{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:42:48Z","timestamp":1772196168276,"version":"3.50.1"},"reference-count":112,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["PTDC\/OCE-ETA\/32567\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/32567\/2017"]}]},{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]},{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["PD\/00193\/2012"],"award-info":[{"award-number":["PD\/00193\/2012"]}]},{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"national funds from the Portuguese National Funding Agency, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-MCTES)","award":["UIDB\/00068\/2020"],"award-info":[{"award-number":["UIDB\/00068\/2020"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["PTDC\/OCE-ETA\/32567\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/32567\/2017"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["PD\/00193\/2012"],"award-info":[{"award-number":["PD\/00193\/2012"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"Radiation Biology and Biophysics Doctoral Training Program","award":["UIDB\/00068\/2020"],"award-info":[{"award-number":["UIDB\/00068\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Biosciences"],"abstract":"<jats:p>Growing demands for sustainable and ecological nanoparticle synthesis methods have incentivized the scientific community to develop new approaches to counteract these challenges. Green synthesis resorts to biocomponents obtained from plants, bacteria, fungi, and other organisms to synthesize nanostructures, with beneficial gains in the economic and ecological cost associated with the process, simplicity of the process, and resource efficiency. Moringa oleifera, a native plant originally from India with immense nutritive value, has long been used by researchers in the biosynthesis of nanoparticles. Leaves, flowers, bark, and seeds are among the \u201cmiracle tree\u201d parts that can be used in nanoparticle green synthesis. Moringa oleifera seed cake, a by-product obtained from defatted seeds, is often overlooked due to its apparent low commercial value. The main objective of this review is to highlight the recent findings reported in the literature on nanoparticles\/nanocomposites synthesized with seed cake biocompounds acting as reducing\/capping agents. Furthermore, we analyzed the methods currently employed for the extraction of bioactive compounds. Moringa oleifera seed for industrial applications was also addressed.<\/jats:p>","DOI":"10.3390\/applbiosci3020013","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:06:38Z","timestamp":1714651598000},"page":"197-212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Moringa oleifera Seed Cake: A Review on the Current Status of Green Nanoparticle Synthesis"],"prefix":"10.3390","volume":"3","author":[{"given":"Nuno","family":"Coelho","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-6073","authenticated-orcid":false,"given":"Alice S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-2661","authenticated-orcid":false,"given":"Pedro","family":"Tavares","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.apjtm.2017.07.002","article-title":"Research advances on the multiple uses of Moringa oleifera: A sustainable alternative for socially neglected population","volume":"10","author":"Brilhante","year":"2017","journal-title":"Asian Pac. 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