{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:36:26Z","timestamp":1768714586882,"version":"3.49.0"},"reference-count":85,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Camellia sinensis is the most consumed beverage worldwide. It contains a wide variety of secondary metabolites, such as alkaloids, saponins, tannins, catechins, and polyphenols, generated through a condensation reaction of cinnamic acid with three malonyl-CoA groups. In addition to the metabolic processes occurring within this plant, there are also some plant-associated bacterial endophytes. These bacteria reside in the living tissues of the host plants without causing any harmful effect to them, thereby stimulating secondary metabolite production with a diverse range of biological effects. Omics technologies reveal understanding of the biological phenomena of transcriptomics, proteomics, and metabolomics. In this sense, the present review aims to provide a comprehensive review of various methods used to identify distinct plant compounds, namely transcriptomic, proteomic, and metabolomic analysis. The role of endophytic bacteria in C. sinensis metabolism, and C. sinensis antioxidant and antimicrobial effects, are also carefully highlighted.<\/jats:p>","DOI":"10.3390\/app9020281","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T12:20:07Z","timestamp":1547468407000},"page":"281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Understanding Camellia sinensis using Omics Technologies along with Endophytic Bacteria and Environmental Roles on Metabolism: A Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-0622","authenticated-orcid":false,"given":"Phumudzo","family":"Tshikhudo","sequence":"first","affiliation":[{"name":"Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X6, Florida 1710, South Africa"}]},{"given":"Khayalethu","family":"Ntushelo","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X6, Florida 1710, South Africa"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-6421","authenticated-orcid":false,"given":"Fhatuwani","family":"Mudau","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X6, Florida 1710, South Africa"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-9797","authenticated-orcid":false,"given":"Bahare","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran"}]},{"given":"Mehdi","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto\u2013Portugal, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, VIII-Bio Bio Region, Concepcion 4070386, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan 3519899951, Iran"},{"name":"Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.foodres.2012.07.057","article-title":"Antioxidant activity of white, green and black tea obtained from the same tea cultivar","volume":"53","author":"Carloni","year":"2013","journal-title":"Food Res. 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