{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:44:37Z","timestamp":1760143477150,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER funds through the Operational Programme Competitiveness Factors-COMPETE","award":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"],"award-info":[{"award-number":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"]}]},{"name":"FCT, Foundation for Science and Technology","award":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"],"award-info":[{"award-number":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"]}]},{"name":"FCT and FEDER\/COMPETE","award":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"],"award-info":[{"award-number":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"],"award-info":[{"award-number":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"]}]},{"name":"FCT","award":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"],"award-info":[{"award-number":["UIDB\/00081\/2020","LA\/P\/0056\/2020","PD\/BD\/135122\/2017","CEECIND\/00823\/2021","UIDB\/50011\/2020","UIDP\/50011\/2020","LA\/P\/0006\/2020","CEECIND\/00553\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>The increasing interest in utilizing psychedelics for therapeutic purposes demands the development of tools capable of efficiently monitoring and accurately identifying these substances, thereby supporting medical interventions. 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) has gained significant popularity as one of the most widely used psychedelic compounds in non-medical settings. In this study, we aimed to create a material with selective recognition of 2C-B by synthesizing a series of molecularly imprinted polymers (MIP) using 2C-B as the template and varying ratios of methacrylic acid (MAA) as the functional monomer (1:2, 1:3, and 1:4). Both thermal and microwave-assisted polymerization processes were employed. The molar ratio between the template molecule (2C-B) and functional monomer (MAA) was 1:4, utilizing a microwave-assisted polymerization process. Isotherm studies revealed a Langmuir\u2019s maximum absorption capacity (Bmax) value of 115.6 \u03bcmol\u00b7mg\u22121 and Kd values of 26.7 \u03bcM for this material. An imprint factor of 4.2 was determined for this material, against the corresponding non-imprinted polymer. The good selectivity against 14 other new psychoactive substances highlighted the material\u2019s potential for applications requiring selective recognition. These findings can contribute to the development of tailored materials for the detection and analysis of 2C-B, supporting advancements in non-medical use monitoring and potential therapeutic models involving psychedelics.<\/jats:p>","DOI":"10.3390\/app14041377","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T11:03:14Z","timestamp":1707303794000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting 4-Bromo-2,5-dimethoxyphenethylamine (2C-B)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1317-2819","authenticated-orcid":false,"given":"Daniel","family":"Martins","sequence":"first","affiliation":[{"name":"CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-0703","authenticated-orcid":false,"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-324X","authenticated-orcid":false,"given":"Ricardo F.","family":"Mendes","sequence":"additional","affiliation":[{"name":"CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-6874","authenticated-orcid":false,"given":"Fernando","family":"Cagide","sequence":"additional","affiliation":[{"name":"CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Ant\u00f3nio Fernando","family":"Silva","sequence":"additional","affiliation":[{"name":"CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-231X","authenticated-orcid":false,"given":"Jorge","family":"Garrido","sequence":"additional","affiliation":[{"name":"CIQUP-IMS, ISEP, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2045125320967197","DOI":"10.1177\/2045125320967197","article-title":"New psychoactive substances: A review and updates","volume":"10","author":"Shafi","year":"2020","journal-title":"Ther. 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