{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:58:03Z","timestamp":1760241483779,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Patients with cleft lip and palate (CLP) have several oral alterations that make the removal of bacterial plaque in the cleft area difficult, which is the main cause of the high incidence of oral health problems. The aim of this study is to develop a toothbrush especially designed to perform the hygiene of the cleft area. This device, called Cleft Toothbrush, is an add-on to a conventional toothbrush to clean hard-to-reach areas that are not accessible by using conventional brush shapes. The design was made in SOLIDWORKS\u00ae (Waltham, MA, USA) 3D and a sample of this device was produced by CURAPROX (Kriens, Switzerland). The efficacy of the Cleft Toothbrush was tested in a preliminary study performed in a four years old child with CLP, compared to that of a conventional toothbrush. A significantly higher reduction of the bacterial plaque was achieved with the Cleft Toothbrush. The child\u2019s parents also felt more confident with this device, as it deals better with sensitive areas, as it did not hurt the child. This innovative toothbrush adapter appears to greatly improve the cleaning areas of high bacterial plaque retention in patients with CLP, together with excellent acceptance.<\/jats:p>","DOI":"10.3390\/app8040576","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T13:06:08Z","timestamp":1523365568000},"page":"576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New Instrument for Oral Hygiene of Children with Cleft Lip and Palate"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-6993","authenticated-orcid":false,"given":"Rita","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, University of Porto, R. Dr. Manuel Pereira da Silva, 93, 4200-393 Porto, Portugal"},{"name":"Faculty of Health Sciences, University Fernando Pessoa, Pra\u00e7a 9 de Abril, 349, 4249-004 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-9574","authenticated-orcid":false,"given":"Maria","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of Porto, R. Dr. Manuel Pereira da Silva, 93, 4200-393 Porto, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV\/REQUIMTE), University of Porto, 4051-401 Porto, Portugal"}]},{"given":"Ant\u00f3nio","family":"Bessa Monteiro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, s\/n, 4200-319 Porto, Portugal"}]},{"given":"Rowney","family":"Furfuro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, s\/n, 4200-319 Porto, Portugal"}]},{"given":"C\u00e1tia","family":"Carvalho Silva","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Fernando Pessoa, Pra\u00e7a 9 de Abril, 349, 4249-004 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-5282","authenticated-orcid":false,"given":"C\u00e9sar","family":"Soares","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s\/n, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-2882","authenticated-orcid":false,"given":"Ricardo","family":"Vardasca","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s\/n, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-1879","authenticated-orcid":false,"given":"Joaquim","family":"Mendes","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s\/n, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-1337","authenticated-orcid":false,"given":"Maria","family":"Manso","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV\/REQUIMTE), University of Porto, 4051-401 Porto, Portugal"},{"name":"Faculty of Health Sciences, University Fernando Pessoa, Fernando Pessoa Energy, Environment and Health Research Unit (FP-ENAS), Pra\u00e7a de 9 de Abril, 349, 4249-004 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/jmedgenet-2012-101013","article-title":"A systematic review of associated structural and chromosomal defects in oral clefts: When is prenatal genetic analysis indicated?","volume":"49","author":"Maarse","year":"2012","journal-title":"J. Med. Genet."},{"key":"ref_2","unstructured":"Sadler, T.W. (2012). 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