{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:31:52Z","timestamp":1768444312644,"version":"3.49.0"},"reference-count":73,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior) and FAPESP (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo)","award":[":"],"award-info":[{"award-number":[":"]}]},{"name":"Portuguese Science and Technology Foundation (FCT\/MCT) and  European Funds (PRODER\/COMPETE)","award":["M-ERA-NET-0004\/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020"],"award-info":[{"award-number":["M-ERA-NET-0004\/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>A new method based on reverse-phase HPLC combined with photodiode array (PDA) was developed to quantify the release of trans-resveratrol (tRES) from solid lipid nanoparticles (SLN). The mobile phase was composed of 75:0:25 (V\/V) water\/methanol\/acetonitrile at 0\u20133.5 min, 32.5:30.0:37.5 (V\/V) water\/methanol\/acetonitrile at 3.6\u20135.8 min, and 75:0:25 (V\/V) water\/methanol\/acetonitrile at 5.9\u201310 min. The flow rate was set at 1.0\u2009mL\/min, and tRES was detected at the wavelength of 306.6 nm. A concentration range of 1\u2013100 \u00b5g\/mL was used to obtain the linear calibration curve. SLN were produced by ultrasound technique to load 0.1% (wt\/wt) of tRES, and the in vitro release of the drug was run in modified Franz diffusion cells. The mean recovery of tRES was found to be 96.84 \u00b1 0.32%. The intra-assay and inter-assay coefficients of variation were less than 5%. The proposed method was applied to in vitro permeability studies, and the Weibull model was found to be the one that best fits the tRES release, which is characterized by a simultaneous lipid chain relaxation and erosion during drug release.<\/jats:p>","DOI":"10.3390\/app9224961","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T11:18:48Z","timestamp":1574075928000},"page":"4961","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Quantification of Trans-Resveratrol-Loaded Solid Lipid Nanoparticles by a Validated Reverse-Phase HPLC Photodiode Array"],"prefix":"10.3390","volume":"9","author":[{"given":"Roberta B.","family":"Rigon","sequence":"first","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Rod. Araraquara-Ja\u00fa, km 1, 14801-902 Araraquara, S\u00e3o Paulo, Araraquara, Brazil"}]},{"given":"Naiara","family":"Fachinetti","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Rod. Araraquara-Ja\u00fa, km 1, 14801-902 Araraquara, S\u00e3o Paulo, Araraquara, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"Tiradentes Institute, University of Tiradentes (Unit) and Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, 49010-390 Aracaju-SE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-9107","authenticated-orcid":false,"given":"Alessandra","family":"Durazzo","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"given":"Massimo","family":"Lucarini","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-0967","authenticated-orcid":false,"given":"Atanas G.","family":"Atanasov","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria"},{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev str., 1113 Sofia, Bulgaria"}]},{"given":"Soukaina","family":"El Mamouni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-0545","authenticated-orcid":false,"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Rod. Araraquara-Ja\u00fa, km 1, 14801-902 Araraquara, S\u00e3o Paulo, Araraquara, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-3327","authenticated-orcid":false,"given":"Antonello","family":"Santini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"ref_1","first-page":"103","article-title":"Resveratrol, a popular dietary supplement for human and animal health","volume":"37","author":"Yeung","year":"2019","journal-title":"Anim. Sci. 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