{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:05:12Z","timestamp":1768518312073,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Bone defects may be a result of different pathologies and represent a challenge in different fields of dentistry. Techniques for the correction of bone defects involving the use of several types of grafts have been proposed. This study evaluated bone repair in rat tibiae after surgically created critical-size defects were filled with \u03b2-tricalcium phosphate (RTR\u00ae, Septodont, FR). Critical-size bone defects were created in the tibiae of 32 male Wistar rats, which were divided into four groups (n = 8): Control 30 days, Control 90 days, RTR\u00ae 30 days, and RTR\u00ae 90 days. After the experimental period, the animals were euthanized and specimens were collected, embedded in paraffin, serially cut, and stained with hematoxylin and eosin to evaluate the inflammatory and repair response. Two parameters were analyzed: neoformed bone tissue areas (NBA) and neoformed cortical areas (NCA). Statistical analysis was performed by ANOVA and Tukey\u2019s test (p &lt; 0.05). The RTR\u00ae group demonstrated superior bone healing compared with the control group in both analyzed parameters (NBA and NCA), with repair of the cortical bone and bone-tissue formation in the central region of the defect, which showed partial repair in the defect area (p &lt; 0.05). RTR\u00ae enhanced bone neoformation in the adopted experimental model and may be a useful biomaterial to boost healing in cases of critical-size bone defects.<\/jats:p>","DOI":"10.3390\/app14093821","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:14:31Z","timestamp":1714464871000},"page":"3821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histological Bone-Healing Evaluation of Critical-Size Defects Filled with \u03b2-Tricalcium Phosphate in Rat Tibiae"],"prefix":"10.3390","volume":"14","author":[{"given":"Ana Maria Veiga","family":"Vasques","sequence":"first","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-2823","authenticated-orcid":false,"given":"Carlos Roberto Emerenciano","family":"Bueno","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]},{"given":"Maria Rosa Felix de Souza Gomide","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Dentistry, School of Dentistry, University Center S\u00e3o Lucas, Porto Velho 76805-846, RO, Brazil"}]},{"given":"Diego","family":"Valentim","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7570-6126","authenticated-orcid":false,"given":"Ana Cl\u00e1udia Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]},{"given":"Francine","family":"Benetti","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-9689","authenticated-orcid":false,"given":"Jo\u00e3o Miguel Marques","family":"Santos","sequence":"additional","affiliation":[{"name":"Institute of Endodontics, Faculty of Medicine, University Coimbra, 3004-531 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]},{"given":"Eloi","family":"Dezan Junior","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1600-0501.2004.01055.x","article-title":"Histomorphometry of human sinus floor augmentation using a porous beta-tricalcium phosphate: A prospective study","volume":"15","author":"Zerbo","year":"2004","journal-title":"Clin. 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