{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:58:13Z","timestamp":1778299093381,"version":"3.51.4"},"reference-count":266,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Biosciences"],"abstract":"<jats:p>The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate is highly favorable to the synthesis of phenolic compounds, stored in olive leaves; their consumption has been linked to a lower incidence of cancer and cardiovascular disorders for which the research interest upon this feature has increased in last decade. This study aimed (i) to review evidence about the importance of olive leaf extract (OLE) on human health and the physiological effect of its major compounds; (ii) to update the state of the art of studies conducted on the health and technological usage of olive leaf extract; (iii) to report potential uses of OLE in pharmaceuticals, food production, and cosmetics; and (iv) to prospect the future of clinical applications of OLE from diverse cultivars, especially in metabolic inflammatory conditions such as polycystic ovary syndrome (PCOS). Overall, cultivars richer in TPC, including TFC, \u03b1T, omega-3 and omega-9, present a main research target for supplementation alone or in conjunction with vitaminic compounds, due to their nutraceutical value in metabolic disorders, chronic inflammatory diseases, and anti-aging treatments, whereas cultivars with less water content might be useful as substrates for food preservation. With regard to future prospects, it would be of great interest to clarify the specific mechanisms underlying the beneficial effects of OLE on neuro-immune and cardiovascular health to design safer and healthier nature-based medicine for a wide array of costly and highly prevalent chronic diseases, such as inflammatory and metabolic-related syndromes, namely, PCOS.<\/jats:p>","DOI":"10.3390\/applbiosci3030026","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T11:40:27Z","timestamp":1727350827000},"page":"392-425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review"],"prefix":"10.3390","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-6338","authenticated-orcid":false,"given":"Nat\u00e1lia M.","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Applied Physiology, ICBAS.UP\u2014School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health-CBSin, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-5445","authenticated-orcid":false,"given":"Jorge","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, ICBAS.UP\u2014School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health-CBSin, 4250-105 Porto, Portugal"}]},{"given":"Maria Helena","family":"Ch\u00e9u","sequence":"additional","affiliation":[{"name":"Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget\u2014ISEIT, Estrada do Alto Gaio, 3515-776 Lordosa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-0715","authenticated-orcid":false,"given":"Lara","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, ICBAS.UP\u2014School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health-CBSin, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-5614","authenticated-orcid":false,"given":"Maria Bego\u00f1a","family":"Criado","sequence":"additional","affiliation":[{"name":"Centre of Biosciences in Integrative Health-CBSin, 4250-105 Porto, Portugal"},{"name":"1H-TOXRUN\u2014One Health Toxicology Research Unit, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13098-022-00920-y","article-title":"The effects of olive leaf extract on cardiovascular risk factors in the general adult population: A systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Razmpoosh","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vijakumaran, U., Shanmugam, J., Heng, J.W., Azman, S.S., Yazid, M.D., Abdullah, N.A.H., and Sulaiman, N. (2023). Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review. Molecules, 28.","DOI":"10.3390\/molecules28041861"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Souabi, S., and Anouzla, A. (2023). Present and Future Perspectives on the Use of Olive-Oil Mill Wastewater in Food Applications. Wastewater from Olive Oil Production: Environmental Impacts, Treatment and Valorisation, Springer. [1st ed.].","DOI":"10.1007\/978-3-031-23449-1"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Barazani, O., Dag, A., and Dunseth, Z. (2023). The history of olive cultivation in the southern Levant. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1131557"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Medda, S., Fadda, A., and Mulas, M. (2022). Influence of Climate Change on Metabolism and Biological Characteristics in Perennial Woody Fruit Crops in the Mediterranean Environment. Horticulturae, 8.","DOI":"10.3390\/horticulturae8040273"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Petruccelli, R., Bartolini, G., Ganino, T., Zelasco, S., Lombardo, L., Perri, E., Durante, M., and Bernardi, R. (2022). Cold Stress, Freezing Adaptation, Varietal Susceptibility of Olea europaea L.: A Review. Plants, 11.","DOI":"10.3390\/plants11101367"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1177\/0959683619826654","article-title":"The origin and spread of olive cultivation in the Mediterranean Basin: The fossil pollen evidence","volume":"29","author":"Langgut","year":"2019","journal-title":"Holocene"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/nph.13181","article-title":"Olive domestication and diversification in the Mediterranean Basin","volume":"206.1","author":"Diez","year":"2015","journal-title":"New Phytol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Saddoud Debbabi, O., Rahmani Mnasri, S., Ben Amar, F., Ben Naceur, M., Montemurro, C., and Miazzi, M.M. (2021). Applications of Microsatellite Markers for the Characterization of Olive Genetic Resources of Tunisia. Genes, 12.","DOI":"10.3390\/genes12020286"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Passeri, V., Sammut, C., Mifsud, D., Domesi, A., Stanzione, V., Baldoni, L., Mousavi, S., Mariotti, R., Pandolfi, S., and Cinosi, N. (2023). The Ancient Olive Trees (Olea europaea L.) of the Maltese Islands: A Rich and Unexplored Patrimony to Enhance Oliviculture. Plants, 12.","DOI":"10.3390\/plants12101988"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-G\u00e1lvez, F.J., Ninot, A., Rodr\u00edguez, J.C., Compa\u00f1, S.P., Andreva, J.U., Rubio, J.A.G., Arag\u00f3n, I.P., Vi\u00f1uales-Andreu, J., Casanova-Gasc\u00f3n, J., and \u0160atovi\u0107, Z. (2024). New insights in the Spanish gene pool of olive (Olea europaea L.) preserved ex situ and in situ based on high-throughput molecular markers. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1267601"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Khadari, B., El Bakkali, A., Essalouh, L., Tollon, C., Pinatel, C., and Besnard, G. (2019). Cultivated Olive Diversification at Local and Regional Scales: Evidence From the Genetic Characterization of French Genetic Resources. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.01593"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Brito, C., Dinis, L.-T., Moutinho-Pereira, J., and Correia, C.M. (2019). Drought Stress Effects and Olive Tree Acclimation under a Changing Climate. Plants, 8.","DOI":"10.3390\/plants8070232"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nicol\u00ec, F., Negro, C., Vergine, M., Aprile, A., Nutricati, E., Sabella, E., Miceli, A., Luvisi, A., and De Bellis, L. (2019). Evaluation of phytochemical and antioxidant properties of 15 Italian Olea europaea L. cultivar leaves. Molecules, 24.","DOI":"10.3390\/molecules24101998"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125243","DOI":"10.1016\/j.foodchem.2019.125243","article-title":"Multivariate approach to assess the chemical composition of Italian virgin olive oils as a function of variety and harvest period","volume":"300","author":"Deiana","year":"2019","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Selim, S., Albqmi, M., Al-Sanea, M.M., Alnusaire, T.S., Almuhayawi, M.S., AbdElgawad, H., Al Jaouni, S.K., Elkelish, A., Hussein, S., and Warrad, M. (2022). Valorizing the usage of olive leaves, bioactive compounds, biological activities, and food applications: A comprehensive review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1008349"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez, E.M., Brenes, M., Romero, C., and Medina, E. (2023). Olive Leaf Processing for Infusion Purposes. Foods, 12.","DOI":"10.3390\/foods12030591"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., and Bernini, R. (2019). Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.. Nutrients, 11.","DOI":"10.3390\/nu11081776"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ronca, C.L., Duque-Soto, C., Samaniego-S\u00e1nchez, C., Morales-Hern\u00e1ndez, M.E., Olalla-Herrera, M., Lozano-S\u00e1nchez, J., and Mart\u00ednez, R.G. (2024). Exploring the Nutritional and Bioactive Potential of Olive Leaf Residues: A Focus on Minerals and Polyphenols in the Context of Spain\u2019s Olive Oil Production. Foods, 13.","DOI":"10.3390\/foods13071036"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"142508","DOI":"10.1016\/j.scitotenv.2020.142508","article-title":"Harvesting system sustainability in Mediterranean olive cultivation: Other principal cultivar","volume":"766","author":"Bernardi","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cuffaro, D., Bertini, S., Macchia, M., and Digiacomo, M. (2023). Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment. Nutrients, 15.","DOI":"10.3390\/nu15051073"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/joim.13333","article-title":"The Mediterranean diet and health: A comprehensive overview","volume":"290","author":"Willett","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Parri, S., Cai, G., Romi, M., Cantini, C., Pinto, D.C.G.A., Silva, A.M.S., and Dias, M.C.P. (2024). Comparative metabolomics of leaves and stems of three Italian olive cultivars under drought stress. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1408731"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Giudice, V.L., Faraone, I., Bruno, M.R., Ponticelli, M., Labanca, F., Bisaccia, D., Massarelli, C., Milella, L., and Todaro, L. (2021). Olive Trees By-Products as Sources of Bioactive and Other Industrially Useful Compounds: A Systematic Review. Molecules, 26.","DOI":"10.3390\/molecules26165081"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6125638","DOI":"10.1155\/2020\/6125638","article-title":"Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity","volume":"2020","author":"Giacometti","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sadgrove, N.J., and Jones, G.L. (2020). From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02470"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, J., Chen, J., Xu, J., Xue, C., and Mao, Z. (2023). Plant-derived compounds for treating autosomal dominant polycystic kidney disease. Front. Nephrol., 3.","DOI":"10.3389\/fneph.2023.1071441"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"707","DOI":"10.21873\/invivo.11529","article-title":"Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice","volume":"33","author":"Jung","year":"2019","journal-title":"In Vivo"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Romero-M\u00e1rquez, J.M., Forbes-Hern\u00e1ndez, T.Y., Navarro-Hortal, M.D., Quirantes-Pin\u00e9, R., Grosso, G., Giampieri, F., Lipari, V., S\u00e1nchez-Gonz\u00e1lez, C., Battino, M., and Quiles, J.L. (2023). Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054353"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1039\/C9FO00698B","article-title":"Characterization of bioactive compounds in commercial olive leaf extracts, and olive leaves and their infusions","volume":"10","author":"Medina","year":"2019","journal-title":"Food Funct."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"402993","DOI":"10.1016\/j.mrgentox.2018.12.001","article-title":"Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro","volume":"845","author":"Dekanski","year":"2019","journal-title":"Mutat. Res. Toxicol. Environ. Mutagen."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pang, K.L., Lumintang, J.N., and Chin, K.Y. (2021). Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13020529"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1080\/19390211.2021.1914267","article-title":"Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats","volume":"19","author":"Abdelkarem","year":"2022","journal-title":"J. Diet. Suppl."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Romero-M\u00e1rquez, J.M., Navarro-Hortal, M.D., Forbes-Hern\u00e1ndez, T.Y., Varela-L\u00f3pez, A., Puentes, J.G., Del Pino-Garc\u00eda, R., S\u00e1nchez-Gonz\u00e1lez, C., Elio, I., Battino, M., and Garc\u00eda, R. (2023). Exploring the Antioxidant, Neuroprotective, and Anti-Inflammatory Potential of Olive Leaf Extracts from Spain, Portugal, Greece, and Italy. Antioxidants, 12.","DOI":"10.3390\/antiox12081538"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Losada-Echeberr\u00eda, M., Naranjo, G., Malouche, D., Taamalli, A., Barraj\u00f3n-Catal\u00e1n, E., and Micol, V. (2022). Influence of Drying Temperature and Harvesting Season on Phenolic Content and Antioxidant and Antiproliferative Activities of Olive (Olea europaea) Leaf Extracts. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010054"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1002\/ptr.7587","article-title":"Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition","volume":"36","author":"Ercolano","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s11262-022-01934-4","article-title":"Identification and complete genome sequencing of a divergent olive virus T isolate and an olive leaf yellowing-associated virus isolate naturally infecting olive trees in Greece","volume":"58","author":"Katsiani","year":"2022","journal-title":"Virus Genes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/1541-4337.12882","article-title":"Olive byproducts and their bioactive compounds as a valuable source for food packaging applications","volume":"21","author":"Khwaldia","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/ics.12742","article-title":"Olive leaf-derived PPAR agonist complex induces collagen IV synthesis in human skin models","volume":"43","author":"Majewski","year":"2021","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63102","DOI":"10.1007\/s11356-021-15240-3","article-title":"Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats","volume":"28","author":"Ahmed","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rishmawi, S., Haddad, F., Dokmak, G., and Karaman, R. (2022). A Comprehensive Review on the Anti-Cancer Effects of Oleuropein. Life, 12.","DOI":"10.3390\/life12081140"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Feng, S., Zhang, C., Liu, L., Xu, Z., Chen, T., Zhou, L., Yuan, M., Li, T., and Ding, C. (2021). Comparison of Phenolic Compounds in Olive Leaves by Different Drying and Storage Methods. Separations, 8.","DOI":"10.3390\/separations8090156"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"C\u00f6r Andrej\u010d, D., Butinar, B., Knez, \u017d., Toma\u017ei\u010d, K., and Knez Marevci, M. (2022). The Effect of Drying Methods and Extraction Techniques on Oleuropein Content in Olive Leaves. Plants, 11.","DOI":"10.3390\/plants11070865"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e22217","DOI":"10.1016\/j.heliyon.2023.e22217","article-title":"Comparative chemical composition and antioxidant activity of olive leaves Olea europaea L. of Tunisian and Algerian varieties","volume":"9","author":"Khelouf","year":"2023","journal-title":"Heliyon"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1007\/s13197-019-03904-5","article-title":"Nutritional profile and nutraceutical components of olive (Olea europaea L.) seeds","volume":"56","author":"Maestri","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Borjan, D., Leitgeb, M., Knez, \u017d., and Hrn\u010di\u010d, M.K. (2020). Microbiological and Antioxidant Activity of Phenolic Compounds in Olive Leaf Extract. Molecules, 25.","DOI":"10.3390\/molecules25245946"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Se\u00e7meler, \u00d6., and Galanakis, C.M. (2019). Olive fruit and olive oil. Innovations in Traditional Foods, Woodhead Publishing.","DOI":"10.1016\/B978-0-12-814887-7.00008-3"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"140042","DOI":"10.1016\/j.foodchem.2024.140042","article-title":"Olive tree leaves as A great source of phenolic compounds: Comprehensive profiling of NADES extracts","volume":"456","author":"Granados","year":"2024","journal-title":"Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zakraoui, M., Hannachi, H., Paskovi\u0107, I., Vidovi\u0107, N., Paskovi\u0107, M.P., Pal\u010di\u0107, I., Major, N., Ban, S.G., and Hamrouni, L. (2023). Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves. Foods, 12.","DOI":"10.3390\/foods12132565"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"de Oliveira, N.M., Machado, J., Ch\u00e9u, M.H., Lopes, L., Barroso, M.F., Silva, A., Sousa, S., Domingues, V.F., and Grosso, C. (2024). Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles. Pharmaceuticals, 17.","DOI":"10.3390\/ph17030274"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1590\/0103-8478cr20131139","article-title":"Chemical composition of olive leaves (Olea europaea L.) from the region of cacapava do Sul, RS, Brazil\/Composicao quimica de folhas de oliveira (Olea europaea L.) da regiao de cacapava do Sul, RS","volume":"44","author":"Cavalheiro","year":"2014","journal-title":"Ci\u00eancia Rural"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ferreira, D.M., de Oliveira, N.M., Ch\u00e9u, M.H., Meireles, D., Lopes, L., Oliveira, M.B., and Machado, J. (2023). Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea. Plants, 12.","DOI":"10.3390\/plants12030688"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gulisano, M., Consoli, V., Sorrenti, V., and Vanella, L. (2024). Red Oranges and Olive Leaf Waste-Derived Bioactive Extracts Promote Adipocyte Functionality In Vitro. Nutrients, 16.","DOI":"10.3390\/nu16121959"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2023.07.010","article-title":"A novel polyphenol-rich combination of 5 plant extracts prevents high-fat diet-induced body weight gain by regulating intestinal macronutrient absorption in mice","volume":"118","author":"Chavanelle","year":"2023","journal-title":"Nutr. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16346","DOI":"10.1007\/s11356-022-23341-w","article-title":"Olive leaf (Olea europaea L. folium) extract influences liver microsomal detoxifying enzymes in rats orally exposed to 2-amino-l-methyI-6-phenyI-imidazo pyridine (PhIP)","volume":"30","author":"Abulnaja","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e11173","DOI":"10.7717\/peerj.11173","article-title":"Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: A systematic review and meta-analysis","volume":"9","author":"Ismail","year":"2021","journal-title":"PeerJ"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"\u00c1lvares, A.A., Garc\u00eaz, A., Silva, L.T., Averbuch, N., and Garavaglia, J. (2024). Olive leaf extract effect on cardiometabolic risk factors: A systematic review and meta-analysis of randomized clinical trials. Nutr. Rev., nuad164.","DOI":"10.1093\/nutrit\/nuad164"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Magyari-Pavel, I.Z., Moac\u0103, E.-A., Avram, \u0218., Diaconeasa, Z., Haidu, D., \u0218tef\u0103nu\u021b, M.N., Rostas, A.M., Muntean, D., Bora, L., and Badescu, B. (2024). Antioxidant Extracts from Greek and Spanish Olive Leaves: Antimicrobial, Anticancer and Antiangiogenic Effects. Antioxidants, 13.","DOI":"10.3390\/antiox13070774"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"\u0160imat, V., Skroza, D., Tabanelli, G., \u010cagalj, M., Pasini, F., G\u00f3mez-Caravaca, A.M., Fern\u00e1ndez-Fern\u00e1ndez, C., Sterni\u0161a, M., Mo\u017eina, S.S., and Ozogul, Y. (2022). Antioxidant and Antimicrobial Activity of Hydroethanolic Leaf Extracts from Six Mediterranean Olive Cultivars. Antioxidants, 11.","DOI":"10.3390\/antiox11091656"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhang, C., Xin, X., Zhang, J., Zhu, S., Niu, E., Zhou, Z., and Liu, D. (2022). Comparative Evaluation of the Phytochemical Profiles and Antioxidant Potentials of Olive Leaves from 32 Cultivars Grown in China. Molecules, 27.","DOI":"10.3390\/molecules27041292"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Paskovi\u0107, I., Luki\u0107, I., \u017durga, P., Germek, V.M., Brklja\u010da, M., Koprivnjak, O., Major, N., Grozi\u0107, K., Frani\u0107, M., and Ban, D. (2020). Temporal Variation of Phenolic and Mineral Composition in Olive Leaves Is Cultivar Dependent. Plants, 9.","DOI":"10.3390\/plants9091099"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Navarro, M.E., Cebri\u00e1n-Taranc\u00f3n, C., Alonso, G.L., and Salinas, M.R. (2021). Determination of the Variability of Bioactive Compounds and Minerals in Olive Leaf along an Agronomic Cycle. Agronomy, 11.","DOI":"10.3390\/agronomy11122447"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Borghini, F., Tamasi, G., Loiselle, S.A., Baglioni, M., Ferrari, S., Bisozzi, F., Costantini, S., Tozzi, C., Riccaboni, A., and Rossi, C. (2024). Phenolic Profiles in Olive Leaves from Different Cultivars in Tuscany and Their Use as a Marker of Varietal and Geographical Origin on a Small Scale. Molecules, 29.","DOI":"10.3390\/molecules29153617"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/jsfa.10758","article-title":"Development and validation of an HPLC-DAD method for determination of oleuropein and other bioactive compounds in olive leaf by-products","volume":"101","author":"Lorenzo","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kabbash, E.M., Abdel-Shakour, Z.T., El-Ahmady, S.H., Wink, M., and Ayoub, I.M. (2023). Comparative metabolic profiling of olive leaf extracts from twelve different cultivars collected in both fruiting and flowering seasons. Sci. Rep., 13.","DOI":"10.1038\/s41598-022-27119-5"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"112752","DOI":"10.1016\/j.fct.2021.112752","article-title":"Protective effect of olive leaves phenolic compounds against neurodegenerative disorders: Promising alternative for Alzheimer and Parkinson diseases modulation","volume":"159","author":"Hadrich","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Villalva, M., Silvan, J.M., Guerrero-Hurtado, E., Gutierrez-Docio, A., del Hierro, J.N., Alarc\u00f3n-Cavero, T., Prodanov, M., Martin, D., and Martinez-Rodriguez, A.J. (2022). Influence of In Vitro Gastric Digestion of Olive Leaf Extracts on Their Bioactive Properties against H. pylori. Foods, 11.","DOI":"10.3390\/foods11131832"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s13668-021-00350-8","article-title":"The Anti-cancer Effect of Olea europaea L. Products: A Review","volume":"10","author":"Antoniou","year":"2021","journal-title":"Curr. Nutr. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Morandi, F., Bensa, V., Calarco, E., Pastorino, F., Perri, P., Corrias, M.V., Ponzoni, M., and Brignole, C. (2021). The Olive Leaves Extract Has Anti-Tumor Effects against Neuroblastoma through Inhibition of Cell Proliferation and Induction of Apoptosis. Nutrients, 13.","DOI":"10.3390\/nu13072178"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Albogami, S., and Hassan, A.M. (2021). Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models. Molecules, 26.","DOI":"10.3390\/molecules26134069"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Dzah, C.S., Duan, Y., Zhang, H., Wen, C., Zhang, J., Chen, G., and Ma, H. (2020). The effects of ultrasound assisted extraction on yield, antioxidant, anticancer and antimicrobial activity of polyphenol extracts: A review. Food Biosci., 35.","DOI":"10.1016\/j.fbio.2020.100547"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.semcancer.2020.11.011","article-title":"Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence","volume":"73","author":"Julve","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Farag, M.A., and Gad, M.Z. (2022). Omega-9 fatty acids: Potential roles in inflammation and cancer management. J. Genet. Eng. Biotechnol., 20.","DOI":"10.1186\/s43141-022-00329-0"},{"key":"ref_74","first-page":"3","article-title":"Antioxidant and antithrombotic properties of fruit, leaf, and seed extracts of the Halhal\u0131 olive (Olea europaea L.) native to the Hatay region in Turkey","volume":"1","author":"Yilmaztekin","year":"2023","journal-title":"Health"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Mirsoleimani, A., Najafi-Ghiri, M., and Amin, H. (2024). Comparison of leaf and root nutrients concentration in twenty olive cultivars grown on a calcareous soil. J. Plant Nutr., 1\u201315.","DOI":"10.1080\/01904167.2024.2376248"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"103671","DOI":"10.1016\/j.jfca.2020.103671","article-title":"Phytochemical profile and mineral content of Royal variety olive fruits. Influence of the ripening stage","volume":"95","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"de Oliveira, N.M., Lopes, L., Ch\u00e9u, M.H., Soares, E., Meireles, D., and Machado, J. (2023). Updated Mineral Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea. Plants, 12.","DOI":"10.3390\/plants12040916"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kourti, M., Skaperda, Z., Tekos, F., Stathopoulos, P., Koutra, C., Skaltsounis, A.L., and Kouretas, D. (2024). The Bioactivity of a Hydroxytyrosol-Enriched Extract Originated after Direct Hydrolysis of Olive Leaves from Greek Cultivars. Molecules, 29.","DOI":"10.3390\/molecules29020299"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez, E.M., Brenes, M., Romero, C., and Medina, E. (2022). Chemical and Enzymatic Characterization of Leaves from Spanish Table Olive Cultivars. Foods, 11.","DOI":"10.3390\/foods11233879"},{"key":"ref_80","first-page":"495","article-title":"18\u2014Valorization of phenolic extracts from Olea europaea L. by membrane operations","volume":"Volume 31","author":"Iulianelli","year":"2022","journal-title":"Membrane Engineering in the Circular Economy"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1002\/jsfa.10986","article-title":"The challenge of exploiting polyphenols from olive leaves: Adition to foods to improve their shelf-life and nutritional value","volume":"101","author":"Difonzo","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2174\/1871520619666190416101622","article-title":"Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves","volume":"19","author":"Bouallagui","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"107719","DOI":"10.1016\/j.jmgm.2020.107719","article-title":"In silico characterisation of olive phenolic compounds as potential cyclooxygenase modulators. Part 1","volume":"101","author":"Liang","year":"2020","journal-title":"J. Mol. Graph. Model."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Dong, Y., Yu, M., Wu, Y., Xia, T., Wang, L., Song, K., Zhang, C., Lu, K., and Rahimnejad, S. (2022). Hydroxytyrosol Promotes the Mitochondrial Function through Activating Mitophagy. Antioxidants, 11.","DOI":"10.3390\/antiox11050893"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1039\/D2FO00839D","article-title":"Hydroxytyrosol improves strenuous exercise-associated cardiac pathological changes via modulation of mitochondrial homeostasis","volume":"13","author":"Xiong","year":"2022","journal-title":"Food Funct."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2240894","DOI":"10.1155\/2022\/2240894","article-title":"Hydroxytyrosol Ameliorates Intervertebral Disc Degeneration and Neuropathic Pain by Reducing Oxidative Stress and Inflammation","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Alkhalifa, A.E., Al-Ghraiybah, N.F., and Kaddoumi, A. (2024). Extra-Virgin Olive Oil in Alzheimer\u2019s Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031914"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-200443","article-title":"The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer\u2019s Disease","volume":"77","author":"Calfio","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Grubi\u0107 Kezele, T., and \u0106urko-Cofek, B. (2022). Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties. Nutrients, 14.","DOI":"10.3390\/nu14214533"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2147\/IJWH.S409897","article-title":"Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence","volume":"16","author":"Alabadi","year":"2024","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., and Stefani, M. (2021). Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants, 10.","DOI":"10.3390\/antiox10071044"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ptr.7325","article-title":"An updated review on the potential antineoplastic actions of oleuropein","volume":"36","author":"Zheng","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-S\u00e1nchez, A., Mart\u00ednez-Ortega, A.J., Rem\u00f3n-Ruiz, P.J., Pi\u00f1ar-Guti\u00e9rrez, A., Pereira-Cunill, J.L., and Garc\u00eda-Luna, P.P. (2022). Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update. Nutrients, 14.","DOI":"10.3390\/nu14071440"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Fytili, C., Nikou, T., Tentolouris, N., Tseti, I.K., Dimosthenopoulos, C., Sfikakis, P.P., Simos, D., Kokkinos, A., Skaltsounis, A.L., and Katsilambros, N. (2022). Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized DoubleBlind Prospective Human Study. Nutrients, 14.","DOI":"10.3390\/nu14071525"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Serreli, G., Le Sayec, M., Diotallevi, C., Teissier, A., Deiana, M., and Corona, G. (2021). Conjugated Metabolites of Hydroxytyrosol and Tyrosol Contribute to the Maintenance of Nitric Oxide Balance in Human Aortic Endothelial Cells at Physiologically Relevant Concentrations. Molecules, 26.","DOI":"10.3390\/molecules26247480"},{"key":"ref_96","first-page":"371","article-title":"Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: A review of the current knowledge","volume":"79","author":"Trepiana","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"De Leonardis, A., Macciola, V., and Iacovino, S. (2020). Delivery Systems for Hydroxytyrosol Supplementation: State of the Art. Colloids Interfaces, 4.","DOI":"10.3390\/colloids4020025"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.37175\/stemedicine.v3i2.125","article-title":"Oleuropein inhibits pancreatic cancer through miR-190b-5p induction","volume":"3","author":"Xu","year":"2022","journal-title":"STEMedicine"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Panera, N., Braghini, M.R., Crudele, A., Smeriglio, A., Bianchi, M., Condorelli, A.G., Nobili, R., Conti, L.A., De Stefanis, C., and Lioci, G. (2022). Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis. Nutrients, 14.","DOI":"10.3390\/nu14183791"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jbiotec.2019.12.016","article-title":"Hydroxytyrosol: A natural compound with promising pharmacological activities","volume":"309","author":"Bertelli","year":"2020","journal-title":"J. Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2021.02.011","article-title":"Acute administration of the olive constituent, oleuropein, combined with ischemic postconditioning increases myocardial protection by modulating oxidative defense","volume":"166","author":"Tsoumani","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1007\/s11064-021-03351-9","article-title":"Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings","volume":"46","author":"Mnafgui","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_103","first-page":"341","article-title":"Managing Hypertension Using Combination Therapy","volume":"101","author":"Smith","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Gomar, I., Ben\u00edtez-Camacho, J., Cejudo-Bastante, C., Casas, L., Moreno-Luna, R., Mantell, C., and Dur\u00e1n-Ruiz, M.C. (2022). Pro-Angiogenic Effects of Natural Antioxidants Extracted from Mango Leaf, Olive Leaf and Red Grape Pomace over Endothelial Colony-Forming Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11050851"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Nediani, C., Ruzzolini, J., Romani, A., and Calorini, L. (2019). Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases. Antioxidants, 8.","DOI":"10.3390\/antiox8120578"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Gervasi, F., and Pojero, F. (2024). Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030502"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Moukham, H., Lambiase, A., Barone, G.D., Tripodi, F., and Coccetti, P. (2024). Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review. Nutrients, 16.","DOI":"10.3390\/nu16091298"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"118913","DOI":"10.1016\/j.lfs.2020.118913","article-title":"Downregulation of redox imbalance and iNOS\/NF-\u0138B\/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats","volume":"266","author":"Famurewa","year":"2021","journal-title":"Life Sci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Rai, M., and Kosalec, I. (2022). The Antimicrobial Activities of Oleuropein and Hydroxytyrosol. Promising Antimicrobials from Natural Products, Springer. [1st ed.].","DOI":"10.1007\/978-3-030-83504-0"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Serreli, G., and Deiana, M. (2020). Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging. Cells, 9.","DOI":"10.3390\/cells9020478"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zhang, J., Nugrahaningrum, D.A., Marcelina, O., Ariyanti, A.D., Wang, G., Liu, C., Wu, S., and Kasim, V. (2019). Tyrosol Facilitates Neovascularization by Enhancing Skeletal Muscle Cells Viability and Paracrine Function in Diabetic Hindlimb Ischemia Mice. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00909"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Jomova, K., Makova, M., Alomar, S.Y., Alwasel, S.H., Nepovimova, E., Kuca, K., Rhodes, C.J., and Valko, M. (2022). Essential metals in health and disease. Chem. Biol. Interact., 367.","DOI":"10.1016\/j.cbi.2022.110173"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Alkhatib, A. (2020). Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus. Nutrients, 12.","DOI":"10.3390\/nu12092633"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Garg, A., and Lee, J.C. (2022). Vitamin E: Where Are We Now in Vascular Diseases?. Life, 12.","DOI":"10.3390\/life12020310"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/biof.1873","article-title":"Revisiting the therapeutic potential of tocotrienol","volume":"48","author":"Ranasinghe","year":"2022","journal-title":"BioFactors"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00394-019-01962-1","article-title":"Vitamin E and cancer: An update on the emerging role of \u03b3 and \u03b4 tocotrienols","volume":"59","author":"Constantinou","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_117","first-page":"905","article-title":"Antioxidant Activity of Polyphenols in Combating Atherosclerosis","volume":"9","author":"Nambiar","year":"2022","journal-title":"Int. J. Res. Anal. Rev."},{"key":"ref_118","unstructured":"Nabavi, S.M., and Silva, A.S. (2022). Vitamin E (tocopherols and tocotrienols) (natural-occurring antioxidant; bright and dark side). Antioxidants Effects in Health, Elsevier."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Traber, M.G., Leonard, S.W., Vasu, V.T., Morrissey, B.M., Lei, H., Atkinson, J., and Cross, C.E. (2022). \u03b1-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration. Nutrients, 14.","DOI":"10.3390\/nu14183717"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s13530-022-00152-7","article-title":"L-ascorbic acid and \u03b1-tocopherol treatment alleviates parabenzoquinone-induced hemato-biochemical and histopathological changes in Wistar rats","volume":"14","author":"Mishra","year":"2022","journal-title":"Toxicol. Environ. Health Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Mancebo-Campos, V., Salvador, M.D., and Fregapane, G. (2022). Modelling Virgin Olive Oil Potential Shelf-Life from Antioxidants and Lipid Oxidation Progress. Antioxidants, 11.","DOI":"10.3390\/antiox11030539"},{"key":"ref_122","first-page":"439","article-title":"Effect of High Cholesterol Diet and \u03b1Tocopherol Supplementation on Endoplasmic Ret\u00fcculum Stress and Apoptosis in Hippocampus Tissue","volume":"12","author":"Sozen","year":"2022","journal-title":"Clin. Exp. Health Sci."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Pinto-Ribeiro, L., Silva, C., Andrade, N., and Martel, F. (2022). \u03b1-tocopherol prevents oxidative stress-induced proliferative dysfunction in first-trimester human placental (HTR-8\/SVneo) cells. Reprod. Biol., 22.","DOI":"10.1016\/j.repbio.2022.100602"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Misra, D., Dutta, W., Jha, G., and Ray, P. (2023). Interactions and Regulatory Functions of Phenolics in Soil-Plant-Climate Nexus. Agronomy, 13.","DOI":"10.3390\/agronomy13020280"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s11694-021-01257-2","article-title":"Instant controlled pressure drop (DIC) effect on compositional analysis of olive leaves (Olea europaea L.)","volume":"16","author":"Mkaouar","year":"2022","journal-title":"J. Food Meas. Charact."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Papakonstantinou, A., Koumarianou, P., Rigakou, A., Diamantakos, P., Frakolaki, E., Vassilaki, N., Chavdoula, E., Melliou, E., Magiatis, P., and Boleti, H. (2022). New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative\/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010003"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Marrero, A.D., Quesada, A.R., Mart\u00ednez-Poveda, B., and Medina, M. (2024). Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil. Nutrients, 16.","DOI":"10.3390\/nu16091283"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"122498","DOI":"10.1016\/j.ijpharm.2022.122498","article-title":"Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives","volume":"631","author":"Nardi","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2147\/IJN.S385166","article-title":"A Novel Nanoemulsion Formula for an Improved Delivery of a Thalidomide Analogue to Triple-Negative Breast Cancer; Synthesis, Formulation, Characterization and Molecular Studies","volume":"18","author":"Tawfik","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Moral, R., and Escrich, E. (2022). Influence of olive oil and its components on breast cancer: Molecular mechanisms. Molecules, 27.","DOI":"10.3390\/molecules27020477"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Shekari, S., Fathi, S., Roumi, Z., Akbari, M.E., Tajadod, S., Afsharfar, M., Ardekanizadeh, N.H., Bourbour, F., Keshavarz, S.A., and Sotoudeh, M. (2022). Association between dietary intake of fatty acids and colorectal cancer, a case-control study. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.856408"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Santa-Mar\u00eda, C., L\u00f3pez-Enr\u00edquez, S., la Paz, S.M.-D., Geniz, I., Reyes-Quiroz, M.E., Moreno, M., Palomares, F., Sobrino, F., and Alba, G. (2023). Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid. Nutrients, 15.","DOI":"10.3390\/nu15010224"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1007\/s11356-022-22401-5","article-title":"Target-based virtual screening and molecular interaction studies for lead identification of natural olive compounds against glioblastoma multiforme","volume":"30","author":"Ghosh","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Ilesanmi-Oyelere, B.L., Brough, L., Coad, J., Roy, N., and Kruger, M.C. (2019). The Relationship between Nutrient Patterns and Bone Mineral Density in Postmenopausal Women. Nutrients, 11.","DOI":"10.3390\/nu11061262"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/ijmm.2023.5333","article-title":"Role of vitamins beyond vitamin D3 in bone health and osteoporosis (Review)","volume":"53","author":"Skalny","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1007\/s00784-020-03579-9","article-title":"Systemic treatment with alpha-tocopherol and\/or sodium selenite decreases the progression of experimental periodontitis","volume":"25","author":"Bas","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.job.2021.04.001","article-title":"Effect of vitamin E on periodontitis: Evidence and proposed mechanisms of action","volume":"63","author":"Shadisvaaran","year":"2021","journal-title":"J. Oral Biosci."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Liu, X., Yang, G., Luo, M., Lan, Q., Shi, X., Deng, H., Wang, N., Xu, X., and Zhang, C. (2021). Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0261259"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Agha-Hosseini, F., Pourpasha, M., Amanlou, M., and Moosavi, M.-S. (2021). Mouthwash Containing Vitamin E, Triamcinolon, and Hyaluronic Acid Compared to Triamcinolone Mouthwash Alone in Patients with Radiotherapy-Induced Oral Mucositis: Randomized Clinical Trial. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.614877"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.radonc.2022.01.024","article-title":"Randomised single centre double-blind placebo controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline in patients suffering long-term gastrointestinal adverse effects of radiotherapy for pelvic cancer: The PPALM study","volume":"168","author":"Andreyev","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00280-021-04347-6","article-title":"The use of vitamin E in preventing taxane-induced peripheral neuropathy","volume":"88","author":"Heiba","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_142","first-page":"174","article-title":"Does vitamin E mitigate cisplatin-induced nephrotoxicity in cancer patients: Results from a randomized placebo-controlled clinical trial","volume":"11","author":"Ashrafi","year":"2020","journal-title":"Middle East J. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12032-019-1334-5","article-title":"Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: A randomized, controlled study","volume":"37","author":"Sayed","year":"2020","journal-title":"Med. Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00520-019-04684-6","article-title":"The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer","volume":"27","author":"Keshavarzi","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Krejbich, P., and Birringer, M. (2022). The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2\u2014A Systematic Review. Antioxidants, 11.","DOI":"10.3390\/antiox11112149"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Lled\u00f3, I., Ib\u00e1\u00f1ez, B., Melero, A., Montoro, A., Merino-Torres, J.F., Onofre, N.S., and Soriano, J.M. (2023). Vitamins and Radioprotective Effect: A Review. Antioxidants, 12.","DOI":"10.3390\/antiox12030611"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clnesp.2022.11.001","article-title":"Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review","volume":"53","author":"Pereira","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Donnelly, J., Appathurai, A., Yeoh, H.-L., Driscoll, K., and Faisal, W. (2022). Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials. Nutrients, 14.","DOI":"10.3390\/nu14204329"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Campo, C., Gangemi, S., Pioggia, G., and Allegra, A. (2024). Beneficial Effect of Olive Oil and Its Derivates: Focus on Hematological Neoplasm. Life, 14.","DOI":"10.3390\/life14050583"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.repc.2021.05.011","article-title":"Oral administration of oleuropein and olive leaf extract has cardioprotective effects in rodents: A systematic review","volume":"41","author":"Menezes","year":"2022","journal-title":"Rev. Port. Cardiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000505508","article-title":"Olive Leaf (Olea europaea L. folium): Potential Effects on Glycemia and Lipidemia","volume":"76","year":"2020","journal-title":"Ann. Nutr. Metab."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e030319","DOI":"10.1161\/JAHA.123.030319","article-title":"Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional-Based Italian Database","volume":"13","author":"Tikhonoff","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00394-020-02397-9","article-title":"The effect of olive leaf extract on cardiovascular health markers: A randomized placebo-controlled clinical trial","volume":"60","author":"Stevens","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_154","first-page":"CD003177","article-title":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease","volume":"3","author":"Abdelhamid","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"D\u2019angelo, C., Franceschelli, S., Quiles, J.L., and Speranza, L. (2020). Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases. Cells, 9.","DOI":"10.3390\/cells9091932"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nutres.2019.05.003","article-title":"Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: An exploratory randomized controlled trial","volume":"67","author":"Araki","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4327\/jsnfs.71.121","article-title":"An Exploratory Study of the Effects of Continuous Intake of Olive Leaf Tea on Physique and Glucose and Lipid Metabolism","volume":"71","author":"Araki","year":"2018","journal-title":"Nippon. Eiyo Shokuryo Gakkaishi"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3923\/pjbs.2019.342.348","article-title":"Effects of Olive Leaf Extract on Metabolic Response, Liver and Kidney Functions and Inflammatory Biomarkers in Hypertensive Patients","volume":"22","author":"Javadi","year":"2019","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_159","first-page":"372","article-title":"Determining cardiometabolic and antioxidant effects of olive leaf extract in patients with essential hypertension","volume":"23","author":"Yaghoobzadeh","year":"2019","journal-title":"J. Inflamm. Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.17113\/ftb.57.02.19.5921","article-title":"Polyphenol-Based Design of Functional Olive Leaf Infusions","volume":"57","year":"2019","journal-title":"Food Technol. Biotechnol."},{"key":"ref_161","first-page":"4","article-title":"What do people prefer to support diabetes treatment in Turkiye? A study on olive lead and diabetes","volume":"48","author":"Mancak","year":"2024","journal-title":"J. Fac. Pharm. Ank. Univ."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.clnu.2018.11.009","article-title":"Olive leaf tea may have hematological health benefit over green tea","volume":"38","author":"Ferdousi","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00394-016-1188-y","article-title":"Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomised controlled trial","volume":"56","author":"Lockyer","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Ferreira, D.M., de Oliveira, N.M., Lopes, L., Machado, J., and Oliveira, M.B. (2022). Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles. Plants, 11.","DOI":"10.3390\/plants11192638"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Turner, R.M., and Pirmohamed, M. (2019). Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010022"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40885-021-00177-z","article-title":"Real-world evidence on the strategy of olmesartan-based triple single-pill combination in Korean hypertensive patients: A prospective, multicenter, observational study (RESOLVE-PRO)","volume":"27","author":"Sohn","year":"2021","journal-title":"Clin. Hypertens."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40256-018-00321-5","article-title":"Efficacy and Safety of Dual Blockade of the Renin-Angiotensin-Aldosterone System in Diabetic Kidney Disease: A Meta-Analysis","volume":"19","author":"Feng","year":"2019","journal-title":"Am. J. Cardiovasc. Drugs Drugs Devices Other Interv."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1039\/D1FO00979F","article-title":"MUFA in metabolic syndrome and associated risk factors: Is MUFA the opposite side of the PUFA coin?","volume":"12","author":"Sheashea","year":"2021","journal-title":"Food Funct."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"106599","DOI":"10.1016\/j.phrs.2022.106599","article-title":"Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives","volume":"187","author":"Fiore","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Djuricic, I., and Calder, P.C. (2024). Omega-3 (n-3) Fatty Acid\u2013Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease. Nutrients, 16.","DOI":"10.3390\/nu16070962"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.7196\/SAMJ.2020.v110i12.14730","article-title":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease","volume":"110","author":"Jaca","year":"2020","journal-title":"South Afr. Med. J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/1753-0407.12508","article-title":"Effect of olive leaf extract on glucose levels in diabetes-induced rats: A systematic review and meta-analysis","volume":"9","author":"Abunab","year":"2017","journal-title":"J. Diabetes"},{"key":"ref_173","first-page":"62","article-title":"[A multidirectional effect of metformin]","volume":"50","author":"Latocha","year":"2022","journal-title":"Pol. Merkur. Lek."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Wasner, H.K. (2022). Metformin\u2019s Mechanism of Action Is Stimulation of the Biosynthesis of the Natural Cyclic AMP Antagonist Prostaglandylinositol Cyclic Phosphate (Cyclic PIP). Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042200"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"bqac162","DOI":"10.1210\/endocr\/bqac162","article-title":"Metformin\u2019s Impact on the Microvascular Response to Insulin","volume":"163","author":"Love","year":"2022","journal-title":"Endocrinology"},{"key":"ref_176","first-page":"5545","article-title":"Role of metformin in inflammation","volume":"16","author":"Feng","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Cao, G., Gong, T., Du, Y., Wang, Y., Ge, T., and Liu, J. (2022). Mechanism of metformin regulation in central nervous system: Progression and future perspectives. Biomed. Pharmacother., 156.","DOI":"10.1016\/j.biopha.2022.113686"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"De Bock, M., Derraik, J.G., Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L., and Cutfield, W.S. (2013). Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057622"},{"key":"ref_179","first-page":"CD004192","article-title":"Dietary interventions for multiple sclerosis-related outcomes","volume":"2020","author":"Parks","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Sokal-Dembowska, A., Jarmakiewicz-Czaja, S., Ferenc, K., and Filip, R. (2024). Can Nutraceuticals Support the Treatment of MASLD\/MASH, and thus Affect the Process of Liver Fibrosis?. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105238"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Reiner, M.F., Bertschi, D.A., Werlen, L., Wiencierz, A., Aeschbacher, S., Lee, P., Rodondi, N., Moutzouri, E., Bonati, L., and Reichlin, T. (2024). Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients, 16.","DOI":"10.3390\/nu16020178"},{"key":"ref_182","first-page":"19","article-title":"Omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases","volume":"84","author":"Tutor","year":"2024","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_183","first-page":"CD013157","article-title":"Nutritional supplementation for nonalcohol-related fatty liver disease: A network meta-analysis","volume":"2021","author":"Komolafe","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Guerra, J.V.S., Dias, M.M.G., Brilhante, A.J.V.C., Terra, M.F., Garc\u00eda-Ar\u00e9valo, M., and Figueira, A.C.M. (2021). Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases. Nutrients, 13.","DOI":"10.3390\/nu13082830"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e2100517","DOI":"10.1002\/ardp.202100517","article-title":"The medicinal perspective of 2,4-thiazolidinediones based ligands as antimicrobial, antitumor and antidiabetic agents: A review","volume":"355","author":"Kajal","year":"2022","journal-title":"Arch. Pharm."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"155332","DOI":"10.1016\/j.metabol.2022.155332","article-title":"Pharmacotherapy of type 2 diabetes: An update and future directions","volume":"137","author":"DeMarsilis","year":"2022","journal-title":"Metabolism"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"604","DOI":"10.31989\/ffhd.v11i11.829","article-title":"Hypoglycemic effects of antioxidant-rich plant extracts on postprandial glycemic responses in participants with prediabetes (GLARE study)","volume":"11","author":"Lim","year":"2021","journal-title":"Funct. Foods Health Dis."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00394-018-1662-9","article-title":"Nutritional implications of olives and sugar: Attenuation of post-prandial glucose spikes in healthy volunteers by inhibition of sucrose hydrolysis and glucose transport by oleuropein","volume":"58","author":"Kerimi","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"420","DOI":"10.21608\/niles.2023.296455","article-title":"Efficacy of the traditional use of Olive Leaves decoction as Anti-diabetic Agent in Geriatrics","volume":"6.2","author":"Basuny","year":"2023","journal-title":"NILES J. Geriatr. Gerontol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12964-023-01276-0","article-title":"The mechanism of oleic acid inhibiting platelet activation stimulated by collagen","volume":"21","author":"Zhou","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3892\/etm.2021.10138","article-title":"Fatty acids and their role in type-2 diabetes (Review)","volume":"22","author":"Shetty","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13668-024-00561-9","article-title":"The Role of Omega-3 Polyunsaturated Fatty Acids in Diabetes Mellitus Management: A Narrative Review","volume":"13","author":"Bayram","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Hartnett, K.B., Ferguson, B.J., Hecht, P.M., Schuster, L.E., Shenker, J.I., Mehr, D.R., Fritsche, K.L., Belury, M.A., Scharre, D.W., and Horwitz, A.J. (2023). Potential Neuroprotective Effects of Dietary Omega-3 Fatty Acids on Stress in Alzheimer\u2019s Disease. Biomolecules, 13.","DOI":"10.3390\/biom13071096"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"104506","DOI":"10.1016\/j.jff.2021.104506","article-title":"Potential role of hydroxytyrosol in neuroprotection","volume":"82","author":"Chen","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_195","first-page":"CD011016","article-title":"Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease","volume":"12","author":"Downie","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"110362","DOI":"10.1016\/j.isci.2024.110362","article-title":"Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes","volume":"27","author":"Longarzo","year":"2024","journal-title":"iScience"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"106439","DOI":"10.1016\/j.jff.2024.106439","article-title":"Pro-resolving metabolites: Future of the fish oil supplements","volume":"121","author":"Maliha","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Pangrazzi, L., Balasco, L., and Bozzi, Y. (2020). Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?. Antioxidants, 9.","DOI":"10.3390\/antiox9121186"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Ruiz-Sastre, P., G\u00f3mez-S\u00e1nchez-Lafuente, C., Mart\u00edn-Mart\u00edn, J., Herrera-Imbroda, J., Mayoral-Cleries, F., Santos-Amaya, I., de Fonseca, F.R., Guzm\u00e1n-Parra, J., Rivera, P., and Su\u00e1rez, J. (2024). Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 134.","DOI":"10.1016\/j.pnpbp.2024.111056"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Therdyothin, A., Prokopidis, K., Galli, F., Witard, O.C., and Isanejad, M. (2024). The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: A systematic review and meta-analysis. Nutr. Rev., nuae055.","DOI":"10.1093\/nutrit\/nuae055"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Fujitaka, Y., Hamada, H., Uesugi, D., Kuboki, A., Shimoda, K., Iwaki, T., Kiriake, Y., and Saikawa, T. (2019). Synthesis of Daidzein Glycosides, \u03b1-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics. Molecules, 24.","DOI":"10.3390\/molecules24162975"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1017\/S0007114521003627","article-title":"Interactions between dietary flavonoids and the gut microbiome: A comprehensive review","volume":"128","author":"Baky","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"108595","DOI":"10.1016\/j.pharmthera.2024.108595","article-title":"Olea europaea L.-derived secoiridoids: Beneficial health effects and potential therapeutic approaches","volume":"254","author":"Filardo","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2147\/IJN.S443965","article-title":"High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract","volume":"19","author":"Alghamdi","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Medfai, W., Oueslati, I., Dumas, E., Harzalli, Z., Viton, C., Mhamdi, R., and Gharsallaoui, A. (2023). Physicochemical and Biological Characterization of Encapsulated Olive Leaf Extracts for Food Preservation. Antibiotics, 12.","DOI":"10.3390\/antibiotics12060987"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Alowaiesh, B.F., Alhaithloul, H.A.S., Saad, A.M., and Hassanin, A.A. (2023). Green Biogenic of Silver Nanoparticles Using Polyphenolic Extract of Olive Leaf Wastes with Focus on Their Anticancer and Antimicrobial Activities. Plants, 12.","DOI":"10.3390\/plants12061410"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Famiglietti, M., Savastano, A., Gaglione, R., Arciello, A., Naviglio, D., and Mariniello, L. (2022). Edible Films Made of Dried Olive Leaf Extract and Chitosan: Characterization and Applications. Foods, 11.","DOI":"10.3390\/foods11142078"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s13197-020-04702-0","article-title":"Determination of theoretical calculations by DFT method and investigation of antioxidant, antimicrobial properties of olive leaf extracts from different regions","volume":"58","author":"Baysal","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Martiny, T.R., Raghavan, V., de Moraes, C.C., da Rosa, G.S., and Dotto, G.L. (2020). Bio-Based Active Packaging: Carrageenan Film with Olive Leaf Extract for Lamb Meat Preservation. Foods, 9.","DOI":"10.3390\/foods9121759"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Saleh, E., Morshdy, A.E., El-Manakhly, E., Al-Rashed, S., FHetta, H., Jeandet, P., Yahia, R., El-Saber Batiha, G., and Ali, E. (2020). Effects of Olive Leaf Extracts as Natural Preservative on Retailed Poultry Meat Quality. Foods, 9.","DOI":"10.3390\/foods9081017"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Moura-Alves, M., Souza, V.G.L., Silva, J.A., Esteves, A., Pastrana, L.M., Saraiva, C., and Cerqueira, M.A. (2023). Characterization of Sodium Alginate-Based Films Blended with Olive Leaf and Laurel Leaf Extracts Obtained by Ultrasound-Assisted Technology. Foods, 12.","DOI":"10.3390\/foods12224076"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Allegretta, C., Difonzo, G., Caponio, F., Tamma, G., and Laselva, O. (2023). Olive Leaf Extract (OLE) as a Novel Antioxidant That Ameliorates the Inflammatory Response in Cystic Fibrosis. Cells, 12.","DOI":"10.3390\/cells12131764"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Arismendi Sosa, A.C., Mariani, M.L., Vega, A.E., and Penissi, A.B. (2022). Extra virgin olive oil inhibits Helicobacter pylori growth in vitro and the development of mice gastric mucosa lesions in vivo. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.961597"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Guti\u00e9rrez, M., Basc\u00f3n-Villegas, I., Rodr\u00edguez, A., P\u00e9rez-Rodr\u00edguez, F., Fern\u00e1ndez-Prior, \u00c1., Rosal, A., and Carrasco, E. (2021). Valorisation of Olea europaea L. Olive Leaves through the Evaluation of Their Extracts: Antioxidant and Antimicrobial Activity. Foods, 10.","DOI":"10.3390\/foods10050966"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Nazzaro, F., Fratianni, F., Cozzolino, R., Martignetti, A., Malorni, L., De Feo, V., Cruz, A.G., and D\u2019acierno, A. (2019). Antibacterial Activity of Three Extra Virgin Olive Oils of the Campania Region, Southern Italy, Related to Their Polyphenol Content and Composition. Microorganisms, 7.","DOI":"10.3390\/microorganisms7090321"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Munekata, P.E.S., Nieto, G., Pateiro, M., and Lorenzo, J.M. (2020). Phenolic Compounds Obtained from Olea europaea By-Products and Their Use to Improve the Quality and Shelf Life of Meat and Meat Products\u2014A Review. Antioxidants, 9.","DOI":"10.3390\/antiox9111061"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/nu14010137","article-title":"Polyphenols-Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics","volume":"14","author":"Plamada","year":"2021","journal-title":"Nutrients"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tifs.2018.11.005","article-title":"From extraction of valuable compounds to health promoting benefits of olive leaves through bioaccessibility, bioavailability and impact on gut microbiota","volume":"83","author":"Abdelkebir","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Baruk\u010di\u0107, I., Filipan, K., Jakopovi\u0107, K.L., Bo\u017eani\u0107, R., Bla\u017ei\u0107, M., and Repaji\u0107, M. (2022). The Potential of Olive Leaf Extract as a Functional Ingredient in Yoghurt Production: The Effects on Fermentation, Rheology, Sensory, and Antioxidant Properties of Cow Milk Yoghurt. Foods, 11.","DOI":"10.3390\/foods11050701"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"e0301086","DOI":"10.1371\/journal.pone.0301086","article-title":"Abdelgawad SM. In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2","volume":"19","author":"Majrashi","year":"2024","journal-title":"PLoS ONE"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"20402066211063391","DOI":"10.1177\/20402066211063391","article-title":"Anti-influenza virus activity of the elenolic acid rich olive leaf (Olea europaea L.) extract Isenolic\u00ae","volume":"29","author":"Salamanca","year":"2021","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.explore.2021.01.003","article-title":"The efficacy of olive leaf extract on healing herpes simplex virus labialis: A randomized double-blind study","volume":"18","author":"Toulabi","year":"2022","journal-title":"Explore"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/ccr3.3723","article-title":"Treatment of genital herpes using olive leaf extract","volume":"9","author":"Lorzadeh","year":"2021","journal-title":"Clin. Case Rep."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Lafi, O., Essid, R., Lachaud, L., Jimenez, C., Rodr\u00edguez, J., Ageitos, L., Mhamdi, R., and Abaza, L. (2023). Synergistic antileishmanial activity of erythrodiol, uvaol, and oleanolic acid isolated from olive leaves of cv. Chemlali. 3 Biotech, 13.","DOI":"10.1007\/s13205-023-03825-3"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Floris, B., Galloni, P., Conte, V., and Sabuzi, F. (2021). Tailored Functionalization of Natural Phenols to Improve Biological Activity. Biomolecules, 11.","DOI":"10.3390\/biom11091325"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Monteiro, M., Silva, A.F.R., Resende, D., Braga, S.S., Coimbra, M.A., Silva, A.M.S., and Cardoso, S.M. (2021). Strategies to Broaden the Applications of Olive Biophenols Oleuropein and Hydroxytyrosol in Food Products. Antioxidants, 10.","DOI":"10.3390\/antiox10030444"},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Zawawi, A., Naser, A.Y., Alwafi, H., and Minshawi, F. (2021). Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.666223"},{"key":"ref_228","unstructured":"Investigators, T.R.-C., and Derde, L.P.G. (2021). Effectiveness of Tocilizumab, Sarilumab, and Anakinra for critically ill patients with COVID-19 The REMAP-CAP COVID-19 Immune Modulation Therapy Domain Randomized Clinical Trial. MedRxiv."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Abdelgawad, S.M., El Hassab, M.A., Abourehab, M.A.S., Elkaeed, E.B., and Eldehna, W.M. (2022). Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.879118"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Boadu, A., Agoni, C., Karpoormath, R., Soliman, M., and Nlooto, M. (2022). Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-14558-3"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Kocyigit, A., Kan\u0131mdan, E., Yenigun, V.B., Ozman, Z., Bal\u0131bey, F.B., Durmu\u015f, E., and Yasar, O. (2024). Olive Leaf Extract Downregulates the Protein Expression of Key SARS-CoV-2 Entry Enzyme ACE-2, TMPRSS2, and Furin. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202400717"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Clodoveo, M.L., Crupi, P., Annunziato, A., and Corbo, F. (2021). Innovative Extraction Technologies for Development of Functional Ingredients Based on Polyphenols from Olive Leaves. Foods, 11.","DOI":"10.3390\/foods11010103"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s11694-019-00310-5","article-title":"Phytochemical composition, antioxidant and antimicrobial activities of leaves of Olea europaea wild variety","volume":"14","author":"Khan","year":"2020","journal-title":"J. Food Meas. Charact."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Tadi\u0107, J., Dumi\u010di\u0107, G., Ver\u0161i\u0107 Bratin\u010devi\u0107, M., Vitko, S., Liber, Z., and Radi\u0107 Brkanac, S. (2024). Comparative analysis of cultivated and wild olive genotypes to salinity and drought stress. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1423761"},{"key":"ref_235","first-page":"75","article-title":"Phenolic Content and In-vitro Antioxidant Activity of Olea europaea L. subs. oleaster Leaves by Supercritical CO2 Extraction","volume":"3","author":"Argon","year":"2023","journal-title":"Ere\u011fli Tar\u0131m Bilim. Derg."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, M., Aiello, A., Rodr\u00edguez-P\u00e9rez, M., Accardi, G., Burgos-Ramos, E., and Silva, P. (2024). Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol. Nutrients, 16.","DOI":"10.3390\/nu16060818"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Zupo, R., Castellana, F., Crupi, P., Desantis, A., Rondanelli, M., Corbo, F., and Clodoveo, M.L. (2023). Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Metabolites, 13.","DOI":"10.3390\/metabo13121187"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Soldo, B., Bilu\u0161i\u0107, T., Giacometti, J., Ljubenkov, I., \u010cike\u0161 \u010culi\u0107, V., Bratani\u0107, A., Bo\u0161kovi\u0107, P., \u0160ola, I., and Ili\u0107, K. (2024). A Comparative Study of Oleuropein Extraction from Wild Olive Leaves (Olea europea subsp. oleaster, Hoffmanns. & Link), Its Gastrointestinal Stability, and Biological Potential. Appl. Sci., 14.","DOI":"10.3390\/app14020869"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"de Oliveira, N.M., Machado, J., Huang, Z., and Criado, M.B. (2022). Acupuncture in Women with Human Polycystic Ovary\/Ovarian Syndrome: Protocol for a Randomized Controlled Trial. Healthcare, 10.","DOI":"10.3390\/healthcare10101999"},{"key":"ref_240","first-page":"314","article-title":"Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort","volume":"6 Pt B","author":"Vine","year":"2023","journal-title":"CJC Open"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3831\/KPI.2023.26.2.105","article-title":"A Review on Acupuncture Efficiency in Human Polycystic Ovary\/Ovarian Syndrome","volume":"26","author":"Machado","year":"2023","journal-title":"J. Pharmacopunct."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Wen, X., Wang, L., and Bai, E. (2024). Metabolic characteristics of different phenotypes in reproductive-aged women with polycystic ovary syndrome. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1370578"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1573404820666230301115706","article-title":"A New Predictor for Insulin Resistance in Polycystic Ovary Syndrome: InsuTAG","volume":"20","author":"Omma","year":"2023","journal-title":"Curr. Women S Health Rev."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Herbert, S., and Woolf, K. (2023). Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS). Nutrients, 15.","DOI":"10.3390\/nu15245069"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Lu, L., Li, X., Lv, L., Xu, Y., Wu, B., and Huang, C. (2022). Associations between omega-3 fatty acids and insulin resistance and body composition in women with polycystic ovary syndrome. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1016943"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Barrea, L., Arnone, A., Annunziata, G., Muscogiuri, G., Laudisio, D., Salzano, C., Pugliese, G., Colao, A., and Savastano, S. (2019). Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients, 11.","DOI":"10.3390\/nu11102278"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1080\/09513590.2022.2148647","article-title":"The association between serum fatty acids and pregnancy in PCOS women undergoing ovulation induction","volume":"38","author":"Li","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12944-021-01433-9","article-title":"The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: A randomized controlled trial","volume":"20","author":"Yahay","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1080\/10408398.2018.1438349","article-title":"Comparison of blood lipid-lowering effects of olive oil and other plant oils: A systematic review and meta-analysis of 27 randomized placebo-controlled clinical trials","volume":"59","author":"Ghobadi","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.nut.2014.12.016","article-title":"Effects of extra virgin olive oil and fish oil on lipid profile and oxidative stress in patients with metabolic syndrome","volume":"31","author":"Venturini","year":"2015","journal-title":"Nutrition"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/BF03345747","article-title":"Effects of extra virgin olive oil supplementation at two different low doses on lipid profile in mild hypercholesterolemic subjects: A randomised clinical trial","volume":"32","author":"Violante","year":"2009","journal-title":"J. Endocrinol. Investig."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.sdentj.2013.09.001","article-title":"The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. A randomized clinical trial","volume":"25","author":"Ahmed","year":"2013","journal-title":"Saudi Dent. J."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"e14875","DOI":"10.1111\/iwj.14760","article-title":"Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta-analysis of randomized controlled trials","volume":"21","author":"Zamanifard","year":"2024","journal-title":"Int. Wound J."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez Macarro, M., Mart\u00ednez Rodr\u00edguez, J.P., Bernal Morell, E., P\u00e9rez-Pi\u00f1ero, S., Victoria-Montesinos, D., Garc\u00eda-Mu\u00f1oz, A.M., C\u00e1novas Garc\u00eda, F., Castillo S\u00e1nchez, J., and L\u00f3pez-Rom\u00e1n, F.J. (2020). Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk: An Exploratory Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects. Nutrients, 12.","DOI":"10.3390\/nu12051475"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7762\/cnr.2021.10.4.314","article-title":"Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial","volume":"10","author":"Haidari","year":"2021","journal-title":"Clin. Nutr. Res."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Szewczyk, K., Chojnacka, A., and G\u00f3rnicka, M. (2021). Tocopherols and Tocotrienols\u2014Bioactive Dietary Compounds; What Is Certain, What Is Doubt?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126222"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"9961","DOI":"10.2147\/IJN.S276355","article-title":"Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability","volume":"15","author":"Ng","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/1573409915666190614113733","article-title":"In Silico Docking of Vitamin E Isomers on Transport Proteins","volume":"16","author":"Zulkiflee","year":"2020","journal-title":"Curr. Comput. Aided-Drug Des."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1024\/0300-9831\/a000441","article-title":"Optimization the formulation parameters in preparation of \u03b1-tocopherol nanodispersions using low-energy solvent displacement technique","volume":"90","author":"Jaberi","year":"2020","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1039\/D4FB00044G","article-title":"Effect of storage, temperature, and pH on the preservation of the oleuropein content of olive leaf extracts","volume":"2","author":"Markhali","year":"2024","journal-title":"Sustain. Food Technol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/jsfa.12371","article-title":"Effect of heat treatment on phenolic composition and radical scavenging activity of olive leaf extract at different pH conditions: A spectroscopic and kinetic study","volume":"103","author":"Pittia","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Lemonakis, N., Mougios, V., Halabalaki, M., Dagla, I., Tsarbopoulos, A., Skaltsounis, A.-L., and Gikas, E. (2022). Effect of Supplementation with Olive Leaf Extract Enriched with Oleuropein on the Metabolome and Redox Status of Athletes\u2019 Blood and Urine\u2014A Metabolomic Approach. Metabolites, 12.","DOI":"10.3390\/metabo12020195"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Duque-Soto, C., Leyva-Jim\u00e9nez, F.J., Quirantes-Pin\u00e9, R., L\u00f3pez-Basc\u00f3n, M.A., Lozano-S\u00e1nchez, J., and Borr\u00e1s-Linares, I. (2023). Evaluation of Olive Leaf Phenolic Compounds\u2019 Gastrointestinal Stability Based on Co-Administration and Microencapsulation with Non-Digestible Carbohydrates. Nutrients, 16.","DOI":"10.3390\/nu16010093"},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Pattamatta, M., Chapple, I., and Listl, S. (2024). The value-for money of preventing and managing periodontitis: Opportunities and challenges. Periodontology.","DOI":"10.1111\/prd.12569"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.explore.2022.10.020","article-title":"Efficacy of olive leaves extract on the outcomes of hospitalized COVID-19 patients: A randomized, triple-blinded clinical trial","volume":"19","author":"Ahmadpour","year":"2023","journal-title":"Explore"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1089\/jicm.2022.0554","article-title":"Assessment of Association Between the Potential Immunomodulatory Activity and Drinking Olive Leaf Tea in the Coronavirus Disease-2019 Pandemic: An Observational Study","volume":"28","author":"Kocyigit","year":"2022","journal-title":"J. Integr. Complement. Med."}],"container-title":["Applied Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2813-0464\/3\/3\/26\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:02:06Z","timestamp":1760112126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2813-0464\/3\/3\/26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,22]]},"references-count":266,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["applbiosci3030026"],"URL":"https:\/\/doi.org\/10.3390\/applbiosci3030026","relation":{},"ISSN":["2813-0464"],"issn-type":[{"value":"2813-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,22]]}}}