinning and Nanotechnology Applications (GPEA-Nano), Department of Materials Science, Federal University of S\u00e3o Francisco Valley, Juazeiro 48902-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-1869","authenticated-orcid":false,"given":"Carlos Yure B.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Phycology, Department of Botany, Federal University of Santa Catarina, Florian\u00f3polis 88040-535, Brazil"}]},{"given":"Mylena","family":"Nunes","sequence":"additional","affiliation":[{"name":"Formulation & Application Services\u2014Health Care Department, Evonik Brasil Ltd., S\u00e3o Paulo 04711-904, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-9839","authenticated-orcid":false,"given":"Ginetton F.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Research and Extension Center, Laboratory of Fuels and Materials (NPE\/LACOM), Department of Chemistry, Federal University of Para\u00edba, Campus I, Jo\u00e3o Pessoa 58051-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-9766","authenticated-orcid":false,"given":"Pedro M.","family":"Faia","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering Department\u2014CEMMPRE, FCTUC, Polo 2, University of Coimbra, 3030-290 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-2368","authenticated-orcid":false,"given":"Evando S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Research Group on Electrospinning and Nanotechnology Applications (GPEA-Nano), Department of Materials Science, Federal University of S\u00e3o Francisco Valley, Juazeiro 48902-300, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejpb.2023.01.004","article-title":"Development of multifunctional drug delivery system via hot-melt extrusion paired with fused deposition modeling 3D printing techniques","volume":"183","author":"Zhang","year":"2023","journal-title":"Eur. 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