{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:45:21Z","timestamp":1776109521161,"version":"3.50.1"},"reference-count":236,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycosides, furanocoumarins, furocoumarin, limonene, psoralen, xanthotoxin, and selinene. Some of their pharmacological properties include anticancer, antioxidant, antimicrobial, antifungal, nematocidal, anti-rheumatism, antiasthma, anti-bronchitis, hepatoprotective, appetizer, anticonvulsant, antispasmodic, breast milk inducer, anti-jaundice, antihypertensive, anti-dysmenorrhea, prevention of cardiovascular diseases, and spermatogenesis induction. The present review summarizes data on ecology, botany, cultivation, habitat, medicinal use, phytochemical composition, preclinical and clinical pharmacological efficacy of Apium plants and provides future direction on how to take full advantage of Apium plants for the optimal benefit to mankind.<\/jats:p>","DOI":"10.3390\/app9173547","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T11:26:22Z","timestamp":1567077982000},"page":"3547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Apium Plants: Beyond Simple Food and Phytopharmacological Applications"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-9797","authenticated-orcid":false,"given":"Bahare","family":"Salehi","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-6739","authenticated-orcid":false,"given":"Alessandro","family":"Venditti","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Universit\u00e0 di Roma \u201cLa Sapienza\u201d, Piazzale Aldo Moro 5, 00185 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-5264","authenticated-orcid":false,"given":"Claudio","family":"Frezza","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Ambientale, Universit\u00e0 di Roma \u201cLa Sapienza\u201d, Piazzale Aldo Moro 5, 00185 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-6323","authenticated-orcid":false,"given":"Aysun","family":"Y\u00fccetepe","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Engineering, Aksaray University, Aksaray 68100, Turkey"}]},{"given":"\u00dcmit","family":"Altunta\u015f","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}]},{"given":"Sibel","family":"Uluata","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Inonu University, Malatya 44280, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-5000","authenticated-orcid":false,"given":"Monica","family":"Butnariu","sequence":"additional","affiliation":[{"name":"Chemistry &amp; Biochemistry Discipline, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645, Calea Aradului 119, Timis, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-2102","authenticated-orcid":false,"given":"Ioan","family":"Sarac","sequence":"additional","affiliation":[{"name":"Chemistry &amp; Biochemistry Discipline, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645, Calea Aradului 119, Timis, Romania"}]},{"given":"Shabnum","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Chemotaxonomic Lab., Lahore College for Women University, Lahore 54000, Pakistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-7960","authenticated-orcid":false,"given":"Spyridon","family":"A. Petropoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Vegetable Production, University of Thessaly, Fytokou Street, 38446 N. Ionia, Magnissia, Greece"}]},{"given":"Karl","family":"R. Matthews","sequence":"additional","affiliation":[{"name":"Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA"}]},{"given":"Ceyda","family":"Sibel K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara 06100, Turkey"}]},{"given":"Maria","family":"Atanassova","sequence":"additional","affiliation":[{"name":"Scientific Consulting, Chemical Engineering, UCTM, P.O. Box 1756 Sofia, Bulgaria"}]},{"given":"Charles","family":"Oluwaseun Adetunji","sequence":"additional","affiliation":[{"name":"Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University, Iyamho, Edo State 300271, Nigeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-1304","authenticated-orcid":false,"given":"Adedayo","family":"Oluwaseun Ademiluyi","sequence":"additional","affiliation":[{"name":"Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria"}]},{"given":"Beraat","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"},{"name":"Bioactive Research &amp; Innovation Food Manufac. Indust. Trade Ltd., Katar Street, Teknokent ARI-3, B110, Sar\u0131yer, Istanbul 34467, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-3527","authenticated-orcid":false,"given":"Patrick","family":"Valere Tsouh Fokou","sequence":"additional","affiliation":[{"name":"Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde, Cameroon"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William","family":"C. Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.foodchem.2009.10.013","article-title":"Effect of enzymes on extraction of volatiles from celery seeds","volume":"120","author":"Sowbhagya","year":"2010","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Malhotra, S.K. (2012). Celery. Handbook of Herbs and Spices, Woodhead Publishing Limited. 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